LOCUS       NM_001419946            6195 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus dedicator of cytokinesis 2 (Dock2), transcript
            variant 1, mRNA.
ACCESSION   NM_001419946 XM_039087139
VERSION     NM_001419946.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6195)
  AUTHORS   Cao,B.J., Wang,X.W., Zhu,L., Zou,R.J. and Lu,Z.Q.
  TITLE     Dedicator of cytokinesis 2 silencing therapy inhibits neointima
            formation and improves blood flow in rat vein grafts
  JOURNAL   J Mol Cell Cardiol 128, 134-144 (2019)
   PUBMED   30716327
  REMARK    GeneRIF: DOCK2 silencing gene therapy effectively attenuates
            neointimal hyperplasia in vein grafts. Knock-down of DOCK2 would be
            a potential therapeutic approach for the treatment of vein graft
            failure.
REFERENCE   2  (bases 1 to 6195)
  AUTHORS   Guo,X., Shi,N., Cui,X.B., Wang,J.N., Fukui,Y. and Chen,S.Y.
  TITLE     Dedicator of cytokinesis 2, a novel regulator for smooth muscle
            phenotypic modulation and vascular remodeling
  JOURNAL   Circ Res 116 (10), e71-e80 (2015)
   PUBMED   25788409
  REMARK    GeneRIF: Identify DOCK2 as a novel regulator for smooth muscle cell
            phenotypic modulation and vascular lesion formation after vascular
            injury.
REFERENCE   3  (bases 1 to 6195)
  AUTHORS   Ippagunta,S.K., Malireddi,R.K., Shaw,P.J., Neale,G.A., Vande
            Walle,L., Green,D.R., Fukui,Y., Lamkanfi,M. and Kanneganti,T.D.
  TITLE     The inflammasome adaptor ASC regulates the function of adaptive
            immune cells by controlling Dock2-mediated Rac activation and actin
            polymerization
  JOURNAL   Nat Immunol 12 (10), 1010-1016 (2011)
   PUBMED   21892172
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6195)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 6195)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 6195)
  AUTHORS   Sanui,T., Inayoshi,A., Noda,M., Iwata,E., Oike,M., Sasazuki,T. and
            Fukui,Y.
  TITLE     DOCK2 is essential for antigen-induced translocation of TCR and
            lipid rafts, but not PKC-theta and LFA-1, in T cells
  JOURNAL   Immunity 19 (1), 119-129 (2003)
   PUBMED   12871644
REFERENCE   7  (bases 1 to 6195)
  AUTHORS   Nishihara,H., Maeda,M., Tsuda,M., Makino,Y., Sawa,H., Nagashima,K.
            and Tanaka,S.
  TITLE     DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2
            transcription
  JOURNAL   Biochem Biophys Res Commun 296 (3), 716-720 (2002)
   PUBMED   12176041
REFERENCE   8  (bases 1 to 6195)
  AUTHORS   Fukui,Y., Hashimoto,O., Sanui,T., Oono,T., Koga,H., Abe,M.,
            Inayoshi,A., Noda,M., Oike,M., Shirai,T. and Sasazuki,T.
  TITLE     Haematopoietic cell-specific CDM family protein DOCK2 is essential
            for lymphocyte migration
  JOURNAL   Nature 412 (6849), 826-831 (2001)
   PUBMED   11518968
REFERENCE   9  (bases 1 to 6195)
  AUTHORS   Nishihara,H., Kobayashi,S., Hashimoto,Y., Ohba,F., Mochizuki,N.,
            Kurata,T., Nagashima,K. and Matsuda,M.
  TITLE     Non-adherent cell-specific expression of DOCK2, a member of the
            human CDM-family proteins
  JOURNAL   Biochim Biophys Acta 1452 (2), 179-187 (1999)
   PUBMED   10559471
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 24, 2023 this sequence version replaced XM_039087139.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.39762.1,
                                           SRR26643284.13018.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               JAXUCZ010000010.1  19748858-19748969   c
            113-196             JAXUCZ010000010.1  19719810-19719893   c
            197-237             JAXUCZ010000010.1  19703111-19703151   c
            238-293             JAXUCZ010000010.1  19702048-19702103   c
            294-390             JAXUCZ010000010.1  19701187-19701283   c
            391-539             JAXUCZ010000010.1  19696957-19697105   c
            540-675             JAXUCZ010000010.1  19690849-19690984   c
            676-830             JAXUCZ010000010.1  19688504-19688658   c
            831-912             JAXUCZ010000010.1  19684067-19684148   c
            913-1048            JAXUCZ010000010.1  19679386-19679521   c
            1049-1124           JAXUCZ010000010.1  19677910-19677985   c
            1125-1201           JAXUCZ010000010.1  19677054-19677130   c
            1202-1327           JAXUCZ010000010.1  19676310-19676435   c
            1328-1452           JAXUCZ010000010.1  19674865-19674989   c
            1453-1551           JAXUCZ010000010.1  19668728-19668826   c
            1552-1624           JAXUCZ010000010.1  19665452-19665524   c
            1625-1728           JAXUCZ010000010.1  19665234-19665337   c
            1729-1912           JAXUCZ010000010.1  19662167-19662350   c
            1913-2010           JAXUCZ010000010.1  19661947-19662044   c
            2011-2100           JAXUCZ010000010.1  19660165-19660254   c
            2101-2201           JAXUCZ010000010.1  19658881-19658981   c
            2202-2336           JAXUCZ010000010.1  19657938-19658072   c
            2337-2445           JAXUCZ010000010.1  19628048-19628156   c
            2446-2516           JAXUCZ010000010.1  19609853-19609923   c
            2517-2623           JAXUCZ010000010.1  19607522-19607628   c
            2624-2772           JAXUCZ010000010.1  19571697-19571845   c
            2773-2868           JAXUCZ010000010.1  19543765-19543860   c
            2869-2967           JAXUCZ010000010.1  19418669-19418767   c
            2968-3062           JAXUCZ010000010.1  19416296-19416390   c
            3063-3141           JAXUCZ010000010.1  19406203-19406281   c
            3142-3242           JAXUCZ010000010.1  19398811-19398911   c
            3243-3301           JAXUCZ010000010.1  19398662-19398720   c
            3302-3450           JAXUCZ010000010.1  19386662-19386810   c
            3451-3536           JAXUCZ010000010.1  19377716-19377801   c
            3537-3693           JAXUCZ010000010.1  19372067-19372223   c
            3694-3734           JAXUCZ010000010.1  19370376-19370416   c
            3735-3825           JAXUCZ010000010.1  19366334-19366424   c
            3826-3945           JAXUCZ010000010.1  19365349-19365468   c
            3946-4035           JAXUCZ010000010.1  19362168-19362257   c
            4036-4140           JAXUCZ010000010.1  19360622-19360726   c
            4141-4282           JAXUCZ010000010.1  19358014-19358155   c
            4283-4364           JAXUCZ010000010.1  19353473-19353554   c
            4365-4449           JAXUCZ010000010.1  19352357-19352441   c
            4450-4536           JAXUCZ010000010.1  19351578-19351664   c
            4537-4713           JAXUCZ010000010.1  19344171-19344347   c
            4714-4797           JAXUCZ010000010.1  19342762-19342845   c
            4798-4935           JAXUCZ010000010.1  19337391-19337528   c
            4936-5063           JAXUCZ010000010.1  19336090-19336217   c
            5064-5232           JAXUCZ010000010.1  19335161-19335329   c
            5233-5353           JAXUCZ010000010.1  19334075-19334195   c
            5354-5496           JAXUCZ010000010.1  19332985-19333127   c
            5497-6195           JAXUCZ010000010.1  19331412-19332110   c
FEATURES             Location/Qualifiers
     source          1..6195
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..6195
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /note="dedicator of cytokinesis 2"
                     /db_xref="GeneID:360509"
                     /db_xref="RGD:1564189"
     exon            1..112
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..5559
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dedicator of cytokinesis protein 2"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 2 isoform 1"
                     /protein_id="NP_001406875.1"
                     /db_xref="GeneID:360509"
                     /db_xref="RGD:1564189"
                     /translation="MAPWRKTDKERHGVAIYNFQGSGAQHLTLQIGDVVRIQETCGDW
                     YRGYLIKHKMSQGIFPTSFIHLKEVTVEKRRNIENIIPAEIPLAQEVATTLWEWGSIW
                     KQLYVASKKERFLQVQSMMYDLMEWRSQLLSGTLPKDELKELKQKVTSKIDFGNKILE
                     LDLIVRDEDGNILDPDNTSVISLFHAHEEATHKITERIKEETCKDQPDYGIYSRISSS
                     PTHSLYVFVRNFVCRIGEDAELFMSLYDPHKQMVISENYLVRWGSKGFPKEIEMLNNL
                     KVVFTDLGNKDLNRDKIFLICQIVRIGKMDLKDINVKKCTQGLRRPFGVAVMDITDII
                     KGKAESDEEKQHFIPFHPVSAENDFLHSLLGKVIASKGDSGGQGLWVTMKMLVGDIIQ
                     IRKDYPHLVDRTTVVARKLGFPEIIMPGDVRNDIYITLLQGDFDKYTKTTQRNVEVIM
                     CVCTEDGNVLPNAICVGAGDKAMNEYHSVVYYQVKQPRWMETVKVAVPIEDMQRIHLR
                     FMFRHRSSLESKDKGEKNFAMSYVKLMKEDGTTLQDGYHELVVLKGDSKKMEDASAYL
                     TLPSYRYHVENKGATLSRSSSSVGGLSVSSRDVFSISILVCSTKLTQNVGLLGLLKWR
                     MRPQLLQENLEKLKIVDGEEVVKFLQDTLDALFNIMMEHAQSNEYDILVFDALIYIIG
                     LIADRKFQHFNTVLEAYIQQHFSATLAYKKLMTVLKTYLDTSSRGEQCEPILRTLKAL
                     EYVFKFIVRSRRLFSQLYEGKEQMEFEESMRRLFESINNLMKSQHKTTILLQVAALKY
                     IPSVLHDVETVFDAKLLSQLLYEFYTCIPPVKLQKQKVQSMNEIVQSNLFKKQECRDI
                     LLPVITKELKELLEQRDDGQHQALEKKYCVELLNSILEVLSCQDAAFTYDHIQEIMVQ
                     LLRTVNRTVITMGRDHSLISHFVACMTAILDQMGDQHYSFYIETFQTSSDLVDFLMET
                     FIMFKDLIGKNVYPGDWIAMSMVQNRVFLRAINKFAETMNQKFLEHTSFEFQLWNNYF
                     HLAVAFITQDSLQLEQFTHAKYNKILNKYGDMRRLVGFSIRDMWYKLGQNKICFIPGM
                     VGPILEMTLIPEAELRKATIPIFFDMMLCEYQRTGAFKKFENEIILKLDHEVEGGRGD
                     EQYMQLLESILMECAAEHPTIAKSVENFVSLVKGLLEKLLDYRGVMTDESKDNRMSCT
                     VNLLNFYKDHNREEMYIRYLYKLRDLHLDCDNYTEAAYTLLLHTWLLKWSDEQCASQV
                     MQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEVFDYELLSQ
                     NLTQQAKFYENIMKILRPKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQMQL
                     LSQFPNAEKMNTTSAPGDDVKNAPGQYIQCFTVQPVLDEHPRFKNKPVPDQIINFYKS
                     NYVQTFHYSRPVRRGTVDPENEFASMWIERTSFLTAYKLPGILRWFEVVHMSQTTISP
                     LENAIETMSTANEKILMMINQYQSDESLPINPLSMLLNGIVDPAVMGGFAKYEKAFFT
                     EEYSREHPEDQDKLSRLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLK
                     MKVEKEYGVREMPDFDDRRLGRPRSMLRSYRQMSIISLASMNSDCSTPSKVVSESFDL
                     ESVTPKTPKVEEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESELKRLSRKH
                     EFMSDTNLSEHATVPTRVSVLSQMSFASQSMPTIPALTLSVAGVPGLDEASTSPRLSQ
                     TFFQVSDSDKKTLKKKKVNQFFKTMLASKSGEESKQIPDILSTDM"
     exon            113..196
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            197..237
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            238..293
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            294..390
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..539
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..675
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            676..830
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..912
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1048
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1124
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1201
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1327
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1452
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1551
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1624
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1728
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1912
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2010
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2100
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2201
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2336
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2445
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2516
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2623
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2772
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2868
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..2967
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3062
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3063..3141
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3242
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3301
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3302..3450
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3451..3536
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3537..3693
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3694..3734
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3735..3825
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..3945
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3946..4035
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4036..4140
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4141..4282
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4283..4364
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4365..4449
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4450..4536
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4537..4713
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4714..4797
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4798..4935
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4936..5063
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            5064..5232
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            5233..5353
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            5354..5496
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
     exon            5497..6195
                     /gene="Dock2"
                     /gene_synonym="AABR07029272.1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggcgccta accaccccag ccagcttctt cactagagga caggaggctc tcaaggctcc
       61 ggtctagcca tggccccctg gcgcaaaact gacaaggagc ggcacggagt ggccatctac
      121 aacttccaag gcagcggagc ccagcacctc actctacaga ttggcgatgt ggttcgaata
      181 caggagacct gtggagactg gtacagaggg tacctcataa agcataaaat gtcacagggc
      241 atttttccta catcctttat ccatctcaag gaagtgacag tggagaagag aaggaacata
      301 gaaaatatca tccctgcaga gatccctctg gcacaagaag tggcaacgac tctctgggag
      361 tggggaagca tttggaagca gctctatgtg gccagcaaaa aggaacgctt cctccaagtg
      421 cagtccatga tgtacgacct gatggaatgg cgctcccagc tcctctcggg aacactaccc
      481 aaggatgagt tgaaggaact gaagcagaaa gtcacatcta agatcgactt tggcaacaaa
      541 atccttgagc tggatctcat tgtccgagat gaagacggaa acatattgga ccctgataat
      601 accagcgtca tcagcttgtt tcatgctcac gaggaagcaa ctcacaaaat cacggagcgc
      661 atcaaagaag aaacgtgcaa agaccagcca gattatggga tttattcgcg aatctcctca
      721 tcccccaccc acagcctcta cgtctttgtg agaaactttg tgtgccgaat tggggaggat
      781 gctgaactct tcatgtctct ctatgacccc cacaagcaaa tggtcataag tgagaactat
      841 ctggtgcgat ggggcagcaa aggattccca aaggaaatcg agatgctcaa taacctgaag
      901 gtcgtcttca cggatcttgg aaacaaagac ctcaacaggg ataagatttt cttgatctgt
      961 caaatagtcc gaatcgggaa gatggatctt aaggacataa atgtcaagaa gtgcacccag
     1021 gggctgagga gaccctttgg ggtggcagta atggacatca ccgatatcat caagggcaag
     1081 gcagagagtg atgaagagaa gcaacatttt attccctttc acccggtctc agctgagaat
     1141 gatttccttc acagccttct gggcaaagtc atagcatcca agggcgacag tggagggcaa
     1201 ggcctttggg tgaccatgaa gatgctggtg ggtgacatca ttcagatccg caaggactac
     1261 ccacacttag tggacaggac caccgtggta gcccggaagc tgggcttccc agagatcatt
     1321 atgccagggg atgtcaggaa cgacatctac atcactctct tacaaggtga ctttgacaag
     1381 tacaccaaga ccacgcagcg gaacgtggaa gtgattatgt gtgtgtgcac agaggatggc
     1441 aatgtcttac ctaatgcaat ttgtgtggga gccggggaca aggccatgaa cgagtatcac
     1501 tcagttgtgt actaccaagt caaacagcca cgctggatgg aaacagtcaa ggtggctgtc
     1561 cctattgaag acatgcagag gatccatctg cggttcatgt tccgtcaccg gtcgtcactg
     1621 gaatctaaag ataaaggaga aaagaacttt gctatgtcct atgtgaagct catgaaagaa
     1681 gacggaacca ctctgcagga cggataccac gagttggtgg ttcttaaggg agacagcaag
     1741 aaaatggaag atgccagcgc ttacttgaca cttccttctt atcgatacca tgtggaaaac
     1801 aagggagcca ctctgagccg gagctccagc agtgttgggg gcctttctgt cagctcccgg
     1861 gatgtgttct ccatttccat cctggtgtgt tccacaaagc tcacgcagaa cgtgggtttg
     1921 cttggtttgc tgaagtggcg tatgaggccg caactactcc aggagaatct agagaagctg
     1981 aagattgtgg acggagagga agtagtgaag ttcctccagg acactctgga tgccctcttc
     2041 aacatcatga tggagcatgc tcagagtaac gagtatgaca tcctcgtctt tgatgctttg
     2101 atctacataa taggactcat tgcagaccgg aaattccagc attttaacac cgtgttggag
     2161 gcttacatcc aacagcattt cagtgctacc ttggcctaca agaaattaat gacggtgctg
     2221 aagacttact tggatacctc cagtaggggc gagcagtgtg agcccatcct cagaactctc
     2281 aaggctttgg aatacgtgtt caagttcatt gtccggtcca ggagattatt ctcacagctt
     2341 tacgaaggca aagagcagat ggagtttgaa gaatccatga gacggctctt cgaatctatc
     2401 aacaacctga tgaaaagtca gcacaagacc accattcttt tgcaggtggc agctttgaaa
     2461 tacatcccat cagtccttca cgatgtggaa acagtctttg atgccaagtt gctcagccag
     2521 ctcctgtatg agttctacac ttgcatccct cccgtgaagc tgcagaagca gaaggttcag
     2581 tccatgaacg agatcgtgca gagcaacctc ttcaaaaagc aagaatgccg ggacattctg
     2641 cttcctgtca tcaccaaaga gctgaaggag ctgctggagc agagggacga tgggcagcac
     2701 caggccttgg agaaaaagta ctgtgtggaa ctgctcaaca gcatcctaga ggtcctcagc
     2761 tgtcaggacg cggccttcac ttatgaccac atccaggaga tcatggttca gctgcttcgc
     2821 acagtgaaca ggacggtcat cacgatgggg cgagatcatt ctctgattag tcacttcgtg
     2881 gcatgcatga cagccatctt ggaccagatg ggcgaccaac actattcctt ttatattgag
     2941 accttccaga ccagctcaga ccttgtggac ttcttgatgg aaacattcat catgttcaag
     3001 gacctcattg ggaagaatgt gtaccctgga gactggatag ccatgagcat ggtccagaac
     3061 agggtcttcc tcagagctat caacaagttt gcagaaacca tgaaccagaa gtttctagaa
     3121 cacacaagtt ttgagttcca gctgtggaac aactattttc atctggcagt ggcttttatc
     3181 actcaggact ctctacagct ggagcagttc acgcacgcta agtacaacaa aatcctgaat
     3241 aagtatgggg acatgagacg gctcgtggga ttctccatcc gtgatatgtg gtacaagctt
     3301 ggccagaaca aaatctgctt catcccaggc atggtgggac ctatattaga gatgacactt
     3361 atcccagagg ctgagctcag gaaggccacc atccccatct tcttcgacat gatgctgtgc
     3421 gaatatcaaa ggactggggc tttcaaaaag tttgaaaatg aaatcatcct gaagctggac
     3481 catgaggtgg aaggaggccg gggggatgag cagtacatgc agctgctgga gtccatcctc
     3541 atggagtgcg cagcggaaca cccgaccatt gccaagtcgg tggagaactt cgtgagcttg
     3601 gtcaaagggc tgctggagaa gctgctggat taccggggag tgatgacgga tgagagcaaa
     3661 gacaaccgta tgagctgcac cgtgaatttg ctgaatttct acaaagatca caaccgggag
     3721 gagatgtaca ttagatacct gtataaattg cgtgaccttc acctggactg tgacaactac
     3781 acagaggctg cctacacact cctcctccac acctggcttc tcaagtggtc agatgagcag
     3841 tgtgcgtcac aggtcatgca gacaggccag cagcaccctc agacccaccg gcagctgaag
     3901 gagacactct atgagaccat tataggctac tttgacaaag gaaagatgtg ggaggaggcc
     3961 atcagcctgt gcaaggagct ggcggaacag tatgagatgg aggtctttga ctacgagctg
     4021 ctcagccaga acctgaccca gcaggccaag ttctatgaaa acatcatgaa gatcctcaga
     4081 cccaaaccag actactttgc cgttggatac tatggccagg ggttcccctc ctttctacgg
     4141 aacaaagtgt tcatctaccg agggaaggag tacgagcgga gagaggactt ccagatgcag
     4201 cttttgagcc agttccccaa cgcagaaaag atgaatacaa cctctgcccc aggagacgat
     4261 gtgaagaacg ccccaggcca gtacatccaa tgtttcactg tgcagcctgt cctggatgaa
     4321 caccccaggt tcaagaacaa accagtgcct gaccagatca taaactttta caagtccaat
     4381 tatgtgcaaa cattccacta ctccaggcct gtgcgcaggg gcacggtaga cccagaaaac
     4441 gagtttgctt ccatgtggat tgagagaact tcgttcctga ccgcgtacaa gctgcccggc
     4501 atcctgcgct ggttcgaggt agttcacatg tctcagacca caattagtcc tctggagaat
     4561 gccatcgaga ccatgtccac agccaatgag aagatcctga tgatgataaa ccagtaccag
     4621 agtgatgaaa gcctccccat caaccctctc tccatgctcc tcaacgggat cgtggaccct
     4681 gctgtcatgg gaggcttcgc caagtatgag aaggccttct tcactgaaga gtatagcagg
     4741 gagcacccag aggaccagga caagctgagc cgcctcaagg acctaattgc atggcagatc
     4801 cccttcctgg gagcaggaat taagattcac gagaaaaggg tgtcagacaa cctgcgcccc
     4861 ttccatgacc ggatggagga gtgcttcaag aacctgaaaa tgaaggtgga aaaggagtat
     4921 ggtgtccgag agatgcctga ctttgacgac cggagactgg gccgccccag gtccatgctg
     4981 cgttcctata ggcagatgtc catcatctcc ctggcctcca tgaattctga ctgcagcacc
     5041 cccagcaagg tcgtctcaga aagctttgat ctagagtcag tgacacccaa gactcccaaa
     5101 gtggaggagg agcccatctc cccagggagc actctgccag aggtcaagct gaggagatcc
     5161 aagaaaagga ccaagaggag cagcgtggtg tttgcagacg agaaggcagc agcggagtca
     5221 gaactgaagc ggctttctag aaagcacgag ttcatgagtg acaccaatct ctcggagcat
     5281 gcaaccgtcc ccaccagggt gtctgtcctc tctcagatga gttttgccag ccagtccatg
     5341 cccaccatcc cagccctcac actctcggtg gcaggcgtgc ctgggttgga tgaggccagc
     5401 acatctcccc gcctgagtca gaccttcttc caagtctcag acagtgacaa gaagaccctg
     5461 aaaaagaaga aagtcaatca gttcttcaag accatgctgg ctagcaagtc gggtgaagaa
     5521 agcaagcaga tcccagacat cctgtccaca gacatgtgag gcactgctga gccaagccct
     5581 gtggagttcc agcagggaag catgcacatg accttggagt tccacaagga gacaaggctt
     5641 taaaagagac agatgatccc aaggggcccc cagaactcaa gtgatgacaa gcctcgcatc
     5701 ttctgtggcc accaccaaca gtgatggatg gctcaacaga caaagactca ccaccaccac
     5761 caccaccacc accaccacca ccaccaccac caccaccatc accatggatt cttggacttc
     5821 aaggagccag ccagtgctgg atgaatgttc tccccagcat tcaagggaca caggtcataa
     5881 ctcaaattca cagctaggag gagctgtctt ttgttttctt tcctaagtct cagcacttga
     5941 aagaactgat ttaaaatgtt ttgttttggg gctgaggatt tagctcagtg gtagagcgct
     6001 tacctaggaa gcacaaggcc ctgggttcgg tccccagctc cgaaaaaaag aaccaaaaaa
     6061 aaaaatgttt tgttttcgat taacattttt atacttttac attttttttt aaataagccc
     6121 cttgctactc catcaccttc aaactgccgc tcttccttac cgtcattaaa aaaatgatgc
     6181 catggctcaa atgaa
//
