LOCUS       NM_001143858            6785 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Rattus norvegicus dedicator of cyto-kinesis 1 (Dock1), mRNA.
ACCESSION   NM_001143858 XM_219424
VERSION     NM_001143858.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6785)
  AUTHORS   Ubba,V., Soni,U.K., Chadchan,S., Maurya,V.K., Kumar,V., Maurya,R.,
            Chaturvedi,H., Singh,R., Dwivedi,A. and Jha,R.K.
  TITLE     RHOG-DOCK1-RAC1 Signaling Axis Is Perturbed in DHEA-Induced
            Polycystic Ovary in Rat Model
  JOURNAL   Reprod Sci 24 (5), 738-752 (2017)
   PUBMED   27662902
  REMARK    GeneRIF: RHOG can mediate signaling through downstream effectors
            DOCK1 and RAC1 during ovarian follicular development (theca and
            granulosa cells and oocyte), but dehydroepiandrosterone
            downregulated them in the polycystic ovarian syndrome ovary.
REFERENCE   2  (bases 1 to 6785)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   3  (bases 1 to 6785)
  AUTHORS   Liu,X.L., Li,G., Wang,Z.H., Zhao,W.J. and Wang,L.P.
  TITLE     Increased expression of Dock180 protein in the noninfarcted
            myocardium in rats
  JOURNAL   J Chin Med Assoc 76 (3), 164-168 (2013)
   PUBMED   23497970
  REMARK    GeneRIF: Dock180 protein is expressed in the myocardium in rats.
            Furthermore, its expression is significantly increased in the
            noninfarcted myocardium of the peri-infarct zones.
REFERENCE   4  (bases 1 to 6785)
  AUTHORS   Yan,A., Li,G., Zhang,X., Zhu,B. and Linghu,H.
  TITLE     Pro-survival effect of Dock180 overexpression on rat-derived H9C2
            cardiomyocytes
  JOURNAL   Med Sci Monit Basic Res 19, 12-19 (2013)
   PUBMED   23314417
  REMARK    GeneRIF: Dock180 could act as a pro-survival molecule in H9C2
            cardiomyocytes via activation of its downstream pro-survival
            signaling molecule, AKT.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6785)
  AUTHORS   Kim,J.Y., Oh,M.H., Bernard,L.P., Macara,I.G. and Zhang,H.
  TITLE     The RhoG/ELMO1/Dock180 signaling module is required for spine
            morphogenesis in hippocampal neurons
  JOURNAL   J Biol Chem 286 (43), 37615-37624 (2011)
   PUBMED   21900250
  REMARK    GeneRIF: The RhoG/ELMO1/Dock180 signaling module is required for
            spine morphogenesis in hippocampal neurons.
REFERENCE   6  (bases 1 to 6785)
  AUTHORS   Sanders,M.A., Ampasala,D. and Basson,M.D.
  TITLE     DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell
            spreading and migration on collagen IV
  JOURNAL   J Biol Chem 284 (1), 27-35 (2009)
   PUBMED   19004829
REFERENCE   7  (bases 1 to 6785)
  AUTHORS   Kobashigawa,Y., Sakai,M., Naito,M., Yokochi,M., Kumeta,H.,
            Makino,Y., Ogura,K., Tanaka,S. and Inagaki,F.
  TITLE     Structural basis for the transforming activity of human
            cancer-related signaling adaptor protein CRK
  JOURNAL   Nat Struct Mol Biol 14 (6), 503-510 (2007)
   PUBMED   17515907
REFERENCE   8  (bases 1 to 6785)
  AUTHORS   Pratt,S.J., Epple,H., Ward,M., Feng,Y., Braga,V.M. and
            Longmore,G.D.
  TITLE     The LIM protein Ajuba influences p130Cas localization and Rac1
            activity during cell migration
  JOURNAL   J Cell Biol 168 (5), 813-824 (2005)
   PUBMED   15728191
REFERENCE   9  (bases 1 to 6785)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   10 (bases 1 to 6785)
  AUTHORS   Brugnera,E., Haney,L., Grimsley,C., Lu,M., Walk,S.F.,
            Tosello-Trampont,A.C., Macara,I.G., Madhani,H., Fink,G.R. and
            Ravichandran,K.S.
  TITLE     Unconventional Rac-GEF activity is mediated through the
            Dock180-ELMO complex
  JOURNAL   Nat Cell Biol 4 (8), 574-582 (2002)
   PUBMED   12134158
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 8, 2009 this sequence version replaced XM_219424.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.3973.1,
                                           SRR26643299.4894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               JAXUCZ010000001.1  198897045-198897208
            165-248             JAXUCZ010000001.1  198953144-198953227
            249-289             JAXUCZ010000001.1  198959478-198959518
            290-345             JAXUCZ010000001.1  198962523-198962578
            346-442             JAXUCZ010000001.1  198965992-198966088
            443-591             JAXUCZ010000001.1  198969587-198969735
            592-727             JAXUCZ010000001.1  198972748-198972883
            728-885             JAXUCZ010000001.1  198973504-198973661
            886-967             JAXUCZ010000001.1  198974973-198975054
            968-1103            JAXUCZ010000001.1  198975446-198975581
            1104-1176           JAXUCZ010000001.1  198996908-198996980
            1177-1256           JAXUCZ010000001.1  199000423-199000502
            1257-1382           JAXUCZ010000001.1  199004561-199004686
            1383-1507           JAXUCZ010000001.1  199008394-199008518
            1508-1606           JAXUCZ010000001.1  199009767-199009865
            1607-1679           JAXUCZ010000001.1  199010742-199010814
            1680-1783           JAXUCZ010000001.1  199015998-199016101
            1784-1967           JAXUCZ010000001.1  199016723-199016906
            1968-2065           JAXUCZ010000001.1  199021688-199021785
            2066-2155           JAXUCZ010000001.1  199026346-199026435
            2156-2256           JAXUCZ010000001.1  199026759-199026859
            2257-2391           JAXUCZ010000001.1  199033664-199033798
            2392-2500           JAXUCZ010000001.1  199050674-199050782
            2501-2571           JAXUCZ010000001.1  199096572-199096642
            2572-2678           JAXUCZ010000001.1  199099385-199099491
            2679-2806           JAXUCZ010000001.1  199119912-199120039
            2807-2902           JAXUCZ010000001.1  199122090-199122185
            2903-3004           JAXUCZ010000001.1  199228523-199228624
            3005-3099           JAXUCZ010000001.1  199235351-199235445
            3100-3178           JAXUCZ010000001.1  199315390-199315468
            3179-3279           JAXUCZ010000001.1  199319649-199319749
            3280-3338           JAXUCZ010000001.1  199328905-199328963
            3339-3487           JAXUCZ010000001.1  199337595-199337743
            3488-3573           JAXUCZ010000001.1  199347058-199347143
            3574-3730           JAXUCZ010000001.1  199347328-199347484
            3731-3771           JAXUCZ010000001.1  199352380-199352420
            3772-3862           JAXUCZ010000001.1  199353774-199353864
            3863-3982           JAXUCZ010000001.1  199356898-199357017
            3983-4072           JAXUCZ010000001.1  199372998-199373087
            4073-4177           JAXUCZ010000001.1  199373844-199373948
            4178-4319           JAXUCZ010000001.1  199378266-199378407
            4320-4398           JAXUCZ010000001.1  199378530-199378608
            4399-4483           JAXUCZ010000001.1  199380172-199380256
            4484-4570           JAXUCZ010000001.1  199384135-199384221
            4571-4747           JAXUCZ010000001.1  199385795-199385971
            4748-4831           JAXUCZ010000001.1  199386812-199386895
            4832-4969           JAXUCZ010000001.1  199391921-199392058
            4970-5115           JAXUCZ010000001.1  199398144-199398289
            5116-5314           JAXUCZ010000001.1  199403288-199403486
            5315-5468           JAXUCZ010000001.1  199407050-199407203
            5469-5617           JAXUCZ010000001.1  199408326-199408474
            5618-6785           JAXUCZ010000001.1  199412469-199413636
FEATURES             Location/Qualifiers
     source          1..6785
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..6785
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /note="dedicator of cyto-kinesis 1"
                     /db_xref="GeneID:309081"
                     /db_xref="RGD:1566072"
     exon            1..164
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..5713
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /note="dedicator of cytokinesis protein 1-like"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 1"
                     /protein_id="NP_001137330.1"
                     /db_xref="GeneID:309081"
                     /db_xref="RGD:1566072"
                     /translation="MTRWVPTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEG
                     WYRGYTLRKKSKKGIFPASYIHLKEAIVEGKGQHETVIPGDLPLIQEVTTTLREWSTI
                     WRQLYVQDNREMFRSVRHMIYDLIEWRSQILSGTLPQDELKELKKKVTAKIDYGNRIL
                     DLDLVVRDEDGNILDPELTSTISLFRAHEVASKQVEERLQEEKSQKQNMDINRQAKFA
                     ATPSLALFVNLKNVVCKIGEDAEVLMSLYDPVESKFISENYLVRWSSSGLPKDIDRLH
                     NLRAVFTDLGSKDLKREKISFVCQIVRVGRMELRDSNTRKLTSGLRRPFGVAVMDVTD
                     IINGKVDDEDKQHFIPFQPVAGENDFLQTVINKVIAAKEVNHKGQGLWVTLKLLPGDI
                     HQIRKEFPHLVDRTTAVARKTGFPEIIMPGDVRNDIYVTLVQGDFDKGSKTTAKNVEV
                     TVSVYDEDGKRLEHVIFPGAGDEAISEYKSVIYYQVKQPRWFETLKVAIPIEDVNRSH
                     LRFTFRHRSSQDSKDKSEKIFALAFVKLMRYDGTTLRDGEHDLIVYKAEAKKLEDAAT
                     YLSLPSTKGELEEKGHSATGKGMQSLGSCTISKDSFQISTLVCSTKLTQNVDLLGLLK
                     WRSNTNLLQQNLRQLMKVDGGEVVKFLQDTLDALFNIMMENSESETFDTLVFDALVFI
                     IGLIADRKFQHFNPVLETYIKKHFSATLAYTKLTKVLRTYVASAEKPGINEQLYKAIK
                     ALEYIFKFIVRSRVLFNQLYENKGEADFVESLLQLFRSINDMMSSMSELTVRVKGAAL
                     KYLPTIVNDVKLVFDPKELSKMFTEFILNVPVGLLTVQKLYCLIEIVHSDLFTQHDCR
                     EILLPMMTDQLKYHLERQEDLEACCQLLSNILEVLYRKDVGPTQRHVQIIMEELLRTV
                     NRTVISMGRDSELIGNFVACMTAILRQMEDFHYAHLIKTFGKMRTDVVDFLMETFIMF
                     KNLIGKNVYPFDWVIMNTMQNKVFLRAINQYADMLNKKFLDQANFELQLWNNYFHLAV
                     AFLTQESLQLENFSSAKRAKILNKYGDMRRQIGFEIRDMWYNLGQHKIKFIPEMVGPI
                     LEMTLIPETELRKATLPIFFDMMQCEFHSTRSFQMFENEIITKLDHEVEGGRGDEQYK
                     VLFDKILLEHCRKHKYLAKTGETFVKLVVRLMERLLDYRTIMHDENKDNRMSCTVNVL
                     NFYKEIEREEMYIRYLYKLCDLHKECDNYTEAAYTLLLHAKLLKWSEDACAAHLIQRD
                     GFQATTQGQLKEQLYQEIIHYFDKGKMWEEAIALGKELAEQYETELFDYEQLSELLKK
                     QAQFYENIVKVIRPKPDYFAVGYYGQGFPSFLRGKVFIYRGKEYERREDFEARLLTQF
                     PNAEKMKTTSPPGDDIKTSPGQYIQCFTVKPKLDLPPKFHRPVSEQIVSFYRVNEVQR
                     FEYSRPIRKGEKNPDNEFANMWIERTIYTTAYKLPGILRWFEVKSVFMVEISPLENAI
                     ETMQLTNDKISSMIQQHLDDPGLPINPLSMLLNGIVDPAVMGGFANYEKAFFTDRYLQ
                     EHPEAHGQIEKLKDLIAWQIPFLAEGIRIHGDKVTEALRPFHERMEACFKQLKEKVEK
                     QYGVRTMPSGLDDRRGSRPRSMVRSFTMPSSSRPLSVASVSSFSSDSTPSRPGSDGFA
                     LEPLLPKKMHSRSQDKLDKDDPDKEKKDKKKEKRNSKHQEIFDKEFKPADSSLQQSEA
                     VILSETISPLRPQRPKSQVINVIGSERRFSVSPASPCSQPTPPPVTPRAKLSFSIQPN
                     LELNGMMGMDVADVPPPLPLKGNMADYGNLMENQDLMGSPTSPPPPPQRQQPPPLPSK
                     TPPPPPPKTTRKQTSVDSGIVQ"
     exon            165..248
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            249..289
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            290..345
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            346..442
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            443..591
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            592..727
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            728..885
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            886..967
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1103
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1176
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1256
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1382
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1507
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1606
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1679
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1783
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1967
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2065
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2155
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2256
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2391
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2500
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2571
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2678
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2806
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2902
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            2903..3004
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3099
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            3100..3178
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            3179..3279
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3338
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            3339..3487
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            3488..3573
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            3574..3730
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            3731..3771
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            3772..3862
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            3863..3982
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            3983..4072
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            4073..4177
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            4178..4319
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            4320..4398
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            4399..4483
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            4484..4570
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            4571..4747
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            4748..4831
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            4832..4969
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            4970..5115
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            5116..5314
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            5315..5468
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            5469..5617
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
     exon            5618..6785
                     /gene="Dock1"
                     /gene_synonym="RGD1566072"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccatcctgtc gcggcgggga aggaatggaa gatggcggcc taggcgcaca gtttcctgcc
       61 cgagcagcgg cggcggcagc ggcagcggcg gctccagtgg gctgcggcca gcgccaccat
      121 gacgcgctgg gtccccacca aacgagagga gaagtacggc gtggcttttt ataactacga
      181 tgccagggga gctgatgaat tgtccttaca aataggagac acggtgcaca tcctagaaac
      241 ttatgaaggg tggtacagag gctacacctt aaggaaaaag tctaaaaagg gtatatttcc
      301 tgcttcgtat attcatctta aagaagccat tgttgaagga aaagggcagc atgaaactgt
      361 catccccggg gacctccccc tcatacagga agtcaccaca acgctccgag agtggtctac
      421 catctggaga caactttatg tgcaagataa tagggagatg tttcgaagtg ttcggcacat
      481 gatctatgac cttattgagt ggcggtcgca gattctttct ggaactctgc cccaggatga
      541 gctcaaagag ctgaagaaga aggtcacagc caaaatcgat tatggaaaca gaattcttga
      601 tttggacttg gtggtgaggg atgaagatgg gaacattttg gatccggaac taactagcac
      661 catcagtctc ttccgagcac atgaagttgc ttctaaacaa gtagaagaga gactgcaaga
      721 ggagaaatct caaaaacaga atatggatat caacagacaa gccaagttcg cagccacccc
      781 atctctggcc ttgtttgtta acctcaaaaa tgtggtttgt aaaataggag aagatgccga
      841 agtcctcatg tctctttatg accctgtgga gtccaaattc atcagtgaga actacctggt
      901 ccgctggtca agttcaggat taccaaaaga cattgatagg ttacataact tgcgtgcggt
      961 gtttacggat ctggggagca aagacctgaa aagggagaaa attagtttcg tctgccagat
     1021 tgtccgagtt ggtcgtatgg agctgaggga cagcaacacg aggaaactga cttcggggct
     1081 ccggcgacct tttggcgtgg ctgtgatgga cgtaacagac atcataaacg ggaaagtgga
     1141 cgatgaagat aaacagcact tcatcccctt ccagccggtg gcaggggaga atgacttcct
     1201 tcaaactgtc ataaacaaag tcattgcagc caaagaagtc aaccacaagg gacaaggttt
     1261 gtgggtaacc ttgaaattac ttcctggaga catccatcag attcggaagg agtttcctca
     1321 cttggtggac aggaccacag ctgtggcccg caagactggg tttccagaga tcatcatgcc
     1381 aggtgatgtt cgaaatgata tctatgtgac attagttcaa ggggattttg ataaaggcag
     1441 taaaacaacc gcgaagaatg tggaggtgac ggtgtctgtc tatgatgaag atgggaagcg
     1501 attggagcac gtgatcttcc ccggtgctgg cgacgaggcc atctctgagt acaaatcagt
     1561 gatttattac caagtgaagc agcctcgttg gttcgagacc cttaaggtgg ccatccccat
     1621 cgaggacgtg aaccggagtc accttcgatt taccttccgc catagatcct ctcaggactc
     1681 caaggataaa tctgagaaga tcttcgcact ggcctttgtg aagctgatga gatatgatgg
     1741 gaccaccctg agagacgggg agcatgacct tattgtctac aaggctgaag ccaaaaagct
     1801 ggaagacgct gccacatatt tgagcctccc tagtaccaag ggagagttgg aagaaaaggg
     1861 ccactcagcc acaggcaaag gaatgcagag tcttgggagt tgcaccatca gtaaagattc
     1921 tttccagatc tctacgctgg tgtgctccac caaactgacc cagaatgtgg acctcctggg
     1981 gctgttgaag tggagatcca acaccaacct tctgcagcag aacttgagac agttgatgaa
     2041 ggtggatggt ggcgaagtgg taaagttcct gcaggacacc ttggatgccc tcttcaacat
     2101 catgatggag aactccgaga gtgagacgtt tgataccttg gtgtttgatg cgctggtctt
     2161 tatcattgga ctaatcgcgg ataggaagtt tcagcatttt aatcctgttt tggagactta
     2221 cattaagaaa cacttcagtg cgacattagc ctacacgaaa ctgaccaagg tgttaaggac
     2281 ttatgtggcc agcgctgaaa aaccgggaat caacgagcag ctgtacaaag ccataaaagc
     2341 cttggagtac atcttcaagt tcatagtgcg ctcacgggta ctgttcaacc agctgtatga
     2401 aaacaagggg gaggccgact tcgtggagtc cttgttgcaa ctgttccggt ccatcaacga
     2461 catgatgagc agcatgtcgg agctcacagt cagggtgaag ggggcagcat tgaagtactt
     2521 gccaacaatt gtcaatgatg tgaagttggt gtttgatccc aaagagctca gtaaaatgtt
     2581 cacggaattc atcttgaatg ttcctgtggg cttgctgact gtccagaagc tctactgcct
     2641 gattgagatt gttcacagtg atctcttcac acagcatgac tgcagagaga tcctgctccc
     2701 catgatgacg gatcagctca agtaccacct agagaggcag gaggatctgg aggcatgctg
     2761 ccagctgctt agcaacatcc tggaggtgct ataccggaaa gatgtgggcc cgactcagag
     2821 acacgtccag atcatcatgg aggagcttct caggactgtg aacaggacgg tcatttccat
     2881 ggggcgggat tccgaactca ttgggaactt tgtggcttgc atgacagcta ttttacggca
     2941 gatggaagac ttccattatg cacacctgat caagaccttc gggaaaatga ggacagacgt
     3001 cgtggatttt ctgatggaga cattcatcat gtttaagaac ctcatcggga agaatgtcta
     3061 cccctttgac tgggtgataa tgaacacgat gcagaacaaa gttttcctgc gggcgattaa
     3121 tcagtatgca gatatgctga acaagaaatt tctggatcaa gccaactttg agctgcagct
     3181 gtggaacaat tactttcacc tggccgtggc tttcctcact caagagtccc tgcaactgga
     3241 gaatttttca agtgctaaga gagccaaaat ccttaacaag tatggagaca tgaggaggca
     3301 gattggcttt gagatcagag acatgtggta caacttgggt caacacaaga taaaattcat
     3361 cccagaaatg gttggcccta tattggaaat gacattgatt cctgagacag aacttcgaaa
     3421 agccaccctt cccatcttct tcgacatgat gcagtgtgaa ttccactcca cccggagctt
     3481 ccaaatgttt gaaaatgaga tcatcactaa gctggatcat gaagtggaag gaggcagagg
     3541 agacgagcaa tacaaagtgt tatttgataa aatcctcctg gagcactgca ggaagcataa
     3601 atacctggcc aagacaggag aaacttttgt gaagctcgtg gtgcggttga tggagagact
     3661 cctggactac aggaccatca tgcacgacga aaacaaagac aatcgtatga gctgcacagt
     3721 caacgtgctg aatttctaca aagagattga aagagaagag atgtatataa ggtacttgta
     3781 taagctctgc gacctgcaca aagagtgtga caactacaca gaggcggctt acaccttgct
     3841 tctgcatgcg aagcttctaa agtggtcaga ggatgcgtgt gcagctcacc tcattcagcg
     3901 ggacgggttc caggcgacaa cacagggaca gctgaaagaa cagctctacc aagaaatcat
     3961 ccactatttt gacaaaggca agatgtggga ggaggccatc gccctgggca aggaacttgc
     4021 agagcagtac gaaacggagt tgtttgatta tgagcagctg agtgagttgc tgaaaaaaca
     4081 ggcacaattt tatgagaaca tcgtcaaggt gataagaccc aagccggact attttgctgt
     4141 tggctactat gggcaaggct tcccttcatt ccttcgggga aaagtgttca tttaccgagg
     4201 aaaagaatac gagcgacggg aagattttga agctcggcta ttaactcagt ttccaaatgc
     4261 tgagaaaatg aagacgacat ctccacccgg cgatgacatt aagacttctc caggccagta
     4321 cattcagtgc ttcacagtga agcccaagct agatttgccc cctaagtttc accggccagt
     4381 gtctgaacag attgtcagtt tttacagggt gaatgaggtc cagcgatttg aatattcacg
     4441 gcccatccgg aaaggagaaa aaaacccaga caatgaattt gcgaatatgt ggatcgagag
     4501 aaccatctac accacagcct ataaactgcc gggaatttta aggtggtttg aagtcaaatc
     4561 tgtcttcatg gtagagatca gtccactgga gaatgccatc gagacgatgc agctgaccaa
     4621 tgacaagatt agcagcatga tccagcagca cctggatgac ccaggcctgc ctatcaaccc
     4681 tctgtccatg ctcctgaatg gcattgtgga tcctgctgtc atgggaggct ttgccaatta
     4741 tgagaaggct ttcttcacag accgatacct gcaggagcat cctgaggccc atgggcagat
     4801 cgagaagctc aaggacctga tagcctggca gattccattt ttggctgaag ggatcaggat
     4861 tcatggagac aaagtcacag aggccctgag gccattccat gagcgcatgg aagcctgttt
     4921 caagcagctg aaggaaaaag tggaaaagca atatggcgtc aggaccatgc cctcaggctt
     4981 ggatgacagg agaggcagtc gtcctcggtc catggtgcgg tccttcacaa tgccatcatc
     5041 ctctcggcca ctgtcagtgg cttctgtctc ttctttctcc tctgacagca ccccttcaag
     5101 gccaggctct gatggatttg ctctcgagcc tctgctgccg aagaagatgc actccaggtc
     5161 ccaggacaag ctagacaagg acgatccaga taaagagaag aaggacaaga agaaggagaa
     5221 aaggaacagc aaacaccaag agatatttga taaggaattc aagcctgctg acagctccct
     5281 gcagcagtct gaggctgtga tcctgtctga aacgataagt cccctgcgac cccaaagacc
     5341 caagagccag gtgatcaatg tcattggaag cgaaagacgc ttctctgtgt ctccagcttc
     5401 accgtgctcc cagccgacac cccctccagt cacaccaaga gccaagctca gcttcagcat
     5461 tcagcccaat ctggagctga atggcatgat ggggatggat gtggccgatg tcccaccccc
     5521 tctgcccctc aaaggcaaca tggcagatta tggaaatctg atggaaaacc aggatttgat
     5581 gggctcaccc acatctcctc ctcctccccc acagcggcaa cagccacctc cactgcccag
     5641 caaaacacca cctcctcccc ctccgaagac gacccgaaag cagacctcag tggactctgg
     5701 gatcgtgcag tgaatcctgg gaggaggtgg ctatcctcct gcttctcttc tacatctgct
     5761 gtgcctgccg attacctcct ccgggccctg ggatgcttca cctcagagtg attggctttg
     5821 cttggaaagg ggtccgttct agccatggga ccagaggact gaagtatctc agagcacagt
     5881 gggaatggag ccaagtcaga cacagtctgg attgtttttt tggggttggg aatccaccat
     5941 gtcatccttt cagatagcct cagtcttgcc ctgacactct ttcctgttgt gccaaatgac
     6001 ttacattcat ttgcttggcc gatgtgagtt ggccgatgtg gagggatgag accaacaccc
     6061 tacccctact cccgtgagaa gctatgcagt aaccttgtaa ggatcctcag gctgcctctg
     6121 tagcccagac cctagctcac ccccaagggc tggctgctca accctatcct tgcgtggggt
     6181 ggagtgtcac ttcagccgac atcaagcagc taagtgtatc ccttcagtga agatcttgat
     6241 ttcccttggc ataatttaaa gtagggctat ctctcggtta ctaaagagat attaatatat
     6301 gtagtagaga caccattatg gatactggat caaatggaaa atgattatga gcataggaaa
     6361 gtgagttttc attcttttta aaatacgagc ccatacacca ccagaggtgg tttcccttgg
     6421 gtggcttctc tgtgtgtaca gaatatttgt atatacggtg gttctcagag ctccatccgg
     6481 tgagtgtctg tcccccttgc ttcctccagt gggcctctga aaaccaggtc cagtgtgtcc
     6541 tcttcacgtt taactgttgg aaatacttgt tttctaaatc ccacaaaaat tgttttccag
     6601 attttcaagg tctgaaaatg ttggtggaca atgaatcttt tgtttaaaaa actaactttg
     6661 tataacctaa tattttattt gatcatctat atttttttat tcactctgat cacgatactg
     6721 tttgttctag gagagttcaa agttaatcac tgacgaatga aaaataaatg ttatttaaaa
     6781 aggac
//
