LOCUS       NM_001012461            1851 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus DNA nucleotidylexotransferase (Dntt), mRNA.
ACCESSION   NM_001012461 XM_220018
VERSION     NM_001012461.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1851)
  AUTHORS   Lieber MR.
  TITLE     The mechanism of double-strand DNA break repair by the
            nonhomologous DNA end-joining pathway
  JOURNAL   Annu Rev Biochem 79, 181-211 (2010)
   PUBMED   20192759
  REMARK    Review article
REFERENCE   2  (bases 1 to 1851)
  AUTHORS   Fujisaki S, Sato A, Toyomoto T, Hayano T, Sugai M, Kubota T and
            Koiwai O.
  TITLE     Direct binding of TReP-132 with TdT results in reduction of TdT
            activity
  JOURNAL   Genes Cells 11 (1), 47-57 (2006)
   PUBMED   16371131
REFERENCE   3  (bases 1 to 1851)
  AUTHORS   Yamashita N, Shimazaki N, Ibe S, Kaneko R, Tanabe A, Toyomoto T,
            Fujita K, Hasegawa T, Toji S, Tamai K, Yamamoto H and Koiwai O.
  TITLE     Terminal deoxynucleotidyltransferase directly interacts with a
            novel nuclear protein that is homologous to p65
  JOURNAL   Genes Cells 6 (7), 641-652 (2001)
   PUBMED   11473582
REFERENCE   4  (bases 1 to 1851)
  AUTHORS   Trubiani O, Bollum FJ and Di Primio R.
  TITLE     Terminal transferase positive rat thymocytes are resistant to
            steroid-induced apoptosis
  JOURNAL   Cell Struct Funct 20 (6), 455-463 (1995)
   PUBMED   8825066
REFERENCE   5  (bases 1 to 1851)
  AUTHORS   Doyen N, d'Andon MF, Bentolila LA, Nguyen QT and Rougeon F.
  TITLE     Differential splicing in mouse thymus generates two forms of
            terminal deoxynucleotidyl transferase
  JOURNAL   Nucleic Acids Res 21 (5), 1187-1191 (1993)
   PUBMED   8464703
REFERENCE   6  (bases 1 to 1851)
  AUTHORS   Dave VP, Patil MS and Pandey VN.
  TITLE     Nuclear matrix bound terminal deoxynucleotidyl transferase in rat
            thymus nuclei. II. Effect of ATP on free and matrix bound TdT
  JOURNAL   Mol Biol Rep 13 (4), 185-190 (1988)
   PUBMED   3272345
REFERENCE   7  (bases 1 to 1851)
  AUTHORS   Pandey VN, Dave VP and Patil MS.
  TITLE     Nuclear matrix bound terminal deoxynucleotidyl transferase in rat
            thymus nuclei. I. A possible site for TdT mediated function
  JOURNAL   Mol Biol Rep 13 (4), 179-184 (1988)
   PUBMED   3272344
REFERENCE   8  (bases 1 to 1851)
  AUTHORS   Bearman,R.M., Winberg,C.D., Maslow,W.C., Racklin,B., Carlson,F.,
            Nathwani,B.N., Kim,H., Diamond,L.W., Fallis,B. and Rappaport,H.
  TITLE     Terminal deoxynucleotidyl transferase activity in neoplastic and
            nonneoplastic hematopoietic cells
  JOURNAL   Am J Clin Pathol 75 (6), 794-802 (1981)
   PUBMED   7020399
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089904.1.
            
            On Apr 20, 2005 this sequence version replaced XM_220018.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089904.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1851
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1851
                     /gene="Dntt"
                     /note="DNA nucleotidylexotransferase"
                     /db_xref="GeneID:294051"
                     /db_xref="RGD:1305054"
     exon            1..220
                     /gene="Dntt"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..1550
                     /gene="Dntt"
                     /EC_number="2.7.7.31"
                     /note="terminal deoxynucleotidyltransferase;
                     deoxynucleotidyltransferase, terminal"
                     /codon_start=1
                     /product="DNA nucleotidylexotransferase"
                     /protein_id="NP_001012479.1"
                     /db_xref="GeneID:294051"
                     /db_xref="RGD:1305054"
                     /translation="MDPLQAVHLGPRKKRPRQTGASGASTPHDIRFRDLVLFILEKKM
                     GTTRRAFLMELARRKGFRVENELSDSVTHIVAENNSGSDVLEWLQLQNIKASSEFELL
                     DISWLIECMGAGKPVEMAGRHQLVVRRNPSLSPVPGSQTVPPPLMQKISQYACQRRTT
                     LNNHNQLFTDAFDILAENYEFRENEVSCLPFMRAASVLKSLSFPIVSMKDIEGIPCLG
                     DKVKCVIEGIIEDGESSEVKAVLNDERYKSFKLFTSVFGVGLKTAEKWFRMGFRTLSK
                     IKSDKSLRFTHMQKAGFLYYEDLVSCVNRAEAEAVSMLVKEAVVAFLPDALVTMTGGF
                     RRGKMTGHDVDFLITSPEATEEEEQQLLHKVTNFWRQQGLLLYCDIIESTFEKFKLPS
                     RKVDALDHFQKCFLILKLHRGLVRSEESGQQEGKDWKAIRVDLVMCPYERRAFALLGW
                     TGSRQFERDLRRYATHERKMMLDNHALYDKTKRVFLEAESEEEIFAHLGLDYIEPWER
                     NA"
     exon            221..395
                     /gene="Dntt"
                     /inference="alignment:Splign:2.1.0"
     exon            396..524
                     /gene="Dntt"
                     /inference="alignment:Splign:2.1.0"
     exon            525..695
                     /gene="Dntt"
                     /inference="alignment:Splign:2.1.0"
     exon            696..767
                     /gene="Dntt"
                     /inference="alignment:Splign:2.1.0"
     exon            768..891
                     /gene="Dntt"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1024
                     /gene="Dntt"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1133
                     /gene="Dntt"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1379
                     /gene="Dntt"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1463
                     /gene="Dntt"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1826
                     /gene="Dntt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgacagtc tgcttccatg gatccgctgc aagcagtcca cctgggtcct cggaagaaga
       61 gaccgaggca gacgggcgcc tcaggggcct ccacacctca cgacatccga tttcgagact
      121 tggtcctctt cattttggag aagaagatgg gaacaactcg aagagccttc ctcatggagc
      181 tggcccgaag gaaagggttc agggtggaaa atgagctcag tgactctgtc acccacatcg
      241 tggcagagaa caactcggga tccgacgtcc tggagtggct ccagctacag aacatcaaag
      301 ccagctctga gttcgaactc ttggacatct cctggctgat tgaatgcatg ggagccggga
      361 aaccggtgga gatggcgggg agacatcagc tcgttgtgag aagaaaccct tccctgagtc
      421 ctgtcccagg ctcccagacc gttccgccac ctctcatgca gaagatctcc cagtacgctt
      481 gtcagcggag aaccacattg aacaatcaca accaactatt cacggatgcg tttgatatcc
      541 tggctgaaaa ttatgagttt agagagaatg aagtttcttg tctgccattc atgcgagctg
      601 cctctgtact gaaatctctg tccttcccca tcgtcagcat gaaagacata gagggaattc
      661 cttgcctagg ggacaaggtg aagtgtgtca tagagggaat tattgaagat ggagaaagtt
      721 ctgaagtgaa agctgtgtta aatgatgagc gatataaatc cttcaaactc tttacatctg
      781 tgtttggcgt gggactgaag acagctgaga aatggttcag gatggggttc agaactctca
      841 gcaaaataaa gtcagacaaa agcctgaggt tcacacacat gcagaaagca gggttcctct
      901 actatgaaga cctcgttagc tgtgtgaaca gggcagaagc agaggccgtc agcatgctag
      961 ttaaggaggc agttgtggca tttcttccag atgccttggt caccatgact ggggggttcc
     1021 gcaggggtaa gatgaccgga catgacgtag actttctaat taccagccca gaagccacag
     1081 aggaagaaga gcagcagctc ttgcataaag taacaaactt ttggagacag caggggttgc
     1141 ttttgtactg cgacatcata gagtcgacct ttgaaaagtt caagctgccc agcaggaagg
     1201 tggacgccct cgatcacttc cagaagtgct tccttattct gaagctgcac cgtggcctag
     1261 tgcgcagcga ggagagcggc cagcaggaag gaaaggactg gaaggccatc cgtgtagatc
     1321 tggtcatgtg cccctatgag cgccgggcct tcgccctgct cgggtggact ggatccaggc
     1381 aatttgagag agacttgcgg cgctacgcca cacacgagcg gaagatgatg ctggacaacc
     1441 acgctctgta tgacaagacc aagagggtgt ttcttgaagc agaaagtgaa gaagagatct
     1501 ttgcccatct gggattggac tacattgaac catgggaaag aaatgcttaa gaaggagctg
     1561 ttgacaatgt tctcttcagg ttagacaact gtgctctgtt agtaaaagat ggcttgggaa
     1621 agtctgggat tctttggatc ataagtatac tacgcagaga gactattcta aagcaacttt
     1681 gaagtcctga taaaccagaa tgcagtcatg gttcacattc tcaggtcatt tgtcctactg
     1741 cttcatagaa ttcatagttt gttttactgt ctgtttcatt ttaataaaaa tggtcttgcc
     1801 attggagcac catccagaga agtgcaaaaa aaaaaaaaaa aaaaaaaaaa a
//
