LOCUS       NM_133525                545 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
            (Dnph1), mRNA.
ACCESSION   NM_133525
VERSION     NM_133525.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 545)
  AUTHORS   Amiable,C., Paoletti,J., Haouz,A., Padilla,A., Labesse,G.,
            Kaminski,P.A. and Pochet,S.
  TITLE     6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic
            target DNPH1: synthesis, structural studies and cytotoxic
            activities
  JOURNAL   Eur J Med Chem 85, 418-437 (2014)
   PUBMED   25108359
REFERENCE   2  (bases 1 to 545)
  AUTHORS   Padilla,A., Amiable,C., Pochet,S., Kaminski,P.A. and Labesse,G.
  TITLE     Structure of the oncoprotein Rcl bound to three nucleotide
            analogues
  JOURNAL   Acta Crystallogr D Biol Crystallogr 69 (Pt 2), 247-255 (2013)
   PUBMED   23385460
  REMARK    GeneRIF: The crystal structure of oncoprotein Rcl bound to
            thymidine analogue 6-RADP-1-C6PA confirms and more precisely
            reveals the organization of its nucleotide-binding site.
REFERENCE   3  (bases 1 to 545)
  AUTHORS   Buhrke,T., Lengler,I. and Lampen,A.
  TITLE     Analysis of proteomic changes induced upon cellular differentiation
            of the human intestinal cell line Caco-2
  JOURNAL   Dev Growth Differ 53 (3), 411-426 (2011)
   PUBMED   21492153
REFERENCE   4  (bases 1 to 545)
  AUTHORS   Dupouy,C., Zhang,C., Padilla,A., Pochet,S. and Kaminski,P.A.
  TITLE     Probing the active site of the deoxynucleotide N-hydrolase Rcl
            encoded by the rat gene c6orf108
  JOURNAL   J Biol Chem 285 (53), 41806-41814 (2010)
   PUBMED   20962348
  REMARK    GeneRIF: analysis of human deoxynucleotide N-hydrolase Rcl and rat
            gene c6orf108
REFERENCE   5  (bases 1 to 545)
  AUTHORS   Yang,Y., Padilla,A., Zhang,C., Labesse,G. and Kaminski,P.A.
  TITLE     Structural characterization of the mammalian deoxynucleotide
            N-hydrolase Rcl and its stabilizing interactions with two
            inhibitors
  JOURNAL   J Mol Biol 394 (3), 435-447 (2009)
   PUBMED   19822152
  REMARK    GeneRIF: ligand-induced stabilization of the dimer structure of the
            enzyme
REFERENCE   6  (bases 1 to 545)
  AUTHORS   Doddapaneni,K., Mahler,B., Pavlovicz,R., Haushalter,A., Yuan,C. and
            Wu,Z.
  TITLE     Solution structure of RCL, a novel 2'-deoxyribonucleoside
            5'-monophosphate N-glycosidase
  JOURNAL   J Mol Biol 394 (3), 423-434 (2009)
   PUBMED   19720067
  REMARK    GeneRIF: RCL is a symmetric homodimer, with each monomer consisting
            of a five-stranded parallel beta-sheet sandwiched between five
            alpha-helices. Three of the helices form the dimer interface,
            allowing two monomers to pack side by side.
REFERENCE   7  (bases 1 to 545)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 545)
  AUTHORS   Ghiorghi,Y.K., Zeller,K.I., Dang,C.V. and Kaminski,P.A.
  TITLE     The c-Myc target gene Rcl (C6orf108) encodes a novel enzyme,
            deoxynucleoside 5'-monophosphate N-glycosidase
  JOURNAL   J Biol Chem 282 (11), 8150-8156 (2007)
   PUBMED   17234634
  REMARK    GeneRIF: C6orf108 encodes a novel enzyme, deoxynucleoside
            5'-monophosphate N-glycosidase
REFERENCE   9  (bases 1 to 545)
  AUTHORS   Chan,C.P., But,P.P. and Ho,J.W.
  TITLE     Induction of rcl, a novel growth-related gene by coptidis rhizoma
            in rat H4IIE cells
  JOURNAL   Life Sci 70 (14), 1691-1699 (2002)
   PUBMED   11991256
  REMARK    GeneRIF: rcl as an important antiapoptotic protein mediating
            sensitivity to Coptidis Rhizoma induction in cancer cells
REFERENCE   10 (bases 1 to 545)
  AUTHORS   Lewis,B.C., Shim,H., Li,Q., Wu,C.S., Lee,L.A., Maity,A. and
            Dang,C.V.
  TITLE     Identification of putative c-Myc-responsive genes: characterization
            of rcl, a novel growth-related gene
  JOURNAL   Mol Cell Biol 17 (9), 4967-4978 (1997)
   PUBMED   9271375
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133525.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U82591.1, BF400711.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840107,
                                           SAMN12840115 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               JAXUCZ010000009.1  21981451-21981631   c
            182-250             JAXUCZ010000009.1  21979674-21979742   c
            251-361             JAXUCZ010000009.1  21979211-21979321   c
            362-545             JAXUCZ010000009.1  21978894-21979077   c
FEATURES             Location/Qualifiers
     source          1..545
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..545
                     /gene="Dnph1"
                     /gene_synonym="C6orf108; Rcl; RGD620382"
                     /note="2'-deoxynucleoside 5'-phosphate N-hydrolase 1"
                     /db_xref="GeneID:171047"
                     /db_xref="RGD:620382"
     exon            1..181
                     /gene="Dnph1"
                     /gene_synonym="C6orf108; Rcl; RGD620382"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..510
                     /gene="Dnph1"
                     /gene_synonym="C6orf108; Rcl; RGD620382"
                     /note="deoxyribonucleoside 5'-monophosphate N-glycosidase;
                     putative c-Myc-responsive; Nucleoside
                     2-deoxyribosyltransferase domain containing protein
                     RGD620382; c-Myc-responsive protein Rcl"
                     /codon_start=1
                     /product="5-hydroxymethyl-dUMP N-hydrolase"
                     /protein_id="NP_598209.1"
                     /db_xref="GeneID:171047"
                     /db_xref="RGD:620382"
                     /translation="MAASGEQAPCSVYFCGSIRGGREDQALYARIVSRLRRYGKVLTE
                     HVADAELEPLGEEAAGGDQFIHEQDLNWLQQADVVVAEVTQPSLGVGYELGRAVALGK
                     PILCLFRPQSGRVLSAMIRGAADGSRFQVWDYAEGEVETMLDRYFEAYLPQKTASSSH
                     PSA"
     exon            182..250
                     /gene="Dnph1"
                     /gene_synonym="C6orf108; Rcl; RGD620382"
                     /inference="alignment:Splign:2.1.0"
     exon            251..361
                     /gene="Dnph1"
                     /gene_synonym="C6orf108; Rcl; RGD620382"
                     /inference="alignment:Splign:2.1.0"
     exon            362..545
                     /gene="Dnph1"
                     /gene_synonym="C6orf108; Rcl; RGD620382"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcgcgcgc acgcggcgat ggcggcatcc ggggagcagg ctccatgctc cgtgtacttc
       61 tgcgggagca tccgcggcgg gcgcgaggac caagcactgt atgcgcggat cgtgtcgcgg
      121 ctgcgacgct atgggaaggt gctcactgag cacgtggctg atgctgagtt ggagccgctt
      181 ggggaagagg ctgctggggg tgaccagttc atccatgagc aggacctgaa ctggctgcag
      241 caagcagatg tggtagtggc ggaagtgaca cagccatcct tgggtgttgg ctatgaactg
      301 ggccgggcag tagctcttgg gaagccaatt ctgtgcctgt ttcgaccaca gtctggccga
      361 gtgctttccg ccatgatccg cggagcagca gatggctcga ggttccaggt atgggactac
      421 gcagagggag aagtggagac catgctcgat cggtactttg aggcatatct tcctcagaag
      481 acggcttcct ccagtcaccc aagtgcctga ccaccctact gtattaaaaa gaaaattaag
      541 attta
//
