LOCUS       NM_001003964            1618 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus DNA methyltransferase 3 like (Dnmt3l), mRNA.
ACCESSION   NM_001003964 XM_006256250 XM_228066
VERSION     NM_001003964.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1618)
  AUTHORS   Barau,J., Teissandier,A., Zamudio,N., Roy,S., Nalesso,V.,
            Herault,Y., Guillou,F. and Bourc'his,D.
  TITLE     The DNA methyltransferase DNMT3C protects male germ cells from
            transposon activity
  JOURNAL   Science 354 (6314), 909-912 (2016)
   PUBMED   27856912
REFERENCE   2  (bases 1 to 1618)
  AUTHORS   Pastor,W.A., Stroud,H., Nee,K., Liu,W., Pezic,D., Manakov,S.,
            Lee,S.A., Moissiard,G., Zamudio,N., Bourc'his,D., Aravin,A.A.,
            Clark,A.T. and Jacobsen,S.E.
  TITLE     MORC1 represses transposable elements in the mouse male germline
  JOURNAL   Nat Commun 5, 5795 (2014)
   PUBMED   25503965
  REMARK    Erratum:[Nat Commun. 2015 Jul 10;6:7604. doi: 10.1038/ncomms8604..
            PMID: 26159654]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1618)
  AUTHORS   Kim,K.H., Ryu,H.M., Oh,S.H., Oh,E.J., Ahn,J.S., Lee,J.H.,
            Choi,J.Y., Cho,J.H., Kim,C.D., Kim,Y.L. and Park,S.H.
  TITLE     Effect of DNA demethylation in experimental encapsulating
            peritoneal sclerosis
  JOURNAL   Ther Apher Dial 18 (6), 628-636 (2014)
   PUBMED   25256793
REFERENCE   4  (bases 1 to 1618)
  AUTHORS   Sakharkar,A.J., Tang,L., Zhang,H., Chen,Y., Grayson,D.R. and
            Pandey,S.C.
  TITLE     Effects of acute ethanol exposure on anxiety measures and
            epigenetic modifiers in the extended amygdala of adolescent rats
  JOURNAL   Int J Neuropsychopharmacol 17 (12), 2057-2067 (2014)
   PUBMED   24968059
REFERENCE   5  (bases 1 to 1618)
  AUTHORS   Neri,F., Krepelova,A., Incarnato,D., Maldotti,M., Parlato,C.,
            Galvagni,F., Matarese,F., Stunnenberg,H.G. and Oliviero,S.
  TITLE     Dnmt3L antagonizes DNA methylation at bivalent promoters and favors
            DNA methylation at gene bodies in ESCs
  JOURNAL   Cell 155 (1), 121-134 (2013)
   PUBMED   24074865
REFERENCE   6  (bases 1 to 1618)
  AUTHORS   Xie,Z.H., Huang,Y.N., Chen,Z.X., Riggs,A.D., Ding,J.P., Gowher,H.,
            Jeltsch,A., Sasaki,H., Hata,K. and Xu,G.L.
  TITLE     Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect
            its regulation by DNMT3L
  JOURNAL   Hum Mol Genet 15 (9), 1375-1385 (2006)
   PUBMED   16543361
REFERENCE   7  (bases 1 to 1618)
  AUTHORS   Bourc'his,D. and Bestor,T.H.
  TITLE     Meiotic catastrophe and retrotransposon reactivation in male germ
            cells lacking Dnmt3L
  JOURNAL   Nature 431 (7004), 96-99 (2004)
   PUBMED   15318244
REFERENCE   8  (bases 1 to 1618)
  AUTHORS   Lees-Murdock,D.J., McLoughlin,G.A., McDaid,J.R., Quinn,L.M.,
            O'Doherty,A., Hiripi,L., Hack,C.J. and Walsh,C.P.
  TITLE     Identification of 11 pseudogenes in the DNA methyltransferase gene
            family in rodents and humans and implications for the functional
            loci
  JOURNAL   Genomics 84 (1), 193-204 (2004)
   PUBMED   15203217
REFERENCE   9  (bases 1 to 1618)
  AUTHORS   Deplus,R., Brenner,C., Burgers,W.A., Putmans,P., Kouzarides,T., de
            Launoit,Y. and Fuks,F.
  TITLE     Dnmt3L is a transcriptional repressor that recruits histone
            deacetylase
  JOURNAL   Nucleic Acids Res 30 (17), 3831-3838 (2002)
   PUBMED   12202768
REFERENCE   10 (bases 1 to 1618)
  AUTHORS   Hata,K., Okano,M., Lei,H. and Li,E.
  TITLE     Dnmt3L cooperates with the Dnmt3 family of de novo DNA
            methyltransferases to establish maternal imprints in mice
  JOURNAL   Development 129 (8), 1983-1993 (2002)
   PUBMED   11934864
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On or before Jun 4, 2021 this sequence version replaced
            XM_006256250.4, NM_001003964.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.63847.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               JAXUCZ010000020.1  10628807-10628989   c
            184-273             JAXUCZ010000020.1  10628332-10628421   c
            274-318             JAXUCZ010000020.1  10628051-10628095   c
            319-398             JAXUCZ010000020.1  10626853-10626932   c
            399-511             JAXUCZ010000020.1  10626658-10626770   c
            512-683             JAXUCZ010000020.1  10625869-10626040   c
            684-771             JAXUCZ010000020.1  10623171-10623258   c
            772-866             JAXUCZ010000020.1  10622124-10622218   c
            867-942             JAXUCZ010000020.1  10620494-10620569   c
            943-1082            JAXUCZ010000020.1  10620002-10620141   c
            1083-1168           JAXUCZ010000020.1  10618257-10618342   c
            1169-1618           JAXUCZ010000020.1  10614591-10615040   c
FEATURES             Location/Qualifiers
     source          1..1618
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1618
                     /gene="Dnmt3l"
                     /note="DNA methyltransferase 3 like"
                     /db_xref="GeneID:309680"
                     /db_xref="RGD:1303239"
     exon            1..183
                     /gene="Dnmt3l"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1331
                     /gene="Dnmt3l"
                     /note="DNA (cytosine-5-)-methyltransferase 3-like"
                     /codon_start=1
                     /product="DNA (cytosine-5)-methyltransferase 3-like"
                     /protein_id="NP_001003964.2"
                     /db_xref="GeneID:309680"
                     /db_xref="RGD:1303239"
                     /translation="MGSRETPSSCSKTHETLNLETPESSSTDPDSPLEEQWPKSSPDL
                     KEEDSVDMVLEDSKEPLTPSSPPTGREVIRYEVNVNQRNIEDICLCCGSLQVYAQHPL
                     FEGGICAPCKDKFLETLFLYDEDGHQSYCTICCSGHTLFICESPDCTRCYCFECVDIL
                     VGPGTSERINAMACWVCFLCLPFSRSGLLQRRKKWRHQLKAFHDREGASPVEIYKTVS
                     AWKRQPVRVLSLFGNIDKELKSLGFLESSSGSEGGTLKYVEDVTNVVRREVEKWGPFD
                     LVYGSTQPLGYSCDRCPGWYMFQFHRILQYARPRQDSQQPFFWIFVDNLLLTEDDQET
                     TVRFLQTEAVTLQDVRGRVLQNAMRVWSNIPGLKSKHADLTPKEEQSLQTQVRTRSKL
                     AAQKVDSLVKYCLLPLREYFKYFSQNSLPL"
     exon            184..273
                     /gene="Dnmt3l"
                     /inference="alignment:Splign:2.1.0"
     exon            274..318
                     /gene="Dnmt3l"
                     /inference="alignment:Splign:2.1.0"
     exon            319..398
                     /gene="Dnmt3l"
                     /inference="alignment:Splign:2.1.0"
     exon            399..511
                     /gene="Dnmt3l"
                     /inference="alignment:Splign:2.1.0"
     exon            512..683
                     /gene="Dnmt3l"
                     /inference="alignment:Splign:2.1.0"
     exon            684..771
                     /gene="Dnmt3l"
                     /inference="alignment:Splign:2.1.0"
     exon            772..866
                     /gene="Dnmt3l"
                     /inference="alignment:Splign:2.1.0"
     exon            867..942
                     /gene="Dnmt3l"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1082
                     /gene="Dnmt3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1168
                     /gene="Dnmt3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1618
                     /gene="Dnmt3l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaggaccct gctggcacgc ccgccatccc ttggacgcag acccttctag cagattacat
       61 ccatgggttc ccgggagaca ccttcttcct gctctaagac ccatgaaacc ttgaacctgg
      121 agactccgga gagctctagc actgaccctg acagtcccct ggaagagcaa tggccgaaat
      181 cttccccaga tctgaaagag gaagacagcg tggatatggt actggaagac tccaaggagc
      241 ctctaacccc ttcctcaccg ccgacaggca gagaggtcat caggtacgaa gtcaacgtga
      301 accagcggaa catcgaagac atctgcctct gttgcggatc tctccaggtg tacgctcagc
      361 accccttgtt tgagggggga atttgtgccc cgtgtaagga caagttcctg gagaccctct
      421 tcctatacga cgaggatgga caccagagct actgtaccat ctgctgctcc gggcataccc
      481 tgttcatctg cgagagcccc gactgtacca gatgctactg tttcgagtgt gtggatatcc
      541 tggtgggccc cgggacctcg gagcgcatca atgccatggc ctgctgggtt tgcttcctgt
      601 gcctgccttt ctcccggagc ggactgctgc agaggcgcaa gaagtggcgt caccagctga
      661 aggccttcca tgaccgagag ggggcaagcc ctgtggagat atacaagact gtgtctgcat
      721 ggaaaagaca gccagtgagg gtgctgagtc tttttgggaa tattgataaa gaactaaaga
      781 gtttgggctt tttggaaagc agttctggtt ctgagggagg aacgctgaag tacgtggaag
      841 atgtcaccaa tgtcgtgagg agagaagtgg agaaatgggg tccctttgac ttggtgtatg
      901 gctcaaccca gcccctaggc tattcttgtg accgctgtcc tggctggtac atgttccagt
      961 tccaccggat cctgcagtat gcccggcctc gccaagacag ccagcagccc ttcttctgga
     1021 tatttgtgga caatctgctg ctgactgaag atgaccaaga gacaactgtc cgcttccttc
     1081 agacagaggc tgtgaccctc caggatgtcc gcggcagagt cctccagaat gctatgaggg
     1141 tgtggagcaa cattccaggg ctgaagagca agcacgcgga cctgacccct aaggaagagc
     1201 agtctctgca aacccaagtc agaaccagaa gcaagctggc cgcccagaaa gttgactccc
     1261 tagtgaagta ctgccttctc cccctgagag agtacttcaa gtatttttct cagaactcac
     1321 ttcctcttta gaaatgaatc accgtacgac gaagagtctt ccctagaacc gtggcagcct
     1381 tcttcctgtg gccttttccc tctgcagagt tccctcccgt ttgcttgctg ggctttggga
     1441 ttctctcctg tttgaggcat ccatctgaga tgcgaatgcc tctgggcagc tcactgtggg
     1501 ggtccggagg cgcccaacgc tctggacaag atcccgatgg ggtaaccggc catgcttctt
     1561 ccgaacaaaa ctgtgtgtac ctgttgtgaa gtttttcaaa tatatcatag aattgtta
//
