LOCUS       NM_001396349            4122 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Rattus norvegicus DNA methyltransferase 3 beta (Dnmt3b), mRNA.
ACCESSION   NM_001396349
VERSION     NM_001396349.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4122)
  AUTHORS   Du,Y., Zhang,R., Zhang,G., Wu,H., Zhan,S. and Bu,N.
  TITLE     Downregulation of ELAVL1 attenuates ferroptosis-induced neuronal
            impairment in rats with cerebral ischemia/reperfusion via reducing
            DNMT3B-dependent PINK1 methylation
  JOURNAL   Metab Brain Dis 37 (8), 2763-2775 (2022)
   PUBMED   36173508
  REMARK    GeneRIF: Downregulation of ELAVL1 attenuates ferroptosis-induced
            neuronal impairment in rats with cerebral ischemia/reperfusion via
            reducing DNMT3B-dependent PINK1 methylation.
REFERENCE   2  (bases 1 to 4122)
  AUTHORS   Frances,R., Mata-Garrido,J., de la Fuente,R., Carcelen,M.,
            Lafarga,M., Berciano,M.T., Garcia,R., Hurle,M.A. and Tramullas,M.
  TITLE     Identification of Epigenetic Interactions between MicroRNA-30c-5p
            and DNA Methyltransferases in Neuropathic Pain
  JOURNAL   Int J Mol Sci 23 (22), 13994 (2022)
   PUBMED   36430472
  REMARK    GeneRIF: Identification of Epigenetic Interactions between
            MicroRNA-30c-5p and DNA Methyltransferases in Neuropathic Pain.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4122)
  AUTHORS   Balasubramanian,N., Sagarkar,S., Choudhary,A.G., Kokare,D.M. and
            Sakharkar,A.J.
  TITLE     Epigenetic Blockade of Hippocampal SOD2 Via DNMT3b-Mediated DNA
            Methylation: Implications in Mild Traumatic Brain Injury-Induced
            Persistent Oxidative Damage
  JOURNAL   Mol Neurobiol 58 (3), 1162-1184 (2021)
   PUBMED   33099744
  REMARK    GeneRIF: Epigenetic Blockade of Hippocampal SOD2 Via
            DNMT3b-Mediated DNA Methylation: Implications in Mild Traumatic
            Brain Injury-Induced Persistent Oxidative Damage.
REFERENCE   4  (bases 1 to 4122)
  AUTHORS   Yan,Y., He,Y.Y., Jiang,X., Wang,Y., Chen,J.W., Zhao,J.H., Ye,J.,
            Lian,T.Y., Zhang,X., Zhang,R.J., Lu,D., Guo,S.S., Xu,X.Q., Sun,K.,
            Li,S.Q., Zhang,L.F., Zhang,X., Zhang,S.Y. and Jing,Z.C.
  TITLE     DNA methyltransferase 3B deficiency unveils a new pathological
            mechanism of pulmonary hypertension
  JOURNAL   Sci Adv 6 (50) (2020)
   PUBMED   33298433
  REMARK    GeneRIF: DNA methyltransferase 3B deficiency unveils a new
            pathological mechanism of pulmonary hypertension.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4122)
  AUTHORS   Barau,J., Teissandier,A., Zamudio,N., Roy,S., Nalesso,V.,
            Herault,Y., Guillou,F. and Bourc'his,D.
  TITLE     The DNA methyltransferase DNMT3C protects male germ cells from
            transposon activity
  JOURNAL   Science 354 (6314), 909-912 (2016)
   PUBMED   27856912
REFERENCE   6  (bases 1 to 4122)
  AUTHORS   Gowher,H. and Jeltsch,A.
  TITLE     Molecular enzymology of the catalytic domains of the Dnmt3a and
            Dnmt3b DNA methyltransferases
  JOURNAL   J Biol Chem 277 (23), 20409-20414 (2002)
   PUBMED   11919202
REFERENCE   7  (bases 1 to 4122)
  AUTHORS   Mizuno,S., Chijiwa,T., Okamura,T., Akashi,K., Fukumaki,Y., Niho,Y.
            and Sasaki,H.
  TITLE     Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal
            hematopoiesis and in acute and chronic myelogenous leukemia
  JOURNAL   Blood 97 (5), 1172-1179 (2001)
   PUBMED   11222358
REFERENCE   8  (bases 1 to 4122)
  AUTHORS   Xu,G.L., Bestor,T.H., Bourc'his,D., Hsieh,C.L., Tommerup,N.,
            Bugge,M., Hulten,M., Qu,X., Russo,J.J. and Viegas-Pequignot,E.
  TITLE     Chromosome instability and immunodeficiency syndrome caused by
            mutations in a DNA methyltransferase gene
  JOURNAL   Nature 402 (6758), 187-191 (1999)
   PUBMED   10647011
REFERENCE   9  (bases 1 to 4122)
  AUTHORS   Okano,M., Bell,D.W., Haber,D.A. and Li,E.
  TITLE     DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo
            methylation and mammalian development
  JOURNAL   Cell 99 (3), 247-257 (1999)
   PUBMED   10555141
REFERENCE   10 (bases 1 to 4122)
  AUTHORS   Okano,M., Xie,S. and Li,E.
  TITLE     Cloning and characterization of a family of novel mammalian DNA
            (cytosine-5) methyltransferases
  JOURNAL   Nat Genet 19 (3), 219-220 (1998)
   PUBMED   9662389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-291               JAXUCZ010000003.1  162590777-162591067
            292-469             JAXUCZ010000003.1  162604037-162604214
            470-531             JAXUCZ010000003.1  162604741-162604802
            532-648             JAXUCZ010000003.1  162605280-162605396
            649-774             JAXUCZ010000003.1  162607670-162607795
            775-969             JAXUCZ010000003.1  162608320-162608514
            970-1128            JAXUCZ010000003.1  162609482-162609640
            1129-1236           JAXUCZ010000003.1  162611776-162611883
            1237-1381           JAXUCZ010000003.1  162612744-162612888
            1382-1504           JAXUCZ010000003.1  162614523-162614645
            1505-1549           JAXUCZ010000003.1  162614804-162614848
            1550-1629           JAXUCZ010000003.1  162616792-162616871
            1630-1742           JAXUCZ010000003.1  162617135-162617247
            1743-1929           JAXUCZ010000003.1  162617853-162618039
            1930-2014           JAXUCZ010000003.1  162618558-162618642
            2015-2160           JAXUCZ010000003.1  162619356-162619501
            2161-2251           JAXUCZ010000003.1  162619762-162619852
            2252-2400           JAXUCZ010000003.1  162620100-162620248
            2401-2486           JAXUCZ010000003.1  162621064-162621149
            2487-2556           JAXUCZ010000003.1  162625419-162625488
            2557-2675           JAXUCZ010000003.1  162626095-162626213
            2676-4122           JAXUCZ010000003.1  162627867-162629313
FEATURES             Location/Qualifiers
     source          1..4122
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..4122
                     /gene="Dnmt3b"
                     /note="DNA methyltransferase 3 beta"
                     /db_xref="GeneID:444985"
                     /db_xref="RGD:1303274"
     exon            1..291
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            292..469
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..2817
                     /gene="Dnmt3b"
                     /EC_number="2.1.1.37"
                     /note="DNA methyltransferase 3B; DNA
                     (cytosine-5-)-methyltransferase 3 beta"
                     /codon_start=1
                     /product="DNA (cytosine-5)-methyltransferase 3B"
                     /protein_id="NP_001383278.1"
                     /db_xref="GeneID:444985"
                     /db_xref="RGD:1303274"
                     /translation="MKGDSRHLNEEEGASGYEDCIIVNGNCSDQSSDTKDAPSPPVLE
                     AICTEPVCTPETRGRRSSSRLSKREVSSLLNYTQDVVGDGDGEADDGDGSDILMMPKL
                     TRETKDARTPSESPAVRTRNSNSISSLERQRTSPRITRGRQGRYHVQEYPVEFPATKS
                     RRRRASSSASTPWSSPASIELMEDVTPKSSSTPSVDLSQDGPQEGMDATQVDAESRDG
                     DSTEYQDDKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMPGMRWVQWFGDGKFS
                     EIAADKLVALGLFSQHFNLATFNKLVSYRKAMYHTLEKAMVRAGKTFPSRPGDSLEDQ
                     LKPMLEWAHGGFKPTGIEGLKPNNKQPENKSRRRTTIDFAASEYSTPPKRLKTNSYGG
                     KDRGEDEESRERMASDVTNNKGNLEDRCLSCGKKNPVSFHPLFEGGLCQSCRDRFLEL
                     FYMYDEDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAEDAKLQEPWS
                     CYMCLPQRCHGVLRRRKDWNMRLQDFFTTDPDLEEFEPPKLYPAIPAAKRRPIRVLSL
                     FDGIATGYLVLKDLGIKVEKYVASEVCAESIAVGTIKHEGQIKYVNDVRKITKKNIEE
                     WGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYTRPKEGDNRPFFWMF
                     ENVVAMKVNDKKDISRFLACNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKL
                     ELQDCLEFSRTAKLKKVQTITTKSNSIRQGKNQLFPVVMNGKDDVLWCTELERIFGFP
                     AHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE"
     exon            470..531
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            532..648
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            649..774
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            775..969
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1128
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1236
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1381
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1504
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1549
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1629
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1742
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1929
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2014
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2160
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2251
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2400
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2486
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2556
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2675
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..4122
                     /gene="Dnmt3b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccactccc gtgcgcgccc ggcccaaggc gtcttcgtcg ccgcccctcg cctcgcagcc
       61 gaagcccgcg tggacgctct cgcctgagcg ccccggacta agccgggtgg cccactggcg
      121 cgcgggcgag cgcacgggcg ctcccggccg gcagcgcggg ggttaagcgg cccaagtaaa
      181 cgtagcgcgg cgatcggcgc cggagattcg cgagcccggc accccgcgcc gcccgccggc
      241 cacgacccgc ggcgcgaccg cagcgccgcg ccacagccag cctcgcgaca ggaaaccatg
      301 aagggagaca gcagacatct taatgaagaa gagggtgcta gtgggtatga ggactgtatc
      361 attgttaatg ggaactgtag tgaccagtcc tcggacacga aggatgctcc ctcaccccca
      421 gtcttggagg caatctgcac agagccagtc tgtacaccag agaccagagg ccgcagatca
      481 agctcacggc tgtctaagag ggaggtctcc agccttctga attacacgca ggacgtggta
      541 ggagatggag atggtgaagc ggatgatgga gatggctctg atattctcat gatgccaaag
      601 ctcacccgag agaccaagga tgccaggact ccctctgaaa gcccagccgt ccgaacccga
      661 aacagcaaca gtatctccag cctggagagg caaagaacct cccccagaat cacgcgaggc
      721 cggcagggcc gctaccacgt tcaggagtac cccgtggagt tcccagctac caagtctcgg
      781 aggcggcgag catcgtcttc agcaagcacg ccatggtcat cccctgccag catcgagctc
      841 atggaagatg tgacacctaa gagcagcagt acgccatcgg ttgacttgag ccaggacggc
      901 cctcaggagg gcatggatgc cacacaggtg gatgcggaga gcagggatgg tgacagcact
      961 gagtatcagg atgacaagga gtttggaata ggtgaccttg tgtggggaaa gatcaagggc
     1021 ttctcctggt ggcctgccat ggtggtgtcc tggaaagcca cctccaagcg ccaggccatg
     1081 cccggaatgc gctgggtaca gtggtttggc gatggcaagt tttctgagat cgctgctgac
     1141 aagctggtgg ctctgggtct gttcagccag cactttaatc tggccacctt caataagctg
     1201 gtttcttata ggaaggccat gtaccacact ctggagaaag ccatggtgcg agctggcaag
     1261 accttcccca gccgccctgg agactcactg gaggaccagc tgaagcccat gctggagtgg
     1321 gcccacgggg gcttcaagcc cactgggatc gagggcctca aacccaacaa caagcaacca
     1381 gagaacaaaa gtcgaagacg cacaaccatt gactttgccg cttctgagta ctccacaccc
     1441 cctaagcgcc tcaagacaaa tagctatggt gggaaggacc gaggggaaga tgaggagagc
     1501 cgagaacgga tggcttctga tgtcactaac aacaagggca atctggaaga ccgctgtctg
     1561 tcctgcggta agaagaaccc tgtgtccttc caccccctct ttgagggtgg gctctgtcag
     1621 agttgccggg atcgcttcct ggagctcttc tacatgtacg atgaggacgg ctatcagtcc
     1681 tactgcaccg tgtgctgtga gggccgtgaa ctgcttctgt gcagtaacac aagctgctgc
     1741 aggtgcttct gtgtggagtg tctggaggtg ctggtgggta caggcacagc ggaggatgcc
     1801 aagctgcagg aaccctggag ctgctatatg tgcctcccgc agcgctgcca tggggtcctg
     1861 cggcgcagga aggactggaa catgcgcctg caagacttct tcactactga tcctgacctg
     1921 gaagagtttg agccgcccaa gttgtaccca gcgattcctg cagccaaaag gaggcccatt
     1981 agggtcctgt ccctgtttga tggaattgca acagggtact tggtgctcaa ggacttgggt
     2041 attaaagtgg agaagtacgt tgcctctgaa gtctgtgcag agtccattgc tgtaggaacc
     2101 attaagcatg aaggccaaat caaatatgtc aatgacgtcc ggaaaatcac caagaaaaat
     2161 attgaagagt ggggcccatt tgacttggtg attggcggaa gcccatgcaa tgatctttct
     2221 aatgtcaatc ctgccaggaa aggcctgtat gagggcacag gaaggctctt ctttgagttt
     2281 taccacttgc tgaattatac acgccccaag gagggcgaca accgtccatt cttctggatg
     2341 ttcgagaatg ttgtggccat gaaagtgaat gacaagaaag acatctcccg attcctggca
     2401 tgtaacccag tgatgatcga cgccatcaag gtttctgctg ctcacagggc ccggtacttc
     2461 tggggtaatc tacctggaat gaacaggcct gtgatagctt caaagaatga taagctcgag
     2521 ctacaagact gcttggagtt cagtaggaca gcaaagttaa agaaagtaca gacaataacc
     2581 accaagtcga actccatcag acaggggaaa aaccagcttt tccctgtagt catgaatggc
     2641 aaggatgacg ttctgtggtg cactgagctc gaaaggatct tcgggttccc agctcactac
     2701 acagacgtgt ccaacatggg ccggggcgcc cgccagaagc tactgggaag gtcctggagt
     2761 gtgccagtca tcagacacct gtttgccccc ttgaaggact actttgcatg tgaatagttc
     2821 tacccaggac tggggtgctc ttggtcagag ccagtgccca gagtcacccc tccctgaagg
     2881 cacctcacct gtccccttcc ttagctcacc tgtgtggggc ctcacatcac tgtacctcag
     2941 ctttctcctg ctcagtggga gcagagcctc ctggcccctg caggggagcc ccaggtgctc
     3001 cctctgtgca cagctcagac ctggctgctt agagtagcct ggcatggtgc tcaagttttc
     3061 ttatcctgaa attttaaaac ttgaagtagg tatagtaaaa tggctttctt tttccctcct
     3121 gagtttatca ctcagaagtg atggctaaga taccaaaaca acagctctct tagtactcag
     3181 gttcgtgctg caaaatcacc tgagattttg cttttaagta accagagctc cacatttgct
     3241 agagcacgct tttgcgaatg tggactcaga cgaacaaact caagggacca aacatttttt
     3301 ggttttgttt ttttccccta ggagtagttg aagatgacaa atgacgttta tgggttaagt
     3361 cttcctggca ccttcccctt gctttggtac aagggctgga gtcctgtagc atttcccagt
     3421 atgatgatgt cagcagggat gacatcatca cctttagggc ttttcccggg gcgggagccc
     3481 atgtagctag tcctccagaa gactggagta gaatgttttg agctcaggaa ggatgggtgg
     3541 agtggccttc ttccaggtgt gagggactcg aggagggagc ttagggaaac ctatccccac
     3601 tccctctccc tgaccccaat agctcaggtc accagataca tatgaccccc taattcctcc
     3661 tcatgagaag ccaggaccag aagcacattg tttttcctta tctaagtgat ggttggggaa
     3721 atgacaaaga gaaacttggc tcttctggag atttttaagt ccttttcacg ccctgataga
     3781 tatattgtat ttttaagggg tgttctcttt taggggcatc actggaaatg agaaaagctg
     3841 catttcagaa atgccatcgt aatggttttt aaacaccttt tgctctgatt acaggtgcta
     3901 ttttttagaa ggcagatgac attcaggctt tttatacctt tttttaagac tctcagactt
     3961 ctattttcat gtttaacatt tttttgtaac tggagcagtg tcatgagtgg ggagactgcc
     4021 tcatttccag tttgtctcca ctgcttcctc acttttaggt gcaaagatga caggtgccca
     4081 gagtttaccc ttctggttga ttaaaattta tttctctata aa
//
