LOCUS       NM_001003958            4173 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus DNA methyltransferase 3 alpha (Dnmt3a),
            transcript variant 1, mRNA.
ACCESSION   NM_001003958 XM_233941
VERSION     NM_001003958.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4173)
  AUTHORS   Cheng,P., Wei,H.Z., Chen,H.W., Wang,Z.Q., Mao,P. and Zhang,H.H.
  TITLE     DNMT3a-mediated methylation of PPARgamma promote intervertebral
            disc degeneration by regulating the NF-kappaB pathway
  JOURNAL   J Cell Mol Med 28 (2), e18048 (2024)
   PUBMED   37986543
  REMARK    GeneRIF: DNMT3a-mediated methylation of PPARgamma promote
            intervertebral disc degeneration by regulating the NF-kappaB
            pathway.
REFERENCE   2  (bases 1 to 4173)
  AUTHORS   Gu,Y.H., Wang,J., Lu,W.C., Cheng,Y., Tao,R., Zhang,S.J., Xu,T.,
            Zhai,K.W., Luo,S.X. and Xin,W.J.
  TITLE     POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by
            Hypermethylation-Mediated LRFN4 Downregulation Following
            Oxaliplatin Treatment
  JOURNAL   Neurochem Res 48 (12), 3652-3664 (2023)
   PUBMED   37592110
  REMARK    GeneRIF: POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by
            Hypermethylation-Mediated LRFN4 Downregulation Following
            Oxaliplatin Treatment.
REFERENCE   3  (bases 1 to 4173)
  AUTHORS   Kuang,J., Xu,M., Xu,C., Wang,Y., Ni,C., Wei,S., Liu,Z., Kong,M.,
            Zhou,Q., Yao,M. and Ni,H.
  TITLE     miR-199a-3p mediates bone cancer pain through upregulation of
            dnmt3a expression in spinal dorsal horn neurons
  JOURNAL   Biochem Biophys Res Commun 682, 97-103 (2023)
   PUBMED   37804593
  REMARK    GeneRIF: miR-199a-3p mediates bone cancer pain through upregulation
            of dnmt3a expression in spinal dorsal horn neurons.
REFERENCE   4  (bases 1 to 4173)
  AUTHORS   Frances,R., Mata-Garrido,J., de la Fuente,R., Carcelen,M.,
            Lafarga,M., Berciano,M.T., Garcia,R., Hurle,M.A. and Tramullas,M.
  TITLE     Identification of Epigenetic Interactions between MicroRNA-30c-5p
            and DNA Methyltransferases in Neuropathic Pain
  JOURNAL   Int J Mol Sci 23 (22), 13994 (2022)
   PUBMED   36430472
  REMARK    GeneRIF: Identification of Epigenetic Interactions between
            MicroRNA-30c-5p and DNA Methyltransferases in Neuropathic Pain.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4173)
  AUTHORS   Wei,J., Cheng,J., Waddell,N.J., Wang,Z.J., Pang,X., Cao,Q., Liu,A.,
            Chitaman,J.M., Abreu,K., Jasrotia,R.S., Duffney,L.J., Zhang,J.,
            Dietz,D.M., Feng,J. and Yan,Z.
  TITLE     DNA Methyltransferase 3A Is Involved in the Sustained Effects of
            Chronic Stress on Synaptic Functions and Behaviors
  JOURNAL   Cereb Cortex 31 (4), 1998-2012 (2021)
   PUBMED   33230530
  REMARK    GeneRIF: DNA Methyltransferase 3A Is Involved in the Sustained
            Effects of Chronic Stress on Synaptic Functions and Behaviors.
REFERENCE   6  (bases 1 to 4173)
  AUTHORS   Hata,K., Okano,M., Lei,H. and Li,E.
  TITLE     Dnmt3L cooperates with the Dnmt3 family of de novo DNA
            methyltransferases to establish maternal imprints in mice
  JOURNAL   Development 129 (8), 1983-1993 (2002)
   PUBMED   11934864
REFERENCE   7  (bases 1 to 4173)
  AUTHORS   Gowher,H. and Jeltsch,A.
  TITLE     Enzymatic properties of recombinant Dnmt3a DNA methyltransferase
            from mouse: the enzyme modifies DNA in a non-processive manner and
            also methylates non-CpG [correction of non-CpA] sites
  JOURNAL   J Mol Biol 309 (5), 1201-1208 (2001)
   PUBMED   11399089
  REMARK    Erratum:[J Mol Biol 2001 Jul 20;310(4):951]
REFERENCE   8  (bases 1 to 4173)
  AUTHORS   Mizuno,S., Chijiwa,T., Okamura,T., Akashi,K., Fukumaki,Y., Niho,Y.
            and Sasaki,H.
  TITLE     Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal
            hematopoiesis and in acute and chronic myelogenous leukemia
  JOURNAL   Blood 97 (5), 1172-1179 (2001)
   PUBMED   11222358
REFERENCE   9  (bases 1 to 4173)
  AUTHORS   Okano,M., Bell,D.W., Haber,D.A. and Li,E.
  TITLE     DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo
            methylation and mammalian development
  JOURNAL   Cell 99 (3), 247-257 (1999)
   PUBMED   10555141
REFERENCE   10 (bases 1 to 4173)
  AUTHORS   Okano,M., Xie,S. and Li,E.
  TITLE     Cloning and characterization of a family of novel mammalian DNA
            (cytosine-5) methyltransferases
  JOURNAL   Nat Genet 19 (3), 219-220 (1998)
   PUBMED   9662389
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BN000395.1.
            
            On Apr 19, 2005 this sequence version replaced XM_233941.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BN000395.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4173
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..4173
                     /gene="Dnmt3a"
                     /note="DNA methyltransferase 3 alpha"
                     /db_xref="GeneID:444984"
                     /db_xref="RGD:1303336"
     exon            1..234
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2898
                     /gene="Dnmt3a"
                     /EC_number="2.1.1.37"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     methyltransferase 3A; DNA (cytosine-5)-methyltransferase
                     3A; DNA (cytosine-5-)-methyltransferase 3 alpha; cysteine
                     methyltransferase DNMT3A"
                     /codon_start=1
                     /product="DNA (cytosine-5)-methyltransferase 3A isoform 1"
                     /protein_id="NP_001003958.1"
                     /db_xref="GeneID:444984"
                     /db_xref="RGD:1303336"
                     /translation="MPSSGPGDTSISSLEREDDRKEGEEQEENRGKEERQEPSATARK
                     VGRPGRKRKHPPVESSDTPKDPAVTTKSQPTAQDSGPSDLLPNGDLEKRSEPQPEEGS
                     PAAGQKGGAPAEGEGTETPPEASRAVENGCCVTKEGRGASAGEGKEQKQTNIESMKME
                     GSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIA
                     VMNAVEESQASGESQKVEEASPPAVQQPTDPASPTVATTPEPVGADAGDKNATKAADD
                     EPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSV
                     VCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPACHDSDESDTG
                     KAVEVQNKQMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPA
                     KKPRKSTTEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFIGG
                     MCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPG
                     AAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPA
                     EKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGD
                     VRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPK
                     EGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMN
                     RPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILW
                     CTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV"
     exon            235..339
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            340..607
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            608..651
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            652..798
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            799..1014
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1173
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1281
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1438
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1588
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1633
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1713
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1826
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2010
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2095
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2241
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2332
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2481
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2567
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2637
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2756
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..4173
                     /gene="Dnmt3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagagcca cccagcgctg aggcatcact ttccgagggc ttgacatcag gacctatgtt
       61 taagttttag ctcttgctca caaagaccac gataatacct tctctgaagc cctcgcagtc
      121 ccacagcgcc ctcgaagccc cagcctgcct cctactgccc agctgcccgc aatgccctcc
      181 agcggccccg gggacaccag catctcctct ctggagcggg aggatgatcg aaaggaagga
      241 gaggaacagg aggagaaccg tggtaaggaa gagcgtcagg agcccagcgc cacggcccgg
      301 aaagtgggga ggcctggccg gaagcgcaag cacccaccgg tggaaagcag tgacaccccc
      361 aaggacccag cggtgaccac caagtctcag cccacagccc aggactctgg gccctcagat
      421 ctgctaccca atggagactt ggagaagcgg agtgaacccc aacctgagga ggggagccca
      481 gctgcagggc agaagggtgg ggccccagct gaaggagagg gaactgagac cccaccagaa
      541 gcctccagag cagtggagaa tggctgctgc gtaaccaagg aaggccgtgg agcctctgcg
      601 ggagagggca aagaacagaa gcagaccaac atcgaatcca tgaaaatgga gggctcccgg
      661 ggccgactgc gtggtggctt ggggtgggag tccagcctcc gtcagcggcc catgccaaga
      721 ctcaccttcc aggcagggga cccctactac atcagcaaac ggaagcggga tgagtggctg
      781 gcacgttgga aaagggaggc tgagaagaaa gccaaggtga ttgcagtaat gaatgctgtg
      841 gaggaaagcc aggcctctgg ggagtcccag aaggtggagg aggccagccc tcctgcagtg
      901 cagcagccca cggaccctgc atctcccact gtggccacca cccctgagcc agtaggggct
      961 gatgctgggg acaagaatgc taccaaggca gctgatgacg agcccgagta tgaggatggc
     1021 cggggctttg gcattggaga gctggtgtgg gggaaactcc ggggcttctc ctggtggcca
     1081 ggccgaattg tgtcttggtg gatgacaggc cggagccgag cagccgaagg cactcgctgg
     1141 gtcatgtggt tcggagatgg caaattctca gtggtgtgtg tcgagaagct catgcccctg
     1201 agctccttct gcagtgcgtt ccaccaggcc acctacaaca agcagcccat gtaccgcaaa
     1261 gccatctacg aagtcctcca ggtggccagc agccgtgcag ggaagctgtt cccagcatgt
     1321 catgacagcg atgaaagtga cactggcaag gctgtggagg tgcagaacaa gcagatgatt
     1381 gagtgggccc ttggcggctt ccagccctct ggtcccaaag gcctggagcc accagaagag
     1441 gagaagaatc cttacaagga agtttacacc gacatgtggg tggagcctga ggcagctgct
     1501 tatgccccac ccccaccagc caagaaaccc agaaagagca caacagagaa acccaaggtc
     1561 aaggagatca ttgatgaacg cacaagagaa cggctcgtgt atgaggtgcg ccagaagtgc
     1621 cgaaacatcg aggacatttg tatctcatgt gggagcctca atgttaccct ggagcaccca
     1681 ctcttcattg gtggaatgtg ccagaactgt aagaactgct tcttggagtg tgcttaccaa
     1741 tacgatgacg atgggtacca gtcctactgt accatctgct gtggggggcg cgaagtgctc
     1801 atgtgtggga acaacaactg ctgcaggtgc ttttgtgtgg agtgtgtgga tctcttggtg
     1861 gggccagggg ctgcccaagc agccattaag gaagacccct ggaactgcta catgtgtggg
     1921 cacaagggca cgtatgggct gctgcggaga cgggaggact ggccttctcg actccagatg
     1981 ttcttcgcca ataaccacga ccaggaattt gaccccccga aggtttaccc acctgtgcca
     2041 gctgagaaga ggaagcccat ccgggtgcta tctctctttg atgggattgc tacagggctc
     2101 ctggtgctga aggacctggg catccaagtg gaccgctaca tcgcctccga ggtgtgcgag
     2161 gactccatca cagtgggcat ggtgcggcac cagggaaaga tcatgtacgt cggggacgtc
     2221 cgcagcgtca cacagaagca tatccaggag tggggcccat tcgatctggt gattgggggc
     2281 agtccctgca atgacctctc catcgtcaac cctgcccgca agggacttta cgagggcacg
     2341 ggccgcctct tctttgagtt ctaccgcctc ctgcatgacg cgcggcccaa ggagggagat
     2401 gatcgcccct tcttctggct ttttgagaat gtggtggcca tgggcgttag tgacaagagg
     2461 gacatctcga gatttcttga gtctaacccc gtgatgatcg acgccaaaga agtgtctgct
     2521 gcacacaggg cccgttattt ctggggtaac cttcctggca tgaacaggcc attggcatcc
     2581 actgtgaatg ataagctgga gttgcaagag tgtctggaac acggcagaat agccaagttc
     2641 agcaaagtga ggaccattac caccaggtca aactccataa agcagggcaa agaccagcat
     2701 ttccctgtct tcatgaatga gaaggaagac atcctctggt gcactgaaat ggaaagggtg
     2761 tttggcttcc ctgtccacta cacagacgtc tccaacatga gccgcttggc gaggcagaga
     2821 ctgctgggcc gatcgtggag cgtgccagtc atccgccacc tcttcgctcc gctgaaggaa
     2881 tattttgctt gtgtgtaagg gacatggggg caaactgaag tagtgatgat aaccaagtta
     2941 aacaaacaaa aaaacaaaac acaataaaac accaagaacg agaggacgga gagaagttca
     3001 gcacccagaa gagaaaaagg aatttaaagc aaaccacaga ggaggaaatg ccggagggct
     3061 tggccttgca gaagggttgg acatcatctc ttgagttttc aatgttcatc ttcagtccta
     3121 actaaaacgc aggataggcc cctccccttc ctcccctccg gtcctaggag gcgaaccttt
     3181 tgttttctac tctttttttc agaggggttt tctgtttgtt tgggtttttg tttcttgctg
     3241 tgactgaaac aagagagtta attgcagcaa aatcagtaac aacaaaaagt aatgccttgg
     3301 agaggaaagg gagagaggga aaattctata aaaacttaaa atattgtttt ttttttttcc
     3361 ttttctatat atctctttgg ttgtctctag cctgatcaga taggagcaca aacaggaaca
     3421 gaatagagac cctcggaggc agagtctcct ctcgcagccc ccgagcggtc tcaacagcac
     3481 catccctggt catgcagaac agaacccaac tagcagcagg gcgctgagaa taccacacca
     3541 gacacttttc tacagtattt caggtgccta ccacacagga aaccttgaag aaaaccagtt
     3601 tctagaagcc gctgttacct cttgtttaca gtttatatat atacgataga tatgagatat
     3661 atatataaaa ggtactgtta actactgtac atcccaactt cataatggtg ctttcaaaac
     3721 agcgagatga gcaaaaacat caacctccac ctggccctct gtgcaaaggg tttcagccca
     3781 ggatggggga gggaagcagc tagagggtgt cgtttttttt tttttttttt gtccctcttg
     3841 gtttttaaca aaccaaagga ggaaccatat tgcccccacc cccaccccac cccatgccta
     3901 gcttctcctg ccaaaagtgg ggctcagctg aggtggtcgg aacctgggga agcggagtgt
     3961 ggaatttatc cagactcgcg tgcaataacc tttgaatatg aatctaaaac gactgcctca
     4021 gaaaaatggc ttaaaaaaaa aaaaagttgt ccctgatttt gaatctgtca gccacattga
     4081 aggccccctt gtgggataag aaataatcca gagtgaggga aagtgatccg ccattaaccc
     4141 cacctggagc aaataaaaaa acatacaaaa cgt
//
