LOCUS       NM_053354               5917 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus DNA methyltransferase 1 (Dnmt1), mRNA.
ACCESSION   NM_053354
VERSION     NM_053354.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5917)
  AUTHORS   Ding,X., Lin,Y., Chen,C., Yan,B., Liu,Q., Zheng,H., Wu,Y. and
            Zhou,C.
  TITLE     DNMT1 Mediates Chronic Pain-Related Depression by Inhibiting
            GABAergic Neuronal Activation in the Central Amygdala
  JOURNAL   Biol Psychiatry 94 (8), 672-684 (2023)
   PUBMED   37001844
  REMARK    GeneRIF: DNMT1 Mediates Chronic Pain-Related Depression by
            Inhibiting GABAergic Neuronal Activation in the Central Amygdala.
REFERENCE   2  (bases 1 to 5917)
  AUTHORS   Zhang,S., Xie,H., Du,Y., Wang,B., Lan,B. and Wang,H.
  TITLE     DNMT1-induced miR-133b suppression via methylation promotes
            myocardial fibrosis after myocardial infarction
  JOURNAL   Gen Physiol Biophys 42 (5), 417-429 (2023)
   PUBMED   37702447
  REMARK    GeneRIF: DNMT1-induced miR-133b suppression via methylation
            promotes myocardial fibrosis after myocardial infarction.
REFERENCE   3  (bases 1 to 5917)
  AUTHORS   Wu,Q., Xie,J., Zhu,X. and He,J.
  TITLE     Runt-related transcription factor 3, mediated by
            DNA-methyltransferase 1, regulated Schwann cell proliferation and
            myelination during peripheral nerve regeneration via JAK/STAT
            signaling pathway
  JOURNAL   Neurosci Res 192, 1-10 (2023)
   PUBMED   36690210
  REMARK    GeneRIF: Runt-related transcription factor 3, mediated by
            DNA-methyltransferase 1, regulated Schwann cell proliferation and
            myelination during peripheral nerve regeneration via JAK/STAT
            signaling pathway.
REFERENCE   4  (bases 1 to 5917)
  AUTHORS   Wang,H.J., Zhang,F.C., Xu,T.W., Xu,Y.C., Tian,Y.Q., Wu,Y.Y.,
            Xu,J.T., Hu,S. and Xu,G.Y.
  TITLE     DNMT1 involved in the analgesic effect of folic acid on gastric
            hypersensitivity through downregulating ASIC1 in adult offspring
            rats with prenatal maternal stress
  JOURNAL   CNS Neurosci Ther 29 (6), 1678-1689 (2023)
   PUBMED   36852448
  REMARK    GeneRIF: DNMT1 involved in the analgesic effect of folic acid on
            gastric hypersensitivity through downregulating ASIC1 in adult
            offspring rats with prenatal maternal stress.
REFERENCE   5  (bases 1 to 5917)
  AUTHORS   Hou,Y., Shi,J., Guo,Y. and Shi,G.
  TITLE     DNMT1 regulates polarization of macrophage-induced intervertebral
            disc degeneration by modulating SIRT6 expression and promoting
            pyroptosis in vivo
  JOURNAL   Aging (Albany NY) 15 (10), 4288-4303 (2023)
   PUBMED   37199639
  REMARK    GeneRIF: DNMT1 regulates polarization of macrophage-induced
            intervertebral disc degeneration by modulating SIRT6 expression and
            promoting pyroptosis in vivo.
REFERENCE   6  (bases 1 to 5917)
  AUTHORS   Deng,J. and Szyf,M.
  TITLE     Multiple isoforms of DNA methyltransferase are encoded by the
            vertebrate cytosine DNA methyltransferase gene
  JOURNAL   J Biol Chem 273 (36), 22869-22872 (1998)
   PUBMED   9722504
REFERENCE   7  (bases 1 to 5917)
  AUTHORS   Hollnagel,A., Schroder,D. and Gross,G.
  TITLE     Domain-specific gene activation by parathyroid hormone in
            osteoblastic ROS17/2.8 cells
  JOURNAL   J Biol Chem 271 (36), 21870-21877 (1996)
   PUBMED   8702988
REFERENCE   8  (bases 1 to 5917)
  AUTHORS   Ohsawa,K., Imai,Y., Ito,D. and Kohsaka,S.
  TITLE     Molecular cloning and characterization of annexin V-binding
            proteins with highly hydrophilic peptide structure
  JOURNAL   J Neurochem 67 (1), 89-97 (1996)
   PUBMED   8667030
REFERENCE   9  (bases 1 to 5917)
  AUTHORS   Li,E., Bestor,T.H. and Jaenisch,R.
  TITLE     Targeted mutation of the DNA methyltransferase gene results in
            embryonic lethality
  JOURNAL   Cell 69 (6), 915-926 (1992)
   PUBMED   1606615
REFERENCE   10 (bases 1 to 5917)
  AUTHORS   Farrance,I.K. and Ivarie,R.
  TITLE     Ethylation of poly(dC-dG).poly(dC-dG) by ethyl methanesulfonate
            stimulates the activity of mammalian DNA methyltransferase in vitro
  JOURNAL   Proc Natl Acad Sci U S A 82 (4), 1045-1049 (1985)
   PUBMED   3856245
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473993.2.
            
            On Nov 25, 2008 this sequence version replaced NM_053354.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5917
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..5917
                     /gene="Dnmt1"
                     /note="DNA methyltransferase 1"
                     /db_xref="GeneID:84350"
                     /db_xref="RGD:620979"
     exon            1..160
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..4946
                     /gene="Dnmt1"
                     /EC_number="2.1.1.37"
                     /note="MCMT; m.RnoIP; DNA MTase RnoIP; DNA
                     methyltransferase I; DNA methyltransferase (cytosine-5) 1;
                     DNA (cytosine-5-)-methyltransferase 1"
                     /codon_start=1
                     /product="DNA (cytosine-5)-methyltransferase 1"
                     /protein_id="NP_445806.3"
                     /db_xref="GeneID:84350"
                     /db_xref="RGD:620979"
                     /translation="MPARTAPARVPALASPAGSLPDHVRRRLKDLERDGLTEKECVKE
                     KLNLLHEFLQTEIKSQLCDLETKLHKEELSEEGYLAKVKTLLNKDLCLENGTLSLTQK
                     ANGCPANGSRPTWKAEMADSNRSPRSRPKPRGPRRSKSDSETMIEASSSSVATRRTTR
                     QTTITSHFKGPAKRKPKEDSEKGNANESAAEERDQDKKRRVAGTESRASRAGESVEKP
                     ERVRPGTQLCQEEQGEQEDDRRPRRQTRELASRRKSREDPDREARPGTHLDVDDDDEK
                     DKRSSRPRSQPRDLATKRRPKEEVEQITPEPPEGKDEDEREEKRRKTTRKKPEPLSIP
                     VQSRVERKASQGKASAIPKLNPPQCPECGQYLDDPDLKYQQHPVDAVDEPQMLTNEAL
                     SVFDSNSSWFETYDSSPMHKFTFFSVYCSRGHLCPVDTGLIEKNVELYFSGVAKAIHE
                     ENPSVEGGVNGKNLGPINQWWISGFDGGEKALIGFSTAFAEYFLMEPSPEYAPIFGLM
                     QEKIYISKIVVEFLQSNPDAVYEDLINKIETTVPPSAINVNRFTEDSLLRHAQFVVSQ
                     VESYDDAKDDDETPIFLSPCMRSLIHLAGVSLGQRRATRRTVINSAKVKRKGPTKATT
                     TKLVYQIFDTFFSEQIEKDDKEDKENTMKRRRCGVCEVCQQPECGKCKACKDMVKFGG
                     TGRSKQACLKRRCPNLAVKEADEDEEADDDIPELPSPKKLHQGKKKKQNKDRISWLGE
                     PVKIEENRTYYWKVSIDEETLEVGDCVSVIPDDPSKPLYLARVTALWEDKNGQMFHAH
                     WFCAGTDTVLGATSDPLELFLVGECENMQLSYIHSKVKVIYRGPSPNWAMEGGMDPEA
                     MLPGAEDGKTYFYQFWYSQDYARFESPPKTQPTEDNKHKFCLSCIRLAELRQKEMPKV
                     LEQLEEVDGRVYCSSITKNGVVYRLGDSVYLPPEAFTFNIKMASPMKRSKRDPVNENL
                     YPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIHCGKKKGGKVNEADIKIRLYKFYRPEN
                     THKSIQATYHADINLLYWSDEEAVVDFSDVQGRCTVEYGEDLLESIQDYSQGGPDRFY
                     FLEAYNSKTKSFEDPPNHARSPGNKGKGKGKGKGKGKPQVSEPKEPEAAIKLPKLRTL
                     DVFSGCGGLTEGFHQAGISETLWAIEMWEPAAQAFRLNNPGTTVFTEDCNVLLKLVMA
                     GEVTNSLGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYY
                     RPRFFLLENVRNFVSFRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIIL
                     AAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDL
                     PEIQNGASAPEISYNGEPQSWFQRQLRGSHYQPILRDHICKDMSALVAARMRHIPLSP
                     GSDWRDLPNIQVRLRDGVITNKLRYTFHDTKNGCSSTGALRGVCSCAEGKTCDPASRQ
                     FNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVS
                     VRECARSQGFPDTYRLFGNILDRHRQVGNAVPPPLAKAIGLEIKLCLLASAQESASAA
                     VKGKEETTTED"
     exon            161..197
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            198..305
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..516
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            517..589
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..665
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..697
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..785
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            786..823
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            824..908
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..949
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1028
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1093
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1139
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1220
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1330
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1449
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1542
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1694
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1882
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2063
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2161
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2309
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2425
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2627
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2764
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2938
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3160
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            3161..3353
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            3354..3438
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3567
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            3568..3850
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            3851..3992
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            3993..4159
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            4160..4337
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            4338..4814
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            4815..4905
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            4906..5917
                     /gene="Dnmt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccctccc aattggtttc cgcgcgcgcg aaaaagccgg ggtctcgttc agagctgtcc
       61 tgtcgtctgc aacctgcaag atgccagcac gaacagctcc agcccgagtg cctgcacttg
      121 cctccccggc aggctcgctc cccgaccatg tccgcaggcg gctcaaagac ttggaaagag
      181 atggcttaac agaaaaggag tgtgtgaaag agaaattgaa cttactgcat gaattcctgc
      241 aaacagaaat aaaaagccag ctatgcgact tggaaaccaa actacataaa gaggaattgt
      301 ctgaggaagg ctacctggct aaagtcaaga cccttctaaa taaggatttg tgcctggaga
      361 acggaacact ctctctcact cagaaagcca acggttgtcc tgccaacggg agtcggccaa
      421 cctggaaagc agaaatggca gactcaaacc gatccccaag atccaggccc aagcctcggg
      481 gacccaggag gagcaagtcg gacagtgaga ccatgattga agcttcatct agttcggtgg
      541 ctacgaggag aaccaccagg cagaccacca tcacgtctca cttcaagggt cccgctaaac
      601 ggaaacccaa ggaagactct gaaaagggaa acgcaaatga atctgctgca gaggagagag
      661 accaggataa gaaacgcaga gtcgcaggca cagagagtcg tgccagtcgt gccggagagt
      721 ctgtggagaa acctgaacga gtaaggccag gaacccagct gtgtcaggaa gagcaaggtg
      781 aacaggaaga tgacaggaga cctcgacgtc aaaccagaga gctagcatca aggcggaaat
      841 caagggagga cccagacaga gaagcaaggc caggaactca cttggatgtg gacgatgacg
      901 atgaaaagga caaaagaagt tccaggccca gaagccagcc cagagatcta gccaccaaac
      961 ggagacccaa ggaagaagta gagcagatca ctccagagcc tcccgagggc aaagatgagg
     1021 acgaaaggga ggagaagaga cgaaaaacga cacgtaaaaa gccggaacca ctcagcattc
     1081 ccgtacagag cagagtggag agaaaagcct ctcagggcaa agcaagtgca atcccaaagc
     1141 tcaacccgcc acagtgccct gagtgtggcc agtacctaga tgaccctgac ctgaagtacc
     1201 agcagcaccc tgtggatgct gtggatgaac cccagatgct gaccaatgag gcactgtccg
     1261 tctttgactc caactcgtct tggtttgaga cctatgattc ctctcccatg cataagttca
     1321 ctttcttcag tgtgtattgc agtcgcggtc acttgtgtcc tgtcgacact ggtctcattg
     1381 agaagaacgt tgaactctac ttttctggtg ttgccaaagc aattcatgaa gaaaatccgt
     1441 ctgtggaagg tggtgttaat ggcaagaacc tggggccaat caatcagtgg tggatcagtg
     1501 gctttgacgg tggcgagaag gcgctcattg gcttttctac cgcatttgct gaatactttc
     1561 tgatggagcc cagcccagag tatgcaccaa tatttgggct gatgcaggag aaaatttaca
     1621 tcagcaagat tgtggtcgag ttcttgcaga gcaatcctga cgctgtctat gaagacttga
     1681 tcaataagat cgagaccact gttcctcctt ctgccatcaa tgtgaaccgg ttcaccgagg
     1741 actccctcct acgccatgcc cagtttgtgg tgagccaggt agaaagttac gacgacgcta
     1801 aggacgatga tgagacgccc atcttcttgt ctccctgtat gaggtccctg atccatttgg
     1861 ctggtgtctc gctgggacag aggcgagcaa caaggcgcac ggtcatcaat tctgccaaag
     1921 tgaagcgcaa ggggcccaca aaagccacca ccaccaagct ggtctatcag atcttcgaca
     1981 ctttcttctc ggagcagatc gagaaggatg acaaggagga caaagagaac accatgaagc
     2041 gccgccggtg tggtgtctgt gaggtctgtc aacagcctga gtgtgggaag tgcaaggcgt
     2101 gcaaagacat ggttaagttt ggtggcaccg gacggagtaa acaggcttgc ctcaagagga
     2161 ggtgtcctaa cttggccgta aaggaggcag atgaagacga agaagctgat gatgatatac
     2221 cagagttgcc gtcacccaaa aagttgcacc aagggaagaa gaagaaacag aataaggatc
     2281 gcatctcctg gctcggggag cctgtgaaga tcgaagagaa cagaacttac tattggaagg
     2341 tgagcatcga cgaagagact ctggaggtgg gcgactgcgt ctcggtcatt ccggatgatc
     2401 cctccaaacc actgtatcta gccagggtca cagcactgtg ggaagacaag aacgggcaga
     2461 tgttccatgc acactggttc tgcgcgggga cagacacggt cctcggagcc acctctgacc
     2521 ctctggagct gttccttgta ggcgagtgtg aaaacatgca actttcctac atccacagca
     2581 aggtcaaggt catctacaga gggccttccc caaactgggc catggaggga ggcatggacc
     2641 ctgaggccat gttgccgggg gctgaggatg ggaagaccta cttctaccag ttctggtaca
     2701 gccaggacta cgcaaggttt gagtccccac ccaagaccca gccgacggag gacaataagc
     2761 acaagttctg cctatcttgt atccggctgg ctgagctgag acaaaaagaa atgcccaaag
     2821 tcctggaaca acttgaggag gtggacggcc gggtctactg cagttctatc accaagaacg
     2881 gtgttgtcta ccgactgggt gacagtgtgt acctgcctcc tgaggccttt actttcaaca
     2941 tcaaaatggc cagccccatg aaacgctcta agagggaccc tgtgaatgag aacctgtacc
     3001 ccgagcatta ccgcaagtat tccgactaca tcaaaggaag caacctggac gcccctgaac
     3061 cctatcggat tggtcggata aaagagatcc actgtggcaa gaagaaaggt ggcaaggtca
     3121 atgaggcaga catcaagatc aggctctaca agttctatag gcctgagaac acccacaagt
     3181 ccatccaggc aacctaccac gccgacatca acctgctcta ctggagcgat gaggaagccg
     3241 tggtggactt cagcgacgtg caaggccgct gcaccgtgga gtacggagag gacctgcttg
     3301 agagcatcca ggattactca cagggcggcc ccgaccgctt ctactttctc gaggcctaca
     3361 attcaaagac taaaagcttt gaagaccctc cgaaccatgc ccgcagccct gggaacaaag
     3421 gcaaaggaaa ggggaaaggg aaagggaagg gaaaacctca ggtatcagag cccaaagagc
     3481 ccgaggcagc catcaaactg cctaagctgc ggaccctgga tgtgttttct ggctgtggag
     3541 gattaacaga aggattccac caagcaggca tctcggagac gctgtgggcc atcgagatgt
     3601 gggaaccagc agcccaggca tttcggctga acaaccctgg caccacggtg ttcacagagg
     3661 actgcaacgt gcttctcaag ctggtcatgg ctggtgaggt gaccaactct ctgggccaga
     3721 ggctgccaca gaagggcgat gtggagatgc tgtgtggtgg gccgccctgc cagggcttca
     3781 gtggcatgaa ccgtttcaac tctcgtactt actccaagtt caaaaactcc ctcgtggtct
     3841 ccttcctcag ctactgtgac tactaccggc ctcggttctt cctcttggag aatgtcagga
     3901 acttcgtgtc cttcaggcgc tccatggtgc tgaagctcac actgcgctgc ctggtccgca
     3961 tgggctacca gtgcaccttc ggtgtgctcc aggctggaca gtatggtgtg gcccagacac
     4021 gaaggagggc catcatcttg gctgcagccc ctggagagaa gctgcctctg ttcccagaac
     4081 ctctacacgt gtttgccccc cgtgcctgcc agctgagtgt tgtggtggac gacaagaagt
     4141 tcgttagcaa cattacaagg ctaagctcgg gtcccttccg aaccatcacg gtgcgagata
     4201 ccatgtctga cctccctgag atccagaatg gagcctcagc ccccgagatc tcctacaatg
     4261 gagagccaca gtcctggttc cagaggcagc tgcgagggtc gcactaccag cccatcctca
     4321 gggaccatat ctgcaaggac atgagcgcgc tggtggctgc ccgtatgcgg cacatcccgc
     4381 tgtccccagg atcggattgg cgtgacctgc ccaacataca agtgcggctg agagatggcg
     4441 tcataaccaa taaacttcgc tacactttcc acgacacgaa gaacggctgc agcagcaccg
     4501 gggccctgcg tggggtctgc tcctgtgcgg aaggcaagac ctgcgaccct gcttccagac
     4561 aattcaacac gctcatcccc tggtgcctgc cgcacactgg gaaccggcac aaccactggg
     4621 ctggcctcta cgggcgtctg gagtgggatg gcttcttcag taccaccgtc accaaccctg
     4681 agcccatggg caagcaaggc cgggtgctcc atcccgagca gcaccgggtc gtgagtgtgc
     4741 gggaatgtgc tcgctcccaa ggctttccag atacctaccg gttattcggc aacatcctgg
     4801 acagacaccg gcaggtgggg aacgctgtgc caccaccact ggccaaagcc atcggcctgg
     4861 agattaagct ctgtctgctg gccagcgctc aggagagtgc ctcagctgca gttaaaggaa
     4921 aggaggagac tactaccgag gactagtgct ctcacccaga gccccacgtg cactgatgtt
     4981 ttttaacccg tcgagcccca tcatttgaag tgttctgctc agtgtctgtg accatggctg
     5041 acactaagct gttggaggtt tgttttgtga ccaagccgtg tagcactttg tgcattctga
     5101 attttaaggt tttgtttttt tgtttttttg ttttgttttt ttattctgta ttctatcaga
     5161 tctgccactg tgtgggtggc aagtgagact tgatgtagtt ttatatgttg taatatttct
     5221 tcaaaataaa gcgcttctat aaagcaccca gctagtgatc gatgtctctg gcagcatccc
     5281 cactatcagg ggatggggga aggggctcgt gtccatggac cctccactgc agctacctcg
     5341 gtgggttaca tttccgtgac tcctttctgc ccagtgaaaa gcaaacggaa ctttctagta
     5401 gatctttcca gaaagcccct taaaacctct tggctaatct tcatgggcac tttgcccttt
     5461 ttgtcttgga gttgatcttt tcttgtggtg tctggtaaca aagcagccgt cctgggatcg
     5521 tgatgtcgta agacctggat catggagcag gaagagagac catggctaaa ccgccctcag
     5581 tactgtctat ctgccctatc tgcagaactc tagttggttt aagacttaga agacattggg
     5641 gttggggatt tagctcagtg gtagagcgct tgcctagcaa gcgcaaggcc ctgggttcgg
     5701 tccccagctc tgttaaaaaa aaaaaaaaaa aagacttaga agacacaagc ctacaagagt
     5761 ctcctgggtc tttggatctg actcaacaca cataactttt tgatatattg tgtaaccatg
     5821 tctgaccatt atatccactg tatagctcag gctggaccac tagttgtggc agtccttcca
     5881 agtgccactg tactaaacta gagcagtaat ttaaggc
//
