LOCUS       NP_445806               1621 aa            linear   ROD 03-APR-2024
DEFINITION  DNA (cytosine-5)-methyltransferase 1 [Rattus norvegicus].
ACCESSION   NP_445806
VERSION     NP_445806.3
DBSOURCE    REFSEQ: accession NM_053354.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1621)
  AUTHORS   Ding,X., Lin,Y., Chen,C., Yan,B., Liu,Q., Zheng,H., Wu,Y. and
            Zhou,C.
  TITLE     DNMT1 Mediates Chronic Pain-Related Depression by Inhibiting
            GABAergic Neuronal Activation in the Central Amygdala
  JOURNAL   Biol Psychiatry 94 (8), 672-684 (2023)
   PUBMED   37001844
  REMARK    GeneRIF: DNMT1 Mediates Chronic Pain-Related Depression by
            Inhibiting GABAergic Neuronal Activation in the Central Amygdala.
REFERENCE   2  (residues 1 to 1621)
  AUTHORS   Zhang,S., Xie,H., Du,Y., Wang,B., Lan,B. and Wang,H.
  TITLE     DNMT1-induced miR-133b suppression via methylation promotes
            myocardial fibrosis after myocardial infarction
  JOURNAL   Gen Physiol Biophys 42 (5), 417-429 (2023)
   PUBMED   37702447
  REMARK    GeneRIF: DNMT1-induced miR-133b suppression via methylation
            promotes myocardial fibrosis after myocardial infarction.
REFERENCE   3  (residues 1 to 1621)
  AUTHORS   Wu,Q., Xie,J., Zhu,X. and He,J.
  TITLE     Runt-related transcription factor 3, mediated by
            DNA-methyltransferase 1, regulated Schwann cell proliferation and
            myelination during peripheral nerve regeneration via JAK/STAT
            signaling pathway
  JOURNAL   Neurosci Res 192, 1-10 (2023)
   PUBMED   36690210
  REMARK    GeneRIF: Runt-related transcription factor 3, mediated by
            DNA-methyltransferase 1, regulated Schwann cell proliferation and
            myelination during peripheral nerve regeneration via JAK/STAT
            signaling pathway.
REFERENCE   4  (residues 1 to 1621)
  AUTHORS   Wang,H.J., Zhang,F.C., Xu,T.W., Xu,Y.C., Tian,Y.Q., Wu,Y.Y.,
            Xu,J.T., Hu,S. and Xu,G.Y.
  TITLE     DNMT1 involved in the analgesic effect of folic acid on gastric
            hypersensitivity through downregulating ASIC1 in adult offspring
            rats with prenatal maternal stress
  JOURNAL   CNS Neurosci Ther 29 (6), 1678-1689 (2023)
   PUBMED   36852448
  REMARK    GeneRIF: DNMT1 involved in the analgesic effect of folic acid on
            gastric hypersensitivity through downregulating ASIC1 in adult
            offspring rats with prenatal maternal stress.
REFERENCE   5  (residues 1 to 1621)
  AUTHORS   Hou,Y., Shi,J., Guo,Y. and Shi,G.
  TITLE     DNMT1 regulates polarization of macrophage-induced intervertebral
            disc degeneration by modulating SIRT6 expression and promoting
            pyroptosis in vivo
  JOURNAL   Aging (Albany NY) 15 (10), 4288-4303 (2023)
   PUBMED   37199639
  REMARK    GeneRIF: DNMT1 regulates polarization of macrophage-induced
            intervertebral disc degeneration by modulating SIRT6 expression and
            promoting pyroptosis in vivo.
REFERENCE   6  (residues 1 to 1621)
  AUTHORS   Deng,J. and Szyf,M.
  TITLE     Multiple isoforms of DNA methyltransferase are encoded by the
            vertebrate cytosine DNA methyltransferase gene
  JOURNAL   J Biol Chem 273 (36), 22869-22872 (1998)
   PUBMED   9722504
REFERENCE   7  (residues 1 to 1621)
  AUTHORS   Hollnagel,A., Schroder,D. and Gross,G.
  TITLE     Domain-specific gene activation by parathyroid hormone in
            osteoblastic ROS17/2.8 cells
  JOURNAL   J Biol Chem 271 (36), 21870-21877 (1996)
   PUBMED   8702988
REFERENCE   8  (residues 1 to 1621)
  AUTHORS   Ohsawa,K., Imai,Y., Ito,D. and Kohsaka,S.
  TITLE     Molecular cloning and characterization of annexin V-binding
            proteins with highly hydrophilic peptide structure
  JOURNAL   J Neurochem 67 (1), 89-97 (1996)
   PUBMED   8667030
REFERENCE   9  (residues 1 to 1621)
  AUTHORS   Li,E., Bestor,T.H. and Jaenisch,R.
  TITLE     Targeted mutation of the DNA methyltransferase gene results in
            embryonic lethality
  JOURNAL   Cell 69 (6), 915-926 (1992)
   PUBMED   1606615
REFERENCE   10 (residues 1 to 1621)
  AUTHORS   Farrance,I.K. and Ivarie,R.
  TITLE     Ethylation of poly(dC-dG).poly(dC-dG) by ethyl methanesulfonate
            stimulates the activity of mammalian DNA methyltransferase in vitro
  JOURNAL   Proc Natl Acad Sci U S A 82 (4), 1045-1049 (1985)
   PUBMED   3856245
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473993.2.
            
            On Nov 25, 2008 this sequence version replaced NP_445806.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1621
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     Protein         1..1621
                     /product="DNA (cytosine-5)-methyltransferase 1"
                     /EC_number="2.1.1.37"
                     /note="MCMT; m.RnoIP; DNA MTase RnoIP; DNA
                     methyltransferase I; DNA methyltransferase (cytosine-5) 1;
                     DNA (cytosine-5-)-methyltransferase 1"
                     /calculated_mol_wt=182909
     Region          16..106
                     /region_name="DMAP_binding"
                     /note="DMAP1-binding Domain; pfam06464"
                     /db_xref="CDD:368923"
     Region          109..>327
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     Region          405..540
                     /region_name="DNMT1-RFD"
                     /note="Cytosine specific DNA methyltransferase replication
                     foci domain; pfam12047"
                     /db_xref="CDD:463444"
     Region          649..695
                     /region_name="zf-CXXC"
                     /note="CXXC zinc finger domain; pfam02008"
                     /db_xref="CDD:366873"
     Region          759..881
                     /region_name="BAH_Dnmt1_I"
                     /note="BAH, or Bromo Adjacent Homology domain, first copy
                     present in DNA (Cytosine-5)-methyltransferases from
                     Bilateria, Dnmt1 and similar proteins. DNA methylation, or
                     the covalent addition of a methyl group to cytosine within
                     the context of the CpG...; cd04760"
                     /db_xref="CDD:240107"
     Region          969..1105
                     /region_name="BAH_Dnmt1_II"
                     /note="BAH, or Bromo Adjacent Homology domain, second copy
                     present in DNA (Cytosine-5)-methyltransferases from
                     Bilateria, Dnmt1 and similar proteins. DNA methylation, or
                     the covalent addition of a methyl group to cytosine within
                     the context of the CpG...; cd04711"
                     /db_xref="CDD:240062"
     Region          1141..1599
                     /region_name="Dcm"
                     /note="DNA-cytosine methylase [Replication, recombination
                     and repair]; COG0270"
                     /db_xref="CDD:440040"
     CDS             1..1621
                     /gene="Dnmt1"
                     /coded_by="NM_053354.3:81..4946"
                     /db_xref="GeneID:84350"
                     /db_xref="RGD:620979"
ORIGIN      
        1 mpartaparv palaspagsl pdhvrrrlkd lerdglteke cvkeklnllh eflqteiksq
       61 lcdletklhk eelseegyla kvktllnkdl clengtlslt qkangcpang srptwkaema
      121 dsnrsprsrp kprgprrsks dsetmieass ssvatrrttr qttitshfkg pakrkpkeds
      181 ekgnanesaa eerdqdkkrr vagtesrasr agesvekper vrpgtqlcqe eqgeqeddrr
      241 prrqtrelas rrksredpdr earpgthldv ddddekdkrs srprsqprdl atkrrpkeev
      301 eqitpeppeg kdedereekr rkttrkkpep lsipvqsrve rkasqgkasa ipklnppqcp
      361 ecgqylddpd lkyqqhpvda vdepqmltne alsvfdsnss wfetydsspm hkftffsvyc
      421 srghlcpvdt glieknvely fsgvakaihe enpsveggvn gknlgpinqw wisgfdggek
      481 aligfstafa eyflmepspe yapifglmqe kiyiskivve flqsnpdavy edlinkiett
      541 vppsainvnr ftedsllrha qfvvsqvesy ddakdddetp iflspcmrsl ihlagvslgq
      601 rratrrtvin sakvkrkgpt katttklvyq ifdtffseqi ekddkedken tmkrrrcgvc
      661 evcqqpecgk ckackdmvkf ggtgrskqac lkrrcpnlav keadedeead ddipelpspk
      721 klhqgkkkkq nkdriswlge pvkieenrty ywkvsideet levgdcvsvi pddpskplyl
      781 arvtalwedk ngqmfhahwf cagtdtvlga tsdplelflv gecenmqlsy ihskvkviyr
      841 gpspnwameg gmdpeamlpg aedgktyfyq fwysqdyarf esppktqpte dnkhkfclsc
      901 irlaelrqke mpkvleqlee vdgrvycssi tkngvvyrlg dsvylppeaf tfnikmaspm
      961 krskrdpvne nlypehyrky sdyikgsnld apepyrigri keihcgkkkg gkvneadiki
     1021 rlykfyrpen thksiqatyh adinllywsd eeavvdfsdv qgrctveyge dllesiqdys
     1081 qggpdrfyfl eaynsktksf edppnharsp gnkgkgkgkg kgkgkpqvse pkepeaaikl
     1141 pklrtldvfs gcggltegfh qagisetlwa iemwepaaqa frlnnpgttv ftedcnvllk
     1201 lvmagevtns lgqrlpqkgd vemlcggppc qgfsgmnrfn srtyskfkns lvvsflsycd
     1261 yyrprfflle nvrnfvsfrr smvlkltlrc lvrmgyqctf gvlqagqygv aqtrrraiil
     1321 aaapgeklpl fpeplhvfap racqlsvvvd dkkfvsnitr lssgpfrtit vrdtmsdlpe
     1381 iqngasapei syngepqswf qrqlrgshyq pilrdhickd msalvaarmr hiplspgsdw
     1441 rdlpniqvrl rdgvitnklr ytfhdtkngc sstgalrgvc scaegktcdp asrqfntlip
     1501 wclphtgnrh nhwaglygrl ewdgffsttv tnpepmgkqg rvlhpeqhrv vsvrecarsq
     1561 gfpdtyrlfg nildrhrqvg navppplaka igleiklcll asaqesasaa vkgkeettte
     1621 d
//
