LOCUS       NM_001395001            6071 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus dynamin binding protein (Dnmbp), transcript
            variant 1, mRNA.
ACCESSION   NM_001395001 XM_006231570
VERSION     NM_001395001.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6071)
  AUTHORS   Baek,J.I., Kwon,S.H., Zuo,X., Choi,S.Y., Kim,S.H. and
            Lipschutz,J.H.
  TITLE     Dynamin Binding Protein (Tuba) Deficiency Inhibits Ciliogenesis and
            Nephrogenesis in Vitro and in Vivo
  JOURNAL   J Biol Chem 291 (16), 8632-8643 (2016)
   PUBMED   26895965
REFERENCE   2  (bases 1 to 6071)
  AUTHORS   Saheki,Y. and De Camilli,P.
  TITLE     Synaptic vesicle endocytosis
  JOURNAL   Cold Spring Harb Perspect Biol 4 (9), a005645 (2012)
   PUBMED   22763746
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6071)
  AUTHORS   Casoli,T., Di Stefano,G., Fattoretti,P., Giorgetti,B., Balietti,M.,
            Lattanzio,F., Aicardi,G. and Platano,D.
  TITLE     Dynamin binding protein gene expression and memory performance in
            aged rats
  JOURNAL   Neurobiol Aging 33 (3), 618 (2012)
   PUBMED   21232816
  REMARK    GeneRIF: A deficit in long term memory formation during
            physiological aging is associated with lower Dnmbp expression.
REFERENCE   4  (bases 1 to 6071)
  AUTHORS   Otani,T., Ichii,T., Aono,S. and Takeichi,M.
  TITLE     Cdc42 GEF Tuba regulates the junctional configuration of simple
            epithelial cells
  JOURNAL   J Cell Biol 175 (1), 135-146 (2006)
   PUBMED   17015620
REFERENCE   5  (bases 1 to 6071)
  AUTHORS   Kovacs,E.M., Makar,R.S. and Gertler,F.B.
  TITLE     Tuba stimulates intracellular N-WASP-dependent actin assembly
  JOURNAL   J Cell Sci 119 (Pt 13), 2715-2726 (2006)
   PUBMED   16757518
REFERENCE   6  (bases 1 to 6071)
  AUTHORS   Salazar,M.A., Kwiatkowski,A.V., Pellegrini,L., Cestra,G.,
            Butler,M.H., Rossman,K.L., Serna,D.M., Sondek,J., Gertler,F.B. and
            De Camilli,P.
  TITLE     Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl
            homology domains, links dynamin to regulation of the actin
            cytoskeleton
  JOURNAL   J Biol Chem 278 (49), 49031-49043 (2003)
   PUBMED   14506234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On May 21, 2021 this sequence version replaced XM_006231570.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000001.1  252778580-252778642 c
            64-219              JAXUCZ010000001.1  252749142-252749297 c
            220-342             JAXUCZ010000001.1  252747352-252747474 c
            343-2334            JAXUCZ010000001.1  252737752-252739743 c
            2335-2528           JAXUCZ010000001.1  252710307-252710500 c
            2529-2628           JAXUCZ010000001.1  252709650-252709749 c
            2629-2776           JAXUCZ010000001.1  252705615-252705762 c
            2777-2794           JAXUCZ010000001.1  252705008-252705025 c
            2795-2994           JAXUCZ010000001.1  252704237-252704436 c
            2995-3125           JAXUCZ010000001.1  252702979-252703109 c
            3126-3230           JAXUCZ010000001.1  252702058-252702162 c
            3231-3359           JAXUCZ010000001.1  252694478-252694606 c
            3360-3692           JAXUCZ010000001.1  252692968-252693300 c
            3693-3872           JAXUCZ010000001.1  252692349-252692528 c
            3873-4071           JAXUCZ010000001.1  252690676-252690874 c
            4072-4622           JAXUCZ010000001.1  252688467-252689017 c
            4623-6071           JAXUCZ010000001.1  252685406-252686854 c
FEATURES             Location/Qualifiers
     source          1..6071
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..6071
                     /gene="Dnmbp"
                     /gene_synonym="Tuba"
                     /note="dynamin binding protein"
                     /db_xref="GeneID:309362"
                     /db_xref="RGD:1583840"
     exon            1..63
                     /gene="Dnmbp"
                     /gene_synonym="Tuba"
                     /inference="alignment:Splign:2.1.0"
     exon            64..219
                     /gene="Dnmbp"
                     /gene_synonym="Tuba"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..4808
                     /gene="Dnmbp"
                     /gene_synonym="Tuba"
                     /note="isoform 1 is encoded by transcript variant 1;
                     scaffold protein Tuba"
                     /codon_start=1
                     /product="dynamin-binding protein isoform 1"
                     /protein_id="NP_001381930.1"
                     /db_xref="GeneID:309362"
                     /db_xref="RGD:1583840"
                     /translation="MEPGSVVRAIFDFCPSVSEELPLFVGDVIEVLTVVDEFWLLGKK
                     EDVTGQFPSSFVEIVTIPSLKEGERLFVCTCDFISREPNSLSLHRGDLVIIDGTPTAG
                     WLQGRSSLGARGFFPSSCIHELCLSSQSRQWHSQNMLLQVPEYSMGQARALMGLSAQL
                     DEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLRTADESVNAGSGD
                     DSTLNDEVDVSPEEVESEGDEDDQQAGTYGIALYRFQALESNELDFEVGDKIRILGTL
                     EDGWLEGRLKGKTGIFPHRFVKLCPSNRSEETMALPQGDSFPKNSESSAGEMGDSVVE
                     EARQDPQECEEETPDSGLPEQTSEEPLDHVAPECVVDKISGQDEDASGSSPDVDLEGP
                     RAEDPSTPDLSQEVNGISSLPPQVPLQPEEEKSQHYLTAGGSRQCPDTFSKLFPLEAK
                     TRNYSSLPPRRTYTQGWSLQKPAPHLHRASSLTASRVNRPGHFSHTAMASCAQKHQTS
                     AENAASLCCAPERPKRRPGLPDKEPATEITPASQGDNLDLDSKLTQQLIEFEKSLSGP
                     STEPKKIVRRFSIMDFYSEKDIVRGSSNSLPSRNFPERRKALRPPPPRPHTPTSTSPH
                     LLVDQSPKPGPPLVVRPSRPAPLPPPTQQRLNTASPKPTSCALPGWEAPEKEGSEYTE
                     KSPAQLFPCPSVLARIQDVEHDLDMHTRAQEELNLLLEEKQDESLRAETLETLKSYES
                     TIQSLNLELQQLREMTLLSSQSSSLAAPSGSVSTEKPEQRMLEKRAKVVAELLQTEKD
                     YIRDLEMCVERVMVPLQQAQVPNIDFEGLFGNMQTVIKVSKQLLAALEITDAVGPVFL
                     DHRDELEGTYRLYCQNHDEAISLLDIYEKDERIQKHLQDYLADLKSLYHEWGCTNYIN
                     LGSFLIKPVQRIMRYPLLLMELLNSTPESHPDKAPLTSAVLAIKEINANINEYKRRKD
                     LVLKYRKADEDSLMEKISKLNIHSIIKKSSRVSSHLKHLTGFAPQLKDEAFEETEKNF
                     RMQERLIKSFIRDLSLYLQHIRESACVKVVAAMSIWDLCMERGHHDLEQFEKVHRYIS
                     DQLFTRFKERTERLVINPLNQLLNMFTGPYKLVQKRFDKLLDFYNCTERAEKLKDKKT
                     LEDLQSARNNYEALNSQLLDELPKFQQYAQSLFTNCIHGYAEAHCDFVQKALEQLQPL
                     LSLLKASDREGNLIAIFHEEHSRVLQQLQVFTFFPEALPAPRKPFERKTTDRQSSRKA
                     LLGMPSYMLQSEELRSSLLARYPPEKLFHVQRNFNAAQDLDVSLLEGDLVGVIKKKDP
                     MGSQNRWLVDNGVTKGFVYSSFLKPYNPRCSHSDSSVVSHSSTESEHSGSSPSFHRQN
                     SSSALTFNSNSMTVSFTSGLPQKQPQDTSPLRECVPETLGVSSNTGNPETGPSPCPSD
                     PGFSCQRRPGNPADGTREISQPASTLRGCQRRSLHSEVLGYPVPGRSDQGSDSIKGTS
                     RACQTAGDRDRGLGSSEAEGNQVYFAIYTFKARNPNELTVLANQRLRILEFKDVTGNT
                     EWWLAEVNGKKGYVPSNYIRKTEYT"
     exon            220..342
                     /gene="Dnmbp"
                     /gene_synonym="Tuba"
                     /inference="alignment:Splign:2.1.0"
     exon            343..2334
                     /gene="Dnmbp"
                     /gene_synonym="Tuba"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2528
                     /gene="Dnmbp"
                     /gene_synonym="Tuba"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2628
                     /gene="Dnmbp"
                     /gene_synonym="Tuba"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2776
                     /gene="Dnmbp"
                     /gene_synonym="Tuba"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2794
                     /gene="Dnmbp"
                     /gene_synonym="Tuba"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2994
                     /gene="Dnmbp"
                     /gene_synonym="Tuba"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3125
                     /gene="Dnmbp"
                     /gene_synonym="Tuba"
                     /inference="alignment:Splign:2.1.0"
     exon            3126..3230
                     /gene="Dnmbp"
                     /gene_synonym="Tuba"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3359
                     /gene="Dnmbp"
                     /gene_synonym="Tuba"
                     /inference="alignment:Splign:2.1.0"
     exon            3360..3692
                     /gene="Dnmbp"
                     /gene_synonym="Tuba"
                     /inference="alignment:Splign:2.1.0"
     exon            3693..3872
                     /gene="Dnmbp"
                     /gene_synonym="Tuba"
                     /inference="alignment:Splign:2.1.0"
     exon            3873..4071
                     /gene="Dnmbp"
                     /gene_synonym="Tuba"
                     /inference="alignment:Splign:2.1.0"
     exon            4072..4622
                     /gene="Dnmbp"
                     /gene_synonym="Tuba"
                     /inference="alignment:Splign:2.1.0"
     exon            4623..6071
                     /gene="Dnmbp"
                     /gene_synonym="Tuba"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccgcggcc gggctgggcc accagtggcc gtgcgcggag ggaacgccga gcgcagagag
       61 cagcaccagg aagcatggag cctgggtccg tggtgcgtgc catctttgac ttctgcccta
      121 gcgtctcgga ggagctgcca ctcttcgtgg gggacgtaat tgaggtgttg accgtggtgg
      181 atgaattttg gcttttaggg aagaaggaag atgttacagg acagttcccc agcagtttcg
      241 tggagatcgt gacaattccc agtctgaaag agggagagag gctgtttgtt tgcacctgcg
      301 atttcatatc tcgagagccg aatagtcttt ccctccatcg aggagacctg gtgattattg
      361 atggtactcc cacagcagga tggctgcagg gccgaagctc cctgggcgcc aggggtttct
      421 ttccgtcttc gtgcatccat gagctctgcc tctcctctca aagccgacag tggcattccc
      481 agaacatgct gctgcaggtt ccagagtact ccatgggaca agcacgggcc ctcatgggcc
      541 tctctgccca gttggatgag gagttagact tcagggaagg agacgtgatc accattatcg
      601 gggtgcctga accaggctgg tttgagggag agctagaggg ccgaaggggc attttcccag
      661 aaggttttgt agagcttctg gggcccctga ggactgcgga tgagtcggta aacgctggaa
      721 gtggagatga ctccacgctc aatgatgaag tggatgtgtc tccagaagaa gtggagagtg
      781 agggtgacga ggacgaccag caggcgggga cctatgggat tgccctctac agattccaag
      841 ccctggaatc aaatgagttg gattttgagg taggggacaa aattcgaatt ctggggacct
      901 tggaggatgg ctggctggaa gggcgtctga agggcaagac aggcatcttt ccccatcgct
      961 ttgtgaagtt atgtcctagc aacagatcag aggaaaccat ggctctgccc cagggagaca
     1021 gcttccccaa gaactctgaa agctcagcgg gcgagatggg ggactccgtg gtggaggaag
     1081 caagacagga tccacaggag tgtgaagaag aaacacctga ctctggtctc ccagaacaaa
     1141 cctctgagga gcccctggat catgtggccc ccgagtgtgt tgtagataag atctctggtc
     1201 aggatgaaga tgcctcagga agctccccag atgtggatct tgaagggcct cgtgctgaag
     1261 acccttccac acctgacctc tcccaggaag tcaatggcat ttcttccctg cctccacagg
     1321 tacctcttca acccgaagag gagaagagcc agcattattt aacagcagga gggagccgcc
     1381 aatgcccaga cacattctcc aagcttttcc ctctagaagc caagaccagg aactactcca
     1441 gcctgcctcc aagaagaaca tatacccagg gctggtcgct tcagaagcca gcgccccacc
     1501 tccacagggc ctcctccctc acagcgtcaa gagtaaacag acctggccac tttagccaca
     1561 cagccatggc cagctgtgct cagaagcacc aaacatctgc agaaaatgct gccagcctct
     1621 gctgtgcacc tgagagacca aagaggaggc ctggcctacc agacaaggaa cccgccacag
     1681 aaataacccc agcgtcacag ggggacaacc tggacttaga ttccaagttg acccaacagc
     1741 tgatagagtt tgagaagagt ctgtcagggc ccagcacaga gccaaagaaa attgtacgcc
     1801 gcttttcaat catggacttt tactcagaga aggatatcgt gagaggctcc tcaaactcac
     1861 taccctcacg gaatttccct gagaggagaa aggccctgag gccaccgccg cccagacctc
     1921 ataccccaac atccacttct ccccatttgc tggttgacca gagcccaaaa cctggacccc
     1981 ccttggttgt gaggccatcc cgcccggctc ccctgccacc tcctacccag cagaggctga
     2041 acacagcctc tcccaagccc acctcctgtg cccttcctgg ctgggaggct ccagagaagg
     2101 agggctctga gtacacagag aagagcccag cccagctttt tccgtgccca tctgtgctgg
     2161 cgaggattca ggatgtggaa cacgacttgg acatgcacac cagggctcag gaagagctga
     2221 acttgctgtt agaggaaaag caagatgaat cgttgagggc ggagactctc gagactctca
     2281 aatcctacga gagcaccatt cagagtctga acctggagct ccagcagctg agagagatga
     2341 cgctcctctc ctcccagtct tcatccctgg cggccccctc tgggtctgtg tccaccgaaa
     2401 agcctgagca gaggatgctg gagaagagag ccaaggtggt ggctgagctt ttgcagacgg
     2461 aaaaagacta catccgggat ctggagatgt gcgtcgagag ggtcatggtg cccctgcagc
     2521 aggcacaggt accaaacatt gattttgaag gactttttgg aaacatgcaa acggtgatta
     2581 aagtctcaaa gcagttgttg gcagccttgg aaatcaccga tgctgtagga cccgtgtttc
     2641 tggatcaccg ggacgaactt gaggggacgt acagacttta ctgccagaac cacgacgaag
     2701 ccatttcact gctagatatc tacgagaagg acgagaggat ccagaagcat ctccaggact
     2761 acttggcaga tctcaagagc ctgtaccacg aatggggatg caccaattac atcaacctgg
     2821 gctctttcct catcaagccc gtacagagaa taatgcgtta cccgctgctg ctaatggagc
     2881 tgctgaattc caccccggaa tcccacccgg ataaagcgcc tttaaccagc gcagtcctgg
     2941 ccatcaagga aatcaatgct aacattaatg aatataagcg tcggaaggat ctagtgctta
     3001 agtaccgcaa agcggatgaa gacagcctca tggagaagat ctccaagctc aacatccact
     3061 ccatcatcaa gaagtccagc cgggttagca gtcacctgaa acacctcact ggcttcgctc
     3121 cccagctaaa agatgaagca tttgaagaga cagaaaagaa cttccggatg caggagagat
     3181 tgattaaatc ttttatccga gacctgtccc tctacctcca gcacatacgg gaatctgctt
     3241 gtgtgaaggt ggtggcagcc atgagcatat gggatctgtg catggagagg ggacatcatg
     3301 acctggaaca gtttgagaag gtgcatcgat acatcagcga ccagctcttc acacggttta
     3361 aagagaggac cgagcggctt gtcatcaatc ccttaaacca gctgttgaac atgttcacgg
     3421 ggccctacaa gctggtgcag aagcgtttcg acaagctcct ggacttctac aactgcactg
     3481 agcgagcgga gaagcttaag gacaagaaga ctctggagga tctccagtca gcccgaaaca
     3541 actacgaggc cctgaactcc cagctgctgg acgagctgcc caagttccag cagtacgccc
     3601 agagcctctt caccaactgc atccacggct acgccgaagc ccactgtgac ttcgtgcaga
     3661 aggcgctgga gcagctgcag cccctgctgt cgctactgaa agccagcgac cgagaaggca
     3721 acctgatcgc catcttccac gaggagcaca gccgggtcct tcagcagctc caggtcttca
     3781 ctttcttccc cgaggccctc ccagccccca ggaagccctt cgagaggaaa accacagacc
     3841 gccagtcatc acggaaggcc ctcctgggca tgccaagcta catgctgcag tcagaagaac
     3901 tgcggagctc cctgctggcg aggtacccac cggaaaagct cttccatgtc caacgcaact
     3961 tcaacgcagc tcaggacttg gatgtctccc ttttggaagg tgatctggtg ggcgtgatca
     4021 aaaagaaaga ccccatgggc agccagaacc gctggctcgt ggacaacgga gtcaccaaag
     4081 gctttgtcta cagctccttc ctgaagcctt acaaccctcg atgcagccat tcggattcct
     4141 ctgtggtcag ccactcttcc acagagtccg agcacagcgg ctcctccccc agcttccatc
     4201 gccagaacag cagcagtgcc ttgaccttca actccaacag catgactgtg tccttcacct
     4261 cagggcttcc ccagaagcag cctcaggaca catctccact gagggaatgt gtccccgaaa
     4321 ctcttggtgt gtcctcgaac acggggaacc cagaaactgg accttcccca tgcccttcag
     4381 atccaggctt ctcctgccag cgcaggccgg gcaaccctgc agatggcacc cgagagatca
     4441 gccaacctgc ttcaaccttg aggggctgcc agcgacgctc cctgcattcc gaagtgctcg
     4501 gttaccctgt gccagggcgc agtgaccaag gcagtgactc cataaaagga acctcaagag
     4561 cctgtcagac cgcaggagac agagacagag ggctcggaag cagcgaggca gagggcaacc
     4621 aggtctattt tgccatctac accttcaagg cacgaaaccc aaatgagctg actgtgttgg
     4681 ccaatcagag actcaggatc cttgagttta aagacgtcac aggcaataca gagtggtggt
     4741 tggctgaagt taacggaaag aagggctacg tcccgtccaa ctatatccga aaaactgagt
     4801 acacctgagc caagttgcct tgggtcccca cctcgaggcc gctttcagtc cactgagaag
     4861 ttctggtggg ctccaggcac ctgctgtcaa gcagggctcc accccactgc ctatccataa
     4921 cgcggagcgc acaataagct ttgttctgat tgggttgtac actttgatgc tcgctagaat
     4981 ttgacgtggg tggaccccaa aggtttgcca gtgactcagt gtccacagga agcaggccaa
     5041 atgctggtgt cagctttggg aaatgagaca ttcccaatca gaaatgcagt attgtatgcc
     5101 ggaagctgta tggcatcaga ggatgctggc attggctgcc tcgtacgcct tggtcaactg
     5161 agtagtcacg gggtgaggag gagtgggttc caagaccttc tccatctcgc ctccatacac
     5221 aggaacagtt atgtcaggat cacaccaaac ctggtgtgtc aaggtgtcta agacaccccg
     5281 gtgcccggca gccttctctc tctgacactt gcccctcact cctagttctt aacacgatag
     5341 cctttcactg cttccccgtt gaatgtttac agtctaactt ttcttccacc cgtgagtctg
     5401 gaccatgtgt ctggaaggtt ctcttacctt gtcgaacatg gtcatctgcc tcttccctga
     5461 cactcatctt aattttattt gatcttgatg gtgtctccta acctttctcc ctatacttat
     5521 tgactgacaa gatttcccta gtctagcggg cttggcactc cggccagcca ctgaaagtat
     5581 tctgctgggt ggaagccaga cgcctgcccc acccccttcc accgcagcac tctgctgcgg
     5641 tctagtcacc tccacacgtg ctcaagacaa cccacgtggc ttattttgaa gtaggtagga
     5701 ccggtggccg aagaagcttg ccttagagtt tggaaataag aattttcttt ctcaccacca
     5761 actgccatac ttcaaggaca atatttcaaa gtcagacaga tgctaatgtg cctaatgaga
     5821 cctcgaaccc aaggctggaa ggtgatcgct aaaccctcat gtgaagaaac ggtcccagag
     5881 acttgtctca gcatgggtcc tagactgcag ccttccagat gcacatgtgg ccttaaaatc
     5941 ctggtgaatc agggcagcct gtggacaccc cggctgcacc actggtcgga gcctcttatg
     6001 aagtgtttat atttagagat gtttatattt aagtcgctat tttttaaata aagcatttct
     6061 attgaccgta a
//
