LOCUS       NM_138538               3240 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus dynamin 3 (Dnm3), mRNA.
ACCESSION   NM_138538
VERSION     NM_138538.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3240)
  AUTHORS   Reubold,T.F., Faelber,K., Plattner,N., Posor,Y., Ketel,K.,
            Curth,U., Schlegel,J., Anand,R., Manstein,D.J., Noe,F., Haucke,V.,
            Daumke,O. and Eschenburg,S.
  TITLE     Crystal structure of the dynamin tetramer
  JOURNAL   Nature 525 (7569), 404-408 (2015)
   PUBMED   26302298
REFERENCE   2  (bases 1 to 3240)
  AUTHORS   Li,J., Zhang,D.S., Ye,J.C., Li,C.M., Qi,M., Liang,D.D., Xu,X.R.,
            Xu,L., Liu,Y., Zhang,H., Zhang,Y.Y., Deng,F.F., Feng,J., Shi,D.,
            Chen,J.J., Li,L., Chen,G., Sun,Y.F., Peng,L.Y. and Chen,Y.H.
  TITLE     Dynamin-2 mediates heart failure by modulating Ca2+ -dependent
            cardiomyocyte apoptosis
  JOURNAL   Int J Cardiol 168 (3), 2109-2119 (2013)
   PUBMED   23410488
  REMARK    GeneRIF: DNM2 mediates HF by modulating Ca(2+)-dependent apoptotic
            death of cardiomyocyte.
REFERENCE   3  (bases 1 to 3240)
  AUTHORS   Ikeuchi,Y., de la Torre-Ubieta,L., Matsuda,T., Steen,H., Okazawa,H.
            and Bonni,A.
  TITLE     The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling
            link that orchestrates ciliary morphogenesis in postmitotic neurons
  JOURNAL   Cell Rep 4 (5), 879-889 (2013)
   PUBMED   23994472
REFERENCE   4  (bases 1 to 3240)
  AUTHORS   Grossman,G.H., Ebke,L.A., Beight,C.D., Jang,G.F., Crabb,J.W. and
            Hagstrom,S.A.
  TITLE     Protein partners of dynamin-1 in the retina
  JOURNAL   Vis Neurosci 30 (4), 129-139 (2013)
   PUBMED   23746204
REFERENCE   5  (bases 1 to 3240)
  AUTHORS   Tanifuji,S., Funakoshi-Tago,M., Ueda,F., Kasahara,T. and Mochida,S.
  TITLE     Dynamin isoforms decode action potential firing for synaptic
            vesicle recycling
  JOURNAL   J Biol Chem 288 (26), 19050-19059 (2013)
   PUBMED   23687302
  REMARK    GeneRIF: dynamin isoforms select appropriate vesicle reuse pathways
            associated with specific neuronal firing patterns
REFERENCE   6  (bases 1 to 3240)
  AUTHORS   Gray,N.W., Fourgeaud,L., Huang,B., Chen,J., Cao,H., Oswald,B.J.,
            Hemar,A. and McNiven,M.A.
  TITLE     Dynamin 3 is a component of the postsynapse, where it interacts
            with mGluR5 and Homer
  JOURNAL   Curr Biol 13 (6), 510-515 (2003)
   PUBMED   12646135
REFERENCE   7  (bases 1 to 3240)
  AUTHORS   Zhang,Y., Moheban,D.B., Conway,B.R., Bhattacharyya,A. and
            Segal,R.A.
  TITLE     Cell surface Trk receptors mediate NGF-induced survival while
            internalized receptors regulate NGF-induced differentiation
  JOURNAL   J Neurosci 20 (15), 5671-5678 (2000)
   PUBMED   10908605
REFERENCE   8  (bases 1 to 3240)
  AUTHORS   Cao,H., Garcia,F. and McNiven,M.A.
  TITLE     Differential distribution of dynamin isoforms in mammalian cells
  JOURNAL   Mol Biol Cell 9 (9), 2595-2609 (1998)
   PUBMED   9725914
REFERENCE   9  (bases 1 to 3240)
  AUTHORS   Cook,T., Mesa,K. and Urrutia,R.
  TITLE     Three dynamin-encoding genes are differentially expressed in
            developing rat brain
  JOURNAL   J Neurochem 67 (3), 927-931 (1996)
   PUBMED   8752097
REFERENCE   10 (bases 1 to 3240)
  AUTHORS   Nakata,T., Takemura,R. and Hirokawa,N.
  TITLE     A novel member of the dynamin family of GTP-binding proteins is
            expressed specifically in the testis
  JOURNAL   J Cell Sci 105 (Pt 1), 1-5 (1993)
   PUBMED   8360266
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 27, 2020 this sequence version replaced NM_138538.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF201839.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               JAXUCZ010000013.1  77371058-77371346   c
            290-363             JAXUCZ010000013.1  77297301-77297374   c
            364-513             JAXUCZ010000013.1  77240975-77241124   c
            514-717             JAXUCZ010000013.1  77239796-77239999   c
            718-816             JAXUCZ010000013.1  77215985-77216083   c
            817-977             JAXUCZ010000013.1  77215253-77215413   c
            978-1120            JAXUCZ010000013.1  77212750-77212892   c
            1121-1256           JAXUCZ010000013.1  77207732-77207867   c
            1257-1324           JAXUCZ010000013.1  77205597-77205664   c
            1325-1463           JAXUCZ010000013.1  77202373-77202511   c
            1464-1550           JAXUCZ010000013.1  77190691-77190777   c
            1551-1621           JAXUCZ010000013.1  77181775-77181845   c
            1622-1673           JAXUCZ010000013.1  77169168-77169219   c
            1674-1703           JAXUCZ010000013.1  77168277-77168306   c
            1704-1817           JAXUCZ010000013.1  77130509-77130622   c
            1818-1927           JAXUCZ010000013.1  77034331-77034440   c
            1928-2039           JAXUCZ010000013.1  76990952-76991063   c
            2040-2204           JAXUCZ010000013.1  76926535-76926699   c
            2205-2431           JAXUCZ010000013.1  76918517-76918743   c
            2432-2668           JAXUCZ010000013.1  76917749-76917985   c
            2669-3240           JAXUCZ010000013.1  76900999-76901570   c
FEATURES             Location/Qualifiers
     source          1..3240
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..3240
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="dynamin 3"
                     /db_xref="GeneID:171574"
                     /db_xref="RGD:727949"
     exon            1..289
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..2738
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /EC_number="3.6.5.5"
                     /note="T-dynamin; dynamin, testicular; testicular dynamin"
                     /codon_start=1
                     /product="dynamin-3"
                     /protein_id="NP_612547.1"
                     /db_xref="GeneID:171574"
                     /db_xref="RGD:727949"
                     /translation="MGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGK
                     SSVLENFVGRDFLPRGSGIVTRRPLVLQLVTSKAEYAEFLHCKGKKFTDFDEVRHEIE
                     AETDRVTGMNKGISSVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIRDMI
                     MQFITRENCLILAVTPANTDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARD
                     VLENKLLPLRRGYVGVVNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHIADRMGTPH
                     LQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEVEAFKNFKPEDPTRKTKALLQMVQ
                     QFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHERFPFEIVKMEFNEKELRREISYAI
                     KNIHGIRTGLFTPDMAFEAIVKKQIVKLKGPSLKSVDLVMQELINTVKKCTKRLANFP
                     RLCEETERIVANHIREREGKTKDQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHK
                     KSTIGNQGTNLPPSRQIVIRKGWLTVSNIGIMKGGSKGYWFVLTAESLSWYKDDEEKE
                     KKYMLPLDNLKVRDVEKGFMSSKHVFALFNTEQRNVYKDYRSLELACDSQEDVDSWKA
                     SLLRAGVYPDKSFTENDENGQAENFSMDPQLERQVETIRNLVDSYMSIINKCIRDLIP
                     KTIMHLMINNVKDFINSELLAQLYSSEDQNTLMEESVEQAQRRDEMLRMYQALKEALA
                     IIGDINTVTVSTPAPPPVDDSWLQHSRRSPPPSPTTQRRLTLSAPLPRPASSRGPAPA
                     IPSPGPHSGAPPVPFRPGPLPPFPNSSDSYGAPPQVPSRPTRAPPSVPSRRPPPSPTR
                     PTIIRPLESSLLD"
     exon            290..363
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            364..513
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            514..717
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            718..816
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            817..977
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1120
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1256
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1324
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1463
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1550
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1621
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1673
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1703
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1817
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1927
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2039
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2204
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2431
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2668
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..3240
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acggtgccgg gactcagcgg tgtgagcccc gcgcatcaac aaaccggaca agtgctgcga
       61 ggcccgggct gcctgccagg tcgctgagtc gcgcagggac ctgtggggca gttggccgca
      121 caggcaagat ggggaaccgg gagatggaag aactgatccc tctggtgaac cgtctgcagg
      181 acgctttctc ggctctggga cagagctgtc tgctggagct gccacagatc gccgtggtgg
      241 gcggccagag cgccggcaag agctcagtgc tcgagaactt cgtgggcagg gactttcttc
      301 ctcgaggctc gggcattgtg accagacgac ctcttgtact ccagcttgtc acctctaaag
      361 cagaatatgc cgagtttcta cattgcaaag gaaaaaaatt tacagatttt gatgaagttc
      421 gccacgagat cgaagcagaa acggaccgag taacaggaat gaataaaggc atctcctctg
      481 tacccattaa ccttcgagtc tactctcccc acgtgttaaa cctaacgcta atcgacctac
      541 ctggaataac gaaagtgccc gtgggagacc agccgccaga tattgagtat cagatcagag
      601 atatgattat gcagttcatc accagggaga actgtctgat tttggctgtc acaccagcca
      661 acaccgatct tgcgaactca gatgccctga agctagccaa agaagtcgat cctcaaggcc
      721 tgaggaccat tggcgttatc accaagctgg atctcatgga tgaagggacg gatgccaggg
      781 atgtactaga gaacaagctg ctacctctcc gcaggggcta tgtgggggtg gtcaaccgaa
      841 gccagaagga catagatgga aagaaggaca ttaaggcagc tatgctggca gaaaggaaat
      901 tttttctctc tcatccagca tatagacaca ttgctgatcg gatggggacc ccacacctcc
      961 agaaggtcct gaatcagcaa cttaccaacc atatccgaga taccctgccc aacttcagga
     1021 acaagctaca ggggcagctg ctctccatag aacatgaagt agaagccttc aaaaacttca
     1081 aaccggaaga ccccacaagg aagaccaaag cactgctaca gatggtccaa cagttcgctg
     1141 tggactttga gaagagaatc gaagggtcgg gggatcaagt agacacgtta gagctctctg
     1201 gcggtgctaa gatcaatcgc attttccacg aacgctttcc ttttgagata gtgaagatgg
     1261 agttcaatga gaaagaactg agaagagaaa taagctatgc aatcaaaaac atacacggga
     1321 tcaggacagg gttgtttact ccagacatgg cgtttgaggc aatagtcaaa aaacagatag
     1381 taaaactgaa agggccttct ttgaagagtg tggacctggt gatgcaggaa ctgatcaaca
     1441 cggtgaagaa gtgcaccaag aggctggcca acttccccag actttgtgaa gaaacagaaa
     1501 ggattgttgc taaccacatc cgtgagcgag aaggaaagac caaggaccag gtcctgctac
     1561 tgattgacat tcaagtctct tacattaaca ccaaccatga ggacttcatc ggctttgcaa
     1621 atgctcagca gagaagcagt caggttcaca agaaaagcac aattggaaat cagggaacca
     1681 atcttccgcc ttcaaggcaa attgtgattc ggaagggctg gctgaccgtc agcaacattg
     1741 gcatcatgaa aggaggctcg aagggctact ggtttgtcct cacggcagaa agcttgtcct
     1801 ggtataaaga cgatgaggag aaagaaaaga agtatatgct tccactggac aacctgaaag
     1861 tccgggacgt ggagaaaggc ttcatgtcca gcaagcacgt cttcgcactc ttcaacacag
     1921 aacaaaggaa tgtctacaaa gactatcgtt ccctggagct ggcctgtgat tcccaggagg
     1981 atgtggacag ctggaaggcg tctctgctca gagctggcgt ctatccagac aagtctttta
     2041 ctgaaaatga tgaaaatgga caagcagaaa acttctccat ggacccgcag ttggagaggc
     2101 aagtggagac tattcgcaac ctcgtagact cctacatgtc gataatcaac aaatgcatcc
     2161 gagacctaat tccaaaaaca ataatgcacc ttatgatcaa taatgttaaa gacttcatca
     2221 actctgaact cctagcacag ctctactcct ctgaggacca gaacacacta atggaagaat
     2281 ccgtggagca ggctcagcgc cgggatgaga tgctccggat gtaccaagcc ctgaaagaag
     2341 ccctcgcgat cattggcgac atcaacacgg tcactgtgtc caccccagcc ccacctccag
     2401 tagatgactc ctggctccag cattccagaa ggtcacctcc tccaagcccc accacccaaa
     2461 gaaggctgac tctaagtgct cccctcccga ggcccgcatc tagccgtgga ccagctcctg
     2521 ccattccctc tccaggcccc cactctgggg ctcccccagt cccattccgt ccaggcccat
     2581 tacctccttt tcccaacagc agtgactcct acggagcccc tccacaggtt ccatccaggc
     2641 ccacaagggc accccccagt gttccaagcc ggaggccacc cccatcacca actcgcccca
     2701 ctataatccg tccactagag tcctcactgt tagactaaac gaagtgtccg gcatggcaat
     2761 taaatcacta atgattcatg caaaagcagc attcggttac ctttgcagcc aaccatgagt
     2821 agtcgcatgt atggacctcc ataggcaagt agccagtcct actaacatgt tcatcgctca
     2881 tcttcattgc tcatggtggg ttagacctta gggtttgact ctgaaaacct gctcacctgt
     2941 agagaggctt aatatgttgt attgaccgag gtagttttat agaacagtcc tatactttgg
     3001 taccacttac ctgtccaaca gatagcagaa attgctttgg aagagttttc taggctgtct
     3061 acagaggagc ttacgaggct tccgaacaga cacaagagtg tgagcttgga accacaccga
     3121 cttctcccac attctgtttt gggtggcaga aactctgctg tctgatatta atgccaccac
     3181 tcagtccgca gttgcttatt taggcttctt tccctcctta tttcataaga ctgctaaaaa
//
