LOCUS       NP_612547                869 aa            linear   ROD 24-JUN-2024
DEFINITION  dynamin-3 [Rattus norvegicus].
ACCESSION   NP_612547
VERSION     NP_612547.1
DBSOURCE    REFSEQ: accession NM_138538.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 869)
  AUTHORS   Reubold,T.F., Faelber,K., Plattner,N., Posor,Y., Ketel,K.,
            Curth,U., Schlegel,J., Anand,R., Manstein,D.J., Noe,F., Haucke,V.,
            Daumke,O. and Eschenburg,S.
  TITLE     Crystal structure of the dynamin tetramer
  JOURNAL   Nature 525 (7569), 404-408 (2015)
   PUBMED   26302298
REFERENCE   2  (residues 1 to 869)
  AUTHORS   Li,J., Zhang,D.S., Ye,J.C., Li,C.M., Qi,M., Liang,D.D., Xu,X.R.,
            Xu,L., Liu,Y., Zhang,H., Zhang,Y.Y., Deng,F.F., Feng,J., Shi,D.,
            Chen,J.J., Li,L., Chen,G., Sun,Y.F., Peng,L.Y. and Chen,Y.H.
  TITLE     Dynamin-2 mediates heart failure by modulating Ca2+ -dependent
            cardiomyocyte apoptosis
  JOURNAL   Int J Cardiol 168 (3), 2109-2119 (2013)
   PUBMED   23410488
  REMARK    GeneRIF: DNM2 mediates HF by modulating Ca(2+)-dependent apoptotic
            death of cardiomyocyte.
REFERENCE   3  (residues 1 to 869)
  AUTHORS   Ikeuchi,Y., de la Torre-Ubieta,L., Matsuda,T., Steen,H., Okazawa,H.
            and Bonni,A.
  TITLE     The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling
            link that orchestrates ciliary morphogenesis in postmitotic neurons
  JOURNAL   Cell Rep 4 (5), 879-889 (2013)
   PUBMED   23994472
REFERENCE   4  (residues 1 to 869)
  AUTHORS   Grossman,G.H., Ebke,L.A., Beight,C.D., Jang,G.F., Crabb,J.W. and
            Hagstrom,S.A.
  TITLE     Protein partners of dynamin-1 in the retina
  JOURNAL   Vis Neurosci 30 (4), 129-139 (2013)
   PUBMED   23746204
REFERENCE   5  (residues 1 to 869)
  AUTHORS   Tanifuji,S., Funakoshi-Tago,M., Ueda,F., Kasahara,T. and Mochida,S.
  TITLE     Dynamin isoforms decode action potential firing for synaptic
            vesicle recycling
  JOURNAL   J Biol Chem 288 (26), 19050-19059 (2013)
   PUBMED   23687302
  REMARK    GeneRIF: dynamin isoforms select appropriate vesicle reuse pathways
            associated with specific neuronal firing patterns
REFERENCE   6  (residues 1 to 869)
  AUTHORS   Gray,N.W., Fourgeaud,L., Huang,B., Chen,J., Cao,H., Oswald,B.J.,
            Hemar,A. and McNiven,M.A.
  TITLE     Dynamin 3 is a component of the postsynapse, where it interacts
            with mGluR5 and Homer
  JOURNAL   Curr Biol 13 (6), 510-515 (2003)
   PUBMED   12646135
REFERENCE   7  (residues 1 to 869)
  AUTHORS   Zhang,Y., Moheban,D.B., Conway,B.R., Bhattacharyya,A. and
            Segal,R.A.
  TITLE     Cell surface Trk receptors mediate NGF-induced survival while
            internalized receptors regulate NGF-induced differentiation
  JOURNAL   J Neurosci 20 (15), 5671-5678 (2000)
   PUBMED   10908605
REFERENCE   8  (residues 1 to 869)
  AUTHORS   Cao,H., Garcia,F. and McNiven,M.A.
  TITLE     Differential distribution of dynamin isoforms in mammalian cells
  JOURNAL   Mol Biol Cell 9 (9), 2595-2609 (1998)
   PUBMED   9725914
REFERENCE   9  (residues 1 to 869)
  AUTHORS   Cook,T., Mesa,K. and Urrutia,R.
  TITLE     Three dynamin-encoding genes are differentially expressed in
            developing rat brain
  JOURNAL   J Neurochem 67 (3), 927-931 (1996)
   PUBMED   8752097
REFERENCE   10 (residues 1 to 869)
  AUTHORS   Nakata,T., Takemura,R. and Hirokawa,N.
  TITLE     A novel member of the dynamin family of GTP-binding proteins is
            expressed specifically in the testis
  JOURNAL   J Cell Sci 105 (Pt 1), 1-5 (1993)
   PUBMED   8360266
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF201839.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..869
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     Protein         1..869
                     /product="dynamin-3"
                     /EC_number="3.6.5.5"
                     /note="T-dynamin; dynamin, testicular; testicular dynamin"
                     /calculated_mol_wt=97784
     Region          6..245
                     /region_name="DYNc"
                     /note="Dynamin, GTPase; smart00053"
                     /db_xref="CDD:197491"
     Region          38..45
                     /region_name="G1 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2)"
     Site            38..45
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206738"
     Site            order(39,41..46,59..60,65,136,206,208..209,235..239,242)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206738"
     Site            order(40..41,140,153,178,180,182..185,187..188,209,
                     211..214,238..240)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:206738"
     Region          64..66
                     /region_name="G2 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2)"
     Site            65
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206738"
     Site            69..71
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206738"
     Region          136..139
                     /region_name="G3 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2)"
     Site            136..139
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206738"
     Site            order(138..139,169..170)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206738"
     Region          205..208
                     /region_name="G4 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2)"
     Site            205..208
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206738"
     Region          215..502
                     /region_name="Dynamin_M"
                     /note="Dynamin central region; pfam01031"
                     /db_xref="CDD:460033"
     Site            231
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39052; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2)"
     Region          235..238
                     /region_name="G5 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2)"
     Site            235..237
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206738"
     Site            299
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P39054; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2)"
     Region          526..635
                     /region_name="PH_dynamin"
                     /note="Dynamin pleckstrin homology (PH) domain; cd01256"
                     /db_xref="CDD:269958"
     Site            order(526,528..529,531,548,617..618,621,624..625,628)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:269958"
     Site            603
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39052; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2)"
     Site            604
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P50570; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2)"
     Region          655..745
                     /region_name="GED"
                     /note="Dynamin GTPase effector domain; pfam02212"
                     /db_xref="CDD:460495"
     Region          752..869
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2)"
     Region          <753..841
                     /region_name="MISS"
                     /note="MAPK-interacting and spindle-stabilising
                     protein-like; pfam15822"
                     /db_xref="CDD:318115"
     Site            769
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:17376771,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2)"
     Site            773
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:17376771,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2)"
     Site            853
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:17376771; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2)"
     CDS             1..869
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /coded_by="NM_138538.2:129..2738"
                     /db_xref="GeneID:171574"
                     /db_xref="RGD:727949"
ORIGIN      
        1 mgnremeeli plvnrlqdaf salgqsclle lpqiavvggq sagkssvlen fvgrdflprg
       61 sgivtrrplv lqlvtskaey aeflhckgkk ftdfdevrhe ieaetdrvtg mnkgissvpi
      121 nlrvysphvl nltlidlpgi tkvpvgdqpp dieyqirdmi mqfitrencl ilavtpantd
      181 lansdalkla kevdpqglrt igvitkldlm degtdardvl enkllplrrg yvgvvnrsqk
      241 didgkkdika amlaerkffl shpayrhiad rmgtphlqkv lnqqltnhir dtlpnfrnkl
      301 qgqllsiehe veafknfkpe dptrktkall qmvqqfavdf ekriegsgdq vdtlelsgga
      361 kinrifherf pfeivkmefn ekelrreisy aiknihgirt glftpdmafe aivkkqivkl
      421 kgpslksvdl vmqelintvk kctkrlanfp rlceeteriv anhireregk tkdqvlllid
      481 iqvsyintnh edfigfanaq qrssqvhkks tignqgtnlp psrqivirkg wltvsnigim
      541 kggskgywfv ltaeslswyk ddeekekkym lpldnlkvrd vekgfmsskh vfalfnteqr
      601 nvykdyrsle lacdsqedvd swkasllrag vypdksften dengqaenfs mdpqlerqve
      661 tirnlvdsym siinkcirdl ipktimhlmi nnvkdfinse llaqlyssed qntlmeesve
      721 qaqrrdemlr myqalkeala iigdintvtv stpapppvdd swlqhsrrsp ppspttqrrl
      781 tlsaplprpa ssrgpapaip spgphsgapp vpfrpgplpp fpnssdsyga ppqvpsrptr
      841 appsvpsrrp ppsptrptii rplesslld
//
