LOCUS       NM_013199               3460 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus dynamin 2 (Dnm2), mRNA.
ACCESSION   NM_013199
VERSION     NM_013199.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3460)
  AUTHORS   Nakakura,T., Tanaka,H. and Suzuki,T.
  TITLE     Regulation of fenestra formation via actin-dynamin2 interaction in
            rat pituitary endothelial cells
  JOURNAL   Cell Tissue Res 390 (3), 441-451 (2022)
   PUBMED   36102975
  REMARK    GeneRIF: Regulation of fenestra formation via actin-dynamin2
            interaction in rat pituitary endothelial cells.
REFERENCE   2  (bases 1 to 3460)
  AUTHORS   Hamasaki,E., Wakita,N., Yasuoka,H., Nagaoka,H., Morita,M.,
            Takashima,E., Uchihashi,T., Takeda,T., Abe,T., Lee,J.W., Iimura,T.,
            Saleem,M.A., Ogo,N., Asai,A., Narita,A., Takei,K. and Yamada,H.
  TITLE     The Lipid-Binding Defective Dynamin 2 Mutant in Charcot-Marie-Tooth
            Disease Impairs Proper Actin Bundling and Actin Organization in
            Glomerular Podocytes
  JOURNAL   Front Cell Dev Biol 10, 884509 (2022)
   PUBMED   35620056
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3460)
  AUTHORS   Catsburg,L.A., Westra,M., van Schaik,A.M. and MacGillavry,H.D.
  TITLE     Dynamics and nanoscale organization of the postsynaptic endocytic
            zone at excitatory synapses
  JOURNAL   Elife 11, e74387 (2022)
   PUBMED   35072626
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3460)
  AUTHORS   Lynn,K.S., Easley,K.F., Martinez,F.J., Reed,R.C., Schlingmann,B.
            and Koval,M.
  TITLE     Asymmetric distribution of dynamin-2 and beta-catenin relative to
            tight junction spikes in alveolar epithelial cells
  JOURNAL   Tissue Barriers 9 (3), 1929786 (2021)
   PUBMED   34107845
  REMARK    GeneRIF: Asymmetric distribution of dynamin-2 and beta-catenin
            relative to tight junction spikes in alveolar epithelial cells.
REFERENCE   5  (bases 1 to 3460)
  AUTHORS   Scheefhals,N., Catsburg,L.A.E., Westerveld,M.L., Blanpied,T.A.,
            Hoogenraad,C.C. and MacGillavry,H.D.
  TITLE     Shank Proteins Couple the Endocytic Zone to the Postsynaptic
            Density to Control Trafficking and Signaling of Metabotropic
            Glutamate Receptor 5
  JOURNAL   Cell Rep 29 (2), 258-269 (2019)
   PUBMED   31597090
REFERENCE   6  (bases 1 to 3460)
  AUTHORS   Zhang,Y., Moheban,D.B., Conway,B.R., Bhattacharyya,A. and
            Segal,R.A.
  TITLE     Cell surface Trk receptors mediate NGF-induced survival while
            internalized receptors regulate NGF-induced differentiation
  JOURNAL   J Neurosci 20 (15), 5671-5678 (2000)
   PUBMED   10908605
REFERENCE   7  (bases 1 to 3460)
  AUTHORS   Cao,H., Garcia,F. and McNiven,M.A.
  TITLE     Differential distribution of dynamin isoforms in mammalian cells
  JOURNAL   Mol Biol Cell 9 (9), 2595-2609 (1998)
   PUBMED   9725914
REFERENCE   8  (bases 1 to 3460)
  AUTHORS   Jones,S.M., Howell,K.E., Henley,J.R., Cao,H. and McNiven,M.A.
  TITLE     Role of dynamin in the formation of transport vesicles from the
            trans-Golgi network
  JOURNAL   Science 279 (5350), 573-577 (1998)
   PUBMED   9438853
REFERENCE   9  (bases 1 to 3460)
  AUTHORS   Sontag,J.M., Fykse,E.M., Ushkaryov,Y., Liu,J.P., Robinson,P.J. and
            Sudhof,T.C.
  TITLE     Differential expression and regulation of multiple dynamins
  JOURNAL   J Biol Chem 269 (6), 4547-4554 (1994)
   PUBMED   8308025
REFERENCE   10 (bases 1 to 3460)
  AUTHORS   Cook,T.A., Urrutia,R. and McNiven,M.A.
  TITLE     Identification of dynamin 2, an isoform ubiquitously expressed in
            rat tissues
  JOURNAL   Proc Natl Acad Sci U S A 91 (2), 644-648 (1994)
   PUBMED   8290576
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013199.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L25605.1, L24562.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               JAXUCZ010000008.1  28254589-28254857
            270-343             JAXUCZ010000008.1  28285606-28285679
            344-493             JAXUCZ010000008.1  28293993-28294142
            494-697             JAXUCZ010000008.1  28296068-28296271
            698-796             JAXUCZ010000008.1  28298845-28298943
            797-957             JAXUCZ010000008.1  28301620-28301780
            958-1100            JAXUCZ010000008.1  28302961-28303103
            1101-1236           JAXUCZ010000008.1  28304865-28305000
            1237-1304           JAXUCZ010000008.1  28306491-28306558
            1305-1443           JAXUCZ010000008.1  28307081-28307219
            1444-1530           JAXUCZ010000008.1  28309633-28309719
            1531-1601           JAXUCZ010000008.1  28313882-28313952
            1602-1653           JAXUCZ010000008.1  28317542-28317593
            1654-1665           JAXUCZ010000008.1  28318454-28318465
            1666-1779           JAXUCZ010000008.1  28321937-28322050
            1780-1889           JAXUCZ010000008.1  28327929-28328038
            1890-2001           JAXUCZ010000008.1  28329971-28330082
            2002-2166           JAXUCZ010000008.1  28332190-28332354
            2167-2399           JAXUCZ010000008.1  28333015-28333247
            2400-2651           JAXUCZ010000008.1  28334008-28334259
            2652-3460           JAXUCZ010000008.1  28334874-28335682
FEATURES             Location/Qualifiers
     source          1..3460
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3460
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /note="dynamin 2"
                     /db_xref="GeneID:25751"
                     /db_xref="RGD:2513"
     exon            1..269
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2721
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /EC_number="3.6.5.5"
                     /codon_start=1
                     /product="dynamin-2"
                     /protein_id="NP_037331.1"
                     /db_xref="GeneID:25751"
                     /db_xref="RGD:2513"
                     /translation="MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGK
                     SSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEYAEFLHCKSKKFTDFDEVRQEIE
                     AETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMI
                     LQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARD
                     VLENKLLPLRRGYIGVVNRSQKDIEGRKDIRAALAAERKFFLSHPAYRHMADRMGTPH
                     LQKTLNQQLTNHIRESLPTLRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQ
                     QFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAI
                     KNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELISTVRQCTSKLSSYP
                     RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNK
                     KRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLP
                     LDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAG
                     VYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHL
                     MINNTKAFIHHELLAYLYSSADQSSLMEESAEQAQRRDDMLRMYHALKEALNIIGDIS
                     TSTVSTPVPPPVDDTWLQNTSSHSPTPQRRPVSSVHPPGRPPAVRGPTPGPPLIPMPV
                     GATSSFSAPPIPSRPGPQNVFANNDPFSAPPQIPSRPARIPPGIPPGVPSRRAPAAPS
                     RPTIIRPAEPSLLD"
     exon            270..343
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     exon            344..493
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     exon            494..697
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     exon            698..796
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     exon            797..957
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1100
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1236
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1304
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1443
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1530
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1601
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1653
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1665
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1779
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1889
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2001
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2166
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2399
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2651
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..3460
                     /gene="Dnm2"
                     /gene_synonym="DYIIAAB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggggagccc gggcgggctg gcagagcaga gcaggaggaa gcaacggcca cagacgcatc
       61 gggaccgcga gtcgtagtcg ggggatccgc ggggcggagg cgggcaccat gggcaaccgc
      121 gggatggaag agctcatccc gctggttaac aagctgcagg acgccttcag ctccatcggt
      181 cagagctgcc acctggacct gccgcagatc gccgtggtgg gcggccagag cgccggcaag
      241 agttcggtgc tcgagaactt cgtgggccgg gacttccttc cacgaggatc aggaattgtc
      301 acccggaggc ctctcattct gcagctcatc ttttccaaaa cagaatatgc ggagtttttg
      361 cactgcaagt ccaaaaagtt tacagacttt gatgaagtcc ggcaggagat cgaagcagag
      421 actgaccggg tcacaggcac caacaaaggc atctccccgg tgcccatcaa ccttcgggtc
      481 tattcaccac acgtgttgaa cttgaccctc atcgacctcc caggcatcac taaggtgcca
      541 gtgggggacc agccaccaga catcgagtac cagatcaagg acatgatcct gcagtttatc
      601 agccgggaga gcagcctcat tcttgccgtc acacctgcca acatggactt ggccaactcg
      661 gatgccctca agctggccaa ggaggtggac ccccaaggcc tgcggaccat tggtgtcatc
      721 accaagctag acctgatgga tgaaggcaca gatgccaggg atgtcctgga gaacaagctc
      781 ctgcccttga gaagaggcta catcggcgtg gttaaccgca gccagaaaga catcgagggc
      841 agaaaggaca tccgggcagc tctggcagct gagaggaaat tcttcctctc ccacccagcc
      901 taccggcaca tggctgaccg catgggtacc ccacacttgc agaaaacact gaaccagcaa
      961 ctgaccaacc acatccggga gtcactgcca accctgcgca gcaagctgca gagccaactg
     1021 ctgtccctgg agaaggaagt ggaagagtac aagaatttcc ggcctgacga ccccacacgc
     1081 aagaccaaag ccctgctgca gatggtccag cagtttggag tggactttga gaagcgaatc
     1141 gaaggctctg gagatcaagt cgacaccctg gagctgtctg ggggcgcccg catcaatcgc
     1201 atcttccacg agcgctttcc ctttgagctg gtgaagatgg agtttgacga gaaagacctc
     1261 cgaagagaga tcagctacgc cattaagaac atccacggag tcagaactgg gctcttcacg
     1321 ccggatttgg cgttcgaggc cattgtgaaa aagcaggtgg tcaagctgaa agagccctgt
     1381 ctgaaatgcg tggacctggt tatccaggag ctaatcagta cagttaggca atgcaccagc
     1441 aagctcagtt cctacccccg ccttcgagag gagaccgaac gcattgtcac cacctacatc
     1501 agggagcgag aagggagaac caaggaccag atccttcttc tgattgacat tgagcagtcc
     1561 tacatcaaca caaaccatga agacttcatt ggatttgcca atgcccagca gaggagcacg
     1621 cagctgaaca agaagagggc catacctaac cagggggaga tcttggtgat ccgcaggggc
     1681 tggttgacca tcaacaacat cagcttgatg aaaggcggtt ccaaggagta ctggttcgtg
     1741 ctgactgctg agtcgttgtc ttggtacaag gatgaagagg aaaaagaaaa gaagtacatg
     1801 ctgccactag acaacctcaa aatacgggat gtggagaagg gcttcatgtc caacaagcat
     1861 gtgtttgcca tcttcaacac agagcagagg aacgtctaca aggacctgcg acagatcgaa
     1921 ctggcttgtg actcccagga agatgtggac agctggaagg cttcgttcct gcgagctggg
     1981 gtctacccag agaaggacca ggcagagaac gaggatggag cacaagagaa caccttctcc
     2041 atggacccgc agctggagcg gcaggtggag accatccgca acttggtgga ctcctatgtg
     2101 gccatcatca acaagtccat ccgggacctc atgccaaaga ccatcatgca cctcatgatc
     2161 aacaacacaa aggccttcat ccaccatgag ctgctagcct acctgtactc atcagcagac
     2221 cagagcagcc tcatggagga gtcagctgag caggctcagc ggcgggacga tatgctgcgc
     2281 atgtaccatg cactcaagga agcgctcaac atcattgggg acatcagcac cagcaccgtg
     2341 tccacgcctg tgcccccacc tgtcgatgat acttggctcc agaacaccag cagccacagc
     2401 cccactccac agcgcagacc tgtgtccagt gtgcacccgc cgggccgccc acccgcagtg
     2461 cggggcccca caccggggcc tcccctcatt cctatgcctg tgggggccac atcctccttc
     2521 tcggcacccc ccatcccatc ccggcctgga ccacagaatg tgtttgccaa caatgacccc
     2581 ttctctgcgc cacctcagat accgtctcgg ccagcacgga ttccccctgg gatccctcca
     2641 ggagtgccca gcagaagagc gcctgctgcg cccagccggc ccaccattat ccgcccagcc
     2701 gagccgtccc tgctcgacta ggctgcaggg gacagtgttc tgggggggtc ctcgtgtacc
     2761 tacagtggtc tgggccctgc tactgccccc catgctggga ccaggctccc cgtgggcaag
     2821 cctgccctct cctccctagc cctagtgcac atgataagga gggagagggt gggaaggagg
     2881 cccaaacaaa cagaacttgg gggctttgca ctttggggca agggggagct ctggttagca
     2941 gaacagaaac tgcacccttg ggaccatctg gaaagaaagg tctaggctag tggtggggaa
     3001 ctctacatgg gctcctccat actgtaagcc tttgctcttt ctgaggtaca gaactgtcca
     3061 cctttcccta aggactcctc aggagtgagc caggcccagg aggtccagtg ctggccaccc
     3121 acctggctca agttgtatat atatatatag cttctttggc cacattaacc acacagcctg
     3181 agcccagccc agtctccaca cccagaggtg cctttgtgcc ttccaggcct ggagtgcctc
     3241 agctctggcc tgcctctctc ctcagcccct gttgtggttt gggctgtaag aactctggag
     3301 acatcaggac ctcttggctt ccaaccagat gtctcctaca gggtgggccc tggtgcctct
     3361 gtacagattc tgctcccaac gcttggattg accactgtta agtgcctgcc tctgtatatc
     3421 ctattaataa actaaaataa agggaagccc tctcgtggct
//
