LOCUS       NM_053655               2515 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus dynamin 1-like (Dnm1l), mRNA.
ACCESSION   NM_053655
VERSION     NM_053655.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2515)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 2515)
  AUTHORS   Sun,J., Shao,Y., Pei,L., Zhu,Q., Yu,X. and Yao,W.
  TITLE     AKAP1 alleviates VSMC phenotypic modulation and neointima formation
            by inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Biomed Pharmacother 176, 116858 (2024)
   PUBMED   38850669
  REMARK    GeneRIF: AKAP1 alleviates VSMC phenotypic modulation and neointima
            formation by inhibiting Drp1-dependent mitochondrial fission.
REFERENCE   3  (bases 1 to 2515)
  AUTHORS   Zhang,H., Chen,L., Li,J., Sun,J., Zhao,Q., Wang,S. and Li,G.
  TITLE     STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related
            protein 1) controlled-mitochondrial fission during the development
            of apoptotic-resistance in pulmonary arterial endothelial cells
  JOURNAL   Genes Genomics 46 (7), 751-762 (2024)
   PUBMED   38733520
  REMARK    GeneRIF: STAT3 phosphorylation at Tyr705 affects DRP1
            (dynamin-related protein 1) controlled-mitochondrial fission during
            the development of apoptotic-resistance in pulmonary arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 2515)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   5  (bases 1 to 2515)
  AUTHORS   Fan,R.Z., Sportelli,C., Lai,Y., Salehe,S.S., Pinnell,J.R.,
            Brown,H.J., Richardson,J.R., Luo,S. and Tieu,K.
  TITLE     A partial Drp1 knockout improves autophagy flux independent of
            mitochondrial function
  JOURNAL   Mol Neurodegener 19 (1), 26 (2024)
   PUBMED   38504290
  REMARK    GeneRIF: A partial Drp1 knockout improves autophagy flux
            independent of mitochondrial function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2515)
  AUTHORS   Smirnova,E., Griparic,L., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Dynamin-related protein Drp1 is required for mitochondrial division
            in mammalian cells
  JOURNAL   Mol Biol Cell 12 (8), 2245-2256 (2001)
   PUBMED   11514614
REFERENCE   7  (bases 1 to 2515)
  AUTHORS   Chen,C.H., Hwang,S.L., Howng,S.L., Chou,C.K. and Hong,Y.R.
  TITLE     Three rat brain alternative splicing dynamin-like protein variants:
            interaction with the glycogen synthase kinase 3beta and action as a
            substrate
  JOURNAL   Biochem Biophys Res Commun 268 (3), 893-898 (2000)
   PUBMED   10679301
REFERENCE   8  (bases 1 to 2515)
  AUTHORS   Pitts,K.R., Yoon,Y., Krueger,E.W. and McNiven,M.A.
  TITLE     The dynamin-like protein DLP1 is essential for normal distribution
            and morphology of the endoplasmic reticulum and mitochondria in
            mammalian cells
  JOURNAL   Mol Biol Cell 10 (12), 4403-4417 (1999)
   PUBMED   10588666
REFERENCE   9  (bases 1 to 2515)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   10 (bases 1 to 2515)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085843.1.
            
            On Jun 10, 2007 this sequence version replaced NM_053655.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085843.1, SRR8487230.53896.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2515
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..2515
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
     exon            1..264
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..2313
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /EC_number="3.6.5.5"
                     /note="N-terminal region; dynamin-like protein 1;
                     C-terminal region; dynamin-related protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein"
                     /protein_id="NP_446107.2"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
                     /translation="MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLES
                     LVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENGVEAEEWGKFLHTKNKLYT
                     DFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVPVGDQPK
                     DIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLD
                     LMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSL
                     ANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLL
                     QLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDI
                     LTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYS
                     TQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLM
                     NNNIEEQRRNRLARELPSAVSRDKLIQDNRRETKNVASAGGGIGDGGRIGDGGQEPTT
                     GNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDC
                     EVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTE
                     SEDMAQRRKEAADMLKALQGASQIIAEIRETHLW"
     exon            265..412
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            413..459
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..531
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..618
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..781
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            782..902
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1034
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1241
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1362
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1518
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1608
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1701
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1758
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1791
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1986
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2096
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2256
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2491
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcgtggc ctgccgggag cgggctggga ggtggcggcc tagcccaatg ggtgcgtgct
       61 cccgaggaga gggcggagga gaaaaggaag caagcgggct gcgggctgcg tccccattca
      121 ttgcagtggt ctgctgggtt ggggtccagt gtttccggag tcatggaggc gctgatcccg
      181 gtcatcaata agctgcaaga cgtcttcaac accgtgggcg ccgacatcat ccagctgcct
      241 cagattgtcg tagtgggaac tcagagcagt ggaaagagct cagtgctgga aagcctagtg
      301 gggagggacc ttcttcccag agggactggt gtggtcaccc ggagacctct tattctgcag
      361 ctggtccacg tttcaccaga agataaaaga aaaacaacag gagaagaaaa tggagttgaa
      421 gcagaagaat ggggtaaatt tcttcacacc aaaaacaagc tttacacaga ttttgatgaa
      481 attcgacaag aaattgaaaa tgaaactgaa agaatttcag gaaataataa gggagtaagc
      541 cctgagccaa tccatctcaa ggttttctcg cccaacgttg tcaacctgac gcttgtggat
      601 ttaccaggaa tgaccaaagt acctgtaggt gatcagccca aggatattga gcttcaaatc
      661 agagaactta ttcttcggtt catcagtaat cccaattcca ttatccttgc tgtcactgct
      721 gcaaatacag atatggcaac gtcagaggca cttaagattt ccagagaggt agatccagat
      781 gggcgcagaa ctctagctgt aatcaccaag cttgatctca tggatgcggg tactgatgcc
      841 atggatgtat tgatgggaag ggttattcca gtcaagcttg gaataattgg agtagttaac
      901 aggagccaac tggacattaa caataagaag agtgtaactg attcaatccg tgatgagtat
      961 gcttttcttc aaaagaagta cccatctctg gccaacagaa atggaacaaa gtatcttgct
     1021 aggactctga ataggttact tatgcatcat atcagagact gtttaccaga gctgaaaaca
     1081 agaataaatg tcttagctgc tcagtatcag tctcttctaa atagctatgg tgagcccgtg
     1141 gatgataaaa gtgctacttt actccagctc attaccaagt ttgccacaga gtattgtaac
     1201 actattgaag gaacggcaaa gtacattgaa acttctgagc tatgtggtgg tgctaggatt
     1261 tgttatattt tccatgagac ttttgggcga accttagaat ctgttgatcc actaggtggc
     1321 cttaacacta ttgacatctt gaccgccatt agaaatgcta ctggcccccg tccagcttta
     1381 tttgtgcctg aagtttcatt tgagttactg gtcaaacgtc agattaagcg tctagaggag
     1441 cccagcctcc gctgtgtgga gctggtccac gaggaaatgc agaggatcat tcagcactgt
     1501 agcaactaca gcacacagga actgttacgg ttccctaaac tccatgatgc catagttgaa
     1561 gtagtgactt gtcttcttcg taaaaggttg cccgtgacaa atgaaatggt acataactta
     1621 gtggcaattg agctagcata tatcaacaca aaacaccccg actttgctga tgcctgtggg
     1681 ctaatgaaca ataacataga ggaacaaaga agaaacagac tagcaagaga actaccttcc
     1741 gctgtatcgc gagacaagtt aattcaggac aacagaagag aaactaaaaa tgttgcatct
     1801 gcaggtggtg gaattggaga tggtggtcga attggagatg gtggtcagga accgacaaca
     1861 ggcaactgga gaggaatgct gaaaacttca aaagctgaag aattacttgc tgaagaaaaa
     1921 tcaaaaccaa ttccaattat gccagcaagt ccacaaaaag gccatgctgt caatttgcta
     1981 gatgtgccag ttccagttgc acgaaaactg tctgcccgag aacagcgaga ttgtgaggtt
     2041 attgaaagac tcatcaaatc atattttcta attgtcagaa agaatattca agacagcgtc
     2101 ccaaaggcag taatgcattt tttggttaat catgtgaaag atactcttca gagtgaatta
     2161 gtagggcagc tgtataagtc atccttatta gatgaccttc tgactgaatc cgaggacatg
     2221 gcacagcgaa gaaaagaagc ggctgacatg ctgaaggcat tacaaggagc cagtcaaatt
     2281 attgctgaaa tccgagagac tcatctttgg tgaacagaac tgtttggtct tctacacttt
     2341 gctgacttga acctactagc tactgcctac ctgagtagaa atttatttat ggacttttgt
     2401 gtatcgcagt gtatgaattt gcttgtgtga agactggcta taagctgaaa agtatattat
     2461 tcattacaag acaaatcaca tgtttaattc aaaaaaaaaa aaaaaaaaaa aaaaa
//
