LOCUS       NM_080689               3201 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Rattus norvegicus dynamin 1 (Dnm1), mRNA.
ACCESSION   NM_080689 XM_001081938
VERSION     NM_080689.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3201)
  AUTHORS   Jiang,A., Kudo,K., Gormal,R.S., Ellis,S., Guo,S., Wallis,T.P.,
            Longfield,S.F., Robinson,P.J., Johnson,M.E., Joensuu,M. and
            Meunier,F.A.
  TITLE     Dynamin1 long- and short-tail isoforms exploit distinct recruitment
            and spatial patterns to form endocytic nanoclusters
  JOURNAL   Nat Commun 15 (1), 4060 (2024)
   PUBMED   38744819
  REMARK    GeneRIF: Dynamin1 long- and short-tail isoforms exploit distinct
            recruitment and spatial patterns to form endocytic nanoclusters.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3201)
  AUTHORS   Kong,L., Sochacki,K.A., Wang,H., Fang,S., Canagarajah,B.,
            Kehr,A.D., Rice,W.J., Strub,M.P., Taraska,J.W. and Hinshaw,J.E.
  TITLE     Cryo-EM of the dynamin polymer assembled on lipid membrane
  JOURNAL   Nature 560 (7717), 258-262 (2018)
   PUBMED   30069048
  REMARK    Erratum:[Nature. 2018 Dec;564(7734):E6. doi:
            10.1038/s41586-018-0612-2.. PMID: 30377313]
REFERENCE   3  (bases 1 to 3201)
  AUTHORS   Asinof,S., Mahaffey,C., Beyer,B., Frankel,W.N. and Boumil,R.
  TITLE     Dynamin 1 isoform roles in a mouse model of severe childhood
            epileptic encephalopathy
  JOURNAL   Neurobiol Dis 95, 1-11 (2016)
   PUBMED   27363778
REFERENCE   4  (bases 1 to 3201)
  AUTHORS   Reubold,T.F., Faelber,K., Plattner,N., Posor,Y., Ketel,K.,
            Curth,U., Schlegel,J., Anand,R., Manstein,D.J., Noe,F., Haucke,V.,
            Daumke,O. and Eschenburg,S.
  TITLE     Crystal structure of the dynamin tetramer
  JOURNAL   Nature 525 (7569), 404-408 (2015)
   PUBMED   26302298
REFERENCE   5  (bases 1 to 3201)
  AUTHORS   McAdam,R.L., Varga,K.T., Jiang,Z., Young,F.B., Blandford,V.,
            McPherson,P.S., Gong,L.W. and Sossin,W.S.
  TITLE     The juxtamembrane region of synaptotagmin 1 interacts with dynamin
            1 and regulates vesicle fission during compensatory endocytosis in
            endocrine cells
  JOURNAL   J Cell Sci 128 (12), 2229-2235 (2015)
   PUBMED   25964652
REFERENCE   6  (bases 1 to 3201)
  AUTHORS   Micheva,K.D., Kay,B.K. and McPherson,P.S.
  TITLE     Synaptojanin forms two separate complexes in the nerve terminal.
            Interactions with endophilin and amphiphysin
  JOURNAL   J Biol Chem 272 (43), 27239-27245 (1997)
   PUBMED   9341169
REFERENCE   7  (bases 1 to 3201)
  AUTHORS   Ringstad,N., Nemoto,Y. and De Camilli,P.
  TITLE     The SH3p4/Sh3p8/SH3p13 protein family: binding partners for
            synaptojanin and dynamin via a Grb2-like Src homology 3 domain
  JOURNAL   Proc Natl Acad Sci U S A 94 (16), 8569-8574 (1997)
   PUBMED   9238017
REFERENCE   8  (bases 1 to 3201)
  AUTHORS   Takei,K., McPherson,P.S., Schmid,S.L. and De Camilli,P.
  TITLE     Tubular membrane invaginations coated by dynamin rings are induced
            by GTP-gamma S in nerve terminals
  JOURNAL   Nature 374 (6518), 186-190 (1995)
   PUBMED   7877693
REFERENCE   9  (bases 1 to 3201)
  AUTHORS   Gout,I., Dhand,R., Hiles,I.D., Fry,M.J., Panayotou,G., Das,P.,
            Truong,O., Totty,N.F., Hsuan,J., Booker,G.W. et al.
  TITLE     The GTPase dynamin binds to and is activated by a subset of SH3
            domains
  JOURNAL   Cell 75 (1), 25-36 (1993)
   PUBMED   8402898
REFERENCE   10 (bases 1 to 3201)
  AUTHORS   Obar,R.A., Collins,C.A., Hammarback,J.A., Shpetner,H.S. and
            Vallee,R.B.
  TITLE     Molecular cloning of the microtubule-associated mechanochemical
            enzyme dynamin reveals homology with a new family of GTP-binding
            proteins
  JOURNAL   Nature 347 (6290), 256-261 (1990)
   PUBMED   2144893
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 7, 2020 this sequence version replaced NM_080689.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X54531.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               JAXUCZ010000003.1  36046090-36046289   c
            201-274             JAXUCZ010000003.1  36034815-36034888   c
            275-424             JAXUCZ010000003.1  36034393-36034542   c
            425-628             JAXUCZ010000003.1  36033937-36034140   c
            629-727             JAXUCZ010000003.1  36032565-36032663   c
            728-888             JAXUCZ010000003.1  36032300-36032460   c
            889-1031            JAXUCZ010000003.1  36030745-36030887   c
            1032-1167           JAXUCZ010000003.1  36030495-36030630   c
            1168-1235           JAXUCZ010000003.1  36030300-36030367   c
            1236-1374           JAXUCZ010000003.1  36027563-36027701   c
            1375-1461           JAXUCZ010000003.1  36021932-36022018   c
            1462-1532           JAXUCZ010000003.1  36017354-36017424   c
            1533-1584           JAXUCZ010000003.1  36017116-36017167   c
            1585-1596           JAXUCZ010000003.1  36016878-36016889   c
            1597-1710           JAXUCZ010000003.1  36014675-36014788   c
            1711-1820           JAXUCZ010000003.1  36011120-36011229   c
            1821-1932           JAXUCZ010000003.1  36009949-36010060   c
            1933-1944           JAXUCZ010000003.1  36009556-36009567   c
            1945-2115           JAXUCZ010000003.1  36009083-36009253   c
            2116-2357           JAXUCZ010000003.1  36006863-36007104   c
            2358-2573           JAXUCZ010000003.1  36006301-36006516   c
            2574-2610           JAXUCZ010000003.1  36004599-36004635   c
            2611-3201           JAXUCZ010000003.1  36002535-36003125   c
FEATURES             Location/Qualifiers
     source          1..3201
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..3201
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /note="dynamin 1"
                     /db_xref="GeneID:140694"
                     /db_xref="RGD:71096"
     exon            1..200
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..2595
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /EC_number="3.6.5.5"
                     /note="D100; B-dynamin; dynamin, brain; dynamin I"
                     /codon_start=1
                     /product="dynamin-1"
                     /protein_id="NP_542420.1"
                     /db_xref="GeneID:140694"
                     /db_xref="RGD:71096"
                     /translation="MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGK
                     SSVLENFVGRDFLPRGSGIVTRRPLVLQLVNSTTEYAEFLHCKGKKFTDFEEVRLEIE
                     AETDRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDML
                     MQFVTKENCLILAVSPANSDLANSDALKIAKEVDPQGQRTIGVITKLDLMDEGTDARD
                     VLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPY
                     LQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVDEYKNFRPDDPARKTKALLQMVQ
                     QFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAI
                     KNIHGIRTGLFTPDLAFEATVKKQVQKLKEPSIKCVDMVVSELTSTIRKCSEKLQQYP
                     RLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNK
                     KKTSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLS
                     VDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAG
                     VYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMP
                     KTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALS
                     IIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPARPGSRGP
                     APGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAPPGVPRITISDP"
     exon            201..274
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            275..424
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            425..628
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            629..727
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            728..888
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1031
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1167
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1235
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1374
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1461
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1532
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1584
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1596
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1710
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1820
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1932
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..1944
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2115
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2357
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2573
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2610
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..3201
                     /gene="Dnm1"
                     /gene_synonym="Dnm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggctgccgg gatcgcagcc cgccgggccc gccgcaacca tgggcaaccg cggcatggaa
       61 gacctcatcc cgctggttaa ccggttacag gacgccttct ctgccatcgg ccagaacgcg
      121 gacctcgact tgccgcagat cgccgtggta ggcggccaga gcgccggcaa gagctcggtg
      181 ctggagaatt tcgtgggcag ggacttcttg ccccgaggat ccggcatcgt cacccggcgt
      241 cccctggtcc tgcagctggt taattctacc acagaatatg ccgagttcct gcactgcaag
      301 gggaagaaat tcaccgactt cgaggaggtg cgcctggaga tcgaggctga gaccgaccga
      361 gtcactggca ccaacaaggg catttcgcct gtgcccatca acctgcgtgt ctactcaccc
      421 catgtgctca acctgactct agtggacctg ccaggaatga ccaaggtccc agttggggac
      481 caacctcctg acatcgagtt ccagatccgg gacatgctta tgcagtttgt cactaaggag
      541 aactgcctta tcctggctgt gtcccctgcc aactcggacc tggccaactc tgatgccctc
      601 aagatcgcca aggaggtgga cccccagggt cagcgcacca ttggggtcat caccaagttg
      661 gacctgatgg acgagggcac agatgctcgg gatgtgctgg agaacaagct gctcccattg
      721 cgcagaggct acattggcgt ggtgaaccgg agccagaagg acatagatgg caagaaggat
      781 atcacagccg ccttggctgc cgagcgcaaa ttcttcctct cccacccatc ctaccgccac
      841 ttggctgacc gcatgggcac accctacctg cagaaggtcc tcaaccagca actgaccaac
      901 cacatccggg acacgctgcc gggacttcgg aacaaactgc agagccagct gctgtccatt
      961 gagaaggagg tggacgagta caagaacttc cgaccggatg acccagcgcg caagaccaag
     1021 gccctgctgc agatggtcca gcagtttgca gtggacttcg agaagcgcat tgagggttct
     1081 ggagaccaga tcgacactta tgaactgtca ggtggagccc gcattaaccg gatcttccac
     1141 gaacgcttcc cttttgagct ggttaagatg gagtttgatg agaaggaact gcgaagggag
     1201 atcagctacg ctatcaagaa cattcatggc atcaggacag gcctcttcac tcctgacctc
     1261 gcttttgaag ccacagtgaa aaagcaggtg cagaagctca aagagcccag tatcaagtgt
     1321 gtggacatgg tagtcagtga gctcacgtcc accatcagaa agtgtagtga aaagctccag
     1381 caataccccc gtctgcggga ggaaatggaa cggattgtga ccacccacat ccgagaacgt
     1441 gagggccgca ccaaggagca ggtcatgctt ctcatcgaca ttgagttggc ttacatgaat
     1501 accaaccatg aagacttcat aggctttgcc aatgctcagc agagaagcaa ccagatgaac
     1561 aagaagaaga cttcagggaa ccaggatgag attctggtca ttcgaaaggg gtggctgacc
     1621 atcaacaaca tcggcatcat gaagggaggc tccaaggagt actggtttgt gttgactgct
     1681 gagaatctgt cctggtacaa ggacgatgag gagaaagaga agaagtacat gctgtctgtg
     1741 gataatctga agctgcgtga tgtggagaag ggcttcatgt caagcaagca tatttttgcc
     1801 ctcttcaaca ctgagcagag gaatgtctac aaggattacc ggcagctgga actggcctgt
     1861 gagacacagg aggaggtgga cagttggaag gcttcctttc tgagggctgg cgtgtaccct
     1921 gagcgtgttg gggacaagga gaaagccagt gagactgagg agaacggctc tgacagcttc
     1981 atgcactcca tggaccctca gctggagcgc caggtggaga ccatccggaa cctggtagac
     2041 tcgtacatgg ccattgtcaa caagactgta cgggatctca tgcccaagac catcatgcac
     2101 ctcatgatca acaataccaa ggagtttatc ttctctgagc tgctggccaa cctgtactct
     2161 tgcggggacc agaacacgct gatggaagaa tcggccgaac aggctcagcg gcgcgacgag
     2221 atgctgcgta tgtaccacgc actgaaggag gcgctcagca ttatcggcga catcaacacg
     2281 accaccgtca gcacgcccat gcccccgccc gtggacgact cctggctgca ggtgcagagc
     2341 gtaccggccg gacgcaggtc gcccacgtcc agccccacgc cgcagcgccg agcccccgcc
     2401 gtgcccccag cccggcccgg gtcgcggggc cctgctcctg ggcctccgcc tgctggatcc
     2461 gccctggggg gggctccccc cgtgccctcc aggccggggg cttcccctga cccctttggc
     2521 ccccctcccc aggtgccctc gcgccccaac cgcgccccgc ctggggtccc cagaatcact
     2581 atcagtgacc cctgaggagt gtcagctacg ccgatcgggt caggcaagtc cgtcccgtcc
     2641 tgagagcccc aggcccccct tcgacctcta accagatccc tcctactcct cggagacctc
     2701 ccttatcaag cctgcctgga cagctgttct gtgacttgac agtggctccc ccgaccccaa
     2761 agcgtcctat tcatcatctg tgacttagtc tgttgtagtg gtgagctgat acatccaaat
     2821 gtgatgttgg tgaaaacttg tgcccctctg tggtattgct cctgcgacat tctataaata
     2881 tctataaata tacctatata tacatatata tacatatata tggctgacac agcctcgcct
     2941 gtagtgtcag aatcaaccac catgctgtcc ttgtggagtc ctgtggtcca actacaaggg
     3001 aacgctgtca tcctgacatc ccccctccaa tgtgccacct ccagtgagcc tccctgtccc
     3061 ttggcctgtg gacagccatc cccttggcca tccccaccct gcacaagggg atgctgcacc
     3121 agcagctgtg cggttctctg atggccacca gtcttgctgt ctcttggctg agaataaaac
     3181 ccatttctgg acaatgggga a
//
