LOCUS       NM_001109379            1517 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus DND microRNA-mediated repression inhibitor 1
            (Dnd1), mRNA.
ACCESSION   NM_001109379 XM_001054687
VERSION     NM_001109379.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1517)
  AUTHORS   Yamaji M, Jishage M, Meyer C, Suryawanshi H, Der E, Yamaji M,
            Garzia A, Morozov P, Manickavel S, McFarland HL, Roeder RG, Hafner
            M and Tuschl T.
  TITLE     DND1 maintains germline stem cells via recruitment of the CCR4-NOT
            complex to target mRNAs
  JOURNAL   Nature 543 (7646), 568-572 (2017)
   PUBMED   28297718
REFERENCE   2  (bases 1 to 1517)
  AUTHORS   Yang CX, Wright EC and Ross JW.
  TITLE     Expression of RNA-binding proteins DND1 and FXR1 in the porcine
            ovary, and during oocyte maturation and early embryo development
  JOURNAL   Mol Reprod Dev 79 (8), 541-552 (2012)
   PUBMED   22730312
REFERENCE   3  (bases 1 to 1517)
  AUTHORS   Northrup E, Zschemisch NH, Eisenblatter R, Glage S, Wedekind D,
            Cuppen E, Dorsch M and Hedrich HJ.
  TITLE     The ter mutation in the rat Dnd1 gene initiates gonadal teratomas
            and infertility in both genders
  JOURNAL   PLoS One 7 (5), e38001 (2012)
   PUBMED   22655094
  REMARK    GeneRIF: Dnd1 ter mutation causes germ cell loss, infertility and
            initiates gonadal teratomas.
REFERENCE   4  (bases 1 to 1517)
  AUTHORS   Northrup E, Eisenblatter R, Glage S, Rudolph C, Dorsch M,
            Schlegelberger B, Hedrich HJ and Zschemisch NH.
  TITLE     Loss of Dnd1 facilitates the cultivation of genital ridge-derived
            rat embryonic germ cells
  JOURNAL   Exp Cell Res 317 (13), 1885-1894 (2011)
   PUBMED   21570390
  REMARK    GeneRIF: The inactivation of the putative tumor suppressor gene
            Dnd1 facilitates the immortalization of late EGCs in vitro.
REFERENCE   5  (bases 1 to 1517)
  AUTHORS   Bhattacharya C, Aggarwal S, Kumar M, Ali A and Matin A.
  TITLE     Mouse apolipoprotein B editing complex 3 (APOBEC3) is expressed in
            germ cells and interacts with dead-end (DND1)
  JOURNAL   PLoS One 3 (5), e2315 (2008)
   PUBMED   18509452
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1517)
  AUTHORS   Kedde M, Strasser MJ, Boldajipour B, Oude Vrielink JA, Slanchev K,
            le Sage C, Nagel R, Voorhoeve PM, van Duijse J, Orom UA, Lund AH,
            Perrakis A, Raz E and Agami R.
  TITLE     RNA-binding protein Dnd1 inhibits microRNA access to target mRNA
  JOURNAL   Cell 131 (7), 1273-1286 (2007)
   PUBMED   18155131
REFERENCE   7  (bases 1 to 1517)
  AUTHORS   Youngren KK, Coveney D, Peng X, Bhattacharya C, Schmidt LS,
            Nickerson ML, Lamb BT, Deng JM, Behringer RR, Capel B, Rubin EM,
            Nadeau JH and Matin A.
  TITLE     The Ter mutation in the dead end gene causes germ cell loss and
            testicular germ cell tumours
  JOURNAL   Nature 435 (7040), 360-364 (2005)
   PUBMED   15902260
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473974.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001054687.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1517
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..1517
                     /gene="Dnd1"
                     /note="DND microRNA-mediated repression inhibitor 1"
                     /db_xref="GeneID:679841"
                     /db_xref="RGD:1583648"
     exon            1..71
                     /gene="Dnd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1106
                     /gene="Dnd1"
                     /note="dead end homolog 1"
                     /codon_start=1
                     /product="dead end protein homolog 1"
                     /protein_id="NP_001102849.1"
                     /db_xref="GeneID:679841"
                     /db_xref="RGD:1583648"
                     /translation="MQSKRECEQWCERVNPENKAALEAWVRETGIRLVQVNGQRKYGG
                     PPPGWVGSPPPSGSEVFIGRLPQDVYEHQLIPLFQRVGRLYEFRLMMTFSGLNRGFAY
                     ARYSSRRGAQAAIATLHNHQLRPSCQLLVCRSTEKCELTVDGLPLSLNRRALLLALQP
                     LGPCLQETLLLPSPGSAPSQIALLKFSTHRAAAMAKKALVEGQSRLCGEQVAVEWLKP
                     DLKQHFRQQLAGPSLRFLRPDVSQLAQTRDKLGSQGARAALQQLCQRMKLGCPVFLTK
                     CLGTGPAGWHRFWYQVVIPGHPVPFSGLIWVVLTSDWQDGHEVAKDAVSAQLLETLSE
                     SRTSLWSPRAEAGSVVKQ"
     exon            72..189
                     /gene="Dnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            190..651
                     /gene="Dnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..1517
                     /gene="Dnd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacccaagga agttctaaag aggaaactgc aagacttttg ggaaactatg cagtccaaac
       61 gggagtgtga gcaatggtgt gagagggtga atccagagaa caaggcagcc ctggaggcgt
      121 gggtaaggga gactggcatt cgcctggtgc aggtcaacgg gcaaaggaag tatggcgggc
      181 cacccccagg ctgggtgggc agcccgccac cgtcagggtc cgaggtattt atcggacgac
      241 taccgcagga tgtgtacgag caccagttga tcccactctt ccagcgcgtg ggacgcctct
      301 atgagttccg cctaatgatg acctttagtg gcctgaaccg cggctttgcc tatgcgcgct
      361 acagctcacg gcgcggtgcc caggccgcca ttgctacgct gcacaaccac cagctgcggc
      421 cttcttgcca gctcctggta tgccgaagta ccgagaagtg cgagctgacg gtggacgggc
      481 tccctcttag cttgaaccga cgtgcgttac tgcttgccct gcaaccgctc ggtccctgcc
      541 tgcaggagac attgctgcta ccgagccctg ggtctgcgcc ctctcaaatt gcactgctca
      601 agtttagcac tcaccgagct gctgccatgg ccaaaaaggc tctggtagaa gggcagtcac
      661 gcctctgtgg agagcaggtg gctgtggagt ggctcaagcc agacctgaag cagcacttcc
      721 gccaacagct tgcgggtccc tcactgcggt ttctaaggcc agatgtcagc caactagccc
      781 agaccaggga caagctgggg tcccaagggg ctcgggccgc tctgcaacag ctgtgtcaac
      841 ggatgaagct aggctgccca gtgttcctta ccaagtgttt aggaacgggg cctgccggct
      901 ggcatcgctt ctggtaccaa gttgtgatcc ctgggcatcc agtgcctttc agtggcctca
      961 tttgggttgt gctgacctct gattggcagg atgggcatga ggtggccaag gatgctgtat
     1021 ctgcacagct gctggaaaca ctgagtgaat ctaggaccag cttatggtct cctagggctg
     1081 aagcgggttc tgtggtgaag cagtgacccc ttcttcctac aggcacccta atgggtaagc
     1141 agagcctgtg ccaaccccca gcccagcagg cctgggcagc cactacttat cccaaggaga
     1201 aggtctggtg acagctttcc ctgctgggac aggaccctgt cacacctaag tgctacttta
     1261 gttgtgagga accttgccct cccccactga gcccagggtc tgattagacc tctgacctat
     1321 tatccttagt cagttccctg cttgacaaat aacccgccac acacacacaa gggcttacta
     1381 tgaatctgtg ttttatttgg agaactggct gaaccaaaga gcccttcctc ccaccactgg
     1441 tcactggttt gggcttatat ggttcttgtt ttcctatacc ggttttattt atattaaaac
     1501 cctggttggt atacatg
//
