LOCUS       NM_021664               1480 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus deoxyribonuclease 2 beta (Dnase2b), mRNA.
ACCESSION   NM_021664
VERSION     NM_021664.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1480)
  AUTHORS   Tanuma,S. and Shiokawa,D.
  TITLE     Cloning of a cDNA encoding a rat DNase II-like acid DNase
  JOURNAL   Biochem Biophys Res Commun 265 (2), 395-399 (1999)
   PUBMED   10558878
REFERENCE   2  (bases 1 to 1480)
  AUTHORS   Shiokawa,D. and Tanuma,S.
  TITLE     DLAD, a novel mammalian divalent cation-independent endonuclease
            with homology to DNase II
  JOURNAL   Nucleic Acids Res 27 (20), 4083-4089 (1999)
   PUBMED   10497274
REFERENCE   3  (bases 1 to 1480)
  AUTHORS   Goto,K. and Kondo,H.
  TITLE     A 104-kDa diacylglycerol kinase containing ankyrin-like repeats
            localizes in the cell nucleus
  JOURNAL   Proc Natl Acad Sci U S A 93 (20), 11196-11201 (1996)
   PUBMED   8855332
REFERENCE   4  (bases 1 to 1480)
  AUTHORS   Izuhara,M., Ito,M. and Takagi,Y.
  TITLE     Transcription of the rat liver uricase-encoding gene is regulated
            via a cis-acting element responsive to cAMP
  JOURNAL   Gene 167 (1-2), 267-272 (1995)
   PUBMED   8566790
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_021664.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF178974.1, SRR26643286.9265.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               JAXUCZ010000002.1  238146287-238146558 c
            273-450             JAXUCZ010000002.1  238142940-238143117 c
            451-529             JAXUCZ010000002.1  238138654-238138732 c
            530-691             JAXUCZ010000002.1  238136483-238136644 c
            692-889             JAXUCZ010000002.1  238133744-238133941 c
            890-1480            JAXUCZ010000002.1  238131185-238131775 c
FEATURES             Location/Qualifiers
     source          1..1480
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..1480
                     /gene="Dnase2b"
                     /gene_synonym="Dlad; UOX"
                     /note="deoxyribonuclease 2 beta"
                     /db_xref="GeneID:59296"
                     /db_xref="RGD:70901"
     exon            1..272
                     /gene="Dnase2b"
                     /gene_synonym="Dlad; UOX"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1230
                     /gene="Dnase2b"
                     /gene_synonym="Dlad; UOX"
                     /EC_number="3.1.22.1"
                     /note="DNA for uricase; DNase II beta; endonuclease DLAD;
                     deoxyribonuclease II beta; DNase2-like acid DNase;
                     DNaseII-like acid DNase; deoxyribonuclease DLAD; DNase
                     II-like acid DNase"
                     /codon_start=1
                     /product="deoxyribonuclease-2-beta precursor"
                     /protein_id="NP_067696.2"
                     /db_xref="GeneID:59296"
                     /db_xref="RGD:70901"
                     /translation="MTAQPLKAALPLLFVALSGVLGTPVISCINEDGKAVDWFAFYKL
                     PRRTSRGGTGMGLDYLYLDSTMRTWSKSHHLINSSRSSLGRTLEQLYEAHNAKNDTAY
                     LIYNDAVPASVNYSGNYGHAKGLLVWNRVQGFWLIHSIPKFPPVPEKGYEYPNSGRQY
                     AQSGLCITLKYSQYETIDSQLLVFQPNIYSCFIPNIFRWELIHMPQMCAKSSASKIPS
                     RRLTVLQSAQGLNFLHFAKSTFYTDDIFAAWIAQKLKVHLLVESWQRKNHELPSNCSL
                     PYHVYNIKAIRGPLQSDFPSHHDHSKWCVSTKDSQARWTCIGDLNRSPHQALRSGGFI
                     CSKNRYIYQSFDRLVSHYASCN"
     exon            273..450
                     /gene="Dnase2b"
                     /gene_synonym="Dlad; UOX"
                     /inference="alignment:Splign:2.1.0"
     exon            451..529
                     /gene="Dnase2b"
                     /gene_synonym="Dlad; UOX"
                     /inference="alignment:Splign:2.1.0"
     exon            530..691
                     /gene="Dnase2b"
                     /gene_synonym="Dlad; UOX"
                     /inference="alignment:Splign:2.1.0"
     exon            692..889
                     /gene="Dnase2b"
                     /gene_synonym="Dlad; UOX"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1480
                     /gene="Dnase2b"
                     /gene_synonym="Dlad; UOX"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagcatca gatgacatga gactcagcct cttctgtttg tgcccaagca gtgaacggca
       61 ggagtggata gaacccgcag cggagccggt gcggcctgag agagatttga cgctctgact
      121 ccacagtctg aggcatggaa tgaaagccac agacagaaaa tgacagccca gcctctaaaa
      181 gcagctcttc ctttgctctt cgttgccctg tccggagtcc tggggacacc agtaatctcg
      241 tgcataaacg aagatggtaa agccgtggac tggtttgcct tttataagtt acccagaagg
      301 accagcagag gaggtacagg gatggggctg gattacctgt acctggactc cacaatgaga
      361 acctggagca agagccacca cctgattaac agcagcagga gctccctggg aaggaccctg
      421 gagcagctgt atgaagcaca caatgccaag aatgacacag cctatctgat atacaatgac
      481 gctgtccctg catctgtgaa ttacagcgga aattacgggc atgccaaagg tctgctggta
      541 tggaacagag tgcaggggtt ctggctgatt cattctattc ccaagtttcc cccagttccg
      601 gaaaaaggct atgaataccc aaactcgggg aggcaatatg cacaaagtgg cctctgcatc
      661 actctcaaat acagccagta tgagacaata gattctcagc tcttggtctt ccagccaaac
      721 atctacagct gtttcatccc aaacatcttt cgctgggaac tcatccacat gcctcagatg
      781 tgtgccaagt ccagtgcctc aaagatccct agccggcgcc tcactgtact tcagtcagcc
      841 cagggtctaa acttcctcca ttttgcgaaa tcaacttttt atactgatga catctttgca
      901 gcctggatag ctcaaaagct gaaggtgcat ttgctggtag aatcctggca gcgaaagaac
      961 cacgagcttc cttcaaactg ttccctgcct taccatgtct acaacatcaa ggccattcgg
     1021 ggacctctgc agtccgactt cccttctcat cacgaccatt ccaaatggtg tgtttccaca
     1081 aaggactctc aggctcgctg gacctgtatt ggagacctaa atcggagccc acatcaagcc
     1141 ttgagaagtg gaggatttat ctgttcgaag aatcggtaca tttaccagtc atttgatagg
     1201 ttagtttccc attatgcctc ctgtaactaa gcttggggaa aggtcccacc cactgccctt
     1261 aaagacactg gctctgggac atcttgcctt ggatctattc tccatatgtt aaaggtttct
     1321 gagtgtccta acatctcatc caataaaaaa ctatgagtcc acatttacca ttctgcgttc
     1381 acatcaggag aaatctgagc catttgtgtt tatcaaatta gaaatccaaa tcatggtatg
     1441 taaatagcat gggggaaata gaataaaata ttttcttcca
//
