LOCUS       NM_138539               1464 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus deoxyribonuclease 2, lysosomal (Dnase2), mRNA.
ACCESSION   NM_138539
VERSION     NM_138539.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1464)
  AUTHORS   Jaadane,I., Chahory,S., Lepretre,C., Omri,B., Jonet,L.,
            Behar-Cohen,F., Crisanti,P. and Torriglia,A.
  TITLE     The activation of the atypical PKC zeta in light-induced retinal
            degeneration and its involvement in L-DNase II control
  JOURNAL   J Cell Mol Med 19 (7), 1646-1655 (2015)
   PUBMED   25781645
  REMARK    GeneRIF: PKC zeta interacts with LEI/L-DNase II and controls its
            DNase activity by impairing its nuclear translocation.
REFERENCE   2  (bases 1 to 1464)
  AUTHORS   Tanuma,S. and Shiokawa,D.
  TITLE     Cloning of a cDNA encoding a rat DNase II-like acid DNase
  JOURNAL   Biochem Biophys Res Commun 265 (2), 395-399 (1999)
   PUBMED   10558878
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On May 26, 2021 this sequence version replaced NM_138539.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF178975.1, FQ216710.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760475,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               JAXUCZ010000019.1  40151956-40152225   c
            271-451             JAXUCZ010000019.1  40151633-40151813   c
            452-530             JAXUCZ010000019.1  40151457-40151535   c
            531-695             JAXUCZ010000019.1  40151080-40151244   c
            696-893             JAXUCZ010000019.1  40150799-40150996   c
            894-1464            JAXUCZ010000019.1  40149505-40150075   c
FEATURES             Location/Qualifiers
     source          1..1464
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..1464
                     /gene="Dnase2"
                     /gene_synonym="Dnase2a"
                     /note="deoxyribonuclease 2, lysosomal"
                     /db_xref="GeneID:171575"
                     /db_xref="RGD:621457"
     exon            1..270
                     /gene="Dnase2"
                     /gene_synonym="Dnase2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1228
                     /gene="Dnase2"
                     /gene_synonym="Dnase2a"
                     /EC_number="3.1.22.1"
                     /note="deoxyribonuclease-2-alpha; acid DNase; DNase II
                     alpha; lysosomal DNase II; deoxyribonuclease II alpha;
                     deoxyribonuclease II, lysosomal"
                     /codon_start=1
                     /product="deoxyribonuclease-2-alpha precursor"
                     /protein_id="NP_612548.1"
                     /db_xref="GeneID:171575"
                     /db_xref="RGD:621457"
                     /translation="MAAPSSLLLAALLWVPAEALSCYGDSGRPVDWFVVYKLPANSGS
                     GDKPWKGLMYKYMDQNSEGWQDGVGHIDSKDGAVGLTLQPLYQKNSSQLAFLLYNDQP
                     PKSSSAQDSSSRGHTKGVLLLDQEGGFWLVHSVPRFPSPASSGAYSWPPNARTYGQTL
                     LCVSLPFSQFPGIGKQLTYTYPLVYDHKLEGIFAQKLPDLEEVTKGHHVLREPWNSSV
                     ILTSRAGTTFQSFAKFGKFGDDLYSGWLAAALGTNLQVQFWPNSPGILPSNCSGTHKI
                     LDVTETGFPGPSGPTFNATEDHSKWCVAPEGPWVCVGDMNRNKRETHRGGGTLCTQVP
                     ALWKAFRSLVKACKPC"
     exon            271..451
                     /gene="Dnase2"
                     /gene_synonym="Dnase2a"
                     /inference="alignment:Splign:2.1.0"
     exon            452..530
                     /gene="Dnase2"
                     /gene_synonym="Dnase2a"
                     /inference="alignment:Splign:2.1.0"
     exon            531..695
                     /gene="Dnase2"
                     /gene_synonym="Dnase2a"
                     /inference="alignment:Splign:2.1.0"
     exon            696..893
                     /gene="Dnase2"
                     /gene_synonym="Dnase2a"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1464
                     /gene="Dnase2"
                     /gene_synonym="Dnase2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggttcgct gctgggacaa cttcagagga agccccgcct ccgccccggg cctggcgggc
       61 tcggtctcca ccctcgtgaa gcccagaccc aggtccctga agtctttagg ggaagttggt
      121 ctgaagctcg tgacccggct gtcccgggtc tttcagagtt cattactgtc gcttcatggc
      181 agcaccgagc tcgctgctgt tggctgcgct gctgtgggtt cctgccgaag ccctgagctg
      241 ctatggggac tcggggcggc ctgtggattg gttcgtggta tacaagctgc cggctaacag
      301 cgggtctggg gataagccat ggaagggtct gatgtataaa tacatggacc agaactccga
      361 gggttggcaa gacggtgtag ggcacatcga cagcaaggac ggagccgtgg gcctcaccct
      421 gcagccgttg taccaaaaga actccagtca gctggccttt ctactctaca acgaccaacc
      481 tcccaaatcc agctcagctc aggactcttc cagccgtggg catacgaagg gtgtcctgct
      541 cctggaccaa gaagggggct tctggctggt ccacagtgtg cctcgcttcc catcccctgc
      601 atcctctggt gcatacagct ggcctccgaa cgctcggacc tacggccaga ccctactctg
      661 tgtgtccctt cccttcagtc agtttccagg gattggcaag caactaacct atacctaccc
      721 cctagtctat gaccacaagc tggaaggtat ctttgctcaa aaattacctg acctagaaga
      781 ggtgaccaag ggccaccatg tcctccgtga gccctggaat agtagtgtaa ttctcacttc
      841 tcgagctggg accaccttcc agagctttgc caaatttgga aaatttggag atgacctgta
      901 ctccggctgg ctggcagcag cccttggcac caacctacag gtccagttct ggccaaattc
      961 tccaggcatc ctgccttcca actgctctgg gacccataaa attctggatg tgactgagac
     1021 aggattccct ggcccatctg gaccgacttt caacgccaca gaggatcact ccaaatggtg
     1081 tgtggccccc gaagggccct gggtctgtgt gggtgacatg aatcggaaca aaagagagac
     1141 acaccgcggt gggggcacac tgtgcaccca agtgcctgcc ctctggaagg ccttccggtc
     1201 cttggtgaaa gcctgtaagc cctgttaaaa ggggagctga ctggaagccc aacagaacaa
     1261 agaactcagg gactggcttg gtggggacag gactagcctt tatcccagca cttgggaggc
     1321 agaggcaggc agatctctga gttccgggcc agcctggtct acagagagtt tcagaagagc
     1381 cagggcaaca cagaaacact gtctcaaggg gaaaaaggat aatagaaata aaaataaaat
     1441 aaaaagaaag aaaaactcag agac
//
