LOCUS       NM_053907               1417 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus deoxyribonuclease 1L3 (Dnase1l3), mRNA.
ACCESSION   NM_053907 XM_003751446
VERSION     NM_053907.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1417)
  AUTHORS   Jimenez-Alcazar,M., Rangaswamy,C., Panda,R., Bitterling,J.,
            Simsek,Y.J., Long,A.T., Bilyy,R., Krenn,V., Renne,C., Renne,T.,
            Kluge,S., Panzer,U., Mizuta,R., Mannherz,H.G., Kitamura,D.,
            Herrmann,M., Napirei,M. and Fuchs,T.A.
  TITLE     Host DNases prevent vascular occlusion by neutrophil extracellular
            traps
  JOURNAL   Science 358 (6367), 1202-1206 (2017)
   PUBMED   29191910
REFERENCE   2  (bases 1 to 1417)
  AUTHORS   Errami,Y., Naura,A.S., Kim,H., Ju,J., Suzuki,Y., El-Bahrawy,A.H.,
            Ghonim,M.A., Hemeida,R.A., Mansy,M.S., Zhang,J., Xu,M.,
            Smulson,M.E., Brim,H. and Boulares,A.H.
  TITLE     Apoptotic DNA fragmentation may be a cooperative activity between
            caspase-activated deoxyribonuclease and the poly(ADP-ribose)
            polymerase-regulated DNAS1L3, an endoplasmic reticulum-localized
            endonuclease that translocates to the nucleus during apoptosis
  JOURNAL   J Biol Chem 288 (5), 3460-3468 (2013)
   PUBMED   23229555
REFERENCE   3  (bases 1 to 1417)
  AUTHORS   Shiokawa,D. and Tanuma,S.
  TITLE     Differential DNases are selectively used in neuronal apoptosis
            depending on the differentiation state
  JOURNAL   Cell Death Differ 11 (10), 1112-1120 (2004)
   PUBMED   15167901
  REMARK    GeneRIF: DNase gamma is suggested to be involved in naturally
            occurring apoptosis in developing nervous systems
REFERENCE   4  (bases 1 to 1417)
  AUTHORS   Higami,Y., Tsuchiya,T., To,K., Chiba,T., Yamaza,H., Shiokawa,D.,
            Tanuma,S. and Shimokawa,I.
  TITLE     Expression of DNase gamma during Fas-independent apoptotic DNA
            fragmentation in rodent hepatocytes
  JOURNAL   Cell Tissue Res 316 (3), 403-407 (2004)
   PUBMED   15118903
  REMARK    GeneRIF: DNase gamma plays an important role in Fas-independent
            apoptotic DNA fragmentation in hepatocytes.
REFERENCE   5  (bases 1 to 1417)
  AUTHORS   Shiokawa,D., Kobayashi,T. and Tanuma,S.
  TITLE     Involvement of DNase gamma in apoptosis associated with myogenic
            differentiation of C2C12 cells
  JOURNAL   J Biol Chem 277 (34), 31031-31037 (2002)
   PUBMED   12050166
REFERENCE   6  (bases 1 to 1417)
  AUTHORS   Liu,Q.Y., Pandey,S., Singh,R.K., Lin,W., Ribecco,M.,
            Borowy-Borowski,H., Smith,B., LeBlanc,J., Walker,P.R. and
            Sikorska,M.
  TITLE     DNaseY: a rat DNaseI-like gene coding for a constitutively
            expressed chromatin-bound endonuclease
  JOURNAL   Biochemistry 37 (28), 10134-10143 (1998)
   PUBMED   9665719
REFERENCE   7  (bases 1 to 1417)
  AUTHORS   Shiokawa,D. and Tanuma,S.
  TITLE     Molecular cloning and expression of a cDNA encoding an apoptotic
            endonuclease DNase gamma
  JOURNAL   Biochem J 332 (Pt 3) (Pt 3), 713-720 (1998)
   PUBMED   9620874
REFERENCE   8  (bases 1 to 1417)
  AUTHORS   Shiokawa,D., Iwamatsu,A. and Tanuma,S.
  TITLE     Purification, characterization, and amino acid sequencing of DNase
            gamma from rat spleen
  JOURNAL   Arch Biochem Biophys 346 (1), 15-20 (1997)
   PUBMED   9328279
REFERENCE   9  (bases 1 to 1417)
  AUTHORS   Shiokawa,D., Ohyama,H., Yamada,T. and Tanuma,S.
  TITLE     Purification and properties of DNase gamma from apoptotic rat
            thymocytes
  JOURNAL   Biochem J 326 (Pt 3) (Pt 3), 675-681 (1997)
   PUBMED   9307016
REFERENCE   10 (bases 1 to 1417)
  AUTHORS   Shiokawa,D., Ohyama,H., Yamada,T., Takahashi,K. and Tanuma,S.
  TITLE     Identification of an endonuclease responsible for apoptosis in rat
            thymocytes
  JOURNAL   Eur J Biochem 226 (1), 23-30 (1994)
   PUBMED   7957253
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U75689.1.
            
            On Jun 26, 2012 this sequence version replaced XM_003751446.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231976.1, FQ230990.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1417
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..1417
                     /gene="Dnase1l3"
                     /note="deoxyribonuclease 1L3"
                     /db_xref="GeneID:116687"
                     /db_xref="RGD:620669"
     exon            1..358
                     /gene="Dnase1l3"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1135
                     /gene="Dnase1l3"
                     /function="apoptosis"
                     /note="deoxyribonuclease gamma; DNaseY; DNase I-like 3;
                     DNase gamma; deoxyribonuclease I-like 3; deoxyribonuclease
                     gamma-like; deoxyribonuclease 1-like 3"
                     /codon_start=1
                     /product="deoxyribonuclease gamma precursor"
                     /protein_id="NP_446359.1"
                     /db_xref="GeneID:116687"
                     /db_xref="RGD:620669"
                     /translation="MSLYPASPYLASLLLFILALHGALSLRLCSFNVRSFGESKKENH
                     NAMDIIVKIIKRCDLILLMEIKDSNNNICPMLMEKLNGNSRRSTTYNYVISSRLGRNT
                     YKEQYAFLYKEKLVSVKAKYLYHDYQDGDTDVFSREPFVVWFQAPFTAAKDFVIVPLH
                     TTPETSVKEIDELADVYTDVRRRWKAENFIFMGDFNAGCSYVPKKAWKNIRLRTDPNF
                     VWLIGDQEDTTVKKSTSCAYDRIVLRGQEIVNSVVPRSSGVFDFQKAYELSEEEALDV
                     SDHFPVEFKLQSSRAFTNSRKSVSLKKKKKGSRS"
     exon            359..447
                     /gene="Dnase1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            448..537
                     /gene="Dnase1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            538..650
                     /gene="Dnase1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            651..763
                     /gene="Dnase1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            764..921
                     /gene="Dnase1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1018
                     /gene="Dnase1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1405
                     /gene="Dnase1l3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacgggcatc aagaccagag gactccctaa aggctaactc attgtcttca tttccttggt
       61 gattgaaaac gcgtgatggt gagttcctca gagaagtgaa agtggcccag agggatccag
      121 taattcctgt tatcggccag ctttataagt cagcgagcca ggcgcctgtc ttcatccggc
      181 ctgaagtccc aagagtgcaa agatgtccct gtacccagct tccccatacc tggcctccct
      241 gctactcttc atccttgccc ttcatggtgc cctgtccctg aggctctgct ccttcaatgt
      301 gaggtccttt ggagagagca agaaggaaaa ccacaatgcc atggatatca ttgtgaagat
      361 catcaaacgc tgcgacctca tactgctgat ggaaatcaag gacagcaaca acaacatctg
      421 tcccatgctg atggagaagc tgaatggaaa ctcacgaaga agcacgacat acaactacgt
      481 gattagctct cggcttggaa gaaacacata taaagaacag tatgccttcc tctacaagga
      541 gaagctggtg tctgtgaagg caaaatacct ctaccatgac tatcaggatg gagacacaga
      601 cgtgttttcc agggagccct ttgtggtttg gttccaggcg cccttcactg ctgccaagga
      661 cttcgtgatt gtccccttgc acacaactcc tgaaacctcc gttaaagaga tagatgagct
      721 ggctgacgtc tacacggatg tgagaagacg atggaaggca gagaatttca tcttcatggg
      781 tgatttcaat gctggctgca gctacgtccc caagaaggcc tggaagaaca tccgtttgag
      841 gacagacccc aactttgttt ggctgattgg ggaccaagag gacaccacgg tcaagaagag
      901 caccagctgt gcctatgaca ggattgtgct tcgcggacaa gagatagtca actctgtggt
      961 tccccgctcc agtggcgtct ttgactttca gaaagcttat gagttgtctg aagaggaggc
     1021 cctggatgtc agtgaccact ttccagttga gtttaagcta cagagttcaa gagccttcac
     1081 caacagccga aaatctgttt ctctaaagaa aaagaaaaaa ggcagtcgct cctaggtctc
     1141 atgttgccat tttcttttct taaagtcgtc ccttgcttcc agataaaatg gccctcgtgg
     1201 gtctcagctc tctgcacact caggaattaa gactggctaa gctgttttca ctgtccactc
     1261 tggttaattt tgcctggagc caagttggga ggagagcctt ctgttacatc accctgacca
     1321 cgggcaccct gcgaaccacc atgggtaacc tgaagagaca caaagtctat tccataataa
     1381 atgcgtgtat ttattacacc ataaaaaaaa aaaaaaa
//
