LOCUS       NM_001031647            2250 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus dynein, axonemal, light intermediate chain 1
            (Dnali1), mRNA.
ACCESSION   NM_001031647 XM_233519
VERSION     NM_001031647.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2250)
  AUTHORS   Whitfield,M., Thomas,L., Bequignon,E., Schmitt,A., Stouvenel,L.,
            Montantin,G., Tissier,S., Duquesnoy,P., Copin,B., Chantot,S.,
            Dastot,F., Faucon,C., Barbotin,A.L., Loyens,A., Siffroi,J.P.,
            Papon,J.F., Escudier,E., Amselem,S., Mitchell,V., Toure,A. and
            Legendre,M.
  TITLE     Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer
            Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to
            Asthenozoospermia
  JOURNAL   Am J Hum Genet 105 (1), 198-212 (2019)
   PUBMED   31178125
REFERENCE   2  (bases 1 to 2250)
  AUTHORS   Mali,G.R., Yeyati,P.L., Mizuno,S., Dodd,D.O., Tennant,P.A.,
            Keighren,M.A., Zur Lage,P., Shoemark,A., Garcia-Munoz,A.,
            Shimada,A., Takeda,H., Edlich,F., Takahashi,S., von Kreigsheim,A.,
            Jarman,A.P. and Mill,P.
  TITLE     ZMYND10 functions in a chaperone relay during axonemal dynein
            assembly
  JOURNAL   Elife 7, e34389 (2018)
   PUBMED   29916806
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2250)
  AUTHORS   Abdelhamed,Z., Vuong,S.M., Hill,L., Shula,C., Timms,A., Beier,D.,
            Campbell,K., Mangano,F.T., Stottmann,R.W. and Goto,J.
  TITLE     A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal
            motile cilia development in mice
  JOURNAL   Development 145 (1) (2018)
   PUBMED   29317443
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2250)
  AUTHORS   Jeanson,L., Thomas,L., Copin,B., Coste,A., Sermet-Gaudelus,I.,
            Dastot-Le Moal,F., Duquesnoy,P., Montantin,G., Collot,N.,
            Tissier,S., Papon,J.F., Clement,A., Louis,B., Escudier,E.,
            Amselem,S. and Legendre,M.
  TITLE     Mutations in GAS8, a Gene Encoding a Nexin-Dynein Regulatory
            Complex Subunit, Cause Primary Ciliary Dyskinesia with Axonemal
            Disorganization
  JOURNAL   Hum Mutat 37 (8), 776-785 (2016)
   PUBMED   27120127
REFERENCE   5  (bases 1 to 2250)
  AUTHORS   Dougherty,G.W., Loges,N.T., Klinkenbusch,J.A., Olbrich,H.,
            Pennekamp,P., Menchen,T., Raidt,J., Wallmeier,J., Werner,C.,
            Westermann,C., Ruckert,C., Mirra,V., Hjeij,R., Memari,Y.,
            Durbin,R., Kolb-Kokocinski,A., Praveen,K., Kashef,M.A., Kashef,S.,
            Eghtedari,F., Haffner,K., Valmari,P., Baktai,G., Aviram,M.,
            Bentur,L., Amirav,I., Davis,E.E., Katsanis,N., Brueckner,M.,
            Shaposhnykov,A., Pigino,G., Dworniczak,B. and Omran,H.
  TITLE     DNAH11 Localization in the Proximal Region of Respiratory Cilia
            Defines Distinct Outer Dynein Arm Complexes
  JOURNAL   Am J Respir Cell Mol Biol 55 (2), 213-224 (2016)
   PUBMED   26909801
REFERENCE   6  (bases 1 to 2250)
  AUTHORS   Hjeij,R., Lindstrand,A., Francis,R., Zariwala,M.A., Liu,X., Li,Y.,
            Damerla,R., Dougherty,G.W., Abouhamed,M., Olbrich,H., Loges,N.T.,
            Pennekamp,P., Davis,E.E., Carvalho,C.M., Pehlivan,D., Werner,C.,
            Raidt,J., Kohler,G., Haffner,K., Reyes-Mugica,M., Lupski,J.R.,
            Leigh,M.W., Rosenfeld,M., Morgan,L.C., Knowles,M.R., Lo,C.W.,
            Katsanis,N. and Omran,H.
  TITLE     ARMC4 mutations cause primary ciliary dyskinesia with randomization
            of left/right body asymmetry
  JOURNAL   Am J Hum Genet 93 (2), 357-367 (2013)
   PUBMED   23849778
REFERENCE   7  (bases 1 to 2250)
  AUTHORS   Loges,N.T., Olbrich,H., Becker-Heck,A., Haffner,K., Heer,A.,
            Reinhard,C., Schmidts,M., Kispert,A., Zariwala,M.A., Leigh,M.W.,
            Knowles,M.R., Zentgraf,H., Seithe,H., Nurnberg,G., Nurnberg,P.,
            Reinhardt,R. and Omran,H.
  TITLE     Deletions and point mutations of LRRC50 cause primary ciliary
            dyskinesia due to dynein arm defects
  JOURNAL   Am J Hum Genet 85 (6), 883-889 (2009)
   PUBMED   19944400
REFERENCE   8  (bases 1 to 2250)
  AUTHORS   Rashid,S., Breckle,R., Hupe,M., Geisler,S., Doerwald,N. and
            Neesen,J.
  TITLE     The murine Dnali1 gene encodes a flagellar protein that interacts
            with the cytoplasmic dynein heavy chain 1
  JOURNAL   Mol Reprod Dev 73 (6), 784-794 (2006)
   PUBMED   16496424
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099087.1.
            
            On Aug 12, 2005 this sequence version replaced XM_233519.2.
            
            Sequence Note: This sequence has been modified as follows: removed
            23 bp suspected to be vector contamination from the 5' end.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099087.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2250              BC099087.1         24-2273
FEATURES             Location/Qualifiers
     source          1..2250
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2250
                     /gene="Dnali1"
                     /note="dynein, axonemal, light intermediate chain 1"
                     /db_xref="GeneID:298524"
                     /db_xref="RGD:1309260"
     exon            1..83
                     /gene="Dnali1"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..779
                     /gene="Dnali1"
                     /note="inner dynein arm light chain, axonemal; dynein,
                     axonemal, light intermediate polypeptide 1"
                     /codon_start=1
                     /product="axonemal dynein light intermediate polypeptide
                     1"
                     /protein_id="NP_001026817.1"
                     /db_xref="GeneID:298524"
                     /db_xref="RGD:1309260"
                     /translation="MIPPADSLLKYDTPVLVSRNTEKRSPKARPLKVTVQQPGPSGAG
                     PQPPKAKLPSTSCVPDPTKQAEEILNAILPPREWVEDTQLWIQQVSSTPSTRMDVVHL
                     QEQLDLKLQQRQARETGICPVRRELYSQCFDELIREVTINCAERGLLLLRVRDEIRMT
                     IAAYQTLYESSVAFGMRKALQAEQGKSDMERKITELETEKRDLERQVNEQKAKCEATE
                     KRESERRQVEEKKHNEEIQFLKRTNQQLKAQLEGIIAPKK"
     exon            84..229
                     /gene="Dnali1"
                     /inference="alignment:Splign:2.1.0"
     exon            230..399
                     /gene="Dnali1"
                     /inference="alignment:Splign:2.1.0"
     exon            400..578
                     /gene="Dnali1"
                     /inference="alignment:Splign:2.1.0"
     exon            579..743
                     /gene="Dnali1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..2225
                     /gene="Dnali1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccatgatacc ccccgcagac tctctgctca aatatgacac cccggtgttg gtgagccgga
       61 atacagaaaa acggagcccc aaggctcggc cactgaaagt cacagttcag cagcctggac
      121 cctctggtgc aggcccacaa ccacccaagg ccaagctgcc ctcaacttcc tgtgtcccag
      181 atcctaccaa acaagcagaa gaaatcttga atgccatcct gcctccaagg gagtgggtag
      241 aagacacaca gctatggatc cagcaggtgt ccagcacacc cagcaccaga atggatgtgg
      301 tgcatctcca ggagcagctg gacctgaagc tgcagcagag gcaggccagg gagacgggca
      361 tctgccctgt gcgcagggaa ctctactccc agtgttttga tgagctgatc cgggaggtca
      421 ccatcaactg tgcagagaga ggactgctgt tgctgcgtgt ccgggatgag atccgcatga
      481 ccatcgctgc ctaccagact ctgtatgaaa gcagtgtagc attcggcatg aggaaggcac
      541 tgcaggccga acaggggaag tcagacatgg agaggaaaat tacagaactg gagacagaaa
      601 agagagactt ggagaggcaa gtgaatgaac agaaggcgaa atgtgaggcc accgagaagc
      661 gggagagcga gaggcgacag gtggaggaga agaagcacaa tgaggagatc cagttcctga
      721 aacggactaa tcagcaactg aaggcccaac tggaaggcat tatcgcaccg aagaagtgat
      781 aatttccaca tgggtctcag caggcccctt gccccataag cccattgtaa taaaaagcca
      841 gtttcctcag tgaaccagcc atcccctccc cagtccccac tcatgcgatt gttagaactg
      901 ttgtccccgt gtcatgaaac acctaaggtc tggcgccagg gtcctggctg ggtaatggaa
      961 ggtggtggaa ccctgtccat gtgtggttca taaattggct ggcctgggtc tttgtcacct
     1021 cactaactta gggagcaagt gtttccctaa agagacacct ttgcaccgag tgcagttccc
     1081 agctcactgg ccccaccccc ccatgtcacc tctctaatgt aagcttcagc accttgtttt
     1141 ggagtttggt tttagactgt atcatctcat tcccaactac caagtcagca ggaccctgtc
     1201 cttagtcttt ttggctccaa gaagagacaa cagcagagtc aaagccatgc tcactgagag
     1261 gtacgaaagt ctaggtgtct tgagagctgt ctgcacccca gatcctcctc ctgctggaca
     1321 gcagagcctg actccacact ccctaactag ctagtatgaa cagctgagga ggtggccacc
     1381 tcacacggag ctctagacaa gactggactg aaggcagatt gtagatccag aagacttaaa
     1441 ttacagacag atctccacta ggggaaaacc cagggcggga gaggatgagc tcggtgacac
     1501 ccaccattca atcaagtgac aaggaactgt tcttatactg gagctaacat ttccttccag
     1561 ttggtaggaa ggcctcaagt ccacagtagc cctgaagggg ggccagagga gttcactcct
     1621 gggcagctct gacctccagc ccagtctaag cttactgcaa ggcctctgaa ccccaagtgc
     1681 tgttctgagt tgactggatc ccaacactca gacctcatac tagaagtcac atcttggacc
     1741 ctcacccagt atcctgagga attaggtcac cactagcata acctgcctat gaaacaatgt
     1801 ccctgtggtg tgctggcttt gtgggtggtg caggaaagca tatgtaccct aacaagccaa
     1861 agttgctgga tccctcctca tgtctccaag cctcacctga atgtctctga agcacttgtg
     1921 ctttgtacac tctaggcccc agtgccactt agtagtgtaa gaggaacacc catgtccaca
     1981 gacacacaca agagggtcag tcacatgctg gaggaactaa gggccaggcc aagtgtttga
     2041 gaaactctgg ggttgaggat ttcctgttgc cactagaact ggggtacgcc ctcaccactg
     2101 ggcttcccaa gtgtgctgtg ccttatagat gccacctggg catgggaaaa taaacacagt
     2161 tcctactggc atatttttgt ataatttaat aaacagcttt ctagctgtta ctgcttctgt
     2221 ctgaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
