LOCUS       NM_001109477             619 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus dynein, axonemal, light chain 1 (Dnal1), mRNA.
ACCESSION   NM_001109477 XM_001064725
VERSION     NM_001109477.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 619)
  AUTHORS   Mazor,M., Alkrinawi,S., Chalifa-Caspi,V., Manor,E., Sheffield,V.C.,
            Aviram,M. and Parvari,R.
  TITLE     Primary ciliary dyskinesia caused by homozygous mutation in DNAL1,
            encoding dynein light chain 1
  JOURNAL   Am J Hum Genet 88 (5), 599-607 (2011)
   PUBMED   21496787
REFERENCE   2  (bases 1 to 619)
  AUTHORS   Horvath,J., Fliegauf,M., Olbrich,H., Kispert,A., King,S.M.,
            Mitchison,H., Zariwala,M.A., Knowles,M.R., Sudbrak,R., Fekete,G.,
            Neesen,J., Reinhardt,R. and Omran,H.
  TITLE     Identification and analysis of axonemal dynein light chain 1 in
            primary ciliary dyskinesia patients
  JOURNAL   Am J Respir Cell Mol Biol 33 (1), 41-47 (2005)
   PUBMED   15845866
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EV765393.1 and BF394767.1.
            
            On Jan 11, 2008 this sequence version replaced NM_001109477.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211665.1, FM089520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               EV765393.1         1-159
            160-539             EV765393.1         199-578
            540-619             BF394767.1         29-108              c
FEATURES             Location/Qualifiers
     source          1..619
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..619
                     /gene="Dnal1"
                     /gene_synonym="Dnalc1; LC1"
                     /note="dynein, axonemal, light chain 1"
                     /db_xref="GeneID:685664"
                     /db_xref="RGD:1591349"
     exon            1..10
                     /gene="Dnal1"
                     /gene_synonym="Dnalc1; LC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..580
                     /gene="Dnal1"
                     /gene_synonym="Dnalc1; LC1"
                     /note="axonemal dynein light chain 1; dynein light chain
                     1, axonemal"
                     /codon_start=1
                     /product="dynein axonemal light chain 1"
                     /protein_id="NP_001102947.2"
                     /db_xref="GeneID:685664"
                     /db_xref="RGD:1591349"
                     /translation="MAKATTIKEALSRWEEKTGQKPSDAREIKLYAQIPPIEKMDASL
                     STLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISY
                     NFIEKLKGIHVMRKLKILYISNNLVKDWAEFVKLAELPCLEDLVFVGNPLEEKHSAEG
                     NWIEEATKRVPKLKKLDGTPVIKEDEEEES"
     exon            11..49
                     /gene="Dnal1"
                     /gene_synonym="Dnalc1; LC1"
                     /inference="alignment:Splign:2.1.0"
     exon            50..159
                     /gene="Dnal1"
                     /gene_synonym="Dnalc1; LC1"
                     /inference="alignment:Splign:2.1.0"
     exon            160..215
                     /gene="Dnal1"
                     /gene_synonym="Dnalc1; LC1"
                     /inference="alignment:Splign:2.1.0"
     exon            216..271
                     /gene="Dnal1"
                     /gene_synonym="Dnalc1; LC1"
                     /inference="alignment:Splign:2.1.0"
     exon            272..398
                     /gene="Dnal1"
                     /gene_synonym="Dnalc1; LC1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..539
                     /gene="Dnal1"
                     /gene_synonym="Dnalc1; LC1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..619
                     /gene="Dnal1"
                     /gene_synonym="Dnalc1; LC1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccagaatg gcaaaagcaa caacaatcaa agaagccctg tccagatggg aagaaaagac
       61 cggtcagaag ccatctgatg ccagagaaat aaagctgtat gcccagatcc cccccataga
      121 gaagatggac gcgtctctgt ccacacttgc taactgcgag aagctttccc tgtctacaaa
      181 ctgcattgaa aaaattgcca acctgaatgg cctaaaaaac ttgaggattc tgtccttagg
      241 aagaaacaac atcaagaacc taaatggact ggaagcagtc ggagacacac tagaagaact
      301 gtggatctcc tacaatttta ttgagaagtt gaaagggatc catgtaatga ggaaactgaa
      361 gattctctac atatctaata acctggtaaa agactgggct gagtttgtga agctggctga
      421 gctgccgtgc ctggaggacc tggtatttgt gggcaatccc ctggaggaga agcattctgc
      481 tgagggcaac tggattgaag aagctaccaa gagggtgccc aagctgaaga agctggatgg
      541 tactccagta attaaggagg atgaagaaga ggaaagctaa gagtgttctt tctactttgt
      601 gttaatttat ttaaatgtt
//
