LOCUS       NM_001415921            5509 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus DnaJ heat shock protein family (Hsp40) member C6
            (Dnajc6), mRNA.
ACCESSION   NM_001415921 XM_006238446
VERSION     NM_001415921.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5509)
  AUTHORS   Hunn,B.H., Cragg,S.J., Bolam,J.P., Spillantini,M.G. and
            Wade-Martins,R.
  TITLE     Impaired intracellular trafficking defines early Parkinson's
            disease
  JOURNAL   Trends Neurosci 38 (3), 178-188 (2015)
   PUBMED   25639775
  REMARK    Review article
REFERENCE   2  (bases 1 to 5509)
  AUTHORS   Drouet,V. and Lesage,S.
  TITLE     Synaptojanin 1 mutation in Parkinson's disease brings further
            insight into the neuropathological mechanisms
  JOURNAL   Biomed Res Int 2014, 289728 (2014)
   PUBMED   25302295
  REMARK    Review article
REFERENCE   3  (bases 1 to 5509)
  AUTHORS   Saheki,Y. and De Camilli,P.
  TITLE     Synaptic vesicle endocytosis
  JOURNAL   Cold Spring Harb Perspect Biol 4 (9), a005645 (2012)
   PUBMED   22763746
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5509)
  AUTHORS   Scott,H., Howarth,J., Lee,Y.B., Wong,L.F., Bantounas,I.,
            Phylactou,L., Verkade,P. and Uney,J.B.
  TITLE     MiR-3120 is a mirror microRNA that targets heat shock cognate
            protein 70 and auxilin messenger RNAs and regulates clathrin
            vesicle uncoating
  JOURNAL   J Biol Chem 287 (18), 14726-14733 (2012)
   PUBMED   22393045
  REMARK    GeneRIF: miR-3120 was found to be located in neuronal cell bodies
            and to target Hsc70 and auxilin, and its lentivirus-mediated
            expression inhibited the uncoating of clathrin-coated vesicles.
REFERENCE   5  (bases 1 to 5509)
  AUTHORS   Rothnie,A., Clarke,A.R., Kuzmic,P., Cameron,A. and Smith,C.J.
  TITLE     A sequential mechanism for clathrin cage disassembly by 70-kDa
            heat-shock cognate protein (Hsc70) and auxilin
  JOURNAL   Proc Natl Acad Sci U S A 108 (17), 6927-6932 (2011)
   PUBMED   21482805
  REMARK    GeneRIF: A sequential mechanism for clathrin cage disassembly by
            70-kDa heat-shock cognate protein (Hsc70) and auxilin.
REFERENCE   6  (bases 1 to 5509)
  AUTHORS   Yim,Y.I., Sun,T., Wu,L.G., Raimondi,A., De Camilli,P., Eisenberg,E.
            and Greene,L.E.
  TITLE     Endocytosis and clathrin-uncoating defects at synapses of auxilin
            knockout mice
  JOURNAL   Proc Natl Acad Sci U S A 107 (9), 4412-4417 (2010)
   PUBMED   20160091
REFERENCE   7  (bases 1 to 5509)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   8  (bases 1 to 5509)
  AUTHORS   Zhang,C.X., Engqvist-Goldstein,A.E., Carreno,S., Owen,D.J.,
            Smythe,E. and Drubin,D.G.
  TITLE     Multiple roles for cyclin G-associated kinase in clathrin-mediated
            sorting events
  JOURNAL   Traffic 6 (12), 1103-1113 (2005)
   PUBMED   16262722
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 5, 2023 this sequence version replaced XM_006238446.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.28010.1,
                                           SRR26360172.2594098.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-546               JAXUCZ010000005.1  121290199-121290744
            547-697             JAXUCZ010000005.1  121336896-121337046
            698-747             JAXUCZ010000005.1  121338175-121338224
            748-896             JAXUCZ010000005.1  121338319-121338467
            897-1019            JAXUCZ010000005.1  121357107-121357229
            1020-1153           JAXUCZ010000005.1  121360219-121360352
            1154-1348           JAXUCZ010000005.1  121361871-121362065
            1349-1466           JAXUCZ010000005.1  121363155-121363272
            1467-1546           JAXUCZ010000005.1  121364593-121364672
            1547-1740           JAXUCZ010000005.1  121365498-121365691
            1741-1821           JAXUCZ010000005.1  121365800-121365880
            1822-2256           JAXUCZ010000005.1  121367299-121367733
            2257-2391           JAXUCZ010000005.1  121372733-121372867
            2392-2460           JAXUCZ010000005.1  121374891-121374959
            2461-2580           JAXUCZ010000005.1  121377497-121377616
            2581-2844           JAXUCZ010000005.1  121390957-121391220
            2845-2987           JAXUCZ010000005.1  121392861-121393003
            2988-3164           JAXUCZ010000005.1  121395238-121395414
            3165-5509           JAXUCZ010000005.1  121396431-121398775
FEATURES             Location/Qualifiers
     source          1..5509
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..5509
                     /gene="Dnajc6"
                     /note="DnaJ heat shock protein family (Hsp40) member C6"
                     /db_xref="GeneID:313409"
                     /db_xref="RGD:1309900"
     exon            1..546
                     /gene="Dnajc6"
                     /inference="alignment:Splign:2.1.0"
     CDS             360..3266
                     /gene="Dnajc6"
                     /EC_number="3.1.3.48"
                     /note="DnaJ (Hsp40) homolog, subfamily C, member 6"
                     /codon_start=1
                     /product="putative tyrosine-protein phosphatase auxilin"
                     /protein_id="NP_001402850.1"
                     /db_xref="GeneID:313409"
                     /db_xref="RGD:1309900"
                     /translation="MSLLGSYRKKTSSDGYESLQLVDSHGDSSARGAAAGTQRVTTGA
                     VRSPARQPPHRASTTDSSGASSPDMEPSYGGGLFDMVKGGAGRLFSNLKDNLKDTLKD
                     TSSRVIQSVSSYTKGDLDFTYVTSRIIVMSFPMDSVDIGFRNQVDDIRSFLDSRHLDH
                     YTVYNLSPKSYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNVCVVH
                     CLDGRAASSILVGAMFIFCNLYSTPGPAVRLLYAKRPGIGLSPSHRRYLGYMCDLLAD
                     KPYRPHFKPLTIKAITVSPIPFFNKQRNGCRPYCDVLIGETKIFSTCTDFERMKEYRV
                     QDGKIFIPLNITVQGDVIVSMYHLRSTIGSRLQAKVTNTQIFQLQFHSGFIPLDTTVL
                     KFTKPELDACDVPEKYPQLFQVTLDIEVQPQDKVIDLTPPWEHYCTKDVNPSILFSSQ
                     QEHQDTLALGGQAPADLPPDHPRNLGQGGFFASLCWQDQKSEKSRCEEDHAALVNQES
                     EQSDDELLTLSSPHGNADGDKPHGAKKPGKKQQEPAAPPPPEEVDLLGLEGSDVSTNF
                     SPLAAPPSNSELLSDLFGGGGATGPAQAGQVGVEDVFHPSGPASAQSTPRRATTSASA
                     SPTLRVGEGATFDPFGAPAKPPGQDLLGSFLNTSNASSDPFLQPTRSPSPTVHASSTP
                     AVNIQPDIAGGWDWHAKPGGFGMGSKSAATSPTGSTHGTPTHQSKPQTLDPFADLGTL
                     GSSSFASKPTTPTGLGGGFPPLSSPQKASPQPMGGGWQQPAGYNWQQAQPKPQSSMPH
                     SSPQNRPNYNVSFSAMPAGQSDRGKGSTNLEGKQKAADFEDLLSSQGFNAHKDKKGPR
                     TIAEMRKEEMAKEMDPEKLKILEWIEGKERNIRALLSTMHTVLWAGETKWKPVGMADL
                     VTPEQVKKVYRRAVLVVHPDKATGQPYEQYAKMIFMELNDAWSEFENQGQKPLY"
     exon            547..697
                     /gene="Dnajc6"
                     /inference="alignment:Splign:2.1.0"
     exon            698..747
                     /gene="Dnajc6"
                     /inference="alignment:Splign:2.1.0"
     exon            748..896
                     /gene="Dnajc6"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1019
                     /gene="Dnajc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1153
                     /gene="Dnajc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1348
                     /gene="Dnajc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1466
                     /gene="Dnajc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1546
                     /gene="Dnajc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1740
                     /gene="Dnajc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1821
                     /gene="Dnajc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..2256
                     /gene="Dnajc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2391
                     /gene="Dnajc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2460
                     /gene="Dnajc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2580
                     /gene="Dnajc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..2844
                     /gene="Dnajc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..2987
                     /gene="Dnajc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3164
                     /gene="Dnajc6"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..5509
                     /gene="Dnajc6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttttccgct ttcagcctcc ctccctacga ctctcccctc ctttactctc ttctgtttat
       61 tccctccccc tccagccact ccgggagctg cccggctatt gccgggctac acctacactt
      121 cctcgggcgc tgtccagcct accggtggcc ggggccggtt gggtgcgctg tgcccagggc
      181 ggtggctgca gagcccttcc tggtggccgc tcccttcttt ccctcctctt cgcgtcatgt
      241 cgggcacttg attattattg ttattttttt tcatccctct cttagtctgt cccgtcttcc
      301 cctccccctt cctttcccag gttgattttt ttttcttccc ctcttctccg ggcttgccca
      361 tgagcctcct cgggagctac cggaaaaaga ccagcagcga tggttatgaa tctttgcagc
      421 tggtggacag tcacggggac tcgagcgcac ggggcgcggc ggctggcacg cagagggtga
      481 ccacgggcgc ggtgcgtagt cccgcccggc agcctccgca ccgcgccagc accacggaca
      541 gctcaggtgc ctcatctcca gacatggagc ccagctatgg gggaggcctt tttgatatgg
      601 tgaaaggtgg tgcaggtagg ctattcagta acctgaagga caacttgaaa gacaccctca
      661 aagatacatc ctccagagtc atccagtctg ttagcagcta cacaaaggga gacctagact
      721 ttacttatgt cacttccagg attatcgtga tgtcctttcc tatggacagt gttgacatag
      781 gattcaggaa tcaggttgat gacatccgta gctttttgga ttccagacat cttgaccact
      841 acacagtata caacttgtca cccaagtctt accgaactgc caagttccac agccgggtct
      901 cagagtgcag ttggcccatc aggcaggccc caagtctaca caacctgttt gctgtgtgtc
      961 ggaatatgta taactggctg ctgcagaatc ccaaaaatgt ctgtgttgtc cactgcttgg
     1021 atggacgggc cgcatcatca attctggttg gtgctatgtt cattttctgt aatctctact
     1081 ctacgcctgg ccctgctgtt cgattactct acgcaaagcg accaggaatt ggactgtctc
     1141 cgtcccacag gaggtactta ggctacatgt gtgacctact tgcagataag ccctaccgtc
     1201 ctcacttcaa gccgctcaca atcaaggcaa tcactgtcag cccaattccc ttcttcaata
     1261 aacagaggaa tgggtgccgc ccttactgtg acgtactgat tggagaaact aaaatattct
     1321 caacatgcac agacttcgaa cgaatgaaag aataccgtgt ccaagatggg aaaatcttca
     1381 tccctctgaa catcacagtc caaggtgacg tcattgtttc catgtaccac ttgcggtcaa
     1441 ccatcgggag ccggctgcag gctaaggtga ccaacacaca gatattccag ctccagtttc
     1501 attctggatt tataccactg gacacaacag ttttaaagtt caccaagcct gagttggatg
     1561 catgtgatgt accagaaaaa tatcctcagc tgttccaagt gacactggat atagaagtac
     1621 agccccaaga caaagtgatc gacctaactc caccatggga gcactactgc acaaaggatg
     1681 tgaaccccag catcctcttc tcctctcagc aggagcatca ggatactctg gccttagggg
     1741 gtcaggctcc agcagatctc cctccagacc atccgaggaa tcttgggcaa ggaggcttct
     1801 ttgcctctct gtgttggcaa gatcagaaat cagagaagtc acggtgtgag gaggaccacg
     1861 cagccctggt gaatcaggaa agcgagcagt cggatgatga actactgact ctctcaagcc
     1921 cacatggcaa tgctgatggt gacaagcctc atggagccaa gaagcctggc aaaaagcagc
     1981 aggagccagc tgcgcctcct cccccagagg aggtggacct tctgggcctg gaagggtccg
     2041 atgtgagcac gaacttctcc cccttggcag ctcctcccag caattctgaa ctgctgagtg
     2101 acctgtttgg gggtggaggt gccacaggtc ctgcccaggc aggacaggtt ggagtcgaag
     2161 atgtgtttca cccaagtgga cctgcgtctg cgcagtccac accacgccga gccaccactt
     2221 ccgcctctgc atcgccaacc ctaagagtgg gagaaggtgc cacctttgac ccttttggag
     2281 cccctgctaa gccaccaggt caggatttgt tgggctcctt cctgaacaca tccaatgctt
     2341 ctagcgaccc ctttctgcag cccacgagaa gcccttcccc tacagtgcat gcttctagca
     2401 ctcctgctgt gaacatccaa ccagacattg ctggaggttg ggactggcat gccaaaccag
     2461 gaggttttgg gatgggaagc aaatcggctg ccaccagccc aacaggctca acacacggca
     2521 cccctaccca tcagagcaag ccccagactc tggatccctt cgctgacttg gggacactag
     2581 gcagctcttc atttgccagc aaacccacca caccaactgg attgggtgga ggatttccac
     2641 ctctcagctc accacagaaa gcgtccccac agcccatggg tggagggtgg cagcagccag
     2701 ccggctacaa ctggcagcag gcacagccta agccacagtc tagtatgcct cactcctccc
     2761 ctcagaaccg acccaattac aacgtgagct tctcagctat gcctgcaggg cagagcgacc
     2821 gtggaaaagg atctactaac ttagaaggaa aacagaaggc tgctgacttt gaagatctgc
     2881 tttccagtca aggcttcaat gcccacaaag acaaaaaggg gcctcgaaca atagctgaga
     2941 tgagaaagga ggaaatggct aaggaaatgg atcctgagaa actgaagatc ctggagtgga
     3001 tagaaggcaa agagagaaac atcagagccc tgctttccac aatgcacact gtgctgtggg
     3061 ctggggagac caagtggaaa cctgtgggca tggcagacct ggtgacgcca gagcaagtga
     3121 agaaggtgta caggagagcc gtgctagtgg tgcaccccga caaggctact gggcaaccct
     3181 atgaacaata tgcaaagatg atcttcatgg agctaaatga tgcctggtcc gaatttgaaa
     3241 accaaggcca aaagcccttg tattaatttg tgagcttttc tatgctggct gcagtcctgt
     3301 gatcatgctt agtgtgtacc acggttctga gattttcaca gatgaaccaa aaattctagt
     3361 aatgtatttc cagtactaaa ctgttaagtt cctcgtgaat tcatttctca tgataaggaa
     3421 tgtgaacatt gggtttcttg aagtccgtag caccgagagg aacactagtg aactgacctt
     3481 gcagagtcat gaaatcccag cctgcccttt ggggaagcct attcagcatt ttgcctgggg
     3541 aaataggacc gtggccaccc aaggcggagg cctgacatcc atctcactgt ctgagagtaa
     3601 gatttatgag tggacattat ggtagttgga ttacataatg gttttaagga aatgatttag
     3661 ggattgtgta tgtgtggttt ttgtttttaa agatgtaatt tgagcaatgg ctttacacaa
     3721 actccaagaa tatcaccaac caagtatttt ttaatggaaa cttactgaag cctttatagc
     3781 ttcttcagtt tgtgtctttt ggtcaagagc attaacaatc atagaagtgg ctaaatggtg
     3841 ggaggtggtt atgcagaaat ctaggcatta tccttaactt ttcctggatg cactaagccc
     3901 aagcacatga tagctgaaga aaccaggagc cctaagatgt gttgactcca ggtcagaact
     3961 ttgggggtac tggctccttt cccctttaaa tttgcagttg attaaagaaa aacctttaaa
     4021 tgctaccacc accataattc caaacctatt tgaaatcccc cttctaattg ttgccacgag
     4081 gctcagtgct ctttcttttg cttagccaag aaaacattct tcatgggtga cagtttgtaa
     4141 agcagtttgg ctcattcaca ttcacacttt gtgtagacct ggagttctgg tgattgcaaa
     4201 ccagggggga aatggagaag ataacactga gtactattta gaaagggttt ggttggggag
     4261 agagctgtgg tgtgccttca gatccaattg gatagcttgc cagtttgagg agtcagagtc
     4321 ccacccaccc agtgaatctg ggcccccacc cctgggatta tttccaatgg gtttgctgtt
     4381 ggatgcatgt gaaaactatg taagaatgca actttcccag accgactggt tgcaatttag
     4441 tccagtgctc agagcttccc attgtgcaag ggaggcagct ggtactgctg ggactttgct
     4501 aggtctcctg gtgagcacac gcgcagcatc tatctatcca tccatatatg catatgagta
     4561 tgtctagtgt gcacatacac attcacaaag cgggtggtca aaaagattat catgctgatc
     4621 ttaaaaggtt cacattcaat attgtgaaaa gctttcaaaa gtttgttttt caaagacaat
     4681 cattttgttt gtttgtttct gttttaatat tcttgtgaca aactaaaccg aaaaagcagc
     4741 atgtcagaaa taattttggt tccatataga cctctcttct ctcttttctt ttaaattata
     4801 aaagttcatt atttattttg ccttttactg ataatgtgaa attctcaaaa aaaatattct
     4861 ctttaaaata tgcagttgta aactcttcaa agtaaccatg acaacctagg tgttatttat
     4921 taaggtatta tacaatgatg tctgacccag tatgtgcttg tcctctttaa gattggaatg
     4981 tgagacatgt tgctgtgacc tgttttattt tttgttctgt tttgttttgt tttttttctg
     5041 cctcattcca catttgtaga tattgtgtga actacagtat ataatgacaa taattaagag
     5101 gatattatgt ggctgccaca tacattttga ggtggtagaa ctatattagc tttatatcat
     5161 gttcgcatag gtcattaatg ttcatgattt aaataccatt aaacgttatg cgattagcaa
     5221 tgagaaagaa cccctcctta aatctgggag tttccccacc gctcttcccc agatgcatta
     5281 tgattctgga tgcctgtcta tctcaaaact cttaacacat gcagaccaat aagttctgca
     5341 ttccttttaa ataccaggtc gtgacagttt gttgttggtc agattcactg tctcattcat
     5401 atttattgta atatattttt gttttgtaaa tacgttaaac aaaacaaaat gtcattgttt
     5461 aaaatatttg taatgtatat taaaaagata aaaaatactt gcagaaata
//
