LOCUS       NM_024161                934 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus DnaJ heat shock protein family (Hsp40) member C5
            (Dnajc5), mRNA.
ACCESSION   NM_024161
VERSION     NM_024161.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 934)
  AUTHORS   Chiang,N., Hsiao,Y.T., Yang,H.J., Lin,Y.C., Lu,J.C. and Wang,C.T.
  TITLE     Phosphomimetic mutation of cysteine string protein-alpha increases
            the rate of regulated exocytosis by modulating fusion pore dynamics
            in PC12 cells
  JOURNAL   PLoS One 9 (6), e99180 (2014)
   PUBMED   24956274
  REMARK    GeneRIF: CSPalpha may modulate fusion pore dynamics in a
            phosphorylation-dependent manner.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 934)
  AUTHORS   Wilhelm,B.G., Mandad,S., Truckenbrodt,S., Krohnert,K., Schafer,C.,
            Rammner,B., Koo,S.J., Classen,G.A., Krauss,M., Haucke,V., Urlaub,H.
            and Rizzoli,S.O.
  TITLE     Composition of isolated synaptic boutons reveals the amounts of
            vesicle trafficking proteins
  JOURNAL   Science 344 (6187), 1023-1028 (2014)
   PUBMED   24876496
REFERENCE   3  (bases 1 to 934)
  AUTHORS   Shimomura,H., Imai,A. and Nashida,T.
  TITLE     Characterization of cysteine string protein in rat parotid acinar
            cells
  JOURNAL   Arch Biochem Biophys 538 (1), 1-5 (2013)
   PUBMED   23942053
  REMARK    GeneRIF: both the J-domain and the linker domain of CSP1 are
            necessary to function in an important role in acinar cell
            exocytosis
REFERENCE   4  (bases 1 to 934)
  AUTHORS   Rozas,J.L., Gomez-Sanchez,L., Mircheski,J., Linares-Clemente,P.,
            Nieto-Gonzalez,J.L., Vazquez,M.E., Lujan,R. and Fernandez-Chacon,R.
  TITLE     Motorneurons require cysteine string protein-alpha to maintain the
            readily releasable vesicular pool and synaptic vesicle recycling
  JOURNAL   Neuron 74 (1), 151-165 (2012)
   PUBMED   22500637
REFERENCE   5  (bases 1 to 934)
  AUTHORS   Carnini,A., Scott,L.O., Ahrendt,E., Proft,J., Winkfein,R.J.,
            Kim,S.W., Colicos,M.A. and Braun,J.E.
  TITLE     Cell line specific modulation of extracellular abeta42 by Hsp40
  JOURNAL   PLoS One 7 (5), e37755 (2012)
   PUBMED   22666389
  REMARK    GeneRIF: a biochemical link between Hsp40 expression and Abeta(42)
            proteostasis that is cell specific
REFERENCE   6  (bases 1 to 934)
  AUTHORS   Evans,G.J. and Morgan,A.
  TITLE     Phosphorylation-dependent interaction of the synaptic vesicle
            proteins cysteine string protein and synaptotagmin I
  JOURNAL   Biochem J 364 (Pt 2), 343-347 (2002)
   PUBMED   11931641
  REMARK    GeneRIF: phosphorylation-dependent interaction with synaptotagmin I
REFERENCE   7  (bases 1 to 934)
  AUTHORS   Tobaben,S., Thakur,P., Fernandez-Chacon,R., Sudhof,T.C., Rettig,J.
            and Stahl,B.
  TITLE     A trimeric protein complex functions as a synaptic chaperone
            machine
  JOURNAL   Neuron 31 (6), 987-999 (2001)
   PUBMED   11580898
REFERENCE   8  (bases 1 to 934)
  AUTHORS   Yamada,M., Yamada,M., Yamazaki,S., Takahashi,K., Nara,K., Ozawa,H.,
            Yamada,S., Kiuchi,Y., Oguchi,K., Kamijima,K., Higuchi,T. and
            Momose,K.
  TITLE     Induction of cysteine string protein after chronic antidepressant
            treatment in rat frontal cortex
  JOURNAL   Neurosci Lett 301 (3), 183-186 (2001)
   PUBMED   11257428
REFERENCE   9  (bases 1 to 934)
  AUTHORS   Braun,J.E. and Scheller,R.H.
  TITLE     Cysteine string protein, a DnaJ family member, is present on
            diverse secretory vesicles
  JOURNAL   Neuropharmacology 34 (11), 1361-1369 (1995)
   PUBMED   8606785
REFERENCE   10 (bases 1 to 934)
  AUTHORS   Mastrogiacomo,A. and Gundersen,C.B.
  TITLE     The nucleotide and deduced amino acid sequence of a rat cysteine
            string protein
  JOURNAL   Brain Res Mol Brain Res 28 (1), 12-18 (1995)
   PUBMED   7535880
  REMARK    Erratum:[Brain Res Mol Brain Res 1996 Sep 5;41(1-2):301]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            [WARNING] On Jul 16, 2024 this sequence was replaced by
            NM_024161.4.
            
            On Nov 26, 2020 this sequence version replaced NM_024161.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF323955.1, U39320.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               JAXUCZ010000003.1  188999902-189000012
            112-229             JAXUCZ010000003.1  189027004-189027121
            230-443             JAXUCZ010000003.1  189028046-189028259
            444-615             JAXUCZ010000003.1  189029278-189029449
            616-934             JAXUCZ010000003.1  189029882-189030200
FEATURES             Location/Qualifiers
     source          1..934
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..934
                     /gene="Dnajc5"
                     /gene_synonym="Csp"
                     /note="DnaJ heat shock protein family (Hsp40) member C5"
                     /db_xref="GeneID:79130"
                     /db_xref="RGD:620516"
     exon            1..111
                     /gene="Dnajc5"
                     /gene_synonym="Csp"
                     /inference="alignment:Splign:2.1.0"
     exon            112..229
                     /gene="Dnajc5"
                     /gene_synonym="Csp"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..719
                     /gene="Dnajc5"
                     /gene_synonym="Csp"
                     /note="cysteine string protein; DnaJ (Hsp40) homolog,
                     subfamily C, member 5"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 5"
                     /protein_id="NP_077075.1"
                     /db_xref="GeneID:79130"
                     /db_xref="RGD:620516"
                     /translation="MADQRQRSLSTSGESLYHVLGLDKNATSDDIKKSYRKLALKYHP
                     DKNPDNPEAADKFKEINNAHAILTDATKRNIYDKYGSLGLYVAEQFGEENVNTYFVLS
                     SWWAKALFVVCGLLTCCYCCCCLCCCFNCCCGKCKPKAPEGEETEFYVSPEDLEAQLQ
                     SDEREATDTPIVIQPASATETTQLTADSHPSYHTDGFN"
     exon            230..443
                     /gene="Dnajc5"
                     /gene_synonym="Csp"
                     /inference="alignment:Splign:2.1.0"
     exon            444..615
                     /gene="Dnajc5"
                     /gene_synonym="Csp"
                     /inference="alignment:Splign:2.1.0"
     exon            616..934
                     /gene="Dnajc5"
                     /gene_synonym="Csp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcggccg cctccgcggc tcccggaacg cagaagctgg tgtagggagg cgggcagtga
       61 aggctccgag gcttgttcac attcggggaa gcagaaaatt gcctcatagt tactaaccta
      121 acatggctga ccagaggcag cgctcactct ctacttccgg ggaatcgtta taccatgttc
      181 ttggactgga caagaatgca acctcagatg acattaaaaa gtcctatcgg aagctggccc
      241 tgaaatatca ccctgacaag aaccctgata acccagaggc tgcagacaag tttaaggaga
      301 ttaacaacgc ccacgcaatc ctgacagacg ccacgaaaag aaacatttat gacaagtatg
      361 gctcgctggg gctctatgtg gctgagcaat ttggggagga gaatgtcaac acctacttcg
      421 tactctccag ctggtgggcc aaggcgctgt tcgtcgtctg tggcctcctc acctgctgct
      481 actgctgctg ctgtttatgc tgttgcttta actgctgctg tgggaagtgc aagcccaagg
      541 cacctgaggg tgaagagaca gaattctacg tatcccctga agacttggag gcacagctgc
      601 agtctgatga gagggaggct acagacacac cgatcgtcat acagccagca tccgccacag
      661 agaccaccca gctgacagct gactcccacc ccagctatca caccgacggg ttcaactaaa
      721 ttcaggagag gctgtgatta gaggatgaat cagcatctgg ccactgcaac cttagaatca
      781 tgaactgtag tcactgagat gggaaggcag ccgtcaacct gacccgctgt ggctggtcag
      841 ggccactccc acctcctctt aagtccaccc atctgtcaat ccttgataca tgaagtgcgt
      901 agcatgcagt atttaaagca gtgtagctac ggtc
//
