LOCUS       NM_022232               5110 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus DnaJ heat shock protein family (Hsp40) member C3
            (Dnajc3), mRNA.
ACCESSION   NM_022232
VERSION     NM_022232.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5110)
  AUTHORS   Roobol,A., Roobol,J., Bastide,A., Knight,J.R., Willis,A.E. and
            Smales,C.M.
  TITLE     p58IPK is an inhibitor of the eIF2alpha kinase GCN2 and its
            localization and expression underpin protein synthesis and ER
            processing capacity
  JOURNAL   Biochem J 465 (2), 213-225 (2015)
   PUBMED   25329545
REFERENCE   2  (bases 1 to 5110)
  AUTHORS   Chiasserini,D., van Weering,J.R., Piersma,S.R., Pham,T.V.,
            Malekzadeh,A., Teunissen,C.E., de Wit,H. and Jimenez,C.R.
  TITLE     Proteomic analysis of cerebrospinal fluid extracellular vesicles: a
            comprehensive dataset
  JOURNAL   J Proteomics 106, 191-204 (2014)
   PUBMED   24769233
REFERENCE   3  (bases 1 to 5110)
  AUTHORS   Huber,A.L., Lebeau,J., Guillaumot,P., Petrilli,V., Malek,M.,
            Chilloux,J., Fauvet,F., Payen,L., Kfoury,A., Renno,T., Chevet,E.
            and Manie,S.N.
  TITLE     p58(IPK)-mediated attenuation of the proapoptotic PERK-CHOP pathway
            allows malignant progression upon low glucose
  JOURNAL   Mol Cell 49 (6), 1049-1059 (2013)
   PUBMED   23395000
  REMARK    GeneRIF: Endoplasmic reticulum stress activation and p58(IPK)
            expression control the fate of malignant cells facing glucose
            shortage.
REFERENCE   4  (bases 1 to 5110)
  AUTHORS   Jansen,G., Maattanen,P., Denisov,A.Y., Scarffe,L., Schade,B.,
            Balghi,H., Dejgaard,K., Chen,L.Y., Muller,W.J., Gehring,K. and
            Thomas,D.Y.
  TITLE     An interaction map of endoplasmic reticulum chaperones and foldases
  JOURNAL   Mol Cell Proteomics 11 (9), 710-723 (2012)
   PUBMED   22665516
REFERENCE   5  (bases 1 to 5110)
  AUTHORS   Gao,D., Bambang,I.F., Putti,T.C., Lee,Y.K., Richardson,D.R. and
            Zhang,D.
  TITLE     ERp29 induces breast cancer cell growth arrest and survival through
            modulation of activation of p38 and upregulation of ER stress
            protein p58IPK
  JOURNAL   Lab Invest 92 (2), 200-213 (2012)
   PUBMED   22064321
REFERENCE   6  (bases 1 to 5110)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   7  (bases 1 to 5110)
  AUTHORS   Petrova,K., Oyadomari,S., Hendershot,L.M. and Ron,D.
  TITLE     Regulated association of misfolded endoplasmic reticulum lumenal
            proteins with P58/DNAJc3
  JOURNAL   EMBO J 27 (21), 2862-2872 (2008)
   PUBMED   18923430
REFERENCE   8  (bases 1 to 5110)
  AUTHORS   Oyadomari,S., Yun,C., Fisher,E.A., Kreglinger,N., Kreibich,G.,
            Oyadomari,M., Harding,H.P., Goodman,A.G., Harant,H., Garrison,J.L.,
            Taunton,J., Katze,M.G. and Ron,D.
  TITLE     Cotranslocational degradation protects the stressed endoplasmic
            reticulum from protein overload
  JOURNAL   Cell 126 (4), 727-739 (2006)
   PUBMED   16923392
  REMARK    Erratum:[Cell. 2006 Dec 16;127(6):1284]
REFERENCE   9  (bases 1 to 5110)
  AUTHORS   Yan,W., Frank,C.L., Korth,M.J., Sopher,B.L., Novoa,I., Ron,D. and
            Katze,M.G.
  TITLE     Control of PERK eIF2alpha kinase activity by the endoplasmic
            reticulum stress-induced molecular chaperone P58IPK
  JOURNAL   Proc Natl Acad Sci U S A 99 (25), 15920-15925 (2002)
   PUBMED   12446838
REFERENCE   10 (bases 1 to 5110)
  AUTHORS   Korth,M.J., Lyons,C.N., Wambach,M. and Katze,M.G.
  TITLE     Cloning, expression, and cellular localization of the oncogenic
            58-kDa inhibitor of the RNA-activated human and mouse protein
            kinase
  JOURNAL   Gene 170 (2), 181-188 (1996)
   PUBMED   8666242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Sep 13, 2022 this sequence version replaced NM_022232.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.37454.1,
                                           SRR26643295.51640.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000015.1  102432667-102432872
            207-317             JAXUCZ010000015.1  102445768-102445878
            318-442             JAXUCZ010000015.1  102456910-102457034
            443-517             JAXUCZ010000015.1  102460426-102460500
            518-670             JAXUCZ010000015.1  102463247-102463399
            671-852             JAXUCZ010000015.1  102465634-102465815
            853-972             JAXUCZ010000015.1  102466210-102466329
            973-1078            JAXUCZ010000015.1  102467896-102468001
            1079-1199           JAXUCZ010000015.1  102468211-102468331
            1200-1332           JAXUCZ010000015.1  102469370-102469502
            1333-1481           JAXUCZ010000015.1  102470850-102470998
            1482-5110           JAXUCZ010000015.1  102472015-102475643
FEATURES             Location/Qualifiers
     source          1..5110
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q24"
     gene            1..5110
                     /gene="Dnajc3"
                     /note="DnaJ heat shock protein family (Hsp40) member C3"
                     /db_xref="GeneID:63880"
                     /db_xref="RGD:708518"
     exon            1..206
                     /gene="Dnajc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1639
                     /gene="Dnajc3"
                     /note="dnaJ homolog subfamily C member 3; protein kinase
                     inhibitor of 58 kDa; interferon-induced, double-stranded
                     RNA-activated protein kinase inhibitor; protein kinase
                     inhibitor p58; DnaJ (Hsp40) homolog, subfamily C, member
                     3"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 3 precursor"
                     /protein_id="NP_071568.2"
                     /db_xref="GeneID:63880"
                     /db_xref="RGD:708518"
                     /translation="MVAPGSVRSRLGAVFPFLLVLVDLQYEGAECGVNADVEKHLELG
                     KKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTRVIELKM
                     DFTAARLQRGHLLLKQGRLAEAEDDFKKVLKSNPSENEEKEAQSQLVKADEMQRLRAQ
                     ALDAFDSADYTAAITFLDEILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLK
                     NDNTEAFYKISILYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIGSAE
                     ELIRDGRYTDATSKYESVMKAEPSVAEYTVRSKERICHCFSKDEKPVEAIKICSEVLQ
                     LEPDNVNALKDRAEAYLIEEMYDEAIQDYEAAQEQNENDQQIREGLEKAQRLLKQSQK
                     RDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQSEEEKKKAEKKFIDIAAAKEVLS
                     DPEMRRKFDDGEDPLDAETQQGGGSNPFHRSWDSWQGFNPFSSGGPFRFKFHFN"
     exon            207..317
                     /gene="Dnajc3"
                     /inference="alignment:Splign:2.1.0"
     exon            318..442
                     /gene="Dnajc3"
                     /inference="alignment:Splign:2.1.0"
     exon            443..517
                     /gene="Dnajc3"
                     /inference="alignment:Splign:2.1.0"
     exon            518..670
                     /gene="Dnajc3"
                     /inference="alignment:Splign:2.1.0"
     exon            671..852
                     /gene="Dnajc3"
                     /inference="alignment:Splign:2.1.0"
     exon            853..972
                     /gene="Dnajc3"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1078
                     /gene="Dnajc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1199
                     /gene="Dnajc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1332
                     /gene="Dnajc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1481
                     /gene="Dnajc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..5110
                     /gene="Dnajc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccgcggcc gaggcccgag cgctgaccga ctgagcggac ggcgggcgct tcgctgcggg
       61 ctgttggccg cgcgggctgc tgggccgcgc accttcctgc tcttcggctc aggtgccctt
      121 ggacatggtg gcccccggct cggtgcgcag ccggctgggc gcggtgttcc cgttcctgct
      181 tgtcctggtg gacctgcagt acgaaggtgc tgaatgtgga gtaaatgcag atgtagagaa
      241 gcatcttgaa ctgggaaaga agttacttgc agctggacag ctggccgatg ccttatctca
      301 gtttcatgct gcagtcgatg gtgaccctga taactatatt gcatactata ggagagctac
      361 tgtcttctta gccatgggaa aatccaaagc agcactgcct gatttaacga gagtgattga
      421 actgaagatg gatttcactg cggcaagatt acagagaggt cacttactac tcaaacaagg
      481 aaggctcgcc gaagcagagg atgactttaa gaaagtgctc aaatctaatc caagtgagaa
      541 tgaagagaag gaagcccagt ctcaactcgt aaaagccgat gagatgcagc gcctgcgcgc
      601 ccaagcactc gatgcctttg acagcgctga ctacactgcg gctataacct tccttgatga
      661 gattttagag gtttgtgttt gggatgcaga attgcgtgag ctgcgagcag agtgcttcat
      721 aaaggaagga gagcctagga aagccatcag tgacttaaag gctgcttcaa agctcaagaa
      781 tgacaacaca gaggcgtttt acaagatcag cattctctac taccagctag gagaccacga
      841 gctgtctctc agtgaagttc gtgaatgtct gaaacttgac caggaccaca agcggtgttt
      901 tgcacactat aagcaagtga agaaacttaa caagctgatt gggtcagctg aagagctgat
      961 cagagatggg cgatacacag atgcaaccag caaatacgaa tctgtcatga aggcagagcc
     1021 cagtgttgct gagtacacag tccgctccaa agaaaggatc tgtcactgct tctccaagga
     1081 tgagaagcca gtcgaagcca ttaaaatatg ctctgaagtt ttacagctgg agcccgacaa
     1141 tgtaaatgct ctgaaagatc gagcggaggc ctatctaata gaggaaatgt atgatgaagc
     1201 catccaggac tatgaagctg cccaggaaca gaacgaaaac gatcagcaga ttcgggaagg
     1261 cttagagaaa gcccagcggt tactgaaaca gtcacagaag cgggattatt acaaaatcct
     1321 gggagtaaaa agaaatgcca aaaaacaaga aatcattaaa gcataccgaa agttagcact
     1381 gcagtggcat ccagataatt tccagagtga agaggaaaag aaaaaagcag agaaaaagtt
     1441 cattgacata gcagccgcta aagaagtcct ctccgaccca gaaatgagaa ggaagtttga
     1501 tgacggagaa gaccctcttg atgcggagac tcagcaagga ggtggtagca atcccttcca
     1561 cagaagttgg gactcatggc aagggttcaa tcccttcagc tcaggcggac cgtttagatt
     1621 taaattccac ttcaattaaa ccagctattt tactgctcct cttctttatt attattttta
     1681 acattaaaaa caaattttgt ttgggattct aatggaaaca aaatggaaca aatcttttag
     1741 tttgtctacg accaaagagt tgtttgaaga aaaaaagctg tgcttactgt agacttaagg
     1801 ttgatggggc tgtcaaggtg ggaagcaagg aattgtattt ctgacagagc aggactctca
     1861 ctttgtgact tctgggagaa gtagtctgag gtagttaccc tgtggagggg ttaaaaggca
     1921 ttaaatatgc atttgtcacc ctggggcaga cagagtctat tcaggcctgt gtaccaacca
     1981 tgaggaggag ctgtgatcct tagatggctt gtgtctcagt attcttaagg gagctgaata
     2041 gttgagcttt attttctgag taacagttgt gcttagactt tggtcagtcc attcacttgc
     2101 aagtatttct gtgcctgtgt cagcacagct ctcactgcag gcaggaggcc atcttttcgg
     2161 aagcttccgg gcaggtggta ggtgataagg ccaggtgcag actctggctc ggagtgtttt
     2221 tgttgttatt ttatatctat aggagaatac caatttcact tgaattgtta aactaaacag
     2281 agtaagttaa aatatatgaa agaggctctg tgtattttag ataatacttt tgaaagtcag
     2341 tttgacatat actttttaag aagcgaagtt ccaagttgtt tggtagaaat ttcctgtcac
     2401 aaaattggtt taggaatgga aatttgtgaa catgagcaga gcatatggtt gcctcttagg
     2461 cagcgcggtg aggcagcgtc tccttcccta cacgtttagt ccagctgtct tggctgtact
     2521 gtgtgctggg ttttagactg gatgttccct ggtttatttt tctgctgaga agaagagact
     2581 tgcaaatcca tccagctctg ctgtgcaccc tctatcacct cacataacaa gatggcactt
     2641 cctcctgccc gagacattct ttgtccctct tactttaaga aatgtactat tcagtatctt
     2701 atactgaaga ctttgtccta aaaaatctgt tgctaaatca agaacattga atatttatgg
     2761 aactactgat gaaatactct ggtaagaatt atcacctcta ttctagaaag tttttttttt
     2821 ttgttttttt tttttgtttt ttttgttaac attgtgagag agcttgggca taaaggtcta
     2881 atatgtcgct tttatgaaat gaaacatttc agttgattgt gggagcacga atgtagccaa
     2941 gcccaggtca ttttcttaac ccgtagtcat cctggggaga tgtagaaaag gactgtgtga
     3001 aatgcaagaa caagaatcgc acggttgagt tgggcaaaca cgtgagtgct ttcggcctca
     3061 ctcaggagcc tgttccttac tgaacaccta atggtgcatt tccaaacacc tttcagcctt
     3121 catctcacct cagtgtctca acattcaggg caggcaagaa agcgtgcagc ttttacccta
     3181 gtagagacgg gcagaggcag atggattcct gagattgagg cagcttggtt tacagagtga
     3241 gctccatgcc aggtcctcta ccaaatattc agttcatcca agccagggtg aggcactgca
     3301 gggagataaa acactcttgt gttttcaagt cctaataatc ttacgctagc aacttatgtt
     3361 gcagttgtct ttcagtctga ctccttctgt gatgatgtca ctgacagttg tgaattggag
     3421 tgatggcatc tgtgcgtgtg ctttgcaaag agccgtgctc accagcagaa caaaggaggc
     3481 atcactgtgc ttcccctccc acatagaggg atgctgacag ggttaaatta aggtgggctg
     3541 catggatcct gcatgtgtcc cacattagct gcctcctaac ttgcttccca gagaggtttt
     3601 tttttttctt ttccctccta cttgtaactg aagagtaggc tttctcattg caaactctgg
     3661 tgccaaaggc agctgccacg cagatgaggt agttctgagc ggtgagataa ggatgcccag
     3721 tgtgttccag cctgcgtgct gtcccagagt cacagtgtca aacagtggct ccttctacct
     3781 gcctgacact ggatggcagg caccatggag ccacactacc aacaaagcat tctctgccct
     3841 tttccttttc tttctgcaga actgcttccg cattccaatt tccattttta ggaagtgcag
     3901 gtaacctttg tggtaattct gggaaaagta tgattgaagt tcacctcggc tgcactctgt
     3961 tctgttcata gactttccct cctttgtggt gagcttccta agtgcatggc cactgggctg
     4021 tgtctagtgc tcattgctca ggagggagga gaagcctctg ctagaggggc cactcctcct
     4081 atttcacttc tcatttctaa aagtttactc tttctatgaa tagaagaaaa cctgaaaaac
     4141 atctcggtag tttattaatg tgaattggat gtaacatctt aatttaaaat tatctgtagt
     4201 cagtgttaaa agtctgtttt taaatagcag tatgcagatt tgtcactgga gttctgataa
     4261 tgaatgcaat tttttttttt taaacgtaag caggctcatg cctgtagtcc cagaatgtgg
     4321 ggctgcaata ggatgtcact aggactttag gccccactca aaaataccaa atttaaacac
     4381 acatcctcga aatgtgagag aggactatgg ataactaagt aaaaaatgtc agtagtcacc
     4441 attattcatt cctgggtatt cctgtaatag caaagaagtg gtcagaagct ggcgtgtacc
     4501 agaaggaggt aagctgcact agttagacat ggctgtgcag gccctcgtgt gccgccctgt
     4561 cttacagatg cgtctgggta acgggagtga ggacggcttt cgtgaatgta cttgaccttg
     4621 ccgtagtgat ggagggagga gaggaaatgg taacctctaa tctgatcttc ttccaggtcg
     4681 tatcattcct tttctagtag tggcagcatt tattctgtaa tttcaaatga tgttaaaggg
     4741 ggggaggtat tttttttttt aatagatgat ctcatttgct gaatgattta agagtaaaat
     4801 tagccactgc gtggctctgt gtacagtaac gacaggtttc attgcactgt ctgtggttga
     4861 gatacctgtg caaagagatg tgggcacagg ggaggtaaac attagagacg tttgataaat
     4921 tattactctt acctttatat ttgttttaaa tggtacaaac ctgacttaat ccatctcaat
     4981 ttagtgtttt aatacaaaag gaactaaaat tatttcaact ggggcttaca catgtcaatg
     5041 aatatgggca gtatttttat gcccgtgtat tttcacattt aataaaaata tttatggtca
     5101 tatccaccac
//
