LOCUS       NM_001108776            7731 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus DnaJ heat shock protein family (Hsp40) member C13
            (Dnajc13), mRNA.
ACCESSION   NM_001108776 XM_001072547 XM_003750579 XM_003754453 XM_343462
VERSION     NM_001108776.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7731)
  AUTHORS   Perrett,R.M., Alexopoulou,Z. and Tofaris,G.K.
  TITLE     The endosomal pathway in Parkinson's disease
  JOURNAL   Mol Cell Neurosci 66 (Pt A), 21-28 (2015)
   PUBMED   25701813
  REMARK    Review article
REFERENCE   2  (bases 1 to 7731)
  AUTHORS   Gallon,M. and Cullen,P.J.
  TITLE     Retromer and sorting nexins in endosomal sorting
  JOURNAL   Biochem Soc Trans 43 (1), 33-47 (2015)
   PUBMED   25619244
  REMARK    Review article
REFERENCE   3  (bases 1 to 7731)
  AUTHORS   Freeman,C.L., Hesketh,G. and Seaman,M.N.
  TITLE     RME-8 coordinates the activity of the WASH complex with the
            function of the retromer SNX dimer to control endosomal tubulation
  JOURNAL   J Cell Sci 127 (Pt 9), 2053-2070 (2014)
   PUBMED   24643499
REFERENCE   4  (bases 1 to 7731)
  AUTHORS   Xhabija,B., Taylor,G.S., Fujibayashi,A., Sekiguchi,K. and
            Vacratsis,P.O.
  TITLE     Receptor mediated endocytosis 8 is a novel PI(3)P binding protein
            regulated by myotubularin-related 2
  JOURNAL   FEBS Lett 585 (12), 1722-1728 (2011)
   PUBMED   21510942
  REMARK    GeneRIF: suggest a model in which the localization of RME-8 to
            endosomal compartments is spatially mediated by PI(3)P binding and
            temporally regulated by MTMR2 activity
REFERENCE   5  (bases 1 to 7731)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 7731)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 7731)
  AUTHORS   Fujibayashi,A., Taguchi,T., Misaki,R., Ohtani,M., Dohmae,N.,
            Takio,K., Yamada,M., Gu,J., Yamakami,M., Fukuda,M., Waguri,S.,
            Uchiyama,Y., Yoshimori,T. and Sekiguchi,K.
  TITLE     Human RME-8 is involved in membrane trafficking through early
            endosomes
  JOURNAL   Cell Struct Funct 33 (1), 35-50 (2008)
   PUBMED   18256511
REFERENCE   8  (bases 1 to 7731)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   9  (bases 1 to 7731)
  AUTHORS   Girard,M., Poupon,V., Blondeau,F. and McPherson,P.S.
  TITLE     The DnaJ-domain protein RME-8 functions in endosomal trafficking
  JOURNAL   J Biol Chem 280 (48), 40135-40143 (2005)
   PUBMED   16179350
  REMARK    GeneRIF: RME-8 functions in intracellular trafficking and provides
            the first evidence of a functional role for a DnaJ domain-bearing
            co-chaperone on endosomes
REFERENCE   10 (bases 1 to 7731)
  AUTHORS   Foster,L.J., Zeemann,P.A., Li,C., Mann,M., Jensen,O.N. and
            Kassem,M.
  TITLE     Differential expression profiling of membrane proteins by
            quantitative proteomics in a human mesenchymal stem cell line
            undergoing osteoblast differentiation
  JOURNAL   Stem Cells 23 (9), 1367-1377 (2005)
   PUBMED   16210410
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001108776.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This RefSeq transcript is based on
            transcript alignments from orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.11695.1,
                                           SRR26643295.33214.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               JAXUCZ010000008.1  113755868-113756104 c
            238-318             JAXUCZ010000008.1  113739305-113739385 c
            319-394             JAXUCZ010000008.1  113727035-113727110 c
            395-544             JAXUCZ010000008.1  113726138-113726287 c
            545-586             JAXUCZ010000008.1  113725683-113725724 c
            587-787             JAXUCZ010000008.1  113721042-113721242 c
            788-994             JAXUCZ010000008.1  113718218-113718424 c
            995-1090            JAXUCZ010000008.1  113718031-113718126 c
            1091-1182           JAXUCZ010000008.1  113716923-113717014 c
            1183-1349           JAXUCZ010000008.1  113715663-113715829 c
            1350-1429           JAXUCZ010000008.1  113715490-113715569 c
            1430-1599           JAXUCZ010000008.1  113715233-113715402 c
            1600-1699           JAXUCZ010000008.1  113714646-113714745 c
            1700-1807           JAXUCZ010000008.1  113712917-113713024 c
            1808-1963           JAXUCZ010000008.1  113711693-113711848 c
            1964-2020           JAXUCZ010000008.1  113710873-113710929 c
            2021-2142           JAXUCZ010000008.1  113708421-113708542 c
            2143-2218           JAXUCZ010000008.1  113707187-113707262 c
            2219-2314           JAXUCZ010000008.1  113706869-113706964 c
            2315-2458           JAXUCZ010000008.1  113705799-113705942 c
            2459-2541           JAXUCZ010000008.1  113702239-113702321 c
            2542-2695           JAXUCZ010000008.1  113700785-113700938 c
            2696-2799           JAXUCZ010000008.1  113695973-113696076 c
            2800-2959           JAXUCZ010000008.1  113695733-113695892 c
            2960-3022           JAXUCZ010000008.1  113694255-113694317 c
            3023-3124           JAXUCZ010000008.1  113693673-113693774 c
            3125-3229           JAXUCZ010000008.1  113691904-113692008 c
            3230-3432           JAXUCZ010000008.1  113690529-113690731 c
            3433-3517           JAXUCZ010000008.1  113689409-113689493 c
            3518-3672           JAXUCZ010000008.1  113685901-113686055 c
            3673-3718           JAXUCZ010000008.1  113685222-113685267 c
            3719-3873           JAXUCZ010000008.1  113682839-113682993 c
            3874-4075           JAXUCZ010000008.1  113681964-113682165 c
            4076-4191           JAXUCZ010000008.1  113680485-113680600 c
            4192-4270           JAXUCZ010000008.1  113679577-113679655 c
            4271-4406           JAXUCZ010000008.1  113677884-113678019 c
            4407-4591           JAXUCZ010000008.1  113675887-113676071 c
            4592-4666           JAXUCZ010000008.1  113675366-113675440 c
            4667-4786           JAXUCZ010000008.1  113673970-113674089 c
            4787-4966           JAXUCZ010000008.1  113673102-113673281 c
            4967-5134           JAXUCZ010000008.1  113671825-113671992 c
            5135-5248           JAXUCZ010000008.1  113670241-113670354 c
            5249-5365           JAXUCZ010000008.1  113669305-113669421 c
            5366-5543           JAXUCZ010000008.1  113667931-113668108 c
            5544-5635           JAXUCZ010000008.1  113666058-113666149 c
            5636-5735           JAXUCZ010000008.1  113664240-113664339 c
            5736-5810           JAXUCZ010000008.1  113662024-113662098 c
            5811-5923           JAXUCZ010000008.1  113661540-113661652 c
            5924-6093           JAXUCZ010000008.1  113660420-113660589 c
            6094-6136           JAXUCZ010000008.1  113660260-113660302 c
            6137-6310           JAXUCZ010000008.1  113659623-113659796 c
            6311-6490           JAXUCZ010000008.1  113657538-113657717 c
            6491-6631           JAXUCZ010000008.1  113657155-113657295 c
            6632-6775           JAXUCZ010000008.1  113655587-113655730 c
            6776-6875           JAXUCZ010000008.1  113651815-113651914 c
            6876-7731           JAXUCZ010000008.1  113646573-113647428 c
FEATURES             Location/Qualifiers
     source          1..7731
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..7731
                     /gene="Dnajc13"
                     /note="DnaJ heat shock protein family (Hsp40) member C13"
                     /db_xref="GeneID:363127"
                     /db_xref="RGD:1308046"
     exon            1..237
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            238..318
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..6982
                     /gene="Dnajc13"
                     /note="DnaJ (Hsp40) homolog, subfamily C, member 13"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 13"
                     /protein_id="NP_001102246.2"
                     /db_xref="GeneID:363127"
                     /db_xref="RGD:1308046"
                     /translation="MNIIRENKDLACFYTTKHSWRGKYKRVFSVGTHAVTTYNPNTLE
                     VTNQWPYGDICSISPVGKGQGTEFNLTFRKGSGKKSETLKFSTEHRTELLTEALRFRT
                     DFAEGKITGRRYNCYKHHWSDTRRPVILEVTPGGFDQINPVTNRVLCSYDYRNIEGFV
                     DLSDYQGGFCILYGGFSRLHLFASEQREEIIKSAVEHAGTYIGVSLRTRKEPLEFEQY
                     LSLRFGKYSTDESITSLAEFVVQKISPRHSEPVKRVLAVTETCLVERDPATYNIATLK
                     PLGEVFALVCDSENPQVFTIEFIKGQVRKYSSTERDSLLASLLDGVRASGNRDVCVKM
                     TPTHKGQRWGLLSMPIDEEVESLHLRFLAAPPNGNFADAVFRFNANISYSGVLHAVTQ
                     DGLFSENKEKLINNAITALLAQEGDVVASNAELESQFQAVRRLVASKAGFLAFTQLPK
                     FRERLGMKVVKALKRSNNGVIHAAVDMLCALMCPMHDDYDLRQEQLNKASLLSSKKFL
                     ENLLEKFNSHVDHGTGALVISSLLDFLTFALCAPYSETTEGQQFDMLLEMVASNGRTL
                     FKLFQHPSMAIVKGAGLVMKAIIEEGDREIATKMQDLALSEGALPRHLHTAMFTISSD
                     QRMLTNRQLSRHLVGLWTADNTTATNLLRRILPPGLLAYLDSSDPVPEKDADRMHVRD
                     NVKIAMDQYGKFNKVPEWQRLAGKAAKEVEKFAKEKVDLVLMHWRDRMGIAQKENINQ
                     KPVVLRKRRQRIKIEANWDLFYYRFSQDHARSNLIWNFKTREELKDTLESEMRTFNID
                     RELGSASVISWNHHEFEVKYECLAEEIKIGDYYLRLLLEEDENEESGSIKRSYEFFNE
                     LYHRFLLTPKVNMKCLCLQALAIVYGRCHEDIGPFTDTRYIIGMLERCTDKLERDRLI
                     LFLNKLILNKKNVKDLMDSNGIRILVDLLTLAHLHVSRATVPLQSNVIEASPDMKRES
                     EKEWYFGNADKERSGPYGFHEMQELWAKGMLNAKTRCWAQGMDGWRPLQAIPQLKWCL
                     LASGQAVLNETDLATLILNMLITMCGYFPSRDQDNAIIRPLPRVKRLLSDSTCLPHLI
                     QLLLTFDPILVEKVAILLHHIMQDNPQLPRLYLSGVFFFIMMYTGSNVLPVARFLKYT
                     HTKQAFKSEESKGQDIFQRSILGHILPEAMVCYLENYEPEKFSEIFLGEFDTPEAIWS
                     SEMRRLMIEKIAAHLADFTPRLQSNTRALYQYCPIPVINYPQLENELFCNIYYLKQLC
                     DTLRFPDWPIKDPVKLLKDSLDAWKKEVEKKPPMMSIDDAYEVLNLPVGQGLHDESKI
                     RKAYFRLAQKYHPDKNPEGRDMFEKVNKAYEFLCTKSTKIVDGPDPENIILILKTQSI
                     LFNRHKEELQPYKYAGYPMLIRTITMETSDDLLFSKESPLLPAAAELAFHTVNCSALN
                     AEELRRENGLEVLQEAFSRCVAVLSRSSKPSDMSVQVCGHISRCYSVAAQFEECREKI
                     TEMPGIIKDLCRVLYFGKCIPRVAALAVDCVSSFAVDFWLQTHLFQAGILWYLLVYLF
                     NYDYTLEESGIQKNEETNQQEVANSLAKLSVHALSRLGGYLPEDQATPENPTVRKSLA
                     GMLTPYIARKLAVVSATEILKMLNSNTENPYLMWNNSTRAELLEFLESQQENMIKKGD
                     CDKTYGAEFVYSEHAKELIVGEIFVRVYNEVPTFQLEVPKEFAASLLDYIGSQAQYLH
                     TFMAITHAAKVESEQHGDRLPRVEMALEALRNVIKYNPGSESECIGHFKLIFSLLRVH
                     GAGQVQQLALEVVNIVTSNQDCVNNIAESLVLSNLLALLHSLPSSRQLVLETLYALAS
                     NTKIIKEAMAKGALIYLLDMFCNSTHPQVRSQTAELFAKMTADKLIGPKVRITLMKFL
                     PSVFMDAMRDNPEAAVHIFEGTHENPELIWNDSSRDKVSTTVREMMLEHFKNQRDNPD
                     MNWKLPEDFAVVFGEAEGELAVGGVFLRIFIAQPAWVLRKPREFLIALLEKLTELLEK
                     NNPHGETLETLTMATVCLFSAQPQLADQVPPLGHLPKVIQAMNHRNNAIPKSAIRVIH
                     VLSDNELCVRAMASLETIGPLMNGMRKRADTVGLACEAINRMFQKEQSELVAQALKAE
                     LVPYLLKLLEGIGLESLDSPAATKAQIVKALKAMTRSLQYGEQVNEILSRSSVWSAFK
                     DQKHDLFISDSQTAGYLTGPGVAGYLTAGASSSAMSNLPPPVDHEAGDLGYQT"
     exon            319..394
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            395..544
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            545..586
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            587..787
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            788..994
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1090
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1182
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1349
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1429
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1599
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1699
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1807
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1963
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2020
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2142
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2218
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2314
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2458
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2541
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2695
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2799
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2959
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3022
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3124
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            3125..3229
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3432
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            3433..3517
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            3518..3672
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            3673..3718
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            3719..3873
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            3874..4075
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            4076..4191
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            4192..4270
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            4271..4406
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            4407..4591
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            4592..4666
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            4667..4786
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            4787..4966
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            4967..5134
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            5135..5248
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            5249..5365
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            5366..5543
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            5544..5635
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            5636..5735
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            5736..5810
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            5811..5923
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            5924..6093
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            6094..6136
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            6137..6310
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            6311..6490
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            6491..6631
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            6632..6775
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            6776..6875
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
     exon            6876..7731
                     /gene="Dnajc13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgttggtgt tcagcgctcg cagcctggtg gaagatggcg gcgtccagag cgagcctctg
       61 agaggcagag ggaggagcgg aggggtgggg gccgcggcgc aggaacccgc ggcgataggc
      121 cccggcgggg aaaaggaaag cgagaaggga cggggccggc ggcgcctcat cccactcaag
      181 acgtggagcc ggcggcaggc ggagctcggg ctggagcgcc tccagcctcc tgcgaaggtt
      241 tcagcacaaa atgaacataa ttagggaaaa taaggatctg gcatgtttct acacaaccaa
      301 gcactcatgg agaggaaagt ataagcgagt cttttcagtt ggaacccatg cagttactac
      361 atataatccc aataccttag aagtaacaaa tcagtggcct tatggagaca tttgcagcat
      421 cagccctgtt gggaaaggac aaggaacaga gttcaacctc acatttcgta aaggcagtgg
      481 gaaaaagtca gaaacgttga agttttctac agagcacaga acagagctgc ttacggaagc
      541 tttgagattt agaactgact ttgcagaggg aaaaatcaca ggaaggagat ataactgcta
      601 taagcatcac tggagtgaca caaggagacc tgtgattctg gaagtaactc ctggaggctt
      661 cgaccaaata aatcctgtaa ccaacagagt gctgtgttcc tatgactaca ggaatattga
      721 aggcttcgta gatctttctg attatcaggg aggattttgt atactctacg gaggatttag
      781 tagattgcat ttatttgcat cagagcaaag agaggagatc attaaaagtg cagtagaaca
      841 cgctggcacc tacataggcg tctccctgcg gaccaggaaa gagccactgg agttcgagca
      901 gtacttgagt ctccgctttg ggaaatacag caccgatgaa tccattacat ctctggcaga
      961 gtttgtggtc caaaaaatat ctcctagaca ctcggaacct gtgaaaagag tactagcagt
     1021 cacagaaaca tgtttagtgg aacgagatcc agcaacctat aacattgcaa cactgaagcc
     1081 cttgggagaa gtgtttgcat tggtttgtga ctcagagaac ccacaagttt ttaccattga
     1141 gtttataaaa ggacaagttc ggaaatactc ctcaacagaa agagattcct tgttagcaag
     1201 tttgctggat ggagtaagag cctctggtaa cagagatgtt tgtgttaaga tgacgccgac
     1261 ccacaaaggc cagcgatggg ggttgctcag catgcctata gatgaggaag tcgagagcct
     1321 tcacctcagg ttcctagctg cacctcccaa tggcaacttt gcagatgctg tattcaggtt
     1381 caacgctaac atttcctaca gtggagttct gcatgcggtg acacaggatg gtctcttctc
     1441 agagaacaag gagaagctca tcaataacgc cataacagct ctcttggctc aggaggggga
     1501 tgtcgttgct tcaaatgcag aacttgagag ccagttccaa gctgtgagga ggcttgtagc
     1561 ctccaaagct ggttttctgg ccttcactca gcttccaaag tttcgggagc gcctaggaat
     1621 gaaggtcgtg aaagcactca agagaagcaa caatggagtc atccacgcgg ctgtggatat
     1681 gctctgtgcc ctcatgtgtc ccatgcatga tgactatgac ttaagacaag aacagctaaa
     1741 caaagcttct cttctctctt caaagaagtt tctggaaaac ttattggaga aatttaattc
     1801 ccatgtggat catgggactg gtgcccttgt aattagttca ctcttggact tccttacctt
     1861 tgccctctgt gctccatata gtgagacaac cgaagggcag cagtttgata tgctcttaga
     1921 gatggtagcc tccaatggaa gaacactgtt taaactcttt cagcatcctt ccatggcaat
     1981 tgtaaaggga gcgggattgg ttatgaaggc aataatagag gaaggtgaca gagagattgc
     2041 tactaagatg caggacctcg ccctgagtga gggcgcccta cctcggcacc tgcacacggc
     2101 gatgtttaca atcagctccg atcagcgcat gcttacgaac agacagctaa gtagacatct
     2161 agtggggctc tggacagcag acaacacgac tgccacaaac ttgttgaggc gcattttgcc
     2221 accaggcttg ttggcatact tggacagttc agatccagtt ccagagaagg atgcagaccg
     2281 aatgcacgtc agagacaatg tgaaaatagc aatggatcaa tatggaaaat ttaataaagt
     2341 tcccgagtgg caaagactag ctggaaaagc tgccaaagaa gttgagaagt ttgccaaaga
     2401 aaaggttgat cttgtgttga tgcactggag ggataggatg ggcattgctc agaaagagaa
     2461 cataaatcaa aagccagtag ttcttcgaaa gagaagacag agaataaaaa tagaagcgaa
     2521 ctgggatctc ttctattaca ggtttagtca agaccatgct agatcgaacc ttatttggaa
     2581 ttttaaaaca cgagaagagc tgaaagatac ccttgagtct gagatgagga catttaacat
     2641 cgatagggag ctgggcagcg ccagtgtcat ctcctggaac caccatgagt ttgaggttaa
     2701 atatgagtgc ctggcagagg aaatcaaaat aggagactat tacttgagat tgttgttgga
     2761 ggaggatgag aatgaagaaa gcggatcaat aaaaagatcg tatgaattct tcaatgagct
     2821 ctaccaccgc ttcctgctca ctcccaaagt taacatgaag tgtttgtgtt tacaagccct
     2881 tgccatcgtt tacggcagat gccatgaaga catagggccc ttcacagata cgagatacat
     2941 catcgggatg ttagagaggt gcactgataa acttgaacgg gatagactga tcctcttcct
     3001 gaacaagctg atccttaata agaaaaacgt taaagatctc atggactcca acggcattag
     3061 aatcctcgtg gacctgctca ctctcgcaca tctccatgtg agccgagcca cagtcccctt
     3121 gcaaagcaat gtgatcgagg cttccccaga tatgaagcgg gagagtgaga aggagtggta
     3181 ttttggcaac gcagacaaag aaaggagtgg gccgtatgga tttcatgaga tgcaagaatt
     3241 atgggccaaa ggaatgttga atgcaaaaac cagatgttgg gctcaaggca tggatggatg
     3301 gcgaccgctc caggcgatac ctcagcttaa gtggtgcctg ttagccagtg ggcaggccgt
     3361 tctgaatgaa actgaccttg ctaccttaat actgaacatg ttgatcacaa tgtgtggata
     3421 tttcccgagc agggatcagg acaatgccat cattcgccct ttacccagag tgaaaagact
     3481 gctgtcagat agcacctgcc ttccccatct catccagtta ctgctgacct ttgaccctat
     3541 ccttgttgag aaggttgcta tcttgttaca tcacattatg caagataacc cacagttacc
     3601 tcgcctctat ctcagtggag tgttcttctt catcatgatg tatacaggtt ccaacgtgct
     3661 tcctgttgcc cggtttttga aatatacaca caccaaacag gctttcaagt ctgaggagag
     3721 taaaggacaa gatatttttc agagaagtat acttggacac attcttcctg aagcaatggt
     3781 ttgctaccta gaaaattatg aacctgagaa gttctctgag attttcctcg gtgaatttga
     3841 cactccagaa gcaatctgga gcagtgagat gaggcgcctc atgatcgaga agattgctgc
     3901 ccatcttgct gacttcacac ctcgcctgca gagcaataca agagcacttt atcaatattg
     3961 ccccatcccg gttatcaatt atccacaact agaaaatgaa ctattttgta atatttatta
     4021 cctcaaacaa ctttgtgata cactccgctt tccagattgg ccaattaaag acccagttaa
     4081 acttctgaaa gactcccttg acgcttggaa gaaggaagta gaaaagaagc cacctatgat
     4141 gtccatagac gatgcttatg aagtgcttaa tctgcccgta ggccaggggc tgcacgacga
     4201 aagcaagatt agaaaagctt acttcagact cgcacagaag taccacccgg ataagaaccc
     4261 agaaggaagg gacatgtttg aaaaagtaaa caaagcatat gaatttttat gtaccaagtc
     4321 aacaaaaata gtggatgggc cagatccaga gaatataatt ttaattctga aaacacagag
     4381 catccttttc aaccgccata aagaagagtt acagccttat aaatatgcag gataccccat
     4441 gctaattagg actataacaa tggagacttc agatgacctc ctcttctcaa aagaatcacc
     4501 actgttgcct gcggctgcag agctggcttt ccacacagtc aactgctcag ccctcaacgc
     4561 tgaggagctc agaagagaga acggcttaga ggtgttacag gaggcattta gccgctgtgt
     4621 ggctgtcctg agtcgctcca gtaagccaag cgacatgtcg gtgcaggtgt gtgggcacat
     4681 aagcaggtgc tacagtgtgg ccgcccagtt cgaggagtgc cgggagaaga tcacagaaat
     4741 gcctggcatc atcaaggacc tctgccgagt gctgtatttt ggcaagtgta tcccacgggt
     4801 ggctgccctt gcagtagatt gtgtcagctc ttttgctgtg gatttctggc tacagacaca
     4861 tctatttcag gccggaattt tgtggtatct gcttgtgtat ctgtttaact atgactatac
     4921 attggaagag agtggcattc agaaaaatga agaaacaaac cagcaggaag tagccaacag
     4981 tcttgccaaa ctcagtgtcc atgctctgag tcgccttggt gggtatttgc ctgaagacca
     5041 agccacccca gaaaatccga ccgtaaggaa gagtttagct ggcatgctga cgccctacat
     5101 tgctcgaaag ctagctgtgg ttagtgctac tgagatcctg aagatgctga acagcaacac
     5161 ggagaacccg tatttgatgt ggaacaactc cacaagggca gagctgcttg agtttcttga
     5221 gtctcaacaa gaaaatatga ttaaaaaggg tgattgtgac aaaacttatg gggcagaatt
     5281 tgtctacagt gaacatgcca aagaacttat tgtgggcgag atttttgtta gagtctataa
     5341 tgaagtccca acattccagc tagaggttcc aaaagagttt gctgcaagtc tgttggatta
     5401 catcggctct caggcccagt acctccacac gttcatggct atcactcatg ctgcaaaagt
     5461 ggagtcggag caacacgggg accgcttacc aagagtggaa atggctttgg aggctctgag
     5521 aaatgtgatc aaatacaacc caggttctga aagtgaatgc attgggcact ttaagttaat
     5581 attttctctt ctccgagtcc atggagctgg tcaggtgcag cagctggcat tagaggttgt
     5641 gaatatagtg acatccaacc aagactgtgt caacaacatt gcagagtccc tggttttgtc
     5701 caatttgttg gctcttctac attcgttgcc atcaagccgt cagcttgttc tggagactct
     5761 gtatgctttg gcatcaaata caaagataat caaagaagcc atggcaaaag gagctttgat
     5821 ttatttactg gatatgttct gcaattcaac acacccacaa gttcgatccc agacagcaga
     5881 actttttgcc aaaatgacag cagacaaact aataggtcca aaggttcgaa ttacattaat
     5941 gaaatttctg cccagtgtgt tcatggatgc catgagagac aaccctgaag ccgctgtcca
     6001 tatatttgag gggactcatg aaaatccaga gctgatctgg aatgacagct ccagagataa
     6061 ggtttctaca actgtgaggg agatgatgct agagcacttt aaaaaccaac gggacaaccc
     6121 tgacatgaac tggaagttgc ctgaagattt tgctgtggtg tttggagaag ccgagggtga
     6181 acttgctgtt ggaggagttt tcttgagaat cttcattgca cagccagctt gggtgctgag
     6241 aaaacccaga gagtttctta ttgcactgtt agaaaaatta actgagctcc tagagaagaa
     6301 caatccacat ggagagactc tggaaacact gaccatggcc acagtttgtc tcttcagtgc
     6361 acagcctcag ttggcagatc aagtcccgcc gttgggtcat cttcctaaag ttatccaggc
     6421 gatgaatcac agaaacaacg ctattcctaa gagtgcgatt cgggttattc acgtcctgtc
     6481 tgacaatgag ctgtgtgttc gagccatggc atctttggag accattggcc cgctgatgaa
     6541 tggcatgaga aagcgagcag atactgttgg cttggcctgt gaagcaatta atcggatgtt
     6601 ccagaaggag cagagtgagt tagtagcaca ggctctgaaa gcagagttgg tcccatacct
     6661 cttaaagctg cttgaaggca taggcctcga aagcctcgac agtcctgctg ccaccaaggc
     6721 ccagattgtt aaagctctta aggcaatgac tcgaagtctg cagtatggag aacaggtgaa
     6781 tgaaatcctc tctcgatctt cagtctggag tgccttcaaa gaccagaaac atgatttgtt
     6841 catttctgac tcacaaacag caggatacct cacaggccct ggagttgctg gctaccttac
     6901 tgcaggtgcg tcctcatcag ccatgtctaa cttgccacct cctgtagacc atgaggcagg
     6961 agaccttggc tatcagacgt gaaacactca gagacagtcc atgctgaagg ccagtactgc
     7021 gcccacattc ctccaaccaa catgtcgaaa cagactccgc ctttctcctg gtttcaagac
     7081 agtgttcttc ctttttctat acatagattt ttatttagga gaagagtcca tgattctgac
     7141 gtgtctcgtt ctgagaaagc actctgtggg tcagccacct gggtacacaa gaatttcttc
     7201 ttcttgatgt atgtaagcac attttgttcc tttatatctg tttacaagac tgtgaatcaa
     7261 aaagacaaaa ctttcttcct agtttttata atgttttttt tttttttttt aattactgtg
     7321 actgtgggat taagctgcag tctacaaaca ttgggctaaa tcttatcccc agaaaagggc
     7381 accttcctct cctgcaccag gtctccatgg ccgtcttcct ctcatcgtca gacattagat
     7441 ttctgtccct ccacctgtga ccagaccctc agtcattaac tctacgagag ctcggtgcac
     7501 atcggtgcgt atggcagact tcaccaagct gaacgacagg gagcttgtgc aaaaaattaa
     7561 aactaaaaat ggatgtcaag atgttatgta agagattagt gtaattgtga aatgttctat
     7621 acattatcaa atatataaag ctttctatat tgaatgtaca ttatacagat cattcatatg
     7681 tgtacataaa attttaaaaa ataaagggaa ttgactgctt tgttaatgag a
//
