LOCUS       NM_001106486            4159 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus DnaJ heat shock protein family (Hsp40) member C10
            (Dnajc10), mRNA.
ACCESSION   NM_001106486 XM_001063159 XM_215751
VERSION     NM_001106486.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4159)
  AUTHORS   Oka,O.B., Pringle,M.A., Schopp,I.M., Braakman,I. and Bulleid,N.J.
  TITLE     ERdj5 is the ER reductase that catalyzes the removal of non-native
            disulfides and correct folding of the LDL receptor
  JOURNAL   Mol Cell 50 (6), 793-804 (2013)
   PUBMED   23769672
REFERENCE   2  (bases 1 to 4159)
  AUTHORS   Hagiwara,M., Maegawa,K., Suzuki,M., Ushioda,R., Araki,K.,
            Matsumoto,Y., Hoseki,J., Nagata,K. and Inaba,K.
  TITLE     Structural basis of an ERAD pathway mediated by the ER-resident
            protein disulfide reductase ERdj5
  JOURNAL   Mol Cell 41 (4), 432-444 (2011)
   PUBMED   21329881
REFERENCE   3  (bases 1 to 4159)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 4159)
  AUTHORS   Thomas,C.G. and Spyrou,G.
  TITLE     ERdj5 sensitizes neuroblastoma cells to endoplasmic reticulum
            stress-induced apoptosis
  JOURNAL   J Biol Chem 284 (10), 6282-6290 (2009)
   PUBMED   19122239
REFERENCE   5  (bases 1 to 4159)
  AUTHORS   Ushioda,R., Hoseki,J., Araki,K., Jansen,G., Thomas,D.Y. and
            Nagata,K.
  TITLE     ERdj5 is required as a disulfide reductase for degradation of
            misfolded proteins in the ER
  JOURNAL   Science 321 (5888), 569-572 (2008)
   PUBMED   18653895
REFERENCE   6  (bases 1 to 4159)
  AUTHORS   Dong,M., Bridges,J.P., Apsley,K., Xu,Y. and Weaver,T.E.
  TITLE     ERdj4 and ERdj5 are required for endoplasmic reticulum-associated
            protein degradation of misfolded surfactant protein C
  JOURNAL   Mol Biol Cell 19 (6), 2620-2630 (2008)
   PUBMED   18400946
REFERENCE   7  (bases 1 to 4159)
  AUTHORS   Hosoda,A., Kimata,Y., Tsuru,A. and Kohno,K.
  TITLE     JPDI, a novel endoplasmic reticulum-resident protein containing
            both a BiP-interacting J-domain and thioredoxin-like motifs
  JOURNAL   J Biol Chem 278 (4), 2669-2676 (2003)
   PUBMED   12446677
REFERENCE   8  (bases 1 to 4159)
  AUTHORS   Cunnea,P.M., Miranda-Vizuete,A., Bertoli,G., Simmen,T.,
            Damdimopoulos,A.E., Hermann,S., Leinonen,S., Huikko,M.P.,
            Gustafsson,J.A., Sitia,R. and Spyrou,G.
  TITLE     ERdj5, an endoplasmic reticulum (ER)-resident protein containing
            DnaJ and thioredoxin domains, is expressed in secretory cells or
            following ER stress
  JOURNAL   J Biol Chem 278 (2), 1059-1066 (2003)
   PUBMED   12411443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB577930.1, DY315949.1, CA338978.1, BC100105.1, CX570839.1 and
            CA510153.1.
            
            On May 29, 2008 this sequence version replaced NM_001106486.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                CB577930.1         1-67
            68-689              DY315949.1         1-622
            690-1061            CA338978.1         296-667
            1062-3418           BC100105.1         18-2374
            3419-3807           CX570839.1         174-562
            3808-4159           CA510153.1         1-352               c
FEATURES             Location/Qualifiers
     source          1..4159
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..4159
                     /gene="Dnajc10"
                     /note="DnaJ heat shock protein family (Hsp40) member C10"
                     /db_xref="GeneID:295690"
                     /db_xref="RGD:1307813"
     exon            1..114
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            115..465
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..2643
                     /gene="Dnajc10"
                     /note="dnaJ homolog subfamily C member 10; DnaJ (Hsp40)
                     homolog, subfamily C, member 10"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 10 precursor"
                     /protein_id="NP_001099956.2"
                     /db_xref="GeneID:295690"
                     /db_xref="RGD:1307813"
                     /translation="MGVWLNRDEFIRDVKRISLCLLVLYVVIVVGTDQNFYSLLGVSK
                     TASSREIRQAFKKLALKLHPDKNPNNPNAHGDFLKINRAYEVLKDEDLRKKYDKYGEK
                     GLEDNQGGQYESWSYYRYDFGIYDDDPEIITLERREFDAAVNSGELWFVNFYSPGCSH
                     CHDLAPTWREFAKEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAAVKYNG
                     DRSKESLVSFAMQHVRTTVTELSTGNFVNAIETAFAAGIGWLITFCFKGEDCLTPQTR
                     LRLSGMLDGLVNVGWVDCDTQDSLCKSLDATASTTAYFPPGATLNNKEKSSVLFLNSL
                     DAKEIYMEIIHNLPDFELLSANKLEDRLAHHRWLVFFHFGKNENANDPELKKLKTLLK
                     NEHIQVGRFDCSSAPGICSDLYVFQSCLAVFKGQGTKEYEIHHGKKILYDILAFAKES
                     VNSHVTTLGPQNFPASDKEPWLVDFFAPWCPPCRALLPELRKASTLLYGQLKVGTLDC
                     TIHEGLCNMYNIQAYPTTVVFNQSSVHEYEGHHSAEQILEFIEDLRNPSVVSLTPTTF
                     NELVKQRKHDEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGLINVGSVDCQQYHSFCT
                     QENVQRYPEIRFYPQKSSRAYQYHSYNGWNRDAYSLRSWGLGFLPQASIDLTPQTFNE
                     KVLQGKTHWVIDFYAPWCGPCQNFAPEFELLARMIKGKVKAGKVDCQAYPQTCQKAGI
                     RAYPSVKLYLYERAKKSIWEEQINSRDAKTIAALIYGKLETFQSQVKRNKDEL"
     exon            466..628
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            629..679
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            680..762
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            763..894
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            895..988
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1066
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1110
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1248
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1338
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1452
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1567
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1695
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1812
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1914
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2070
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2204
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2258
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2406
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2526
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2631
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..4143
                     /gene="Dnajc10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggcgcgac gggagcggca gaattgcagc tgcgcgcgtt cgcagtaggc gtccggtcct
       61 gccggctccg gggctaggcg gcctaaggat gggacagtag ctgaagacgc cgaggttaac
      121 atttctgagc tgtgttctga gatgcttgat tgacccttga agtaatgtgg acagagattc
      181 tcacgtgtgt ttattataac caccggaccc agccttgtat cttaatgttc acataagtca
      241 gagcttgcat aagagaagag aatgggagtc tggttaaaca gagatgaatt tatcagagac
      301 gtgaagcgga taagtctctg tcttctagta ctgtatgtgg ttatcgtggt gggcacggat
      361 cagaattttt acagtttact tggagtgtct aaaactgcaa gcagcagaga aataagacaa
      421 gcctttaaga aattagcact gaagttacat cctgataaaa acccgaataa cccaaatgca
      481 catggtgatt ttttaaaaat aaatagagca tatgaagtac tcaaagatga agatctgcgg
      541 aaaaagtatg acaaatacgg agaaaagggc ctggaagata atcagggagg ccagtacgag
      601 agctggagct actaccgcta cgacttcggt atttacgatg atgatcctga gatcataaca
      661 ttagaaagaa gagaatttga tgctgctgtc aactcgggag aactgtggtt tgtaaacttt
      721 tactccccgg gatgttcgca ttgccatgat ttagccccca cttggagaga atttgctaaa
      781 gaagtggatg gattgcttcg aatcggagct gtcaactgtg gtgatgaccg gatgctttgc
      841 cgaatgaaag gagtcaacag ttaccccagc ctcttcatct ttaggtctgg aatggctgca
      901 gtgaagtaca acggggatag gtcaaaggag agcttagtga gcttcgccat gcagcacgtc
      961 aggaccacag tgacagagct gtcaacagga aattttgtta atgccataga aactgccttt
     1021 gctgctggta ttggctggct gatcacattc tgttttaaag gagaagattg tttgacacca
     1081 cagacacgac tccggcttag tggcatgttg gatggccttg ttaacgtggg atgggtggac
     1141 tgtgacacac aggacagcct ctgcaagagc ctggacgcca cagccagcac tactgcctat
     1201 ttccctcctg gagccacttt gaataacaaa gaaaaatcca gtgttttgtt tcttaattct
     1261 ctggatgcta aggaaatata catggaaatc atacataatc ttccagactt tgaacttctt
     1321 tcagcaaata aactagagga tcgtttggca catcatcgct ggcttgtatt ttttcatttt
     1381 ggaaaaaatg aaaatgcaaa tgatcctgaa ttgaaaaaac tgaaaactct acttaaaaat
     1441 gaacatattc aagttggaag gtttgactgc tcttctgcac caggcatctg ctctgatctt
     1501 tatgttttcc agtcttgtct agcagtgttt aaaggacaag gaaccaaaga atatgaaatt
     1561 catcacggaa agaagattct atacgatata cttgcttttg ccaaagaaag tgttaattcg
     1621 cacgttacca cacttggacc tcagaacttc cctgcaagtg acaaagaacc gtggcttgtt
     1681 gacttctttg ccccttggtg tccgccatgc cgtgcgcttt tgccagagtt acggaaagca
     1741 tcaacactgc tctatggtca gctcaaagtt ggtaccctag actgcacaat tcatgaagga
     1801 ctctgcaaca tgtataacat ccaagcttat ccaacaacag tggtgttcaa ccagtccagt
     1861 gttcatgagt atgaaggaca tcattctgcg gaacagatcc tggagttcat agaggatctc
     1921 agaaaccctt ccgtggtctc tcttacaccc accactttca atgaactagt taaacagaga
     1981 aaacatgacg aagtctggat ggttgatttc tattctccat ggtgtcatcc ctgtcaggtc
     2041 ttaatgccag agtggaaacg catggcccgg acgttaactg gattgatcaa tgtaggcagt
     2101 gtggactgcc aacagtatca ttctttttgt actcaagaaa atgtccagag ataccctgag
     2161 ataagatttt atccccaaaa gtcaagtaga gcttatcagt atcatagtta caatggctgg
     2221 aatagggatg cttattccct gagaagctgg ggtctcgggt ttttacccca agcatccata
     2281 gatttaacac ctcagacatt caacgaaaaa gttctacaag ggaaaactca ctgggtgatt
     2341 gatttctatg ctccttggtg tggaccttgc cagaattttg ctcccgagtt tgaactcttg
     2401 gctaggatga tcaaagggaa agtaaaagct gggaaagtgg actgtcaggc ttacccccaa
     2461 acgtgccaga aagctggcat cagagcctac cccagtgtca aactgtacct ctatgaaaga
     2521 gcaaagaaaa gtatttggga agagcaaata aattccagag atgcaaaaac tattgctgcc
     2581 ttaatttatg gaaaattgga aacgttccaa agccaagtaa agagaaataa ggatgagctc
     2641 tgatgatatt gaagaaaaaa gaattataag gaaaagaatc tggaaaatgg catcagagga
     2701 tccctttccc aagtcaagct gctcttgagg aagcaggtgc acatgacctg ggacaggaga
     2761 cacctgtgca gtgctgcacc tgcagatgct tcctgtggag agccaggtgg ccagtgggac
     2821 tggcgtccac atagggttct ttgttgtgtc tttgttgttg ttgttgttaa tccttttaga
     2881 aatacaaaca tcagtcttag ctcagggcca tatagaaatg ttccacaggc caagggcagc
     2941 ccagggacta gtttgctgac cacagaactg atgtttggac acctggccct gcatgtgggt
     3001 ctgtcttcat actgtacaaa gtggacttgg gtttttactt gtaattttgc gataggcctg
     3061 aaaacaagtg acttggtttt cagtcacccc ttctaagaat tctgtctatg accatgtatt
     3121 ttattttgac tattttcaca aatgggaaaa taaaaatgta cccagttttc ctactatgta
     3181 ctactgtata gacaggtttt cttgtaagag ttgaagagct attcttaatt tatcaccaca
     3241 gtaagtgtaa aaatcctgta aactgcggtc ccaagaacaa ggtaagaagt atttacagca
     3301 gttagtgggc tgtgtggatg tcacagggct gacccctgag ccctaagctt agagtgcaca
     3361 ccttcatgtc tttgctttca taagtgtccc tgctaatggt gtcatttgtg ttgtttgacg
     3421 tgtcttcctg atattgacgg atttcccttc agggttcttc gtttggatca ctcacactga
     3481 tttttttccc cctgtagcta tggttttttt ctttgtccaa tgttcactat tccaatagga
     3541 acggtaatta gatttatttt aaatggctca tgatgatgct gttactcagt tactgtcttt
     3601 ttcagtaaag cattgccaga acaactacag ttatttttac taaaatcaag cacatgatgg
     3661 actcttccca tttctcagtt gtttggactt aaagggtcat aggtttctcc ttcaactcca
     3721 aaagcagagt gacctctggt tcagttctct cccccagtgt gtgggatgat cagaggatgc
     3781 cagtgaataa aatcaaatta ttttttctaa aactcttttg aagatgattg ttgtgtttac
     3841 ctgctcccta gtctgtctgc atgaaggtta tgccgtaggt ttgagttggg aaagcagtgc
     3901 actttattgt ttgttgggac ctcattcaaa ttctcctggg ttttattaca ttttaactcc
     3961 ctggctcaga ctctgctgta cttgtgagca cacactgttt gaatcatgac tgataatggc
     4021 aagagccttt catttattaa acttcgaaag cctagaactt ctttttaaag tggcttgttt
     4081 atgcaaaatt ccacaagtgg aatgcccaaa gatgtcttac tcaataaaag tatactaatt
     4141 taaaaaaaaa aaaaaaaaa
//
