LOCUS       NM_001013209            2474 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus DnaJ heat shock protein family (Hsp40) member B6
            (Dnajb6), mRNA.
ACCESSION   NM_001013209 XM_342607
VERSION     NM_001013209.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2474)
  AUTHORS   Smith,C. and D'Mello,S.R.
  TITLE     Cell and Context-Dependent Effects of the Heat Shock Protein DNAJB6
            on Neuronal Survival
  JOURNAL   Mol Neurobiol 53 (8), 5628-5639 (2016)
   PUBMED   26476842
  REMARK    GeneRIF: These results conclude that neurotoxicity resulting from
            elevated DNAJB6 is cell cycle dependent.
REFERENCE   2  (bases 1 to 2474)
  AUTHORS   Sarparanta,J., Jonson,P.H., Golzio,C., Sandell,S., Luque,H.,
            Screen,M., McDonald,K., Stajich,J.M., Mahjneh,I., Vihola,A.,
            Raheem,O., Penttila,S., Lehtinen,S., Huovinen,S., Palmio,J.,
            Tasca,G., Ricci,E., Hackman,P., Hauser,M., Katsanis,N. and Udd,B.
  TITLE     Mutations affecting the cytoplasmic functions of the co-chaperone
            DNAJB6 cause limb-girdle muscular dystrophy
  JOURNAL   Nat Genet 44 (4), 450-455,S1-S2 (2012)
   PUBMED   22366786
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2474)
  AUTHORS   Watson,E.D., Hughes,M., Simmons,D.G., Natale,D.R., Sutherland,A.E.
            and Cross,J.C.
  TITLE     Cell-cell adhesion defects in Mrj mutant trophoblast cells are
            associated with failure to pattern the chorion during early
            placental development
  JOURNAL   Dev Dyn 240 (11), 2505-2519 (2011)
   PUBMED   21972064
REFERENCE   4  (bases 1 to 2474)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 2474)
  AUTHORS   Hageman,J., van Waarde,M.A., Zylicz,A., Walerych,D. and
            Kampinga,H.H.
  TITLE     The diverse members of the mammalian HSP70 machine show distinct
            chaperone-like activities
  JOURNAL   Biochem J 435 (1), 127-142 (2011)
   PUBMED   21231916
REFERENCE   6  (bases 1 to 2474)
  AUTHORS   Zhang,Y., Yang,Z., Cao,Y., Zhang,S., Li,H., Huang,Y., Ding,Y.Q. and
            Liu,X.
  TITLE     The Hsp40 family chaperone protein DnaJB6 enhances Schlafen1
            nuclear localization which is critical for promotion of cell-cycle
            arrest in T-cells
  JOURNAL   Biochem J 413 (2), 239-250 (2008)
   PUBMED   18373498
REFERENCE   7  (bases 1 to 2474)
  AUTHORS   Dai,Y.S., Xu,J. and Molkentin,J.D.
  TITLE     The DnaJ-related factor Mrj interacts with nuclear factor of
            activated T cells c3 and mediates transcriptional repression
            through class II histone deacetylase recruitment
  JOURNAL   Mol Cell Biol 25 (22), 9936-9948 (2005)
   PUBMED   16260608
REFERENCE   8  (bases 1 to 2474)
  AUTHORS   Chuang,J.Z., Zhou,H., Zhu,M., Li,S.H., Li,X.J. and Sung,C.H.
  TITLE     Characterization of a brain-enriched chaperone, MRJ, that inhibits
            Huntingtin aggregation and toxicity independently
  JOURNAL   J Biol Chem 277 (22), 19831-19838 (2002)
   PUBMED   11896048
REFERENCE   9  (bases 1 to 2474)
  AUTHORS   Izawa,I., Nishizawa,M., Ohtakara,K., Ohtsuka,K., Inada,H. and
            Inagaki,M.
  TITLE     Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin
            8/18 filament regulatory protein
  JOURNAL   J Biol Chem 275 (44), 34521-34527 (2000)
   PUBMED   10954706
REFERENCE   10 (bases 1 to 2474)
  AUTHORS   Hunter,P.J., Swanson,B.J., Haendel,M.A., Lyons,G.E. and Cross,J.C.
  TITLE     Mrj encodes a DnaJ-related co-chaperone that is essential for
            murine placental development
  JOURNAL   Development 126 (6), 1247-1258 (1999)
   PUBMED   10021343
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078908.1.
            
            On Apr 20, 2005 this sequence version replaced XM_342607.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078908.1, SRR8487231.173067.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2474
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..2474
                     /gene="Dnajb6"
                     /note="DnaJ heat shock protein family (Hsp40) member B6"
                     /db_xref="GeneID:362293"
                     /db_xref="RGD:1308207"
     exon            1..91
                     /gene="Dnajb6"
                     /inference="alignment:Splign:2.1.0"
     exon            92..182
                     /gene="Dnajb6"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1191
                     /gene="Dnajb6"
                     /note="MRJ; HSJ-2; MSJ-1; hsp40 homolog; heat shock
                     protein J2; DnaJ (Hsp40) homolog, subfamily B, member 6"
                     /codon_start=1
                     /product="dnaJ homolog subfamily B member 6"
                     /protein_id="NP_001013227.1"
                     /db_xref="GeneID:362293"
                     /db_xref="RGD:1308207"
                     /translation="MVDYYEVLGVQRHASPEDIKKAYRKQALKWHPDKNPENKEEAER
                     KFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGGGSHFDSPFEFGFTFRNPDDVFR
                     EFFGGRDPFSFDFFEDPFDDFFGNRRGPRGSRSRGAGSFFSAFSGFPSFGSGFPAFDT
                     GFTPFGSLGHGGLTSFSSASFGGSGMGNFKSISTSTKIVNGKKITTKRIVENGQERVE
                     VEEDGQLKSLTINGVADENALAEECRRRGQPTPALAPGPAPAPARVPSQARPPTPAPT
                     PAPAQTPAPSVSTRPQKPPRPAPTAKLVSKSNWEDEEQDRQRVPGNCDAPMTSAGLKE
                     GGKRKKQKQKEDSKKKKSTKGNH"
     exon            183..292
                     /gene="Dnajb6"
                     /inference="alignment:Splign:2.1.0"
     exon            293..355
                     /gene="Dnajb6"
                     /inference="alignment:Splign:2.1.0"
     exon            356..466
                     /gene="Dnajb6"
                     /inference="alignment:Splign:2.1.0"
     exon            467..598
                     /gene="Dnajb6"
                     /inference="alignment:Splign:2.1.0"
     exon            599..740
                     /gene="Dnajb6"
                     /inference="alignment:Splign:2.1.0"
     exon            741..811
                     /gene="Dnajb6"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1108
                     /gene="Dnajb6"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..2450
                     /gene="Dnajb6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagacgccg ccaccgccac cagcgcactg tgccagagcc gcgaggagac cggccgcctg
       61 acttcccccc tcgctggccg ccgcgtcctc ggatttgttc caacagtctg ttaaaacatg
      121 gtggattact atgaagtgct gggcgtgcag agacatgcct cacctgagga cattaaaaag
      181 gcgtatcgaa aacaggcact caaatggcac ccagacaaaa atcctgaaaa taaagaagaa
      241 gcggagcgga aattcaaaca agtagctgag gcatatgaag tgttatcgga tgctaaaaag
      301 cgggacatct atgacaaata tggcaaagaa ggattaaatg gtggtggagg aggaggtgga
      361 agtcattttg acagtccatt tgagtttggc ttcacattcc ggaacccaga tgatgtcttc
      421 agggaatttt ttggtggaag ggacccattt tcatttgact tctttgaaga tccatttgat
      481 gacttttttg gaaaccgaag gggtccccga ggaagtagaa gccgaggtgc tggctccttt
      541 ttctccgcct tcagtggatt tccttctttt ggaagtggat ttcctgcttt tgatacaggc
      601 tttactccat tcgggtcact aggtcatggg ggtctcactt cattttcttc agcgtcattt
      661 ggcggcagtg gaatgggcaa cttcaaatca atatcaactt caactaaaat agttaatggc
      721 aaaaaaatca ctacaaagag aattgtggag aacggtcagg aaagagtaga agttgaagaa
      781 gacggacagt taaagtccct gacgataaat ggtgtggccg acgagaacgc ccttgcagaa
      841 gaatgccggc ggagaggcca acccacacca gctctggccc ctggcccggc cccagcacca
      901 gcccgggtcc cctctcaggc ccgacccccg accccagctc ccaccccagc tccagcccag
      961 actccagccc cttctgtcag cacccgccca cagaagccac ccaggcctgc cccaacggcc
     1021 aaacttgtgt ctaaaagcaa ctgggaagat gaagagcagg acaggcagcg ggttcctggc
     1081 aactgtgatg cccctatgac ctcagcaggg ctcaaagaag gtggcaagag gaagaagcag
     1141 aagcagaaag aggactcgaa gaagaagaag tcgaccaaag ggaaccacta ggctggactt
     1201 ggcggcagcc acagcagccg ctctcgtgtg tgtgttgcac acgcgcacgg cagcggcatc
     1261 ctttaagtgc cgcccagggt cacttcgctt agcaggatta tggacatgtg cccacggatc
     1321 ggtaggatta ggggcgttgg agacggaggc gacaatcctg ggtggcctgt ataagcttgt
     1381 gacacagcct cagccttgta actctgcttt tcccccaaca ccaaatccat agcgttttcc
     1441 tcgagtctta agggtctgcc tcattgtttt cagcagccca agccctgctt tgagctctga
     1501 ggtagttgta gttgtaggag tccatagggt ccagtaggag ctgggtttgt gttcatgaca
     1561 gactgcctcc tggtggcggt acagtgcgca gttttaagta cagtggaact tatggtaaag
     1621 taagctgtgc cttgagccat gagatgcttt tgattcaggg tactctggca acgtacaggc
     1681 catcaggagc cacttcagat gtagagtctt tccttattta ttgttcaact tttaatcttc
     1741 tccaggtagt caaaaattga caccaaatat agtttagttt ttggaaaatc tcatcgtctt
     1801 ggagaaatat ttgtcctttt tcagtcaaaa ggttttgctt agcaatagca tttctagtaa
     1861 tgataggtca gtgtgctact ggctatttac acaaacacac aagcacacgg aggtgtgtgc
     1921 aaaataatta gctctgaagc aggaagcttg acctcagttc tttaaattgc aaataatggc
     1981 cccttcacaa gcttcatccg gtcccaaccc atgccacgct gtcacctaac ctgtggcttg
     2041 cactgagcac caggtagttc agatgccatc tcacttctgg gctgcacgtg cctctttggg
     2101 gctgtgttcc tttcttttgg ccatgagggt ctgttgcttg aactttgtcc ccttggcagt
     2161 gaggattttg taaagggtgt tggtgagctt gagatgggtc cagcagcatg gaaaggggaa
     2221 gttctgtgag ttatgggcac tgctgtagct aggagctggg acagggttac ctgggttttg
     2281 aagaagtaac catgaagtgt ttgctgtgtt tgcttggttt tggtgggagg aggtgtgggc
     2341 acttatggag tgtggattgg tattaatgtg tgttgtggaa atgtgaccct caaggaggaa
     2401 tgtattttag tgctactgac gtaaataaaa tgtaaacgtc actgagttca aaaaaaaaaa
     2461 aaaaaaaaaa aaaa
//
