LOCUS       NM_001399116            3190 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus DnaJ heat shock protein family (Hsp40) member B2
            (Dnajb2), transcript variant 2, mRNA.
ACCESSION   NM_001399116
VERSION     NM_001399116.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3190)
  AUTHORS   Ottaviani,D., Marin,O., Arrigoni,G., Franchin,C., Vilardell,J.,
            Sandre,M., Li,W., Parfitt,D.A., Pinna,L.A., Cheetham,M.E. and
            Ruzzene,M.
  TITLE     Protein kinase CK2 modulates HSJ1 function through phosphorylation
            of the UIM2 domain
  JOURNAL   Hum Mol Genet 26 (3), 611-623 (2017)
   PUBMED   28031292
REFERENCE   2  (bases 1 to 3190)
  AUTHORS   Novoselov,S.S., Mustill,W.J., Gray,A.L., Dick,J.R., Kanuga,N.,
            Kalmar,B., Greensmith,L. and Cheetham,M.E.
  TITLE     Molecular chaperone mediated late-stage neuroprotection in the
            SOD1(G93A) mouse model of amyotrophic lateral sclerosis
  JOURNAL   PLoS One 8 (8), e73944 (2013)
   PUBMED   24023695
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3190)
  AUTHORS   Gao,X.C., Zhou,C.J., Zhou,Z.R., Wu,M., Cao,C.Y. and Hu,H.Y.
  TITLE     The C-terminal helices of heat shock protein 70 are essential for
            J-domain binding and ATPase activation
  JOURNAL   J Biol Chem 287 (8), 6044-6052 (2012)
   PUBMED   22219199
REFERENCE   4  (bases 1 to 3190)
  AUTHORS   Hageman,J., van Waarde,M.A., Zylicz,A., Walerych,D. and
            Kampinga,H.H.
  TITLE     The diverse members of the mammalian HSP70 machine show distinct
            chaperone-like activities
  JOURNAL   Biochem J 435 (1), 127-142 (2011)
   PUBMED   21231916
REFERENCE   5  (bases 1 to 3190)
  AUTHORS   Gao,X.C., Zhou,C.J., Zhou,Z.R., Zhang,Y.H., Zheng,X.M., Song,A.X.
            and Hu,H.Y.
  TITLE     Co-chaperone HSJ1a dually regulates the proteasomal degradation of
            ataxin-3
  JOURNAL   PLoS One 6 (5), e19763 (2011)
   PUBMED   21625540
REFERENCE   6  (bases 1 to 3190)
  AUTHORS   Borrell-Pages,M., Canals,J.M., Cordelieres,F.P., Parker,J.A.,
            Pineda,J.R., Grange,G., Bryson,E.A., Guillermier,M., Hirsch,E.,
            Hantraye,P., Cheetham,M.E., Neri,C., Alberch,J., Brouillet,E.,
            Saudou,F. and Humbert,S.
  TITLE     Cystamine and cysteamine increase brain levels of BDNF in
            Huntington disease via HSJ1b and transglutaminase
  JOURNAL   J Clin Invest 116 (5), 1410-1424 (2006)
   PUBMED   16604191
  REMARK    GeneRIF: Cystamine and cysteamine increase brain levels of BDNF in
            Huntington disease via HSJ1b and transglutaminase
REFERENCE   7  (bases 1 to 3190)
  AUTHORS   Westhoff,B., Chapple,J.P., van der Spuy,J., Hohfeld,J. and
            Cheetham,M.E.
  TITLE     HSJ1 is a neuronal shuttling factor for the sorting of chaperone
            clients to the proteasome
  JOURNAL   Curr Biol 15 (11), 1058-1064 (2005)
   PUBMED   15936278
REFERENCE   8  (bases 1 to 3190)
  AUTHORS   Chapple,J.P. and Cheetham,M.E.
  TITLE     The chaperone environment at the cytoplasmic face of the
            endoplasmic reticulum can modulate rhodopsin processing and
            inclusion formation
  JOURNAL   J Biol Chem 278 (21), 19087-19094 (2003)
   PUBMED   12754272
REFERENCE   9  (bases 1 to 3190)
  AUTHORS   Maheswaran,S., Englert,C., Zheng,G., Lee,S.B., Wong,J.,
            Harkin,D.P., Bean,J., Ezzell,R., Garvin,A.J., McCluskey,R.T.,
            DeCaprio,J.A. and Haber,D.A.
  TITLE     Inhibition of cellular proliferation by the Wilms tumor suppressor
            WT1 requires association with the inducible chaperone Hsp70
  JOURNAL   Genes Dev 12 (8), 1108-1120 (1998)
   PUBMED   9553041
REFERENCE   10 (bases 1 to 3190)
  AUTHORS   Cheetham,M.E., Jackson,A.P. and Anderton,B.H.
  TITLE     Regulation of 70-kDa heat-shock-protein ATPase activity and
            substrate binding by human DnaJ-like proteins, HSJ1a and HSJ1b
  JOURNAL   Eur J Biochem 226 (1), 99-107 (1994)
   PUBMED   7957263
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1892403.1,
                                           SRR26360190.1306609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-496               JAXUCZ010000009.1  84179768-84180263
            497-606             JAXUCZ010000009.1  84180769-84180878
            607-660             JAXUCZ010000009.1  84182387-84182440
            661-783             JAXUCZ010000009.1  84182604-84182726
            784-876             JAXUCZ010000009.1  84184069-84184161
            877-979             JAXUCZ010000009.1  84184338-84184440
            980-1050            JAXUCZ010000009.1  84184596-84184666
            1051-3190           JAXUCZ010000009.1  84185803-84187942
FEATURES             Location/Qualifiers
     source          1..3190
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..3190
                     /gene="Dnajb2"
                     /note="DnaJ heat shock protein family (Hsp40) member B2"
                     /db_xref="GeneID:689593"
                     /db_xref="RGD:1591035"
     exon            1..496
                     /gene="Dnajb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             432..1406
                     /gene="Dnajb2"
                     /note="isoform 1 is encoded by transcript variant 2; dnaJ
                     homolog subfamily B member 2; DnaJ (Hsp40) homolog,
                     subfamily B, member 2"
                     /codon_start=1
                     /product="dnaJ homolog subfamily B member 2 isoform 1"
                     /protein_id="NP_001386045.1"
                     /db_xref="GeneID:689593"
                     /db_xref="RGD:1591035"
                     /translation="MASYYEILDVPRSASPDDIKKAYRKKALQWHPDKNPDNKEFAEK
                     KFKEVAEAYEVLSDKHKREIYDRYGREGLTGAGSGPSRSETGGMEPGFTFTFRSPEEV
                     FREFFGSGDPFSELFDDLGAFSELQNQGSRLTGPFFTFSSSFPGNSDFSSSSFSFSPG
                     AGAFRSVSTSTTFVQGRRITTRRIMENGQERVEVEEDGQLKSVSINGVPDDLALGLEL
                     SRREQQPSVTPGLGVMQVRPTSVSRPPDSDLSEDEDMQLAMAYSLSEMEASGQKPAGG
                     RGAPQRQHGQPKAQHQDPDVGGLHKGARGEAAKVSPSSEEKASRCLIL"
     exon            497..606
                     /gene="Dnajb2"
                     /inference="alignment:Splign:2.1.0"
     exon            607..660
                     /gene="Dnajb2"
                     /inference="alignment:Splign:2.1.0"
     exon            661..783
                     /gene="Dnajb2"
                     /inference="alignment:Splign:2.1.0"
     exon            784..876
                     /gene="Dnajb2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..979
                     /gene="Dnajb2"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1050
                     /gene="Dnajb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..3190
                     /gene="Dnajb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtagtttcc gcggcgctga cgcatgcttg cgcacacaac ccagcctggc gcgtcgtacg
       61 cagccgccgc gagccgggca gcgggtgcta ggcggttccc ccgcgggggg caggggcggg
      121 actccgggca gaggaggtgc ggccccgtct gggtcaggtt gggggctccg atcgggttac
      181 tggtgttagg gggttcgggt agggctcccc ccgcctgcgg tgagatagcc ctgggcatcg
      241 gcctgcggga ccagataaag gctgcgaaga agcctagtca ccggccgcag gcgtggctcc
      301 ccggccggat tccacctcgc agtgtcttct gcctgccggg ggttgcggcc gcagggagct
      361 ggggtgcctc ggtcggcctg accccttctc tcccgcagcc tggaggaggg ccgcctgacg
      421 gctgagttgc catggcatcc tactacgaga ttctagacgt accgcggagt gcgtcccctg
      481 atgacatcaa gaaggcgtac cgaaagaagg ctctgcagtg gcacccagac aagaacccgg
      541 ataataaaga gtttgctgag aaaaaattta aggaggtggc agaggcctat gaagtactgt
      601 ctgacaagca caaacgggag atctatgacc gctatggccg ggaagggctg acgggggcag
      661 gaagtggtcc ttctcgatcg gaaactggtg gtatggagcc tggcttcaca ttcaccttcc
      721 gtagccctga ggaagtcttc cgggagttct tcgggagtgg agaccccttt tcggagctct
      781 ttgatgactt gggtgccttc tcggagcttc agaaccaggg ttcccgactc accggccctt
      841 tctttacttt ctcttcctcc tttcctggca actctgattt ctcctcctcg tctttctcct
      901 tcagcccggg ggctggtgct ttccgctctg tttctacgtc cacaaccttt gtccaaggcc
      961 gccgcatcac cacacgcaga atcatggaga acgggcagga gcgggtagaa gtggaagagg
     1021 atggacagct gaagtcagtg tcaatcaatg gtgtcccaga tgacctggca ctaggcttgg
     1081 agctgagccg tcgtgagcag cagccttcag tcacccctgg gttgggggtc atgcaggtcc
     1141 ggccgacctc tgtctctcgt ccccctgaca gcgacctttc tgaggatgag gacatgcagc
     1201 ttgccatggc gtacagcctg tcagagatgg aggcatctgg gcagaagcca gcaggtgggc
     1261 ggggggcacc gcaacgacag catgggcagc ccaaggccca gcaccaagac cctgatgtgg
     1321 ggggcctgca taagggggca aggggcgagg cagccaaagt cagcccatcc tcagaggaga
     1381 aggcctctcg ctgcctcatt ctctgagaac caggccgatg ctggactgac gcaggtccca
     1441 actcagagtc caggtcactg tctggagtgc agaatagtgt ggcctgactt gcaggattcc
     1501 aaactgtccc tccacaagtt tccctcccgt gtccacctgt attgtggaca gatttgttgt
     1561 actctgtcca gggctgacag gtccctgggt aaagcccaga ttggggggtg gggggaccag
     1621 tgcctgtgga gctcagaggc actggttgga tcagacactg ctaaaggaca ttagtgggtt
     1681 tggggtgccc aagtcttttc ctgccgttta tgttgctgat gctgtcgagg aaggaggact
     1741 tggcctggca tgctctgagc ttgagcttcc cccagggaat agcacaggcc gaggagcctc
     1801 tgctgtcctt ggccagatgc agccctcccg gtttctgtgt agaactgagc tctcacccac
     1861 tgtctcgttt cccctctggt gctgccttcc tcccactcca ctccactccg caacgcccac
     1921 ccttcggctg caacgcttgc tttcattgct gcttggctag gtctcccttc tccttctctt
     1981 agaagcccag gaagatgctg gggccagtgg gtccataaga tcttctgggg aggctagcta
     2041 ggtagggtgg aagcctctca gccctccaga gtctcaacca gagtcaactc ctcttccctt
     2101 cttcttgctg cctcagcctg ccctggccat aggactaggc agaggtgagg ctggctgtcc
     2161 ctggagaggt gggatagggc cagggtgacc cagagggagg cctaggtggg gactgtattt
     2221 gtactgccca ctcatcacac atcagagctg aggggctggc ctaggagtgc atgctcagct
     2281 ccatcctctt ctgcttgcag ctgaccctct ctcctgtcac ccacccctgc tctctcccca
     2341 gatgtgttct gagctggata tcctggatac agagttgctg cagttccaac aggacagcgc
     2401 cctccccaat gtgctaggag ggatcactac attcctctcc ctcatttatg ctgagtgtag
     2461 agctggggac tggggtggcg ggtggggact gagtgggagg catctgtagt cttggcctct
     2521 taactctctt ccctgggtgc ttagtgctgt gtttggtgga ctacaagtcc cagagtgcaa
     2581 tgcaccttgg cctcggttct tatagctttt atcccagggg aagagctgct cagttacaaa
     2641 gatgagcttc ttgggatttg tagttccaac cctggctagt ctgaattgga agatcttgtc
     2701 ttccattttg tccctggcag gggtggtgag aattgtagat gaccagaacc ttagtccctt
     2761 cttgctagac ccaggttgga gcaagcagat tcatgtagca tctgagagag gttgttttcc
     2821 cttgctaatg gggcagtgga ctgagtagat agggcgtggt cctggacggc tgtgggctgg
     2881 cagaatgtgg gagagaaggc tgccttggct ggagtgtgta tggcaaggat cggcatgcag
     2941 agggagtgtc ggacatattg cttgaatggc tttctttgac ctctgacctt gctgcccact
     3001 ctttcttatc atcaattcat cctccatgag ccacctgtcc tcctgcctgg ggagcccaag
     3061 gccagcaagg ggattggtgg agcaggctgt gaccggcctc tgtaacactg ggcctctgag
     3121 acccatcaaa gccagatgag ctgagctcag actgtgggaa aatggaggca aataaagctg
     3181 agttttgaga
//
