LOCUS       NM_022934               1610 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus DnaJ heat shock protein family (Hsp40) member A1
            (Dnaja1), mRNA.
ACCESSION   NM_022934
VERSION     NM_022934.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1610)
  AUTHORS   Meshalkina,D.A., Shevtsov,M.A., Dobrodumov,A.V., Komarova,E.Y.,
            Voronkina,I.V., Lazarev,V.F., Margulis,B.A. and Guzhova,I.V.
  TITLE     Knock-down of Hdj2/DNAJA1 co-chaperone results in an unexpected
            burst of tumorigenicity of C6 glioblastoma cells
  JOURNAL   Oncotarget 7 (16), 22050-22063 (2016)
   PUBMED   26959111
  REMARK    GeneRIF: The results of this study uncover a completely new role
            for the Hdj2 co-chaperone in tumorigenicity
REFERENCE   2  (bases 1 to 1610)
  AUTHORS   Roder,K., Werdich,A.A., Li,W., Liu,M., Kim,T.Y.,
            Organ-Darling,L.E., Moshal,K.S., Hwang,J.M., Lu,Y., Choi,B.R.,
            MacRae,C.A. and Koren,G.
  TITLE     RING finger protein RNF207, a novel regulator of cardiac excitation
  JOURNAL   J Biol Chem 289 (49), 33730-33740 (2014)
   PUBMED   25281747
REFERENCE   3  (bases 1 to 1610)
  AUTHORS   Stark,J.L., Mehla,K., Chaika,N., Acton,T.B., Xiao,R., Singh,P.K.,
            Montelione,G.T. and Powers,R.
  TITLE     Structure and function of human DnaJ homologue subfamily a member 1
            (DNAJA1) and its relationship to pancreatic cancer
  JOURNAL   Biochemistry 53 (8), 1360-1372 (2014)
   PUBMED   24512202
REFERENCE   4  (bases 1 to 1610)
  AUTHORS   Rauch,J.N. and Gestwicki,J.E.
  TITLE     Binding of human nucleotide exchange factors to heat shock protein
            70 (Hsp70) generates functionally distinct complexes in vitro
  JOURNAL   J Biol Chem 289 (3), 1402-1414 (2014)
   PUBMED   24318877
REFERENCE   5  (bases 1 to 1610)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   6  (bases 1 to 1610)
  AUTHORS   Marschang,P., Brich,J., Weeber,E.J., Sweatt,J.D., Shelton,J.M.,
            Richardson,J.A., Hammer,R.E. and Herz,J.
  TITLE     Normal development and fertility of knockout mice lacking the tumor
            suppressor gene LRP1b suggest functional compensation by LRP1
  JOURNAL   Mol Cell Biol 24 (9), 3782-3793 (2004)
   PUBMED   15082773
REFERENCE   7  (bases 1 to 1610)
  AUTHORS   Gotoh,T., Terada,K., Oyadomari,S. and Mori,M.
  TITLE     hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced
            apoptosis by inhibiting translocation of Bax to mitochondria
  JOURNAL   Cell Death Differ 11 (4), 390-402 (2004)
   PUBMED   14752510
REFERENCE   8  (bases 1 to 1610)
  AUTHORS   Imai,Y., Soda,M., Hatakeyama,S., Akagi,T., Hashikawa,T.,
            Nakayama,K.I. and Takahashi,R.
  TITLE     CHIP is associated with Parkin, a gene responsible for familial
            Parkinson's disease, and enhances its ubiquitin ligase activity
  JOURNAL   Mol Cell 10 (1), 55-67 (2002)
   PUBMED   12150907
REFERENCE   9  (bases 1 to 1610)
  AUTHORS   Pei,L.
  TITLE     Pituitary tumor-transforming gene protein associates with ribosomal
            protein S10 and a novel human homologue of DnaJ in testicular cells
  JOURNAL   J Biol Chem 274 (5), 3151-3158 (1999)
   PUBMED   9915854
REFERENCE   10 (bases 1 to 1610)
  AUTHORS   Leng,C.H., Brodsky,J.L. and Wang,C.
  TITLE     Isolation and characterization of a DnaJ-like protein in rats: the
            C-terminal 10-kDa domain of hsc70 is not essential for stimulating
            the ATP-hydrolytic activity of hsc70 by a DnaJ-like protein
  JOURNAL   Protein Sci 7 (5), 1186-1194 (1998)
   PUBMED   9605323
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U53922.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U53922.1, FQ216722.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1610
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1610
                     /gene="Dnaja1"
                     /gene_synonym="Hsj2"
                     /note="DnaJ heat shock protein family (Hsp40) member A1"
                     /db_xref="GeneID:65028"
                     /db_xref="RGD:620942"
     exon            1..111
                     /gene="Dnaja1"
                     /gene_synonym="Hsj2"
                     /inference="alignment:Splign:2.1.0"
     exon            112..253
                     /gene="Dnaja1"
                     /gene_synonym="Hsj2"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1315
                     /gene="Dnaja1"
                     /gene_synonym="Hsj2"
                     /note="DnaJ-like protein 2; dnaJ-like protein 1; HSJ-2;
                     heat shock protein J2; DnaJ (Hsp40) homolog, subfamily A,
                     member 1"
                     /codon_start=1
                     /product="dnaJ homolog subfamily A member 1"
                     /protein_id="NP_075223.1"
                     /db_xref="GeneID:65028"
                     /db_xref="RGD:620942"
                     /translation="MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEK
                     FKQISQAYEVLADSKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRER
                     RGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQI
                     RIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKD
                     GQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKP
                     ISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFL
                     SPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGV
                     QCQTS"
     exon            254..431
                     /gene="Dnaja1"
                     /gene_synonym="Hsj2"
                     /inference="alignment:Splign:2.1.0"
     exon            432..536
                     /gene="Dnaja1"
                     /gene_synonym="Hsj2"
                     /inference="alignment:Splign:2.1.0"
     exon            537..764
                     /gene="Dnaja1"
                     /gene_synonym="Hsj2"
                     /inference="alignment:Splign:2.1.0"
     exon            765..879
                     /gene="Dnaja1"
                     /gene_synonym="Hsj2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..995
                     /gene="Dnaja1"
                     /gene_synonym="Hsj2"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1096
                     /gene="Dnaja1"
                     /gene_synonym="Hsj2"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1610
                     /gene="Dnaja1"
                     /gene_synonym="Hsj2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccgggcgg aactttccag aacgctcggt gggtggtaga ggagcagcgt ctggccgagc
       61 tgcgctgtgc tacgctcctc tttccgctct ccggcgccgg cccgctcacc ggctgtaaaa
      121 aatggtgaaa gaaactactt actatgatgt tctgggggtc aaacccaatg ccacccagga
      181 agaattgaaa aaggcatata gaaaattggc cttgaagtac caccctgata aaaatccaaa
      241 tgaaggagaa aagtttaaac agatttctca agcttatgaa gttcttgctg attccaagaa
      301 aagggaacta tatgataaag ggggcgagca ggcgattaag gagggcggag caggtggagg
      361 ttttggctcg cccatggata tctttgatat gttctttgga ggaggaggaa ggatgcaaag
      421 agaaaggaga ggtaaaaatg tcgtgcatca gctctcagtg accttagaag acttatataa
      481 tggtgcaaca aggaaactgg ctctgcaaaa aaatgtgatt tgtgacaaat gtgaaggccg
      541 aggtggtaag aaaggagcag tagagtgctg tcccaactgc cgggggactg gcatgcagat
      601 caggattcat cagattggac caggaatggt tcagcaaatt cagtcagtgt gcatggagtg
      661 ccagggtcat ggagaacgca tcagtcctaa agacagatgt aaaagctgca atggaagaaa
      721 gatagttcga gagaagaaaa ttttagaagt tcatattgat aaaggcatga aagatggtca
      781 gaagataaca ttccacggtg aaggagacca agaaccagga ctggagccag gagatattat
      841 cattgtgtta gatcagaagg accatgctgt ttttacaagg cgaggagaag accttttcat
      901 gtgtatggac atacagctgg ttgaagcatt gtgtggcttc caaaagccaa tatctactct
      961 tgacaaccga accatagtca tcacctctca tccaggtcag attgtcaagc atggggatat
     1021 aaaatgtgtg ctaaatgaag gtatgccaat ataccgtcgg ccatatgaaa agggacgtct
     1081 aatcattgag tttaaggtaa actttcctga aaatggcttt ctctctcctg ataaactctc
     1141 tttgctggaa aaactccttc ctgaaaggaa ggaagtagaa gagactgatg aaatggatca
     1201 ggtagaactg gtggactttg atccaaatca ggaaagacgg cgtcattata atggagaagc
     1261 gtatgaggat gatgagcatc accccagagg tggcgttcag tgtcagacct cttaatgggc
     1321 cagtcactct ttgaccttgt gtatgcagta gtgaatgtgg gaaggactgt aatcataata
     1381 tgctcactac ttggctgttg tttttgtttt aatattcaac tatagtagtg ttttaaaagt
     1441 taaatgaaga ataaacacaa atataaaagc tctgactttg ccctgtatgt atgatgactt
     1501 taatgttcaa gatgaaaatg aatacttgta aaaaactagt ttaaaaaatg ccctagcatc
     1561 tgttaggcca tatcttgtgt aactgataat agcgtgtaca ttagactgac
//
