LOCUS       NM_001106627            2433 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus dynein axonemal intermediate chain 7 (Dnai7),
            mRNA.
ACCESSION   NM_001106627 XM_001074789 XM_216310
VERSION     NM_001106627.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2433)
  AUTHORS   Sinnott R, Winters L, Larson B, Mytsa D, Taus P, Cappell KM and
            Whitehurst AW.
  TITLE     Mechanisms promoting escape from mitotic stress-induced tumor cell
            death
  JOURNAL   Cancer Res 74 (14), 3857-3869 (2014)
   PUBMED   24860162
REFERENCE   2  (bases 1 to 2433)
  AUTHORS   Liu Y, Vikis HG, Yi Y, Futamura M, Wang Y and You M.
  TITLE     Degradation of lung adenoma susceptibility 1, a major candidate
            mouse lung tumor modifier, is required for cell cycle progression
  JOURNAL   Cancer Res 67 (21), 10207-10213 (2007)
   PUBMED   17974961
REFERENCE   3  (bases 1 to 2433)
  AUTHORS   Liu P, Wang Y, Vikis H, Maciag A, Wang D, Lu Y, Liu Y and You M.
  TITLE     Candidate lung tumor susceptibility genes identified through
            whole-genome association analyses in inbred mice
  JOURNAL   Nat Genet 38 (8), 888-895 (2006)
   PUBMED   16862160
REFERENCE   4  (bases 1 to 2433)
  AUTHORS   Zhang Z, Futamura M, Vikis HG, Wang M, Li J, Wang Y, Guan KL and
            You M.
  TITLE     Positional cloning of the major quantitative trait locus underlying
            lung tumor susceptibility in mice
  JOURNAL   Proc Natl Acad Sci U S A 100 (22), 12642-12647 (2003)
   PUBMED   14583591
  REMARK    GeneRIF: Identification of mouse Casc1 (Las1) as a candidate for
            lung cancer susceptibility, and comparison of the protein to the
            rat and human orthologs.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC160907.1.
            
            On Nov 26, 2008 this sequence version replaced NM_001106627.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC160907.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132263,
                                           SAMD00132264 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2433
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..2433
                     /gene="Dnai7"
                     /gene_synonym="Casc1; Cfap94; Las1"
                     /note="dynein axonemal intermediate chain 7"
                     /db_xref="GeneID:297720"
                     /db_xref="RGD:1311213"
     exon            1..51
                     /gene="Dnai7"
                     /gene_synonym="Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..2241
                     /gene="Dnai7"
                     /gene_synonym="Casc1; Cfap94; Las1"
                     /note="lung adenoma susceptibility 1; cancer
                     susceptibility candidate 1; cancer susceptibility 1;
                     dynein intermediate chain CFAP94, axonemal; cilia and
                     flagella associated protein 94"
                     /codon_start=1
                     /product="dynein axonemal intermediate chain 7"
                     /protein_id="NP_001100097.2"
                     /db_xref="GeneID:297720"
                     /db_xref="RGD:1311213"
                     /translation="MGPKQKKAPTKKKITKAERLRLLQEEEEKRLKEEEEARLKYEKE
                     EQERLEKQRIEREKWNLLEKKDLERRSEELEELALLECCFPEAEKQKREMRVLAQWKH
                     YTECDGSPDPRIAQEMNTFISLWEEEKNETFEQVMEKSKLVLSLIEKLKLILLETPSC
                     DLDKSTVLQYQGSILRLQELLSLKVNVATELLLRQASNLADLDTGNMEKIIKDENVTL
                     YVWANLKKNPRYRTVKFSQTQVGFEIPRILATSNVALRLLHTHYDHITPLFSTVVTEE
                     KHGSIVAENFKEEERTEKAVPEENVFTEEAADEAEQLKAEEERELSSIPEEEVKFDPT
                     VDTVTQKISDPEEEESQTTQFELERKLLSETVSAAQLSLIENVLEMPETLEPYEVNMC
                     HFAPLGGVYHLEILELPPQSKPVKGWVLAEIRQEGLQKFTYPPENTEEPDPESAFPPI
                     EVTLEIHESAIFFEDPQVVRWDAEGKFWRSDGVTCVYYNRENRLLTFSIDTMGPVTLI
                     QDAHVNMPYQSWELSPLGMNKALLMVTTVFIELQIHIKETHCMLAAVKLKGKSRELRV
                     IGKWMTPIPFILALKEAGLNIFPAVYSHFYVVVNNKVPQMELKAYRQMALLSSAFSFG
                     WSKWNMVCNSTRVVFRVREHISEEEEQNTWALLMFSGDRAQMLKMQEESDQFSETLRE
                     GSEFHSTLYHMMKDFASPEATEKVRHSNCQFIDSVCYMLLSVRVLSYS"
     exon            52..69
                     /gene="Dnai7"
                     /gene_synonym="Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            70..151
                     /gene="Dnai7"
                     /gene_synonym="Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            152..243
                     /gene="Dnai7"
                     /gene_synonym="Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            244..345
                     /gene="Dnai7"
                     /gene_synonym="Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..483
                     /gene="Dnai7"
                     /gene_synonym="Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..630
                     /gene="Dnai7"
                     /gene_synonym="Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            631..734
                     /gene="Dnai7"
                     /gene_synonym="Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            735..1071
                     /gene="Dnai7"
                     /gene_synonym="Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1153
                     /gene="Dnai7"
                     /gene_synonym="Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1314
                     /gene="Dnai7"
                     /gene_synonym="Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1471
                     /gene="Dnai7"
                     /gene_synonym="Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1686
                     /gene="Dnai7"
                     /gene_synonym="Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1854
                     /gene="Dnai7"
                     /gene_synonym="Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1968
                     /gene="Dnai7"
                     /gene_synonym="Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2409
                     /gene="Dnai7"
                     /gene_synonym="Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggctctgca gagttcactt ttccctaggc aaaggtcctt cttctctcat gggtcccaaa
       61 caaaaaaagg ctcccactaa gaaaaagata accaaagctg agcgattgcg tctgctgcag
      121 gaggaggagg agaaacgcct gaaggaggaa gaggaggctc gactgaaata tgaaaaggaa
      181 gaacaggaaa ggctagaaaa acaacggatt gagagagaaa agtggaatct gctggaaaag
      241 aaagacctag aaaggagaag cgaggagttg gaagagcttg ctctgctgga gtgttgtttt
      301 cctgaagcag agaaacagaa gcgggaaatg cgagtactgg ctcagtggaa gcactacacc
      361 gagtgtgatg ggagccccga tcctcggatt gcccaggaaa tgaacacgtt cattagcttg
      421 tgggaggaag agaagaacga gacctttgag caagtgatgg agaaaagtaa actggttctg
      481 tccctgattg aaaagctgaa gttaatttta ctggaaactc cgtcgtgtga cctggacaag
      541 agtactgtcc tgcagtacca agggtcaatt ctgcgcctgc aggagctcct cagtctgaag
      601 gtgaacgtgg ccacagagct gctgcttcga caagctagta acttagccga tctggacacc
      661 gggaatatgg agaaaatcat caaagatgag aatgttaccc tgtacgtgtg ggcaaacctg
      721 aaaaagaatc caaggtaccg aactgtgaaa ttctcacaga cacaagtcgg atttgaaatc
      781 cccaggatac tagccacaag caatgtcgcc ctgcggcttc tgcacacgca ctatgaccac
      841 atcacaccct tgttctccac tgttgtcact gaggaaaaac acgggtccat agtagcagag
      901 aatttcaagg aagaggaaag aacagaaaag gctgtccccg aagaaaacgt ctttactgaa
      961 gaagctgctg acgaagctga gcagctcaag gctgaggagg aaagagagct cagcagcatc
     1021 ccagaggagg aggtcaaatt cgaccccacg gtggacaccg tcacacagaa gatttccgac
     1081 cctgaagagg aagagtccca aaccacccag tttgaactgg agaggaagtt gctgagcgaa
     1141 acagtctcag cagcacagct gagcctgata gagaatgttt tggaaatgcc agaaaccttg
     1201 gaaccctacg aggtgaacat gtgccatttc gcccccctgg gcggcgtgta ccacctggaa
     1261 atcctggagt tgccccctca aagcaaacca gtgaagggct gggtgttagc agagatacgc
     1321 caagaaggat tacaaaagtt tacataccct ccagaaaaca cagaagaacc tgatccagaa
     1381 agtgcctttc cacccataga ggtcacactg gagatccacg agagcgccat cttctttgag
     1441 gatcctcaag tggtcaggtg ggatgctgaa ggtaaattct ggaggtcaga tggcgtcacc
     1501 tgtgtgtatt acaaccgaga aaacaggctc ctaaccttca gtatagatac gatgggccct
     1561 gtgaccttga ttcaggatgc tcatgtcaac atgccttacc agtcctggga gctgagtccc
     1621 ctcggtatga acaaagccct tttaatggtg acgacggttt tcattgagct ccagatacac
     1681 atcaaggaaa cccactgcat gttggctgca gtgaaactga agggcaagag ccgtgagctt
     1741 cgggtaatag gaaaatggat gactccaata cccttcattc tggctttgaa agaagctggg
     1801 ctgaacatct tccctgctgt ctactctcac ttttatgtgg tcgtcaacaa taaggtaccc
     1861 cagatggagc tgaaggccta tcggcaaatg gccctgctca gctctgcctt ctcgtttggc
     1921 tggagcaagt ggaacatggt gtgtaactcc accagagttg tgtttcgggt gagggaacat
     1981 atctcagaag aggaggagca gaacacctgg gcgctcctca tgttcagcgg tgacagggcg
     2041 cagatgctca agatgcagga agaaagcgac cagttctccg agaccctcag ggagggcagc
     2101 gagttccact ccaccttgta ccacatgatg aaggacttcg cctctccaga ggcaacggag
     2161 aaggtcaggc attcgaactg ccagttcatc gactcggtgt gctacatgct gctgtccgtc
     2221 cgggtcctca gctattccta gtccttcaca gcctgtttaa gagcggcaaa ctcttatacc
     2281 tgagaggaat caggaatcat tcccatcagt cactaaaatg atccaagagc acacggcatt
     2341 ccagctgtac tgcacaaaga tccgagtggc ctttatttga tacatttcaa taaagtctta
     2401 tgtctctcaa aaaaaaaaaa aaaaaaaaaa aaa
//
