LOCUS       NM_001007726            2923 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus dynein, axonemal, intermediate chain 2 (Dnai2),
            mRNA.
ACCESSION   NM_001007726 XM_340931
VERSION     NM_001007726.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2923)
  AUTHORS   Mali,G.R., Yeyati,P.L., Mizuno,S., Dodd,D.O., Tennant,P.A.,
            Keighren,M.A., Zur Lage,P., Shoemark,A., Garcia-Munoz,A.,
            Shimada,A., Takeda,H., Edlich,F., Takahashi,S., von Kreigsheim,A.,
            Jarman,A.P. and Mill,P.
  TITLE     ZMYND10 functions in a chaperone relay during axonemal dynein
            assembly
  JOURNAL   Elife 7, e34389 (2018)
   PUBMED   29916806
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2923)
  AUTHORS   Hjeij,R., Lindstrand,A., Francis,R., Zariwala,M.A., Liu,X., Li,Y.,
            Damerla,R., Dougherty,G.W., Abouhamed,M., Olbrich,H., Loges,N.T.,
            Pennekamp,P., Davis,E.E., Carvalho,C.M., Pehlivan,D., Werner,C.,
            Raidt,J., Kohler,G., Haffner,K., Reyes-Mugica,M., Lupski,J.R.,
            Leigh,M.W., Rosenfeld,M., Morgan,L.C., Knowles,M.R., Lo,C.W.,
            Katsanis,N. and Omran,H.
  TITLE     ARMC4 mutations cause primary ciliary dyskinesia with randomization
            of left/right body asymmetry
  JOURNAL   Am J Hum Genet 93 (2), 357-367 (2013)
   PUBMED   23849778
REFERENCE   3  (bases 1 to 2923)
  AUTHORS   Knowles,M.R., Leigh,M.W., Ostrowski,L.E., Huang,L., Carson,J.L.,
            Hazucha,M.J., Yin,W., Berg,J.S., Davis,S.D., Dell,S.D.,
            Ferkol,T.W., Rosenfeld,M., Sagel,S.D., Milla,C.E., Olivier,K.N.,
            Turner,E.H., Lewis,A.P., Bamshad,M.J., Nickerson,D.A., Shendure,J.
            and Zariwala,M.A.
  CONSRTM   Genetic Disorders of Mucociliary Clearance Consortium
  TITLE     Exome sequencing identifies mutations in CCDC114 as a cause of
            primary ciliary dyskinesia
  JOURNAL   Am J Hum Genet 92 (1), 99-106 (2013)
   PUBMED   23261302
REFERENCE   4  (bases 1 to 2923)
  AUTHORS   Loges,N.T., Olbrich,H., Fenske,L., Mussaffi,H., Horvath,J.,
            Fliegauf,M., Kuhl,H., Baktai,G., Peterffy,E., Chodhari,R.,
            Chung,E.M., Rutman,A., O'Callaghan,C., Blau,H., Tiszlavicz,L.,
            Voelkel,K., Witt,M., Zietkiewicz,E., Neesen,J., Reinhardt,R.,
            Mitchison,H.M. and Omran,H.
  TITLE     DNAI2 mutations cause primary ciliary dyskinesia with defects in
            the outer dynein arm
  JOURNAL   Am J Hum Genet 83 (5), 547-558 (2008)
   PUBMED   18950741
REFERENCE   5  (bases 1 to 2923)
  AUTHORS   Yang,Z. and Wu,J.
  TITLE     Mouse dynein axonemal intermediate chain 2: cloning and expression
  JOURNAL   DNA Cell Biol 27 (9), 479-488 (2008)
   PUBMED   18547164
REFERENCE   6  (bases 1 to 2923)
  AUTHORS   Pennarun,G., Chapelin,C., Escudier,E., Bridoux,A.M., Dastot,F.,
            Cacheux,V., Goossens,M., Amselem,S. and Duriez,B.
  TITLE     The human dynein intermediate chain 2 gene (DNAI2): cloning,
            mapping, expression pattern, and evaluation as a candidate for
            primary ciliary dyskinesia
  JOURNAL   Hum Genet 107 (6), 642-649 (2000)
   PUBMED   11153919
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081920.1.
            
            On Nov 29, 2004 this sequence version replaced XM_340931.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081920.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2923
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2923
                     /gene="Dnai2"
                     /gene_synonym="Dnaic2"
                     /note="dynein, axonemal, intermediate chain 2"
                     /db_xref="GeneID:360654"
                     /db_xref="RGD:1359602"
     exon            1..340
                     /gene="Dnai2"
                     /gene_synonym="Dnaic2"
                     /inference="alignment:Splign:2.1.0"
     exon            341..543
                     /gene="Dnai2"
                     /gene_synonym="Dnaic2"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..2220
                     /gene="Dnai2"
                     /gene_synonym="Dnaic2"
                     /note="dynein intermediate chain 2, axonemal; axonemal
                     dynein intermediate chain 2; dynein, axonemal,
                     intermediate polypeptide 2"
                     /codon_start=1
                     /product="dynein axonemal intermediate chain 2"
                     /protein_id="NP_001007727.1"
                     /db_xref="GeneID:360654"
                     /db_xref="RGD:1359602"
                     /translation="MEIVYVYVKKRSEFGKQCNFSDRQAELNIDISPNPELAALYVER
                     NPVDTGIQCSASMSEHEANTERFEMENCGVNHVEGGWPKDVNPQELEQTIRFRKKVEK
                     DENYINAVMQLGSIMEHCIKQNNAIDIYEEYFDDEEAVEVTEEAPSAKTINVFRDPQE
                     IKRTATHLSWHPDGNKKLAVAYSCLQFQRSPMGMSHDSYIWDLENPNRPEIALKPSSP
                     LITLEYNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIEFSHRDPVYGTIWLQSKT
                     GTECFSASTDGQVMWWDIRKISEPTEVVIMDITRKEQLENALGAISLEFESTLPTKFM
                     VGTEQGIVISCNRKAKTPAEKIVCTFSGHHGPIYALQRNPFYPKNFLTVGDWAARIWS
                     EESRESSIMWTRYHMAYLSDGAWSPVRPAVFFTTKMDGTLDIWDLVFKQCDPALSLKV
                     CDDPLFCLRVQDTGCLIACGSELGTTTLLEVSSSLSTLQRNERNIASSIFERETRREK
                     ILEARHREMRLKEKGKAEGRDDDQKEEETALDLDELVNKAEEEFFEVIFAELKRKEAE
                     ALKKKPKPKKASIEVEGEDELEDIAGEEEESGIIMGEDTGEDDMDEKNEGGAP"
     exon            544..705
                     /gene="Dnai2"
                     /gene_synonym="Dnaic2"
                     /inference="alignment:Splign:2.1.0"
     exon            706..827
                     /gene="Dnai2"
                     /gene_synonym="Dnaic2"
                     /inference="alignment:Splign:2.1.0"
     exon            828..970
                     /gene="Dnai2"
                     /gene_synonym="Dnaic2"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1084
                     /gene="Dnai2"
                     /gene_synonym="Dnaic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1224
                     /gene="Dnai2"
                     /gene_synonym="Dnaic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1347
                     /gene="Dnai2"
                     /gene_synonym="Dnaic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1571
                     /gene="Dnai2"
                     /gene_synonym="Dnaic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1707
                     /gene="Dnai2"
                     /gene_synonym="Dnaic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1854
                     /gene="Dnai2"
                     /gene_synonym="Dnaic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2082
                     /gene="Dnai2"
                     /gene_synonym="Dnaic2"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2897
                     /gene="Dnai2"
                     /gene_synonym="Dnaic2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccttggg cgcttcccct gagcagtgta gcaggagaag ctgagttagg ataaggggcg
       61 ggcgtcctgg aggacgtcca agcccgaaaa aaagagctgg cgaaaggagg aaagagccct
      121 cgagagttat aatcaccaac agtgcaagaa atccagaact gtcagatgct ggactcagga
      181 ctggcgctct ccccgctgca ttaatcctcg ctgcccggaa tattcttcaa gctccaggac
      241 ctcctcaacc cctaaccacc ttgtcttctg caccactacc ctactagatc ctaacccggg
      301 ctgtgactcg gagtgggccg aacctctttc aggctttcag ccgccgccgc cgccgccgcc
      361 atggagatcg tctacgtgta cgtgaagaag cgcagtgagt ttgggaagca atgcaacttc
      421 tctgaccgcc aggctgagct gaacattgac atctcaccca accctgagct ggccgcactg
      481 tatgtggagc ggaacccagt ggacacaggc atccagtgct ccgccagtat gtcggaacat
      541 gaggccaaca cagagcggtt tgagatggag aactgtgggg ttaaccacgt cgaggggggc
      601 tggcccaagg atgtgaaccc ccaggagctg gagcagacca tccgcttccg gaagaaagtg
      661 gagaaggatg agaattacat caacgccgtc atgcagctgg gctcgatcat ggagcactgc
      721 atcaagcaga acaatgccat cgacatctac gaggaatatt ttgatgacga ggaggccgtg
      781 gaggtgactg aagaggcccc ttcagccaag accatcaatg tcttcaggga ccctcaggag
      841 atcaagcgga cagccacaca cctctcctgg caccctgatg gtaacaagaa gctggccgtg
      901 gcctattcct gcttgcagtt ccagcgctcg cccatgggca tgagccacga ctcctacatc
      961 tgggacctgg aaaaccccaa ccgacctgag attgccctga agccatcgtc tcctctcatc
     1021 accctggagt acaaccctaa ggattcccac gttctcctag ggggctgcta caatgggcag
     1081 atagcctgct gggatacccg gaagggcagc ctggtggcag agctgtccac cattgagttc
     1141 agccaccgag acccagtgta cggcaccatc tggttgcagt caaagacagg caccgagtgc
     1201 ttctcagcgt ccacggatgg gcaggtcatg tggtgggaca tccgcaagat cagcgagccc
     1261 accgaagttg tcattatgga catcaccaga aaggagcagc tggagaacgc cctgggcgcc
     1321 atctccttgg agttcgagtc taccttgcca accaagttca tggtgggcac tgaacaaggc
     1381 attgtcatct cctgcaaccg caaggccaag acgccagcgg agaagatcgt ttgcaccttt
     1441 tctggccacc acggccctat ctatgccctc cagagaaacc ccttctaccc aaagaacttt
     1501 ctgactgttg gcgactgggc tgcccgcatc tggtctgagg agagtcggga gtcatctatc
     1561 atgtggaccc ggtaccacat ggcttacctc tctgatggag cctggagtcc cgtgagacca
     1621 gcggttttct tcaccaccaa gatggatggg accctggaca tctgggactt ggtgttcaag
     1681 cagtgtgacc ctgccctcag cctgaaggta tgtgacgacc cactcttctg cctccgagtt
     1741 caggacaccg ggtgtctcat cgcctgcggc tccgagctcg gaacaaccac tctgctggag
     1801 gtctccagca gtctctctac tctgcagagg aatgagagga acatagcttc ttccatattt
     1861 gaacgtgaga cccggcggga aaagatccta gaggccagac accgcgagat gcggctgaag
     1921 gagaaaggca aggcagaggg cagagacgac gaccagaagg aggaggagac agccctggac
     1981 ctcgatgagc tagtcaacaa agccgaggag gagttcttcg aagtcatctt cgcagagctg
     2041 aagaggaagg aggcagaggc cttgaagaag aaaccgaaac ctaaaaaagc aagtatagag
     2101 gtggaaggcg aagatgagct ggaagatatt gctggagagg aggaagaatc cggcatcata
     2161 atgggtgaag atacaggtga agatgacatg gatgaaaaga atgagggcgg ggccccctag
     2221 ggcagcctct gcccacaaca ctgccccttc gcgctcaagg ctggccttcc atttgatgcc
     2281 gtctcatctg aaaagcgcaa agttgagttt ccttcttcag ttatcgttgg tgggggacag
     2341 atcagggaca agttactggg ccaagcccca tgtgcatgct tctctagtgt gggaaagggt
     2401 aggacttgtc tctgtgctaa ctcccctggc ctctgcaact ctgaggctaa ctcagactcg
     2461 gggcacacac acagcctcaa gtcagacatt agatgggtcc ctagattctg cttatcacgg
     2521 gttatccaat tagtagttac caatggcttt ctccagaagc ttccagagct catctgtgag
     2581 cttgccttgg tgcccagggg cctccggagc acctgcacag gggcaagttt ctctctctct
     2641 ctctctctct ctctctctct ctctctctct ctctctctct ctctcttccc ctctcaccta
     2701 cttgcaaatc aaaagagaac taactttcat ctccatctat aatgccttcc caagcaacct
     2761 cccaggaggc atcttgacac gtggtcgcac ggtaggggcg ttcccaggtg tggagagtag
     2821 ggtgaacctg atcctccctg tacacacgtg gtttttctgg ctatgtttct cataacatta
     2881 aatcagtgat aacagcaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
