LOCUS       NM_001024342            2441 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus dynein, axonemal, intermediate chain 1 (Dnai1),
            mRNA.
ACCESSION   NM_001024342 XM_575804
VERSION     NM_001024342.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2441)
  AUTHORS   Gao,F.J., Shi,L., Hines,T., Hebbar,S., Neufeld,K.L. and Smith,D.S.
  TITLE     Insulin signaling regulates a functional interaction between
            adenomatous polyposis coli and cytoplasmic dynein
  JOURNAL   Mol Biol Cell 28 (5), 587-599 (2017)
   PUBMED   28057765
REFERENCE   2  (bases 1 to 2441)
  AUTHORS   Jeanson,L., Thomas,L., Copin,B., Coste,A., Sermet-Gaudelus,I.,
            Dastot-Le Moal,F., Duquesnoy,P., Montantin,G., Collot,N.,
            Tissier,S., Papon,J.F., Clement,A., Louis,B., Escudier,E.,
            Amselem,S. and Legendre,M.
  TITLE     Mutations in GAS8, a Gene Encoding a Nexin-Dynein Regulatory
            Complex Subunit, Cause Primary Ciliary Dyskinesia with Axonemal
            Disorganization
  JOURNAL   Hum Mutat 37 (8), 776-785 (2016)
   PUBMED   27120127
REFERENCE   3  (bases 1 to 2441)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   4  (bases 1 to 2441)
  AUTHORS   Nakhleh,N., Francis,R., Giese,R.A., Tian,X., Li,Y., Zariwala,M.A.,
            Yagi,H., Khalifa,O., Kureshi,S., Chatterjee,B., Sabol,S.L.,
            Swisher,M., Connelly,P.S., Daniels,M.P., Srinivasan,A., Kuehl,K.,
            Kravitz,N., Burns,K., Sami,I., Omran,H., Barmada,M., Olivier,K.,
            Chawla,K.K., Leigh,M., Jonas,R., Knowles,M., Leatherbury,L. and
            Lo,C.W.
  TITLE     High prevalence of respiratory ciliary dysfunction in congenital
            heart disease patients with heterotaxy
  JOURNAL   Circulation 125 (18), 2232-2242 (2012)
   PUBMED   22499950
REFERENCE   5  (bases 1 to 2441)
  AUTHORS   Ikegami,K., Sato,S., Nakamura,K., Ostrowski,L.E. and Setou,M.
  TITLE     Tubulin polyglutamylation is essential for airway ciliary function
            through the regulation of beating asymmetry
  JOURNAL   Proc Natl Acad Sci U S A 107 (23), 10490-10495 (2010)
   PUBMED   20498047
REFERENCE   6  (bases 1 to 2441)
  AUTHORS   Kennedy,M.P., Omran,H., Leigh,M.W., Dell,S., Morgan,L.,
            Molina,P.L., Robinson,B.V., Minnix,S.L., Olbrich,H., Severin,T.,
            Ahrens,P., Lange,L., Morillas,H.N., Noone,P.G., Zariwala,M.A. and
            Knowles,M.R.
  TITLE     Congenital heart disease and other heterotaxic defects in a large
            cohort of patients with primary ciliary dyskinesia
  JOURNAL   Circulation 115 (22), 2814-2821 (2007)
   PUBMED   17515466
REFERENCE   7  (bases 1 to 2441)
  AUTHORS   Zariwala,M.A., Leigh,M.W., Ceppa,F., Kennedy,M.P., Noone,P.G.,
            Carson,J.L., Hazucha,M.J., Lori,A., Horvath,J., Olbrich,H.,
            Loges,N.T., Bridoux,A.M., Pennarun,G., Duriez,B., Escudier,E.,
            Mitchison,H.M., Chodhari,R., Chung,E.M., Morgan,L.C., de
            Iongh,R.U., Rutland,J., Pradal,U., Omran,H., Amselem,S. and
            Knowles,M.R.
  TITLE     Mutations of DNAI1 in primary ciliary dyskinesia: evidence of
            founder effect in a common mutation
  JOURNAL   Am J Respir Crit Care Med 174 (8), 858-866 (2006)
   PUBMED   16858015
REFERENCE   8  (bases 1 to 2441)
  AUTHORS   Utton,M.A., Noble,W.J., Hill,J.E., Anderton,B.H. and Hanger,D.P.
  TITLE     Molecular motors implicated in the axonal transport of tau and
            alpha-synuclein
  JOURNAL   J Cell Sci 118 (Pt 20), 4645-4654 (2005)
   PUBMED   16176937
REFERENCE   9  (bases 1 to 2441)
  AUTHORS   Fliegauf,M., Olbrich,H., Horvath,J., Wildhaber,J.H., Zariwala,M.A.,
            Kennedy,M., Knowles,M.R. and Omran,H.
  TITLE     Mislocalization of DNAH5 and DNAH9 in respiratory cells from
            patients with primary ciliary dyskinesia
  JOURNAL   Am J Respir Crit Care Med 171 (12), 1343-1349 (2005)
   PUBMED   15750039
REFERENCE   10 (bases 1 to 2441)
  AUTHORS   Guichard,C., Harricane,M.C., Lafitte,J.J., Godard,P., Zaegel,M.,
            Tack,V., Lalau,G. and Bouvagnet,P.
  TITLE     Axonemal dynein intermediate-chain gene (DNAI1) mutations result in
            situs inversus and primary ciliary dyskinesia (Kartagener syndrome)
  JOURNAL   Am J Hum Genet 68 (4), 1030-1035 (2001)
   PUBMED   11231901
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083662.1.
            
            On May 27, 2005 this sequence version replaced XM_575804.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2441
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..2441
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /note="dynein, axonemal, intermediate chain 1"
                     /db_xref="GeneID:500442"
                     /db_xref="RGD:1565671"
     exon            1..137
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            138..170
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            171..269
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            270..350
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..477
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..626
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..746
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..806
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..941
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1026
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1144
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1188
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1436
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1526
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1614
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1694
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1843
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1943
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2129
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2407
                     /gene="Dnai1"
                     /gene_synonym="Dnaic1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgaagtgga agagagtctg catttcctgt gtgtggagaa acttctcccc gggagaggaa
       61 gcgttttgta ggttttgcag ggtttgaggt gctttctaat ttttgcggca atgccctcga
      121 aacagattcg taagcagagt gtcattttga ccagaggagc caggaagcga gaggaagact
      181 cagggactga tgtgggagaa ggagccgatg actgggccca atccaaagcc gctgtgcggc
      241 cccctgacca gctggagctg actgacgcgg agttaaagga ggagttcact cggatcctga
      301 cagcaaacaa cccacatgca ccccagaata ttgtcaggta cagcttcaaa gaacgcacat
      361 acaagcttat tggttttgtg aaccaaatgg caattcactt cagtcaggtg gggaacctga
      421 tacccaaaga ctcagatgaa ggccgtcgac agcactaccg tgatgagctg gtggcaggtt
      481 cacaggagtc agtcaaggtg gtgacttcag acacagaaat ccttgaagaa gaggaagaac
      541 ccaaagaagg agaaggagaa ggagaaggag aagcagaagg agaagcagaa gctgggagcc
      601 aaacggacgt acctgctgca gccgagacga ctgaaaaggt gattgaagaa gaactgatgg
      661 ctcctgtgca gcccaaggag cgaaaactca cgaaccagtt taacttcagc gagcgagcat
      721 ctcagacctt caacaaccct ctccgggatc gagaatgtca gatggagcct ccacctcgga
      781 caaacttttc agccacagcc aatcagtggg agatctatga tgcctatgta gatgagctcg
      841 agaaactgga aaagaccaaa gagaaggaga agaccaagac tccagtggct aagaaaacag
      901 agaagatggc catgaggaaa ctaacatcta tggagtctca gagtgatgat atcaccaaag
      961 tgacccaagc tgctaaaatc gtggagcgaa tggtcaacca aaatacatac gatgatgtcg
     1021 ctcaagattt taagtactat gaggatgctg ctgatgaata cagggaccag gagggtacgc
     1081 tgctgcctct ctggaagttt caaaatgaca aagccaagcg cctggccgtc accgccctct
     1141 gctggaatcc aaagtacaag gatctttttg ctgtgggaca tggctcctat gacttcatga
     1201 aacagagtcg gggcatgctg ctgctctaca gtatgaagaa ccctagtttc cctgagtaca
     1261 tgttcagcag tgagagcggc atcatgtgtc tggacatgca tatggaccac ccctacctgg
     1321 tggtcgtggg ctactatgac ggcaacgtgg ccatctacaa cctcaagaag cctcactcac
     1381 agccctgctt ccgcagcacc tccaagtctg gcaagcacac ggaccctgta tggcaggtca
     1441 aatggcagaa ggatgacatg gaccacaacc ttaacttctt ttctgtgtca tctgatggca
     1501 ggatcgtgtc atggaccctt gtaaagagcg agctggtcca catcgatgtt atcaagctga
     1561 aggacgaagg cagcactaca gaaatccctg aggggctgca gctgcacact gtaggctgtg
     1621 gcactgcctt tgacttccac aaagagattg actatctgtt cctcgtgggc acagaagagg
     1681 ggaaaatcta caagtgctcc aaatcctact ccagccagtt cttggacacc tatgatgctc
     1741 acaacatggc agtagacgct gtgttatgga acccatacca cgccagggtc ttcatatctt
     1801 gcagttctga ctggacagtg aagatctggg accacgccat caagaccccc atgttcatct
     1861 atgatctgaa cgcagctgtg ggtgacgtgg cctgggcacc gtactcttcc actgtgtttg
     1921 cagcagtcac cacggatggg aaggcccacg tgtttgactt ggctgtcaac aagtatgaag
     1981 ccatctgcaa ccagcctgtg gtggccaaga agaagaacaa gattacccat gtgcagttca
     2041 accccattca ccccatcata atagtgggcg atgaccgtgg acacatcacc tgtctcaagc
     2101 tctctcccaa cttacgaaag atgccgaagg agaagaaggg gcaggaagtg cagaagggtc
     2161 cagctgtgga gatcgcaaaa ttggacaaac tgctaaacct tgtgagggaa gtaaaaacca
     2221 aaacctgagt ctggcccagg ccctgccccg ggttccgaac ccaatacaag caaagacgtg
     2281 cctcaccgtg agcaatccca gtatttactc ctctcgttct ggctcttaag gtcaccacct
     2341 ttctccatga tttgaccctc agccgtcatt atgccctctg cgcaaataaa ggccaactgg
     2401 atgctcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
