LOCUS       NM_001134857            3417 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus dynein, axonemal, assembly factor 5 (Dnaaf5),
            mRNA.
ACCESSION   NM_001134857 XM_001055205
VERSION     NM_001134857.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3417)
  AUTHORS   Diggle,C.P., Moore,D.J., Mali,G., zur Lage,P., Ait-Lounis,A.,
            Schmidts,M., Shoemark,A., Garcia Munoz,A., Halachev,M.R.,
            Gautier,P., Yeyati,P.L., Bonthron,D.T., Carr,I.M., Hayward,B.,
            Markham,A.F., Hope,J.E., von Kriegsheim,A., Mitchison,H.M.,
            Jackson,I.J., Durand,B., Reith,W., Sheridan,E., Jarman,A.P. and
            Mill,P.
  TITLE     HEATR2 plays a conserved role in assembly of the ciliary motile
            apparatus
  JOURNAL   PLoS Genet 10 (9), e1004577 (2014)
   PUBMED   25232951
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3417)
  AUTHORS   Horani,A., Druley,T.E., Zariwala,M.A., Patel,A.C., Levinson,B.T.,
            Van Arendonk,L.G., Thornton,K.C., Giacalone,J.C., Albee,A.J.,
            Wilson,K.S., Turner,E.H., Nickerson,D.A., Shendure,J., Bayly,P.V.,
            Leigh,M.W., Knowles,M.R., Brody,S.L., Dutcher,S.K. and Ferkol,T.W.
  TITLE     Whole-exome capture and sequencing identifies HEATR2 mutation as a
            cause of primary ciliary dyskinesia
  JOURNAL   Am J Hum Genet 91 (4), 685-693 (2012)
   PUBMED   23040496
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Sep 10, 2008 this sequence version replaced XM_001055205.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2024863.1,
                                           SRR26643294.45792.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-583               JAXUCZ010000012.1  20605898-20606480   c
            584-768             JAXUCZ010000012.1  20605032-20605216   c
            769-893             JAXUCZ010000012.1  20603697-20603821   c
            894-1012            JAXUCZ010000012.1  20603105-20603223   c
            1013-1245           JAXUCZ010000012.1  20594395-20594627   c
            1246-1458           JAXUCZ010000012.1  20592929-20593141   c
            1459-1602           JAXUCZ010000012.1  20588913-20589056   c
            1603-1771           JAXUCZ010000012.1  20585165-20585333   c
            1772-1919           JAXUCZ010000012.1  20581537-20581684   c
            1920-2070           JAXUCZ010000012.1  20577902-20578052   c
            2071-2227           JAXUCZ010000012.1  20573250-20573406   c
            2228-2419           JAXUCZ010000012.1  20569810-20570001   c
            2420-3417           JAXUCZ010000012.1  20567482-20568479   c
FEATURES             Location/Qualifiers
     source          1..3417
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..3417
                     /gene="Dnaaf5"
                     /gene_synonym="Heatr2"
                     /note="dynein, axonemal, assembly factor 5"
                     /db_xref="GeneID:304332"
                     /db_xref="RGD:1566028"
     CDS             1..2556
                     /gene="Dnaaf5"
                     /gene_synonym="Heatr2"
                     /note="HEAT repeat-containing protein 2; HEAT repeat
                     containing 2; dynein assembly factor 5, axonemal"
                     /codon_start=1
                     /product="dynein axonemal assembly factor 5"
                     /protein_id="NP_001128329.1"
                     /db_xref="GeneID:304332"
                     /db_xref="RGD:1566028"
                     /translation="MAAPAEAEVAAGFAEADEAAELTRALGRLLPGLETESKLGRRRA
                     LEALEHALEEAVRPGTDSAAFQGPWARLLLPRLLRLLTDPAEGCRALAAHLLDLGLRR
                     AARPRDALPRLLPALTARLARPESTRPPPEPCEELRLALVQLLHLAVDLGGAALAPHL
                     DDAVRALRGALLDPFAAVRREGCECAAALARAIPEHFHMQSESLIGPLMQTISHQHWK
                     VRVAVIEATGTVIQFGNGNSVDDVLSHFAQRLFDDVPQVRQAVTSVVGGWLLNLRDRY
                     SFFHKLTPLLLSSFSDEMPEVRQTATSLWEKVGLQWQEENEADLKDKLDFASPPPPNY
                     PEHESRPGLGCRELVFRNLSKVLPAICHDITDWVVGTRLKAAQLLPVLLLHAEDHITQ
                     HLEIVLRTLHQACTDEEKAVVSSCVRAAELIGTFVSPEVFLKLILAMLKKAPSASGLL
                     ILASVIRGCPRNALQPHLKVIATELAQEHICQGSENNSYLEHLLLCVQTLLSVCQEDC
                     CAASLQLSEVLVTIMAVSDAVSLEKKAQKTMDTLAEVEDIPSSQDLYRKHLGALLERL
                     TASHGEWTVHSVQLLKFTVLLTQAGPAVGEALQHVIPTLRACLQPTTDPHMRLKLFSI
                     LSSLLLRPKDTVDSQGQFHGYLDMVINDILAPNLQWHAGRTAAAIRTATISCLWALIS
                     SDILSAKQVQEAQETLMPQVLATLEDDSQTTRLISCRIISRFLKNSGDTMEPEKFLKV
                     YPELLKRLDDVSNDVRMAAASALLTWLKCIESVDGKSAYQSSVQFLYRELLVHLDDPE
                     SAIQDTVLEVLKEGSVLFPDVLVRETEAVVHKHRSATYCEQLLQHMQTMAAAR"
     exon            1..583
                     /gene="Dnaaf5"
                     /gene_synonym="Heatr2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..768
                     /gene="Dnaaf5"
                     /gene_synonym="Heatr2"
                     /inference="alignment:Splign:2.1.0"
     exon            769..893
                     /gene="Dnaaf5"
                     /gene_synonym="Heatr2"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1012
                     /gene="Dnaaf5"
                     /gene_synonym="Heatr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1245
                     /gene="Dnaaf5"
                     /gene_synonym="Heatr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1458
                     /gene="Dnaaf5"
                     /gene_synonym="Heatr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1602
                     /gene="Dnaaf5"
                     /gene_synonym="Heatr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1771
                     /gene="Dnaaf5"
                     /gene_synonym="Heatr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1919
                     /gene="Dnaaf5"
                     /gene_synonym="Heatr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2070
                     /gene="Dnaaf5"
                     /gene_synonym="Heatr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2227
                     /gene="Dnaaf5"
                     /gene_synonym="Heatr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2419
                     /gene="Dnaaf5"
                     /gene_synonym="Heatr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..3417
                     /gene="Dnaaf5"
                     /gene_synonym="Heatr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcggcgc cggcggaggc ggaggtggcc gcgggcttcg ccgaggcgga tgaagcagcg
       61 gaactgaccc gcgcgctagg tcgtctgtta ccgggactgg agaccgaaag taagctgggg
      121 cggcggcgcg cgctggaagc tctggagcac gcactggaag aggcggtgcg gcccggaacg
      181 gattccgctg ccttccaggg cccatgggct cgtctgctgc tgcctcgcct gctgcgactt
      241 ctgaccgacc cagccgaggg ctgccgcgcg ctggctgctc acctgctgga cttaggcctt
      301 cgccgtgccg cgcggccccg cgatgctctg ccgcgcctgt tgcccgcgct caccgcacgc
      361 cttgcccgac cagaatccac gcggccaccg cctgaaccct gcgaagagct gcgtcttgcc
      421 ctcgtgcaac tgcttcacct ggccgtggac ctgggcggcg ccgcgctcgc gccccacctg
      481 gacgacgcgg tgcgcgcgtt gcggggtgcg ctgctcgacc ccttcgccgc ggtgcgccgg
      541 gagggttgcg agtgcgcagc cgctctggcg cgtgccattc cggagcactt ccacatgcag
      601 tcggagtccc tcataggccc cctgatgcag accatctccc accagcactg gaaggtccgg
      661 gtagctgtca tcgaagccac aggcactgta atccagtttg gcaatgggaa ttcggtggat
      721 gatgttcttt cccactttgc tcaaagactc ttcgatgatg tccctcaggt ccggcaggca
      781 gtgacctcgg tggtgggggg atggctgctc aatctccgtg accgatactc cttctttcac
      841 aaactcaccc cactgttact cagcagcttc agtgacgaaa tgcctgaggt ccgacagaca
      901 gccaccagcc tctgggagaa ggtcgggctg cagtggcagg aggaaaatga ggcagatcta
      961 aaggacaagc tggactttgc ttcacctcct cctcctaact accctgagca cgagagccgt
     1021 cctggcctgg gctgccgaga gctggtcttc aggaacctct ccaaggtgct tcctgccatc
     1081 tgtcacgata tcaccgactg ggtggtgggg acccggctga aggcagcgca gctgctgccg
     1141 gtgctgctgc tgcatgcaga ggaccacatc acacagcacc tggagatcgt cctcagaacc
     1201 ctgcatcagg cgtgcaccga tgaggagaag gctgtggtca gcagctgcgt gagagccgca
     1261 gagctcattg gcaccttcgt cagcccagaa gtatttctga aactgatctt agccatgctg
     1321 aagaaagcac cctcggcctc tggcctcttg atccttgctt ctgtcatccg aggctgtccc
     1381 cgcaatgccc ttcagccaca cctcaaggtc atagccacag agctggccca ggagcacatc
     1441 tgccaggggt ctgagaataa tagctacctg gagcatctgc tgctgtgtgt gcagactctg
     1501 ctgtctgtgt gtcaggaaga ctgctgtgct gccagcctgc agctctcgga ggtgctggtg
     1561 acaataatgg cagtctcaga tgccgtgagt cttgagaaga aggctcagaa gaccatggac
     1621 accctggctg aggtggagga tatccccagc agtcaggacc tctaccgcaa gcatctgggt
     1681 gcactactgg aacggctgac agcctctcat ggcgagtgga cggtgcactc tgtgcagctg
     1741 ctgaagttca ctgtgctcct cacccaggca ggcccagctg tgggagaggc tctgcagcat
     1801 gtgatcccca ctctcagggc ctgtctccag cccaccacag acccacacat gcgcctgaag
     1861 ctcttctcta tcctgtcttc attgctgctg aggcctaagg acaccgtcga ctctcaggga
     1921 cagttccatg gctacttgga tatggtaata aatgacatcc tagcccccaa cctacagtgg
     1981 catgcaggca ggacagctgc agccatccgg acggccacca tatcctgtct gtgggcactt
     2041 atcagcagtg acatcttatc ggccaagcag gttcaagagg cacaggagac cctgatgcca
     2101 caagtgctgg ccacgctgga ggacgactcc cagaccacac gcctgatctc ctgccgtatc
     2161 atcagcaggt tcctcaagaa ctcaggggat accatggagc cagagaaatt tctcaaggtc
     2221 tatcctgagc tcttgaagcg cctagatgat gtctccaatg acgtgagaat ggcagctgct
     2281 tccgccttgc tcacctggct gaagtgcatt gagagcgtgg atgggaaatc cgcctatcag
     2341 agcagcgttc agttcctgta cagggagctg ctggtccacc tggatgaccc agaaagtgcc
     2401 atccaagaca ctgtgctaga agtcctcaag gagggcagcg tcctgtttcc agatgtgctg
     2461 gtgcgggaga cggaggctgt tgtccacaaa caccgctcag ctacctactg cgagcagctg
     2521 ctgcagcata tgcaaaccat ggctgccgct cggtgaccat gcacatcagc cactgaagga
     2581 agacagcggt acccagagac cccgcattta agacagccgt gtccacagcc tcaggatccc
     2641 accagccacc agatggtgct tgagcatcag cttctgtttt tcctaagcag attctgggat
     2701 tttgtaacat gcctactttt cacagaggcc tcagaaagct aaaattaaat ttaaatgccc
     2761 ccacccacgc cagcttccca attagctgct tgaacataat gtttttatca caggccccga
     2821 ggggtcctgg gctgcttcag attcacatgc aggaaagcca actcgattgt aaaaacaacc
     2881 aaccatcctc tcctttgggc tctgctccat cagcctgtga cgaagacaat gtcagtcttg
     2941 actcgctgat aaaatttctc caaatttttt ggggttttga caccgggttt ctctgtgagc
     3001 ctttggctat tctggaactc actctgtaga ccagtctggc cttgaactct cagagatccg
     3061 cctgcctctt cctcccaagt actgggatta aaggcctgta ccactaccac ccggctcctt
     3121 taaaatacac tggaatgtct tgcaatgtgg gtgcaatgtc ctggtgttgt ttctcagtgt
     3181 tagtgatgcc cgtgggtaaa ggatagacag gaaaccagcc ttcatcccta ccacttgctt
     3241 atagcagtca gtaggtggtc attctccagt gtcttttcca ccaagtgcct aaaagatgtt
     3301 taaatggttg ttatcagcag ccaatatttt tgttaagata atgttggggg gcgagtttcc
     3361 aacaaatttt aacatttctg ctttgccttt tatggaatta aattattctt gcagtta
//
