LOCUS       NM_001007010            2012 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus dynein axonemal assembly factor 4 (Dnaaf4), mRNA.
ACCESSION   NM_001007010 XM_343428
VERSION     NM_001007010.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2012)
  AUTHORS   Rendall,A.R., Tarkar,A., Contreras-Mora,H.M., LoTurco,J.J. and
            Fitch,R.H.
  TITLE     Deficits in learning and memory in mice with a mutation of the
            candidate dyslexia susceptibility gene Dyx1c1
  JOURNAL   Brain Lang 172, 30-38 (2017)
   PUBMED   25989970
REFERENCE   2  (bases 1 to 2012)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   3  (bases 1 to 2012)
  AUTHORS   Tarkar,A., Loges,N.T., Slagle,C.E., Francis,R., Dougherty,G.W.,
            Tamayo,J.V., Shook,B., Cantino,M., Schwartz,D., Jahnke,C.,
            Olbrich,H., Werner,C., Raidt,J., Pennekamp,P., Abouhamed,M.,
            Hjeij,R., Kohler,G., Griese,M., Li,Y., Lemke,K., Klena,N., Liu,X.,
            Gabriel,G., Tobita,K., Jaspers,M., Morgan,L.C., Shapiro,A.J.,
            Letteboer,S.J., Mans,D.A., Carson,J.L., Leigh,M.W., Wolf,W.E.,
            Chen,S., Lucas,J.S., Onoufriadis,A., Plagnol,V., Schmidts,M.,
            Boldt,K., Roepman,R., Zariwala,M.A., Lo,C.W., Mitchison,H.M.,
            Knowles,M.R., Burdine,R.D., Loturco,J.J. and Omran,H.
  CONSRTM   UK10K
  TITLE     DYX1C1 is required for axonemal dynein assembly and ciliary
            motility
  JOURNAL   Nat Genet 45 (9), 995-1003 (2013)
   PUBMED   23872636
REFERENCE   4  (bases 1 to 2012)
  AUTHORS   Szalkowski,C.E., Booker,A.B., Truong,D.T., Threlkeld,S.W.,
            Rosen,G.D. and Fitch,R.H.
  TITLE     Knockdown of the candidate dyslexia susceptibility gene homolog
            dyx1c1 in rodents: effects on auditory processing, visual
            attention, and cortical and thalamic anatomy
  JOURNAL   Dev Neurosci 35 (1), 50-68 (2013)
   PUBMED   23594585
  REMARK    GeneRIF: Study describes the impact of Dyx1c1 on behavioral
            functions similar to those affected in language-impaired
            populations as well as information about changes to the brain
            following early disruption of this candidate dyslexia
            susceptibility gene
REFERENCE   5  (bases 1 to 2012)
  AUTHORS   Hoh,R.A., Stowe,T.R., Turk,E. and Stearns,T.
  TITLE     Transcriptional program of ciliated epithelial cells reveals new
            cilium and centrosome components and links to human disease
  JOURNAL   PLoS One 7 (12), e52166 (2012)
   PUBMED   23300604
REFERENCE   6  (bases 1 to 2012)
  AUTHORS   Szalkowski,C.E., Hinman,J.R., Threlkeld,S.W., Wang,Y., LePack,A.,
            Rosen,G.D., Chrobak,J.J., LoTurco,J.J. and Fitch,R.H.
  TITLE     Persistent spatial working memory deficits in rats following in
            utero RNAi of Dyx1c1
  JOURNAL   Genes Brain Behav 10 (2), 244-252 (2011)
   PUBMED   20977651
  REMARK    GeneRIF: These results provide further support for the role of
            Dyx1c1 in neuronal migration and working memory
REFERENCE   7  (bases 1 to 2012)
  AUTHORS   Currier,T.A., Etchegaray,M.A., Haight,J.L., Galaburda,A.M. and
            Rosen,G.D.
  TITLE     The effects of embryonic knockdown of the candidate dyslexia
            susceptibility gene homologue Dyx1c1 on the distribution of
            GABAergic neurons in the cerebral cortex
  JOURNAL   Neuroscience 172, 535-546 (2011)
   PUBMED   21070838
  REMARK    GeneRIF: Transfection with Dyx1c1 small hairpin shRNA results from
            both cell autonomous and non-cell autonomous effects.  There is no
            evidence to support non-cell autonomous disruption of neuronal
            position in the cerebral cortex itself.
REFERENCE   8  (bases 1 to 2012)
  AUTHORS   Massinen,S., Tammimies,K., Tapia-Paez,I., Matsson,H.,
            Hokkanen,M.E., Soderberg,O., Landegren,U., Castren,E.,
            Gustafsson,J.A., Treuter,E. and Kere,J.
  TITLE     Functional interaction of DYX1C1 with estrogen receptors suggests
            involvement of hormonal pathways in dyslexia
  JOURNAL   Hum Mol Genet 18 (15), 2802-2812 (2009)
   PUBMED   19423554
  REMARK    GeneRIF: DYX1C1 comlexes with ERalpha or ERbeta at endogenous
            levels along neurites of primary rat hippocampal neurons.
REFERENCE   9  (bases 1 to 2012)
  AUTHORS   Wang,Y., Paramasivam,M., Thomas,A., Bai,J., Kaminen-Ahola,N.,
            Kere,J., Voskuil,J., Rosen,G.D., Galaburda,A.M. and Loturco,J.J.
  TITLE     DYX1C1 functions in neuronal migration in developing neocortex
  JOURNAL   Neuroscience 143 (2), 515-522 (2006)
   PUBMED   16989952
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY428506.1.
            
            On Nov 22, 2004 this sequence version replaced XM_343428.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY428506.1, BC085838.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2012
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2012
                     /gene="Dnaaf4"
                     /gene_synonym="Dyx1c1; Edem2; Ekn1"
                     /note="dynein axonemal assembly factor 4"
                     /db_xref="GeneID:363096"
                     /db_xref="RGD:1549760"
     exon            1..213
                     /gene="Dnaaf4"
                     /gene_synonym="Dyx1c1; Edem2; Ekn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1353
                     /gene="Dnaaf4"
                     /gene_synonym="Dyx1c1; Edem2; Ekn1"
                     /note="dyslexia susceptibility 1 candidate gene 1 protein
                     homolog; dyslexia susceptibility 1 candidate 1 homolog;
                     dynein assembly factor 4, axonemal"
                     /codon_start=1
                     /product="dynein axonemal assembly factor 4"
                     /protein_id="NP_001007011.1"
                     /db_xref="GeneID:363096"
                     /db_xref="RGD:1549760"
                     /translation="MPVRVSEFSWQQTPAALFLSLPLRGVCVRDADVFCGESYLKVNF
                     PPFLFEVFLYAPIDDGKSKAKIGNDTILFTLYKKEPVLWESLSMPGVDKEMMQRIREK
                     SILQAQEKAKEATEAKAAAKREDQRYALGEMMKIEEEERKKIEDMKENERKKATRELE
                     AWKECQKKADGQKRVQRKEKPLQGKQAEERGALKPQSLPRKAPPTRLPTRGRNWENIF
                     SEKLKEDRVPAPRSAGSIQISFTPRVFPTALRESQVAEEEEWLHKQAEARRAMSTDLP
                     EFSDLKEEEKNPDWLKDKGNKLFATENYLAAIDAYNLAIRLNRKIPVLYLNRAACHLK
                     LKNLHKAIEDSSKALELLTPPVADNANARMKAHVRRGTAFCQLELYVEGLQDYEAALK
                     IDPANTVVQNDAEKIRNIIQGTTLKSHD"
     exon            214..361
                     /gene="Dnaaf4"
                     /gene_synonym="Dyx1c1; Edem2; Ekn1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..495
                     /gene="Dnaaf4"
                     /gene_synonym="Dyx1c1; Edem2; Ekn1"
                     /inference="alignment:Splign:2.1.0"
     exon            496..721
                     /gene="Dnaaf4"
                     /gene_synonym="Dyx1c1; Edem2; Ekn1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..867
                     /gene="Dnaaf4"
                     /gene_synonym="Dyx1c1; Edem2; Ekn1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..977
                     /gene="Dnaaf4"
                     /gene_synonym="Dyx1c1; Edem2; Ekn1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1131
                     /gene="Dnaaf4"
                     /gene_synonym="Dyx1c1; Edem2; Ekn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1237
                     /gene="Dnaaf4"
                     /gene_synonym="Dyx1c1; Edem2; Ekn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1999
                     /gene="Dnaaf4"
                     /gene_synonym="Dyx1c1; Edem2; Ekn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagtgatggt agcctcgcaa tccccgcttc cctagcaacc taattggctc cttagcgacg
       61 tgaagtggct gtgcagtcct tggtcccgcc atgccggtgc gagtgagcga gttcagctgg
      121 cagcagacac cggccgcact cttcctgtcg ctgcctctac ggggcgtctg cgtgcgcgat
      181 gctgatgtgt tctgtgggga aagttacctg aaggttaact ttcctccatt tttatttgag
      241 gtgtttctct atgctcccat agatgatggg aagagcaaag ccaagattgg aaatgacacg
      301 attctcttca cattgtataa aaaggagcca gttctgtggg agagcctttc tatgccaggc
      361 gttgataaag agatgatgca gagaataaga gaaaaatcta tcttgcaagc acaggagaaa
      421 gcaaaagagg ctacagaagc gaaagctgct gccaagcgag aagatcagag atacgcccta
      481 ggcgagatga tgaagattga agaggaagag aggaaaaaaa tagaagatat gaaagaaaat
      541 gaacggaaaa aagcaaccag agaattagaa gcgtggaaag aatgccaaaa gaaagctgac
      601 ggacaaaaac gagtccagag gaaggagaaa ccgctacagg gaaagcaagc tgaagagagg
      661 ggagcactaa aacctcagag tttgccccgg aaggccccgc ccactcgcct ccccacaaga
      721 gggaggaatt gggaaaacat attctctgag aagttaaagg aagacagggt ccctgcacct
      781 cgctctgctg gcagcattca gatcagcttt acccctcgag tgttcccaac cgctctacgg
      841 gaatcccaag ttgcagaaga ggaagagtgg ctgcataaac aagcagaggc ccggagagcc
      901 atgagcactg atcttccgga attttctgac ttaaaagaag aagagaagaa tccagactgg
      961 ttgaaagaca agggaaacaa attgtttgca acagaaaact acttggcagc gattgacgcc
     1021 tataatttag ccatacgatt gaaccgtaag atcccagtac tgtatttgaa tcgggctgct
     1081 tgccacctca agttaaaaaa cttacacaag gccattgagg actcttctaa ggcactagaa
     1141 ttattgacac cacctgttgc cgacaatgcc aatgcaagaa tgaaggcaca tgtccgacga
     1201 gggacagcat tctgccaact agaattgtat gttgaaggct tgcaagatta tgaagctgca
     1261 cttaagatcg acccagccaa cacagttgta cagaatgatg ccgagaagat tcggaatata
     1321 attcaaggga caacactgaa gtctcatgac tagatagata cagctcggta tagcagtccc
     1381 tgcacgtact ctagctctgt aaagcagtgt tagagattct ttgcaatggc agtgcttgag
     1441 ggatcatttc caaggtaaaa actatctctc acggcctttg atcccagtac tgggaaggca
     1501 gaggtaggca ggtctctgtg agcttgaggc cagccagagc tacactgcga gatcctgttt
     1561 caaagtacaa aagaaagcac agagaagggg ccatgtgaat cttcagtctt aggacagggc
     1621 tttgacgttg ctgttctgaa ccgcctgtgc ctgtccttgg aattaagctg ttggcatttc
     1681 caggatacta tggaggaatc aacaggatag aatttccaca tataagattg tgcttataaa
     1741 gtattttatt atattaaata tagtatttca ttctgaatga ttggctttgg tatagacaat
     1801 ttttagtcac ttacagatac acataatcgt attttgttct ttatattatt tgttgttttc
     1861 gtctagacca gttacagtgt aatatgtatt gcataccaac cctgggtctt ctgggtaaaa
     1921 agatgtagaa tgccaggcta gcctgggcaa catagtgaaa ttgtctcacg aaaaagtgaa
     1981 gaaataaaca acagaaaaaa aaaaaaaaaa aa
//
