LOCUS       NM_001271115            2160 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus dynein, axonemal, assembly factor 3 (Dnaaf3),
            mRNA.
ACCESSION   NM_001271115 XM_002728666 XM_003753205
VERSION     NM_001271115.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2160)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   2  (bases 1 to 2160)
  AUTHORS   Mitchison,H.M., Schmidts,M., Loges,N.T., Freshour,J., Dritsoula,A.,
            Hirst,R.A., O'Callaghan,C., Blau,H., Al Dabbagh,M., Olbrich,H.,
            Beales,P.L., Yagi,T., Mussaffi,H., Chung,E.M., Omran,H. and
            Mitchell,D.R.
  TITLE     Mutations in axonemal dynein assembly factor DNAAF3 cause primary
            ciliary dyskinesia
  JOURNAL   Nat Genet 44 (4), 381-389,S1-S2 (2012)
   PUBMED   22387996
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Sep 2, 2012 this sequence version replaced
            XM_002728666.1, XM_003753205.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                JAXUCZ010000001.1  78334169-78334241
            74-162              JAXUCZ010000001.1  78334346-78334434
            163-305             JAXUCZ010000001.1  78334768-78334910
            306-399             JAXUCZ010000001.1  78335494-78335587
            400-557             JAXUCZ010000001.1  78337508-78337665
            558-740             JAXUCZ010000001.1  78338044-78338226
            741-866             JAXUCZ010000001.1  78338466-78338591
            867-989             JAXUCZ010000001.1  78338710-78338832
            990-1107            JAXUCZ010000001.1  78339164-78339281
            1108-1219           JAXUCZ010000001.1  78340496-78340607
            1220-1294           JAXUCZ010000001.1  78340761-78340835
            1295-1634           JAXUCZ010000001.1  78340914-78341253
            1635-2160           JAXUCZ010000001.1  78341506-78342031
FEATURES             Location/Qualifiers
     source          1..2160
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2160
                     /gene="Dnaaf3"
                     /note="dynein, axonemal, assembly factor 3"
                     /db_xref="GeneID:100359753"
                     /db_xref="RGD:2323487"
     exon            1..73
                     /gene="Dnaaf3"
                     /inference="alignment:Splign:2.1.0"
     exon            74..162
                     /gene="Dnaaf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1829
                     /gene="Dnaaf3"
                     /note="Dynein assembly factor 3, axonemal"
                     /codon_start=1
                     /product="dynein axonemal assembly factor 3"
                     /protein_id="NP_001258044.1"
                     /db_xref="GeneID:100359753"
                     /db_xref="RGD:2323487"
                     /translation="MTTPAGSGNGFGTVSWWGLSPALDLQAESPPVDPDSQSKTEHKI
                     PELDALLLGSVDGRHMLRTLARAMLWPLRRFNFYVLENNLEAVARHMLIFSLALEEPE
                     KMGLQERSETFLELWGNALLRPSVAAFLRAQASHLSNLVPEPDRLEELLPWLSLRPLK
                     FRERDALEAVFRFWSGGEKGPEVFPMSRLWDSRLRHYLGSRYDARRGVADWDLRMKLH
                     DRGAQVIHFHEFRRWRDTGVAFELRDLSAYHVPNRTMASGRLLSHRGERVAARGYWGD
                     IATGPFVAFGIEADDKSLLRTSNGQPVKTASEITQHNVTELFRDVAAWRGPRAIKGNV
                     EETKSPEPDAPAQEPFTIHFLPLDSSQTLHHKTCYRGRFQLLYVSCGMIHLLSPELGA
                     CVAPGGNLVVELARYLVDLRPKELKAFSDRVVEIAQAAGFAPHTGTKPSETFARFYKL
                     GDSTRGGGDSAVESGPVPSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMS
                     PPEADQAPPLEAMSPPRADQIPPLEAMSPLQAEVVLPLEAISPPQADLAPPPEVISPV
                     QEALAMSSAIAPLKHVT"
     exon            163..305
                     /gene="Dnaaf3"
                     /inference="alignment:Splign:2.1.0"
     exon            306..399
                     /gene="Dnaaf3"
                     /inference="alignment:Splign:2.1.0"
     exon            400..557
                     /gene="Dnaaf3"
                     /inference="alignment:Splign:2.1.0"
     exon            558..740
                     /gene="Dnaaf3"
                     /inference="alignment:Splign:2.1.0"
     exon            741..866
                     /gene="Dnaaf3"
                     /inference="alignment:Splign:2.1.0"
     exon            867..989
                     /gene="Dnaaf3"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1107
                     /gene="Dnaaf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1219
                     /gene="Dnaaf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1294
                     /gene="Dnaaf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1634
                     /gene="Dnaaf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..2160
                     /gene="Dnaaf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgctggctt tcaggagctc agctcaggac cctgtgggag aagggtcacc tacggatatt
       61 tggaagaata aagagcgatg accacgcctg cgggctccgg taacggcttc ggtactgtgt
      121 cctggtgggg cctctcccca gcgctggacc tacaagctga aagtcctcct gtagacccag
      181 attcacagtc aaaaacagag cacaagatcc cagagctgga tgccctgcta ttaggttctg
      241 tggatgggag acacatgctg cggacgctgg ccagggcgat gctctggcct ctcaggaggt
      301 tcaattttta tgtgctggag aataatctgg aagctgtggc ccgacacatg ctgatcttca
      361 gtctagccct agaggagcct gagaagatgg gactccaaga gcggagtgag accttcctgg
      421 agctgtgggg gaacgcgctg ctgcgaccct ccgttgctgc cttcctgcgc gcccaggcta
      481 gtcacctgtc taatctggtt ccggagcctg atcgcctgga ggagttacta ccctggctta
      541 gccttcggcc gctcaagttc cgggagcggg atgccctgga ggctgtgttc cgcttctggt
      601 caggtgggga gaagggaccg gaagtcttcc ccatgagtcg cctttgggac tcgaggttgc
      661 gccactacct gggttcccgc tacgatgccc ggcgtggtgt tgccgactgg gacttgcgta
      721 tgaagctgca tgatcgaggg gctcaagtca tccatttcca tgaattccga cgctggcggg
      781 acactggtgt tgccttcgaa ctcagagact tgagtgctta ccacgtgccc aacaggacca
      841 tggcttccgg tcgcctcctg agccaccgtg gggaacgcgt ggctgcgcgc ggatactggg
      901 gggacatcgc cacggggccc tttgtggctt ttggcattga ggcggacgac aagagtctct
      961 tacggacgag taacggacaa ccggtcaaga ccgcgagcga gatcacgcag cataatgtta
     1021 cagagctgtt ccgagacgtg gccgcctgga ggggcccgag agccattaag gggaacgtgg
     1081 aggagacaaa gtcgccagag ccagatgcac ctgctcaaga acccttcact atccactttc
     1141 tgcctctgga ctcttcgcag actctccatc ataagacttg ctaccggggc cggttccagc
     1201 tcctgtatgt ctcctgtggg atgatccatc ttctcagccc tgagctcggg gcttgcgtgg
     1261 cccctggagg gaacctggtt gtggaattag ctcggtactt ggtggacctg cggcccaagg
     1321 agttgaaagc attctctgac cgtgttgtgg agatagcgca ggcggctggg ttcgcccctc
     1381 atactggaac caaaccctcc gagacctttg cacgcttcta caagttaggg gactctactc
     1441 ggggtggcgg agactcagct gtggaatctg gacccgtgcc ctctaaagtt ctggctccta
     1501 ctccagaatc gataaaccca ccccaggctg accaggcccc atctctagag gtgatgagcc
     1561 ctccaaaggt tgaccagact ccgcctctag aggctatgag cccacccgag gctgaccagg
     1621 cccctcctct agaagcgatg agcccaccca gagctgacca gattccacct ctagaggcga
     1681 tgagcccact tcaggctgag gtagtcctgc ctctagaagc aatcagtcct ccccaagcag
     1741 acctggcccc tcctccggaa gtgataagtc cagtccagga agctttggca atgtcctcgg
     1801 cgattgcacc tctaaaacat gtaacatgaa ccgcggggac caagaatcct acctttaact
     1861 gctgaagcag gctccaggac tgacaccagc tcagcccact gttttactct gcgttccttc
     1921 tcaaccccag tgatataact agaatttcaa attcctttcc ttgaactctc agttctagtc
     1981 ttttttgggg tgtgtgtgtc ttagatcata atctaagatt tatcctgaca agaatcccag
     2041 gccagaggta caaccctggg ctccacatcc tcttttgcct tgggcctttc ttgacatgct
     2101 actgttggag ggacaaggac atatcctccc ttggatgcgg ttcaaataaa gagcgcaggg
//
