LOCUS       NM_001014154            2204 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus dynein, axonemal, assembly factor 1 (Dnaaf1),
            mRNA.
ACCESSION   NM_001014154 XM_341697
VERSION     NM_001014154.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2204)
  AUTHORS   Duquesnoy,P., Escudier,E., Vincensini,L., Freshour,J.,
            Bridoux,A.M., Coste,A., Deschildre,A., de Blic,J., Legendre,M.,
            Montantin,G., Tenreiro,H., Vojtek,A.M., Loussert,C., Clement,A.,
            Escalier,D., Bastin,P., Mitchell,D.R. and Amselem,S.
  TITLE     Loss-of-function mutations in the human ortholog of Chlamydomonas
            reinhardtii ODA7 disrupt dynein arm assembly and cause primary
            ciliary dyskinesia
  JOURNAL   Am J Hum Genet 85 (6), 890-896 (2009)
   PUBMED   19944405
REFERENCE   2  (bases 1 to 2204)
  AUTHORS   Loges,N.T., Olbrich,H., Becker-Heck,A., Haffner,K., Heer,A.,
            Reinhard,C., Schmidts,M., Kispert,A., Zariwala,M.A., Leigh,M.W.,
            Knowles,M.R., Zentgraf,H., Seithe,H., Nurnberg,G., Nurnberg,P.,
            Reinhardt,R. and Omran,H.
  TITLE     Deletions and point mutations of LRRC50 cause primary ciliary
            dyskinesia due to dynein arm defects
  JOURNAL   Am J Hum Genet 85 (6), 883-889 (2009)
   PUBMED   19944400
REFERENCE   3  (bases 1 to 2204)
  AUTHORS   van Rooijen,E., Giles,R.H., Voest,E.E., van Rooijen,C.,
            Schulte-Merker,S. and van Eeden,F.J.
  TITLE     LRRC50, a conserved ciliary protein implicated in polycystic kidney
            disease
  JOURNAL   J Am Soc Nephrol 19 (6), 1128-1138 (2008)
   PUBMED   18385425
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079038.1.
            
            On Apr 20, 2005 this sequence version replaced XM_341697.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079038.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2204
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2204
                     /gene="Dnaaf1"
                     /gene_synonym="Lrrc50; RGD1310542"
                     /note="dynein, axonemal, assembly factor 1"
                     /db_xref="GeneID:361419"
                     /db_xref="RGD:1310542"
     exon            1..169
                     /gene="Dnaaf1"
                     /gene_synonym="Lrrc50; RGD1310542"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1965
                     /gene="Dnaaf1"
                     /gene_synonym="Lrrc50; RGD1310542"
                     /note="leucine-rich repeat-containing protein 50; dynein
                     assembly factor 1, axonemal; leucine rich repeat
                     containing 50"
                     /codon_start=1
                     /product="dynein axonemal assembly factor 1"
                     /protein_id="NP_001014176.1"
                     /db_xref="GeneID:361419"
                     /db_xref="RGD:1310542"
                     /translation="MHPEASEPPVDSAAEPSLEESAGDHGDAGPGVRKEEINETKETC
                     VGPCTTSCQSQQQPSGDNGSDGLFTHSRDDRDDRGPRMTKQFLQKLCKQHKLYVTPAL
                     NDTLYLHFKGFDRIENLEEYTGLRCLWLECNGIQRIENLQAQSELRCLFLQVNLLHKI
                     ENLEPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNRLETVADIEHLRECLQLCV
                     LDLSHNSLSDPEILSVLETMPCLRVLNLMGNPVTKHIPNYRRTVTVRLKHLTYLDDRP
                     VFPKDRACAEAWARGGYAAEKEERHQWESREHKKITDSLEALAMIKRRAEERKKARDR
                     GETPLPESEKSIPTSPEAQEKPPKGETQQKMESFVKESFEAKDELFPEKPGEGEELSV
                     VVGNRAVEDADLSGNLAHTQTPVVVTPEEVTSPVEATDGARTEDTEAIALETKEKLFI
                     DDLPDLEDVDGTDVSVEDQTKDTGIRKIQAISSLSDDSDLELEELPLSVFEGTPISPT
                     GALSHIFAVSKDPSEAARVPFADICMPTATTDLETQSQDPSTASSHPLIQELGEDELT
                     EGESNQPLPPQSCASDPTLAQSSEGGDSQLPAATPLGDGAENEAQSSLYPEEPSTRIG
                     LEDIEFGLD"
     exon            170..305
                     /gene="Dnaaf1"
                     /gene_synonym="Lrrc50; RGD1310542"
                     /inference="alignment:Splign:2.1.0"
     exon            306..397
                     /gene="Dnaaf1"
                     /gene_synonym="Lrrc50; RGD1310542"
                     /inference="alignment:Splign:2.1.0"
     exon            398..619
                     /gene="Dnaaf1"
                     /gene_synonym="Lrrc50; RGD1310542"
                     /inference="alignment:Splign:2.1.0"
     exon            620..786
                     /gene="Dnaaf1"
                     /gene_synonym="Lrrc50; RGD1310542"
                     /inference="alignment:Splign:2.1.0"
     exon            787..908
                     /gene="Dnaaf1"
                     /gene_synonym="Lrrc50; RGD1310542"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1066
                     /gene="Dnaaf1"
                     /gene_synonym="Lrrc50; RGD1310542"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1324
                     /gene="Dnaaf1"
                     /gene_synonym="Lrrc50; RGD1310542"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1416
                     /gene="Dnaaf1"
                     /gene_synonym="Lrrc50; RGD1310542"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1476
                     /gene="Dnaaf1"
                     /gene_synonym="Lrrc50; RGD1310542"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1870
                     /gene="Dnaaf1"
                     /gene_synonym="Lrrc50; RGD1310542"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2179
                     /gene="Dnaaf1"
                     /gene_synonym="Lrrc50; RGD1310542"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgttggaca gccaacgacg cggactgtag tactggagcg gagtggcggg gcaaggagcg
       61 agcatgcacc ccgaagcctc agagccgccg gtggacagcg cggcggagcc cagtctggag
      121 gagtccgcag gcgatcacgg cgacgcaggc ccaggggtcc gcaaagaaga aattaatgag
      181 accaaggaaa catgtgtggg tccttgtaca acatcctgcc aaagtcagca gcaaccgagc
      241 ggtgacaatg ggtcagatgg cctctttacc cactcgagag atgacagaga tgatcggggc
      301 cccaggatga cgaagcagtt cctccaaaag ctctgtaagc agcacaagct gtacgtcacc
      361 ccggccctga acgacaccct gtatttgcac tttaagggct ttgaccgcat tgagaacctg
      421 gaggagtaca cgggcctgcg ctgcctctgg ctggagtgca acggcatcca gaggatcgag
      481 aatttgcagg cccagagcga gctgcgctgc ctcttcctgc aagtgaacct gttgcacaag
      541 atcgaaaacc tggagccgct ccagaagctg gacgccctca acctgagcaa caactacatc
      601 aagaccattg agaacctctc ctgtctgccg gtccttaaca ctctgcaaat ggcccacaac
      661 cgcctggaga ccgtggcaga cattgagcac ctcagggagt gtctgcaact ctgtgtcctc
      721 gacctctccc acaactcgct gagtgacccc gagatcctga gcgtgcttga gaccatgccc
      781 tgtctgcgtg tgctgaacct gatggggaac ccagtgacca aacacatccc taactaccgc
      841 aggacggtca ctgtccgact gaagcacttg acttatctgg acgacaggcc ggttttcccc
      901 aaggacaggg cgtgtgcaga ggcctgggcc cgaggcgggt atgctgccga gaaggaagag
      961 cgtcaccagt gggagagcag ggaacacaag aagataacag acagcctgga agccttggcc
     1021 atgatcaagc ggcgggccga ggaacggaag aaggcaagag acagagggga gacacctctg
     1081 ccagagagtg aaaagagtat ccccactagc ccagaggctc aggaaaagcc tcccaagggg
     1141 gaaacccagc agaagatgga gtcgtttgtg aaagagagct ttgaggccaa agatgaactg
     1201 tttccagaga agccaggaga aggagaggag ctgtctgtgg tggtggggaa tagagcagtg
     1261 gaagatgcag acctgtccgg gaacctggct cacacccaga cacctgtggt ggtcacccct
     1321 gaagaggtca catctccagt ggaagctact gatggggcca gaacggaaga cacagaggcc
     1381 attgccctgg agaccaagga gaagcttttc atcgatgacc tgcctgactt ggaagatgtt
     1441 gatggtacag atgtgtctgt ggaagaccag acaaaggaca caggcatccg gaaaatccag
     1501 gccatctcca gcttgagtga cgacagtgac ctggagctgg aggagctgcc cctctccgtg
     1561 ttcgagggca ctcccataag ccccacaggc gccctctcac acatatttgc ggtctccaaa
     1621 gacccctcag aggcagccag ggtgcctttc gcagacatat gtatgccaac agcaacaaca
     1681 gacttagaaa ctcaaagtca agaccccagc acagcatctt cacaccccct catccaggag
     1741 ctcggagagg atgagctgac agagggagag tcaaaccagc cactgccacc ccaaagctgt
     1801 gcaagtgacc ccacacttgc ccagtctagt gaaggtggag acagtcagct gcctgcagcc
     1861 actccactag gagatggagc tgagaatgaa gcacagtctt cgttgtaccc agaggagccc
     1921 agcacccgga taggcctgga agatattgaa tttggcttgg actgaacccc aaggcagtct
     1981 acactgttag tctagcagtg gtgcagcgga tgcagggcac cctcttctat gtatccctgc
     2041 tggtttgctc cggcaccctg catggcaggt gctgtgcagc tacaccagtg tgcctgccgt
     2101 gtacccaaca catcggtttc ccctggttac agatcccacg agaacataaa cacttaagac
     2161 ccgcatggtc agcatgttaa aaaaaaaaaa aaaaaaaaaa aaaa
//
