LOCUS       NM_001389622            3663 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus DNA replication helicase/nuclease 2 (Dna2), mRNA.
ACCESSION   NM_001389622
VERSION     NM_001389622.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3663)
  AUTHORS   Shaheen,R., Faqeih,E., Ansari,S., Abdel-Salam,G., Al-Hassnan,Z.N.,
            Al-Shidi,T., Alomar,R., Sogaty,S. and Alkuraya,F.S.
  TITLE     Genomic analysis of primordial dwarfism reveals novel disease genes
  JOURNAL   Genome Res 24 (2), 291-299 (2014)
   PUBMED   24389050
REFERENCE   2  (bases 1 to 3663)
  AUTHORS   Ronchi,D., Di Fonzo,A., Lin,W., Bordoni,A., Liu,C., Fassone,E.,
            Pagliarani,S., Rizzuti,M., Zheng,L., Filosto,M., Ferro,M.T.,
            Ranieri,M., Magri,F., Peverelli,L., Li,H., Yuan,Y.C., Corti,S.,
            Sciacco,M., Moggio,M., Bresolin,N., Shen,B. and Comi,G.P.
  TITLE     Mutations in DNA2 link progressive myopathy to mitochondrial DNA
            instability
  JOURNAL   Am J Hum Genet 92 (2), 293-300 (2013)
   PUBMED   23352259
REFERENCE   3  (bases 1 to 3663)
  AUTHORS   Heyer,W.D., Ehmsen,K.T. and Liu,J.
  TITLE     Regulation of homologous recombination in eukaryotes
  JOURNAL   Annu Rev Genet 44, 113-139 (2010)
   PUBMED   20690856
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000020.1  25689129-25689285   c
            158-340             JAXUCZ010000020.1  25686677-25686859   c
            341-524             JAXUCZ010000020.1  25685487-25685670   c
            525-670             JAXUCZ010000020.1  25682073-25682218   c
            671-802             JAXUCZ010000020.1  25680937-25681068   c
            803-1022            JAXUCZ010000020.1  25679145-25679364   c
            1023-1140           JAXUCZ010000020.1  25676825-25676942   c
            1141-1303           JAXUCZ010000020.1  25675884-25676046   c
            1304-1495           JAXUCZ010000020.1  25675566-25675757   c
            1496-1726           JAXUCZ010000020.1  25674456-25674686   c
            1727-1843           JAXUCZ010000020.1  25673252-25673368   c
            1844-1953           JAXUCZ010000020.1  25673068-25673177   c
            1954-2063           JAXUCZ010000020.1  25671585-25671694   c
            2064-2288           JAXUCZ010000020.1  25670285-25670509   c
            2289-2482           JAXUCZ010000020.1  25669273-25669466   c
            2483-2572           JAXUCZ010000020.1  25667925-25668014   c
            2573-2771           JAXUCZ010000020.1  25667640-25667838   c
            2772-2861           JAXUCZ010000020.1  25666772-25666861   c
            2862-3044           JAXUCZ010000020.1  25665012-25665194   c
            3045-3191           JAXUCZ010000020.1  25662116-25662262   c
            3192-3663           JAXUCZ010000020.1  25660339-25660810   c
FEATURES             Location/Qualifiers
     source          1..3663
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..3663
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /note="DNA replication helicase/nuclease 2"
                     /db_xref="GeneID:309762"
                     /db_xref="RGD:1306791"
     exon            1..157
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..3260
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /EC_number="3.6.4.12"
                     /note="DNA2-like helicase; DNA2 DNA replication helicase
                     2-like; DNA replication ATP-dependent helicase-like
                     homolog; DNA replication helicase 2 homolog"
                     /codon_start=1
                     /product="DNA replication ATP-dependent helicase/nuclease
                     DNA2"
                     /protein_id="NP_001376551.1"
                     /db_xref="GeneID:309762"
                     /db_xref="RGD:1306791"
                     /translation="MEPLDDLDLLLLEEDSGAEAVPRMEILQKKADAFFAETVLSRGV
                     DNRYLVLAVETKLNERGAEEKHLLITVSQEGEQEVLCILRNGWSSVPVEPGDIIHIEG
                     DCTSEPWIVDDDFGYFILSPDMLISGTSVASSIRCLRRAVLSETFRVSDTATRQMLIG
                     TILHEVFQKAISESFAPEKLQELALQTLREVRHLKEMYRLNLSQDEVRCEVEEYLPSF
                     SKWADEFMHKGTKAEFPQMHLSLPSDSSDRSSPCNIEVVKSLDIEESIWSPRFGLKGK
                     IDVTVGVKIHRDCKTKYKIMPLELKTGKESNSIEHRGQVILYTLLSQERREDPEAGWL
                     LYLKTGQMYPVPANHLDKRELLKLRNQLAFSLLHRVSRAAAGEEARLLALPQIIEEEK
                     TCKYCSQMGNCALYSRAVEQVHDTSIPEGMRSKIQEGTQHLTRAHLKYFSLWCLMLTL
                     ESQSKDTKKSHQSIWLTPASKLEESGNCIGSLVRTEPVKRVCDGHYLHNFQRKNGPMP
                     ATNLMAGDRIILSGEERKLFALSKGYVKRIDTAAVTCLLDRNLSTLPETTLFRLDREE
                     KHGDINTPLGNLSKLMENTDSSKRLRELIIDFKEPQFIAYLSSVLPHDAKDTVANILK
                     GLNKPQRQAMKKVLLSKDYTLIVGMPGTGKTTTICALVRILSACGFSVLLTSYTHSAV
                     DNILLKLAKFKIGFLRLGQSHKVHPDIQKFTEEEMCRLRSIASLAHLEELYNSHPVVA
                     TTCMGISHPMFSRKTFDFCIVDEASQISQPICLGPLFFSRRFVLVGDHKQLPPLVLNR
                     EARALGMSESLFKRLERNESAVVQLTIQYRMNRKIMSLSNKLTYEGKLECGSDRVANA
                     VITLPNLKDVRLEFYADYSDNPWLAGVFEPDNPVCFLNTDKVPAPEQIENGGVSNVTE
                     ARLIVFLTSTFIKAGCSPSDIGIIAPYRQQLRTITDLLARSSVGMVEVNTVDKYQGRD
                     KSLILVSFVRSNEDGTLGELLKDWRRLNVAITRAKHKLILLGSVSSLKRFPPLEKLFD
                     HLNAEQLIRNLPSREHESLYHILGDCQRD"
     exon            158..340
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     exon            341..524
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     exon            525..670
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     exon            671..802
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     exon            803..1022
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1140
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1303
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1495
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1726
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1843
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1953
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2063
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2288
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2482
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2572
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2771
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..2861
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..3044
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     exon            3045..3191
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
     exon            3192..3663
                     /gene="Dna2"
                     /gene_synonym="Dna2l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggctcgt cttagcggcg tgagttgcgg gcgctgtcgc cttacgctgc tgcctgctct
       61 tcaggcgggc ttcagcagga atggagccgc tggacgatct ggacctgctg ctgctggaag
      121 aggacagcgg agcggaggcc gtgccgcgga tggagatact tcagaagaag gcagacgctt
      181 tctttgctga gacagttctg agccgaggag tggataaccg atacctggtg ctagccgttg
      241 agaccaagct gaatgaaaga ggagcagagg agaagcacct actcataact gtgtcccagg
      301 aaggagagca ggaagttctg tgcatcctga ggaatggctg gagttcggta ccagttgagc
      361 caggagacat cattcacatc gagggagact gtacatctga gccgtggata gtagacgatg
      421 actttggcta ttttatcctg tccccggaca tgctgatctc tggcacaagc gtcgccagca
      481 gtattcggtg tctgagaaga gctgtcctga gtgagacttt cagggtctct gatacagcca
      541 ctcgccaaat gctgatcggt acaattctcc acgaagtctt tcaaaaagca ataagtgaga
      601 gctttgctcc agaaaagcta caagagcttg ctcttcaaac tctccgagaa gtaaggcatt
      661 tgaaggaaat gtatcgcttg aatctgagtc aagatgaagt aagatgtgaa gtagaagagt
      721 atctcccctc tttctctaag tgggctgacg agttcatgca taagggcact aaggcagaat
      781 tccctcaaat gcatctctct ctgccaagtg atagcagtga cagaagttca ccttgtaaca
      841 ttgaagtagt caagtcacta gatattgaag aaagcatctg gtccccgagg tttggactga
      901 aaggcaaaat agacgtcacc gttggggtca aaatacatcg agattgtaag acgaaatata
      961 agataatgcc actggagctc aaaactggca aagaatcgaa ttctattgaa caccgaggtc
     1021 aggtgatcct gtacacactg ctaagccagg agagacgaga ggatcctgag gctggctggc
     1081 ttctctatct caagaccggg cagatgtacc ctgtgcccgc caaccatctg gacaaaagag
     1141 aactgctgaa gctcaggaac caactggcct tctctctgct gcaccgagtt agcagagcag
     1201 ctgccgggga ggaagcacgg cttttggcct tgccacaaat aattgaggaa gagaaaacct
     1261 gtaaatattg ttcgcagatg ggcaactgtg ctctttatag cagagcagtt gaacaggtac
     1321 atgacacttc catcccagaa ggcatgcggt ccaaaatcca ggaaggaact cagcacctga
     1381 cgcgggcgca cttgaagtat ttcagcctgt ggtgcctcat gttaacgttg gagtcacaat
     1441 ctaaagatac taagaagagt caccagagca tctggttaac gcctgcgtcc aaactggagg
     1501 agagcggcaa ctgcattgga agcctggtca ggacagagcc tgtaaagcga gtttgtgatg
     1561 gacactactt acataatttt cagcggaaaa atggccccat gcccgccacc aatctgatgg
     1621 caggtgacag aatcatttta agtggagaag agagaaaact gtttgctttg tctaaaggct
     1681 acgtgaagag gattgacaca gcagcggtaa cctgcttgct agacaggaac ctgtcaacac
     1741 ttccagaaac aacattgttt cgattagacc gggaagaaaa acatggtgat ataaatactc
     1801 ccttaggaaa tctgtctaaa ttgatggaaa acacagatag cagcaaaaga cttcgagaac
     1861 taatcattga tttcaaggaa cctcagttta tagcctacct cagctccgtt cttccacacg
     1921 atgcgaagga tacagtggcc aacattctaa agggtttgaa taagcctcag agacaagcaa
     1981 tgaagaaggt tcttctttca aaagactaca cactcattgt cgggatgcca gggacaggaa
     2041 agacaaccac aatatgtgcc cttgtaagga tcctctctgc ctgtggtttc agcgttctgc
     2101 tgaccagtta tacgcactct gccgtggaca atattctctt gaagttagcc aagtttaaaa
     2161 ttggattttt gcgtctgggt cagtctcata aggtccatcc agacatccag aagtttacag
     2221 aggaggagat gtgcagactg aggtccattg cgtccttagc ccatctagaa gaactctata
     2281 atagtcaccc tgtcgttgcc acaacctgca tgggaataag ccacccaatg ttttcccgaa
     2341 aaacctttga tttctgtatt gtggatgaag cctctcaaat cagtcagccc atctgcctgg
     2401 gcccactttt cttttctcgg aggtttgtgt tggtggggga ccataagcaa cttcctcccc
     2461 tggtactgaa ccgggaagca agagctctgg gcatgagcga gagcttgttc aagaggctgg
     2521 agaggaacga gagtgctgtt gtgcagctga cgatacagta caggatgaac aggaagatta
     2581 tgtccttgag caataagctc acgtatgaag ggaaactgga gtgtggatca gaccgagtgg
     2641 ccaacgcagt gataaccctg cccaacctca aggatgtcag gctggagttt tatgccgatt
     2701 attctgataa cccctggctg gctggagtgt ttgagccaga caatcccgtt tgtttcctta
     2761 atacagataa ggtcccagct ccagaacaaa ttgaaaatgg tggcgtgagc aatgtcacag
     2821 aagccagact catcgtcttc ctaacctcaa cttttataaa ggcaggctgc agcccctcgg
     2881 atattggcat catcgccccg taccggcagc agctgcggac catcaccgac ctgctggcac
     2941 ggtcttctgt tgggatggtc gaggttaaca cagtggacaa gtaccaagga agggacaaga
     3001 gtctcatcct ggtgtccttt gttaggagca acgaggatgg aactcttggt gagctcctga
     3061 aagattggcg aagactcaac gtggccataa ccagagccaa acataaactg atcctgctgg
     3121 gcagcgtgtc ctcgctgaag cgctttcccc ctttggagaa gctctttgac catctgaacg
     3181 cagagcagtt aatcaggaac cttccatcaa gagagcacga gagtctgtac cacatcctgg
     3241 gtgactgtca gagagactga agcactgcac tgctacctgc cgttcatggc agtgagggga
     3301 tcacatggcc taagctccag cttagctttg ctgggaatgc cacccttaaa cggaagacga
     3361 cgtttagccg aaaggtacaa aaggacgtga atgtaccttt ctcaaagttc cagatttttc
     3421 tcttctgtta ccaggcgaaa ttctacttta aaagtactga tgtacccaag actgagaagt
     3481 caaaatttgg aaatacttca agtatatctg tgtatggcca agctggggga agtaagattt
     3541 ccacttgaaa aacttggggt ctgtactgta atacctaagg ttctgttaga tctcaaggtc
     3601 aagatctcac aaattagaat ttggggtctg attccagaat tgtaaaaggt cagacagact
     3661 ggc
//
