LOCUS       NP_001101421             536 aa            linear   ROD 31-MAR-2024
DEFINITION  doublesex- and mab-3-related transcription factor A2 [Rattus
            norvegicus].
ACCESSION   NP_001101421 XP_001068179 XP_006238651 XP_233363
VERSION     NP_001101421.2
DBSOURCE    REFSEQ: accession NM_001107951.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 536)
  AUTHORS   Saulnier,A., Keruzore,M., De Clercq,S., Bar,I., Moers,V.,
            Magnani,D., Walcher,T., Filippis,C., Kricha,S., Parlier,D.,
            Viviani,L., Matson,C.K., Nakagawa,Y., Theil,T., Gotz,M.,
            Mallamaci,A., Marine,J.C., Zarkower,D. and Bellefroid,E.J.
  TITLE     The doublesex homolog Dmrt5 is required for the development of the
            caudomedial cerebral cortex in mammals
  JOURNAL   Cereb Cortex 23 (11), 2552-2567 (2013)
   PUBMED   22923088
REFERENCE   2  (residues 1 to 536)
  AUTHORS   Rajan,S., Chu Pham Dang,H., Djambazian,H., Zuzan,H., Fedyshyn,Y.,
            Ketela,T., Moffat,J., Hudson,T.J. and Sladek,R.
  TITLE     Analysis of early C2C12 myogenesis identifies stably and
            differentially expressed transcriptional regulators whose
            knock-down inhibits myoblast differentiation
  JOURNAL   Physiol Genomics 44 (2), 183-197 (2012)
   PUBMED   22147266
REFERENCE   3  (residues 1 to 536)
  AUTHORS   Konno,D., Iwashita,M., Satoh,Y., Momiyama,A., Abe,T., Kiyonari,H.
            and Matsuzaki,F.
  TITLE     The mammalian DM domain transcription factor Dmrta2 is required for
            early embryonic development of the cerebral cortex
  JOURNAL   PLoS One 7 (10), e46577 (2012)
   PUBMED   23056351
REFERENCE   4  (residues 1 to 536)
  AUTHORS   Gennet,N., Gale,E., Nan,X., Farley,E., Takacs,K., Oberwallner,B.,
            Chambers,D. and Li,M.
  TITLE     Doublesex and mab-3-related transcription factor 5 promotes
            midbrain dopaminergic identity in pluripotent stem cells by
            enforcing a ventral-medial progenitor fate
  JOURNAL   Proc Natl Acad Sci U S A 108 (22), 9131-9136 (2011)
   PUBMED   21576465
REFERENCE   5  (residues 1 to 536)
  AUTHORS   Murphy,M.W., Zarkower,D. and Bardwell,V.J.
  TITLE     Vertebrate DM domain proteins bind similar DNA sequences and can
            heterodimerize on DNA
  JOURNAL   BMC Mol Biol 8, 58 (2007)
   PUBMED   17605809
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Dec 3, 2020 this sequence version replaced
            XP_006238651.1, NP_001101421.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.2190896.1,
                                           SRR21887622.2190903.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680422, SAMN06680423
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     Protein         1..536
                     /product="doublesex- and mab-3-related transcription
                     factor A2"
                     /note="doublesex and mab-3 related transcription factor
                     like family A2"
                     /calculated_mol_wt=53024
     Region          65..111
                     /region_name="DM"
                     /note="DM DNA binding domain; pfam00751"
                     /db_xref="CDD:459924"
     Region          311..352
                     /region_name="CUE_DMA_DMRTA2"
                     /note="CUE-like DMA domain found in doublesex- and
                     mab-3-related transcription factor A2 (DMRTA2); cd14418"
                     /db_xref="CDD:270601"
     Region          428..507
                     /region_name="DMRT5_DMB"
                     /note="DMRT5, DMB domain; pfam20624"
                     /db_xref="CDD:466773"
     CDS             1..536
                     /gene="Dmrta2"
                     /coded_by="NM_001107951.2:292..1902"
                     /db_xref="GeneID:313471"
                     /db_xref="RGD:1308173"
ORIGIN      
        1 melrselpsv pgaataaata tgppvasvas vaaaaaaaas lpvsvaggll rapplllraa
       61 ekyprtpkca rcrnhgvvsa lkghkrycrw kdclcakctl iaerqrvmaa qvalrrqqaq
      121 eenearelql lygtaeglal aaangiippr payevfgsvc atdgggpgag apagsaggag
      181 gaggaeaklq kfdlfpktll qagrpdspqp ppgkplspdg adsgpgtssp evrpgsgsen
      241 gdgesfsgsp laraskeagg scpgsagasg ggeedspgss splgsesgse adkeeaeaap
      301 tpglgggpgp rqrtpldilt rvfpghrrgv lelvlqgcgg dvvqaieqvl nhhrgglaag
      361 lgpaapleka avsaaaaved awpgrveaaa aggaglpapl qtgpaapphh rpllagamtp
      421 galgslssrs afsplqpnas hfgadagayp lgaplglspl rlaysaaaah srglafmapy
      481 staglvptlg frppmdyafs dlmrdrsaaa aaavhkepgy ggglygpmvn gtpekq
//
