LOCUS       NM_053706               1415 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus doublesex and mab-3 related transcription factor
            1 (Dmrt1), mRNA.
ACCESSION   NM_053706
VERSION     NM_053706.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1415)
  AUTHORS   Murphy MW, Lee JK, Rojo S, Gearhart MD, Kurahashi K, Banerjee S,
            Loeuille GA, Bashamboo A, McElreavey K, Zarkower D, Aihara H and
            Bardwell VJ.
  TITLE     An ancient protein-DNA interaction underlying metazoan sex
            determination
  JOURNAL   Nat Struct Mol Biol 22 (6), 442-451 (2015)
   PUBMED   26005864
REFERENCE   2  (bases 1 to 1415)
  AUTHORS   Krentz AD, Murphy MW, Zhang T, Sarver AL, Jain S, Griswold MD,
            Bardwell VJ and Zarkower D.
  TITLE     Interaction between DMRT1 function and genetic background modulates
            signaling and pluripotency to control tumor susceptibility in the
            fetal germ line
  JOURNAL   Dev Biol 377 (1), 67-78 (2013)
   PUBMED   23473982
REFERENCE   3  (bases 1 to 1415)
  AUTHORS   Jorgensen A, Nielsen JE, Blomberg Jensen M, Graem N and Rajpert-De
            Meyts E.
  TITLE     Analysis of meiosis regulators in human gonads: a sexually
            dimorphic spatio-temporal expression pattern suggests involvement
            of DMRT1 in meiotic entry
  JOURNAL   Mol Hum Reprod 18 (11), 523-534 (2012)
   PUBMED   22899867
REFERENCE   4  (bases 1 to 1415)
  AUTHORS   Krentz AD, Murphy MW, Sarver AL, Griswold MD, Bardwell VJ and
            Zarkower D.
  TITLE     DMRT1 promotes oogenesis by transcriptional activation of Stra8 in
            the mammalian fetal ovary
  JOURNAL   Dev Biol 356 (1), 63-70 (2011)
   PUBMED   21621532
REFERENCE   5  (bases 1 to 1415)
  AUTHORS   Matson CK, Murphy MW, Sarver AL, Griswold MD, Bardwell VJ and
            Zarkower D.
  TITLE     DMRT1 prevents female reprogramming in the postnatal mammalian
            testis
  JOURNAL   Nature 476 (7358), 101-104 (2011)
   PUBMED   21775990
  REMARK    Erratum:[Nature. 2011 Sep 8;477(7363):238]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1415)
  AUTHORS   Kim S, Bardwell VJ and Zarkower D.
  TITLE     Cell type-autonomous and non-autonomous requirements for Dmrt1 in
            postnatal testis differentiation
  JOURNAL   Dev Biol 307 (2), 314-327 (2007)
   PUBMED   17540358
REFERENCE   7  (bases 1 to 1415)
  AUTHORS   Murphy MW, Zarkower D and Bardwell VJ.
  TITLE     Vertebrate DM domain proteins bind similar DNA sequences and can
            heterodimerize on DNA
  JOURNAL   BMC Mol Biol 8, 58 (2007)
   PUBMED   17605809
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1415)
  AUTHORS   Lei N and Heckert LL.
  TITLE     Sp1 and Egr1 regulate transcription of the Dmrt1 gene in Sertoli
            cells
  JOURNAL   Biol Reprod 66 (3), 675-684 (2002)
   PUBMED   11870074
  REMARK    GeneRIF: Sp1, Sp3, and Egr1 transcription factors play a critical
            role in Dmrt1 regulation in the testis
REFERENCE   9  (bases 1 to 1415)
  AUTHORS   Chen JK and Heckert LL.
  TITLE     Dmrt1 expression is regulated by follicle-stimulating hormone and
            phorbol esters in postnatal Sertoli cells
  JOURNAL   Endocrinology 142 (3), 1167-1178 (2001)
   PUBMED   11181532
REFERENCE   10 (bases 1 to 1415)
  AUTHORS   Raymond CS, Murphy MW, O'Sullivan MG, Bardwell VJ and Zarkower D.
  TITLE     Dmrt1, a gene related to worm and fly sexual regulators, is
            required for mammalian testis differentiation
  JOURNAL   Genes Dev 14 (20), 2587-2595 (2000)
   PUBMED   11040213
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF379608.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF379608.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1415
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..1415
                     /gene="Dmrt1"
                     /note="doublesex and mab-3 related transcription factor 1"
                     /db_xref="GeneID:114498"
                     /db_xref="RGD:621640"
     exon            1..450
                     /gene="Dmrt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1227
                     /gene="Dmrt1"
                     /codon_start=1
                     /product="doublesex- and mab-3-related transcription
                     factor 1"
                     /protein_id="NP_446158.1"
                     /db_xref="GeneID:114498"
                     /db_xref="RGD:621640"
                     /translation="MPNDDAFGKPSAPTEVPHAPGAPPQGKAGGYSKATGAMAGAAGG
                     SSAGGSGGASGSGPSGLGSGSKKSPRLPKCARCRNHGYASPLKGHKRFCMWRDCQCKK
                     CSLIAERQRVMAAQVALRRQQAQEEELGISHPIPLPSAAELLVKRENSASNPCLMAES
                     SSSAQPPPASTPTPTVSEGRMVIQDIPAVTSRGHMENAPDLMSDPAYYSSFYQPSLFP
                     YYNNLYNYPQYSMALSAESSSGDVGNPLGGSPVKNSLRSLPAPYVPAQTGNQWQMKTS
                     EGRHPVSSQYRMHSYYGPPSYLGQSMSQIFTFEEGPSYSEAKASVFSPPSSQDSGLVS
                     LSSSSPMSNESTKGVLECESASSEPSSYAVNQVLEEDEDE"
     exon            451..634
                     /gene="Dmrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..918
                     /gene="Dmrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1063
                     /gene="Dmrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1415
                     /gene="Dmrt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttggacta caggtccagc tgcggtgcac ccgcctcctg cactccttct agggagctaa
       61 gcagcctgct ggctggatcc gtgagcaggg ggacgaagct ccatgcctaa cgacgacgca
      121 ttcggcaagc cctctgcacc gacggaggtt cctcacgctc ccggggctcc gccgcagggc
      181 aaagccgggg gctacagcaa agccactggg gcgatggccg gagcagccgg gggctccagt
      241 gcggggggca gcggaggtgc ctcgggctcc gggccgtcgg gcctgggctc tggaagcaag
      301 aagtccccga ggctgcccaa atgcgctcgc tgcaggaacc acggctacgc gtcgccgctc
      361 aagggccaca agcgcttttg catgtggcgg gactgccagt gcaagaagtg cagcctgatt
      421 gccgagcgac agcgggtgat ggccgcgcag gtggccctga gaagacagca ggcccaggaa
      481 gaggagctgg gcatcagcca ccccattccg ctgcccagcg cagcagagct gctggtcaaa
      541 agagagaata gtgccagcaa cccgtgcctg atggctgaga gcagcagctc ggcccagccc
      601 ccaccggcca gcaccccaac ccccactgtc tcagagggac gcatggtcat ccaggatatc
      661 cctgctgtca ccagcagagg gcacatggag aacgcacctg acctgatgtc agaccccgcc
      721 tactacagca gcttttacca gccgtctctg tttccttact acaacaatct gtacaactac
      781 ccccagtact ccatggcctt gtctgctgag tcctcctcag gggacgtggg aaatcccctt
      841 gggggatccc ctgtgaagaa cagcctgcgt agtctcccag caccttatgt gcctgctcag
      901 actggaaacc agtggcagat gaagacctca gagggccgcc acccagtgag ctcccagtac
      961 cggatgcact catactatgg gcctccctcc tacctgggtc agagcatgtc ccagatcttt
     1021 acctttgagg aaggcccctc ctactcagaa gccaaagcaa gtgtgttctc gccgcccagc
     1081 agtcaagatt ctggcttggt ttccctctcc agcagctctc cgatgagcaa cgagagcacg
     1141 aagggagttc tggaatgcga gtctgcgtcc tctgaaccta gcagctacgc ggtcaaccag
     1201 gtcctggaag aggatgagga cgagtgagcc gcgggggcga gcctcggggg cgactcagtt
     1261 cacagggtat taggaggctt gttttgttaa tcggcagggt ttgttgttat ttgaatcggt
     1321 tgtactggcg ctctgtccag tcagaagttt ggttcacgtt agagttaggt taaaaccctt
     1381 gtaacagtgt agaatcccag actaccatct gcaag
//
