LOCUS       NM_001415847            2744 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus DM1 protein kinase (Dmpk), transcript variant 1,
            mRNA.
ACCESSION   NM_001415847 XM_008759043
VERSION     NM_001415847.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2744)
  AUTHORS   Damanafshan,A., Elzenaar,I., Samson-Couterie,B., van der Made,I.,
            Bourajjaj,M., van den Hoogenhof,M.M., van Veen,H.A., Picavet,D.I.,
            Beqqali,A., Ehler,E., De Windt,L.J., Pinto,Y.M. and van Oort,R.J.
  TITLE     The MEF2 transcriptional target DMPK induces loss of sarcomere
            structure and cardiomyopathy
  JOURNAL   Cardiovasc Res 114 (11), 1474-1486 (2018)
   PUBMED   29648621
  REMARK    GeneRIF: MEF2-induced loss of sarcomeres is mediated by DMPK via a
            decrease in sarcomeric gene expression by interfering with SRF
            transcriptional activity, leading to adverse cardiomyocyte
            remodelling and heart failure.
REFERENCE   2  (bases 1 to 2744)
  AUTHORS   Harmon,E.B., Harmon,M.L., Larsen,T.D., Yang,J., Glasford,J.W. and
            Perryman,M.B.
  TITLE     Myotonic dystrophy protein kinase is critical for nuclear envelope
            integrity
  JOURNAL   J Biol Chem 286 (46), 40296-40306 (2011)
   PUBMED   21949239
REFERENCE   3  (bases 1 to 2744)
  AUTHORS   Forner,F., Furlan,S. and Salvatori,S.
  TITLE     Mass spectrometry analysis of complexes formed by myotonic
            dystrophy protein kinase (DMPK)
  JOURNAL   Biochim Biophys Acta 1804 (6), 1334-1341 (2010)
   PUBMED   20188867
  REMARK    GeneRIF: DMPK peptides were identified by high-resolution mass
            spectrometry together with several putative DMPK-binding proteins,
            including several heat shock proteins such as HSP20/HSPB6,
            HSP60/CPN60, HSP70 and HSP90.
REFERENCE   4  (bases 1 to 2744)
  AUTHORS   Harmon,E.B., Harmon,M.L., Larsen,T.D., Paulson,A.F. and
            Perryman,M.B.
  TITLE     Myotonic dystrophy protein kinase is expressed in embryonic
            myocytes and is required for myotube formation
  JOURNAL   Dev Dyn 237 (9), 2353-2366 (2008)
   PUBMED   18729234
REFERENCE   5  (bases 1 to 2744)
  AUTHORS   Andrade,A., de Leon,M.B., Hernandez-Hernandez,O., Cisneros,B. and
            Felix,R.
  TITLE     Myotonic dystrophy CTG repeat expansion alters Ca2+ channel
            functional expression in PC12 cells
  JOURNAL   FEBS Lett 581 (23), 4430-4438 (2007)
   PUBMED   17719582
  REMARK    GeneRIF: Data suggest modifications in the processing of N-type
            Ca(2+) channels in PC12 cells expressing the DM1 mutation.
REFERENCE   6  (bases 1 to 2744)
  AUTHORS   Mistry,D.J., Moorman,J.R., Reddy,S. and Mounsey,J.P.
  TITLE     Skeletal muscle Na currents in mice heterozygous for Six5
            deficiency
  JOURNAL   Physiol Genomics 6 (3), 153-158 (2001)
   PUBMED   11526199
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2744)
  AUTHORS   Muranyi,A., Zhang,R., Liu,F., Hirano,K., Ito,M., Epstein,H.F. and
            Hartshorne,D.J.
  TITLE     Myotonic dystrophy protein kinase phosphorylates the myosin
            phosphatase targeting subunit and inhibits myosin phosphatase
            activity
  JOURNAL   FEBS Lett 493 (2-3), 80-84 (2001)
   PUBMED   11287000
REFERENCE   8  (bases 1 to 2744)
  AUTHORS   Bush,E.W., Helmke,S.M., Birnbaum,R.A. and Perryman,M.B.
  TITLE     Myotonic dystrophy protein kinase domains mediate localization,
            oligomerization, novel catalytic activity, and autoinhibition
  JOURNAL   Biochemistry 39 (29), 8480-8490 (2000)
   PUBMED   10913253
REFERENCE   9  (bases 1 to 2744)
  AUTHORS   Benders,A.A., Groenen,P.J., Oerlemans,F.T., Veerkamp,J.H. and
            Wieringa,B.
  TITLE     Myotonic dystrophy protein kinase is involved in the modulation of
            the Ca2+ homeostasis in skeletal muscle cells
  JOURNAL   J Clin Invest 100 (6), 1440-1447 (1997)
   PUBMED   9294109
REFERENCE   10 (bases 1 to 2744)
  AUTHORS   Boucher,C.A., King,S.K., Carey,N., Krahe,R., Winchester,C.L.,
            Rahman,S., Creavin,T., Meghji,P., Bailey,M.E., Chartier,F.L. et al.
  TITLE     A novel homeodomain-encoding gene is associated with a large CpG
            island interrupted by the myotonic dystrophy unstable (CTG)n repeat
  JOURNAL   Hum Mol Genet 4 (10), 1919-1925 (1995)
   PUBMED   8595416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 4, 2023 this sequence version replaced XM_008759043.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399481.774153.1,
                                           SRR22399481.1760942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               JAXUCZ010000001.1  87858323-87858619
            298-389             JAXUCZ010000001.1  87860388-87860479
            390-473             JAXUCZ010000001.1  87860725-87860808
            474-569             JAXUCZ010000001.1  87860882-87860977
            570-718             JAXUCZ010000001.1  87861251-87861399
            719-812             JAXUCZ010000001.1  87861598-87861691
            813-1019            JAXUCZ010000001.1  87861862-87862068
            1020-1283           JAXUCZ010000001.1  87862306-87862569
            1284-1369           JAXUCZ010000001.1  87863196-87863281
            1370-1481           JAXUCZ010000001.1  87865702-87865813
            1482-1645           JAXUCZ010000001.1  87866476-87866639
            1646-1743           JAXUCZ010000001.1  87866735-87866832
            1744-1790           JAXUCZ010000001.1  87866998-87867044
            1791-1876           JAXUCZ010000001.1  87867351-87867436
            1877-2744           JAXUCZ010000001.1  87867757-87868624
FEATURES             Location/Qualifiers
     source          1..2744
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2744
                     /gene="Dmpk"
                     /gene_synonym="Dm15"
                     /note="DM1 protein kinase"
                     /db_xref="GeneID:308405"
                     /db_xref="RGD:1309825"
     exon            1..297
                     /gene="Dmpk"
                     /gene_synonym="Dm15"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..2036
                     /gene="Dmpk"
                     /gene_synonym="Dm15"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dystrophia myotonica kinase, B15; dystrophia
                     myotonica-protein kinase; myotonin-protein kinase"
                     /codon_start=1
                     /product="myotonin-protein kinase isoform 1"
                     /protein_id="NP_001402776.1"
                     /db_xref="GeneID:308405"
                     /db_xref="RGD:1309825"
                     /translation="MSAEVRLRQLQQLVLDPGFLGLEPLLDLLLGVHQELGASHLAQD
                     KYVADFLQWVEPIAARLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIM
                     NKWDMLKRGEVSCFREERDVLVKGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLL
                     SKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCL
                     KLQPDGTVRSLVAVGTPDYLSPEILQAVGGGPGAGSYGPECDWWALGVFAYEMFYGQT
                     PFYADSTAETYAKIVHYREHLSLPRADMGVPEEAQDLIRGLLCPAEIRLGRGGAGDFQ
                     KHPFFFGLDWEGLRDSVPPFTPDFEGATDTCNFDVVEDRLTAMVSGGGETLSDMQEDM
                     ALGVHLPFVGYSYSCMASRDNQVTDPTPMELEALQLPVSDLQGLDLPPPVSPPDQAAE
                     EADPAAVPVPPAETETMVTLRELQEALEEEVLTRQSLSRELEAIRTANQNFSSQLQEA
                     EVRNRDLEAHVRQLQERMEMLQAPGAAAVTGVPSPRATDPPSHMAPRPWLWASARWWG
                     QAPCTAVTCCSLPGSLGLAYPRRIACSCSPLLWLLPPHWAALGWWPIPAVSPQSGVSR
                     EPPSPPEP"
     exon            298..389
                     /gene="Dmpk"
                     /gene_synonym="Dm15"
                     /inference="alignment:Splign:2.1.0"
     exon            390..473
                     /gene="Dmpk"
                     /gene_synonym="Dm15"
                     /inference="alignment:Splign:2.1.0"
     exon            474..569
                     /gene="Dmpk"
                     /gene_synonym="Dm15"
                     /inference="alignment:Splign:2.1.0"
     exon            570..718
                     /gene="Dmpk"
                     /gene_synonym="Dm15"
                     /inference="alignment:Splign:2.1.0"
     exon            719..812
                     /gene="Dmpk"
                     /gene_synonym="Dm15"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1019
                     /gene="Dmpk"
                     /gene_synonym="Dm15"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1283
                     /gene="Dmpk"
                     /gene_synonym="Dm15"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1369
                     /gene="Dmpk"
                     /gene_synonym="Dm15"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1481
                     /gene="Dmpk"
                     /gene_synonym="Dm15"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1645
                     /gene="Dmpk"
                     /gene_synonym="Dm15"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1743
                     /gene="Dmpk"
                     /gene_synonym="Dm15"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1790
                     /gene="Dmpk"
                     /gene_synonym="Dm15"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1876
                     /gene="Dmpk"
                     /gene_synonym="Dm15"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..2744
                     /gene="Dmpk"
                     /gene_synonym="Dm15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagagaccc aggggatagt cagggacagg cagacatgca gccagggttc tggggcctgg
       61 acaggggcag ccaggccccg tgacgggagg accccgagct ccggcccggg gaggggccat
      121 ggtgttgcct gcccaacatg tcagccgaag tgcggctgag gcagctccag cagctggtgc
      181 tggacccagg cttcctgggg ctggagcccc tgctcgacct tctcctgggc gtccaccagg
      241 agctgggcgc ctcccaccta gcccaggaca agtatgtggc cgactttttg caatgggtgg
      301 agcccattgc agcaaggctt aaggaggtcc gactgcagag ggatgacttt gagattttga
      361 aggtgatcgg gcgtggggcg ttcagtgagg tagcggtggt gaagatgaaa cagaccggcc
      421 aagtgtatgc catgaagatt atgaataagt gggacatgct gaagagaggc gaggtgtcat
      481 gcttccggga agaaagggat gtattagtga aaggggaccg gcgctggatc acacagttgc
      541 actttgcctt ccaggatgag aactacctgt acctggtcat ggaatactac gtgggcgggg
      601 acctgctaac gctgctgagc aagtttgggg agcggatccc cgccgagatg gcgcgcttct
      661 acctggccga gattgtcatg gccatagact cggtgcaccg gctgggctac gtgcacaggg
      721 acatcaaacc agataacatt ctgctggacc gatgtgggca cattcgcctg gcagattttg
      781 gctcctgcct caaattgcag cctgatggaa cggtgaggtc gctggtggct gtgggcaccc
      841 cggactacct gtctcctgag attctgcagg ctgttggtgg agggcctggg gcaggcagct
      901 acgggccaga gtgtgactgg tgggcactgg gcgtgtttgc ctacgaaatg ttctatgggc
      961 agacaccctt ctacgccgac tccacagccg agacgtatgc caaaattgtg cattacaggg
     1021 aacacttgtc tctgcctcgg gcagacatgg gtgtccctga ggaagctcag gacctcattc
     1081 gtgggctgct gtgtcctgct gagataaggc tcggtagagg tggggcaggt gacttccaga
     1141 agcatccttt cttctttggc cttgattggg agggtctccg ggacagcgtg ccccccttca
     1201 caccagactt cgagggtgcc acagacacat gcaattttga tgtggtggag gaccggctca
     1261 ctgccatggt gagcgggggc ggggagacac tgtccgacat gcaggaagac atggcactcg
     1321 gggtgcacct gccttttgtg ggttactcct actcttgcat ggcctcaaga gacaatcagg
     1381 tcacggaccc cacccctatg gaactagagg ccctgcagtt gcctgtgtca gacttgcaag
     1441 ggcttgactt gccgcccccc gtgtccccac cggatcaagc ggctgaagag gctgaccccg
     1501 cggctgtccc tgtccctccg gctgagacag agaccatggt gacgctgcgg gagctccagg
     1561 aagccttgga agaagaggtt ctcacccggc agagcctgag ccgcgagctg gaggccatcc
     1621 gtaccgctaa ccagaacttc tccagccaac tacaggaggc cgaggtccgg aaccgagacc
     1681 tggaggcgca tgttcggcag ctacaggagc ggatggagat gctgcaggcc ccaggagctg
     1741 cagctgtcac gggggtcccc agtccccggg ccacggatcc accttcccat atggcccccc
     1801 ggccgtggct gtgggccagt gcccgctggt ggggccaggc cccatgcacc gccgtcacct
     1861 gctgttccct gccagggtcc ctaggcctgg cctatccgag gcgcattgcc tgctcctgtt
     1921 cgccgctgct ctggctgctg ccgccacact gggctgcact gggttggtgg cctataccgg
     1981 ccgtctcacc ccagtctggt gtttctcggg agccaccttc gccccctgaa ccctaagact
     2041 ccaagccatt tttcatttag gcctcctagg aaggtcgagt gaccagagaa agacccagag
     2101 cctctctgtg cccatattca cccccgaccc cccactgctc tgctccactc cacacttctg
     2161 tgagcctggg tccctatcct gctccgctcc tgtgatccgg gcccgccccc tggcggctgg
     2221 ggagggagga agagggctcg tgcccagcac cccggttcct gcagagctac tgctgactac
     2281 tactgcagcc caggcattcg ccaaccatgc ttttactcag ccccgacgtg gatgggcaaa
     2341 ctggtcagct catccgattt cacttttcac gcccccagcc atcagttaaa agccataagc
     2401 aataagtccc ttatctctgg agacatccca ttcccataag gaaggatgag caagacctct
     2461 gccagcacac atgggagtct ttggcttcgg acagtctcac tcctgggggt tctgcaactc
     2521 cttcctcacg tacactcccg tactctcccg tcggagccac ggctgcacac acccccaagg
     2581 cagtgtgggt atttattgac cttgttctct gactcactga cagactccgg gacccacgtt
     2641 ttggatgcac tgagactcga cattcctcgg tatttattgt ctgtccccac ctacgacctc
     2701 cactcctgac cctcgcaaat aaaatacttc tggctgccct aaaa
//
