LOCUS       NM_203493               2624 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus dentin matrix acidic phosphoprotein 1 (Dmp1),
            mRNA.
ACCESSION   NM_203493
VERSION     NM_203493.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2624)
  AUTHORS   Yuan,H., Zhang,H., Hong,L., Zhao,H., Wang,J., Li,H., Che,H. and
            Zhang,Z.
  TITLE     MicroRNA let-7c-5p Suppressed Lipopolysaccharide-Induced Dental
            Pulp Inflammation by Inhibiting Dentin Matrix Protein-1-Mediated
            Nuclear Factor kappa B (NF-kappaB) Pathway In Vitro and In Vivo
  JOURNAL   Med Sci Monit 24, 6656-6665 (2018)
   PUBMED   30238933
  REMARK    GeneRIF: Findings outlined in the current study demonstrated the
            dental pulp protecting function of let-7c-5p during LPS-induced
            inflammation, which was exerted by inhibiting the DMP1-mediated
            NF-kappaB pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2624)
  AUTHORS   Oya,K., Ishida,K., Nishida,T., Sato,S., Kishino,M., Hirose,K.,
            Ogawa,Y., Ikebe,K., Takeshige,F., Yasuda,H., Komori,T. and
            Toyosawa,S.
  TITLE     Immunohistochemical analysis of dentin matrix protein 1 (Dmp1)
            phosphorylation by Fam20C in bone: implications for the induction
            of biomineralization
  JOURNAL   Histochem Cell Biol 147 (3), 341-351 (2017)
   PUBMED   27614627
  REMARK    GeneRIF: The C-terminal Dmp1 is phosphorylated within osteocytes
            and then secreted into the pericanalicular matrix of mineralized
            bone.
REFERENCE   3  (bases 1 to 2624)
  AUTHORS   Zakhary,I., Alotibi,F., Lewis,J., ElSalanty,M., Wenger,K.,
            Sharawy,M. and Messer,R.L.
  TITLE     Inherent physical characteristics and gene expression differences
            between alveolar and basal bones
  JOURNAL   Oral Surg Oral Med Oral Pathol Oral Radiol 122 (1), 35-42 (2016)
   PUBMED   27039006
  REMARK    GeneRIF: Four genes are expressed significantly higher in basal
            bone than in alveolar bone: SOST, E-11, DMP-1, and MEPE. Three of
            the proteins (SOST, MEPE, and DMP-1) are associated with mature
            osteocytes, indicating that basal bone has more mature osteocyte
            phenotypes because the immature osteocyte converts to a mature
            osteocyte as a result of bone mineralization.
REFERENCE   4  (bases 1 to 2624)
  AUTHORS   Padovano,J.D., Ramachandran,A., Bahmanyar,S., Ravindran,S. and
            George,A.
  TITLE     Bone-specific overexpression of DMP1 influences osteogenic gene
            expression during endochondral and intramembranous ossification
  JOURNAL   Connect Tissue Res 55 Suppl 1 (0 1), 121-124 (2014)
   PUBMED   25158195
  REMARK    GeneRIF: bone-specific Dentin matrix protein 1overexpression
            changes the pattern in osteogenic gene expression pattern thereby
            influencing bone development
REFERENCE   5  (bases 1 to 2624)
  AUTHORS   Jacob,A., Zhang,Y. and George,A.
  TITLE     Transcriptional regulation of dentin matrix protein 1 (DMP1) in
            odontoblasts and osteoblasts
  JOURNAL   Connect Tissue Res 55 Suppl 1, 107-112 (2014)
   PUBMED   25158192
  REMARK    GeneRIF: TCF11 may play an important role in the transcriptional
            regulation of Dentin matrix protein 1 gene
REFERENCE   6  (bases 1 to 2624)
  AUTHORS   Fen,J.Q., Zhang,J., Dallas,S.L., Lu,Y., Chen,S., Tan,X., Owen,M.,
            Harris,S.E. and MacDougall,M.
  TITLE     Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a
            unique bone marker gene
  JOURNAL   J Bone Miner Res 17 (10), 1822-1831 (2002)
   PUBMED   12369786
  REMARK    GeneRIF: Dmp1 first appeared in hypertrophic cartilage cells,
            followed by osteoblasts, and later was expressed strongly in
            osteocytes. Dmp1 may play an important role in bone formation.
REFERENCE   7  (bases 1 to 2624)
  AUTHORS   Toyosawa,S., Shintani,S., Fujiwara,T., Ooshima,T., Sato,A.,
            Ijuhin,N. and Komori,T.
  TITLE     Dentin matrix protein 1 is predominantly expressed in chicken and
            rat osteocytes but not in osteoblasts
  JOURNAL   J Bone Miner Res 16 (11), 2017-2026 (2001)
   PUBMED   11697797
  REMARK    GeneRIF: DMP1 is a bone matrix protein specifically expressed in
            osteocytes and preosteocytes and suggest that DMP1 plays a role in
            bone homeostasis because of its high calcium ion-binding capacity.
REFERENCE   8  (bases 1 to 2624)
  AUTHORS   Kamiya,N. and Takagi,M.
  TITLE     Differential expression of dentin matrix protein 1, type I collagen
            and osteocalcin genes in rat developing mandibular bone
  JOURNAL   Histochem J 33 (9-10), 545-552 (2001)
   PUBMED   12005026
  REMARK    GeneRIF: data show that the developmental expression patterns of
            Dmp1 in osteogenic differentiation differ from those of type I
            collagen and osteocalcin, and Dmp1 appears to be expressed by
            osteocytes throughout ossification in the skeleton.
REFERENCE   9  (bases 1 to 2624)
  AUTHORS   Thotakura,S.R., Karthikeyan,N., Smith,T., Liu,K. and George,A.
  TITLE     Cloning and characterization of rat dentin matrix protein 1 (DMP1)
            gene and its 5'-upstream region
  JOURNAL   J Biol Chem 275 (14), 10272-10277 (2000)
   PUBMED   10744713
REFERENCE   10 (bases 1 to 2624)
  AUTHORS   George,A., Sabsay,B., Simonian,P.A. and Veis,A.
  TITLE     Characterization of a novel dentin matrix acidic phosphoprotein.
            Implications for induction of biomineralization
  JOURNAL   J Biol Chem 268 (17), 12624-12630 (1993)
   PUBMED   8509401
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            [WARNING] On Oct 8, 2024 this sequence was replaced by NM_203493.5.
            
            On Nov 27, 2020 this sequence version replaced NM_203493.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129082.1, L11354.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                JAXUCZ010000014.1  5840020-5840084     c
            66-113              JAXUCZ010000014.1  5839504-5839551     c
            114-146             JAXUCZ010000014.1  5837425-5837457     c
            147-2624            JAXUCZ010000014.1  5833111-5835588     c
FEATURES             Location/Qualifiers
     source          1..2624
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2624
                     /gene="Dmp1"
                     /gene_synonym="DENTMAT"
                     /note="dentin matrix acidic phosphoprotein 1"
                     /db_xref="GeneID:25312"
                     /db_xref="RGD:2508"
     exon            1..65
                     /gene="Dmp1"
                     /gene_synonym="DENTMAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1481
                     /gene="Dmp1"
                     /gene_synonym="DENTMAT"
                     /note="AG1; DMP-1; dentin matrix protein 1"
                     /codon_start=1
                     /product="dentin matrix acidic phosphoprotein 1 precursor"
                     /protein_id="NP_987089.2"
                     /db_xref="GeneID:25312"
                     /db_xref="RGD:2508"
                     /translation="MKTVILLTFLWGLSCALPVARYQNTESESSEERTGNLAQSPPPP
                     MANSDHTDSSESGEELGSDRSQYRPAGGLSKSAGMDADKEEDEDDSGDDTFGDEDNGP
                     GPEERQWGGPSRLDSDEDSADTTQSSEDSTSQENSAQDTPSDSKDHHSDEADSRPEAG
                     DSTQDSESEEYRVGGGSEGESSHGDGSEFDDEGMQSDDPGSTRSDRGHTRMSSAGIRS
                     EESKGDHEPTSTQDSDDSQDVEFSSRKSFRRSRVSEEDDRGELADSNSRETQSDSTED
                     FRSKEESRSETQEDTAETQSQEDSPEGQDPSSESSEEAGEPSQESSSESQEGVASESR
                     GDNPDNTSQTGDQRDSESSEEDRLNTFSSSESQSTEEQGDSESNESLSLSEESQESAQ
                     DEDSSSQEGLQSQSASRESRSQESQSEQDSRSEENRDSDSQDSSRSKEESNSTGSTSS
                     SEEDNHPKNIEADNRKLIVDAYHNKPIGDQDDNDCQDGY"
     exon            66..113
                     /gene="Dmp1"
                     /gene_synonym="DENTMAT"
                     /inference="alignment:Splign:2.1.0"
     exon            114..146
                     /gene="Dmp1"
                     /gene_synonym="DENTMAT"
                     /inference="alignment:Splign:2.1.0"
     exon            147..2624
                     /gene="Dmp1"
                     /gene_synonym="DENTMAT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcatcccaa tatgaagact gttatcctcc ttacgttcct ctgggggctg tcctgtgctc
       61 tccctgtcgc cagataccaa aatactgaat ctgaaagctc cgaagagagg acgggcaatt
      121 tggctcagtc accgccaccg cccatggcaa atagtgacca cacggacagc agtgagtctg
      181 gagaggagct gggctccgac agaagccagt atagaccggc tggtggtctc tctaagagtg
      241 ccgggatgga cgccgataag gaggaggatg aagacgacag tggagatgac acctttggag
      301 acgaagacaa tggcccaggc ccggaagaaa gacagtgggg aggaccctcc agactggaca
      361 gtgacgagga ctcggcagac accacacagt ccagtgaaga cagcacgtct caagaaaaca
      421 gtgcccaaga tacccccagt gacagcaagg accaccacag tgatgaggca gacagccggc
      481 ctgaggcagg agactccact caggacagtg agagtgagga atatcgggta ggaggtggca
      541 gcgaggggga gagtagccac ggggacggct ctgagttcga tgatgagggg atgcagagcg
      601 atgatcccgg gagcaccagg agcgatcgag gccatacccg aatgagcagc gctggtatca
      661 ggtcggaaga atctaaaggg gatcacgagc ccacgagcac tcaggattca gatgacagcc
      721 aggatgtgga attttcaagc aggaaatcct tcagaaggtc ccgggtctct gaggaagacg
      781 acagaggcga gctcgctgac agcaacagca gggaaaccca gagcgactcc acagaggatt
      841 tccgctccaa ggaggaaagc aggagcgaga ctcaagagga cacagccgag acccagtccc
      901 aggaagatag cccagaggga caagacccca gcagtgagtc cagcgaagag gctggtgagc
      961 catcccagga aagcagcagc gagtctcagg aaggggtggc cagtgagtcc aggggtgaca
     1021 acccagataa cacaagccag acaggagacc aaagagacag tgagtccagt gaggaggaca
     1081 gactgaacac gttctccagc tcagaaagtc agtccaccga ggagcaaggt gacagcgagt
     1141 ctaatgagag cctcagcctc tcagaggaga gtcaggagtc ggcccaggat gaggacagtt
     1201 ccagccagga aggcctccag tctcagagtg catcaaggga gagcaggagt caggagagcc
     1261 agtctgagca ggacagccgt tctgaggaaa acagggacag tgactctcag gacagtagcc
     1321 gatccaaaga agagagcaac tcgacgggga gcacttccag cagcgaggag gacaaccacc
     1381 ccaaaaacat tgaagctgac aataggaaac taatagttga tgcttaccac aacaaaccta
     1441 ttggggacca agatgacaat gattgccaag atggctacta gcattagctt gtctaagaaa
     1501 tggctctcac aggacggagt cttgggggcc ccaagagtag agttcactac aagtataatt
     1561 tattgatgtt ttggtcagaa gtaaaacggc tggcgggggg gtgttgtttt gtttgtttgg
     1621 cttttttttt ttaaattttg ttttttgttt gtttgtttgt ttttttctat gaggaattgt
     1681 tggacatgac actcttttct agagtgtctc ccactcctta gaggcttgta tgtgggatga
     1741 cgtcagagca cgcccagtga ggaatcatgc gcatagcagc ttcacagatg ccgtagcccc
     1801 tggctcacca acctgacagt tactgagatt ctgttacata cccgtcacag cactggggtg
     1861 gggtggctgc ttcaggctca gtcttgctcc tgaggagctt gccccaagca gacactcaaa
     1921 tgtaacacat taaacagata cacacaatgg agcccctgta gcagtgagtt tgggttacaa
     1981 ggctttggct cccggagggt aagaaattac ttcaaccagc ccctgccacg gctgaggtgt
     2041 gaccagacag ggaatgggag cgagacaggg aatgaccagc ttcgctttgg agaatcagag
     2101 gttccacacg tagcaaagcc tggagatgga gggtcacata ggctttctcc attgaagaca
     2161 atataaatct atttattctt gagataaaca gtattacacc ttatgcaatt aaatatttag
     2221 tatggaaagg cattctcaaa cgagacggca caatgggata acttggataa catttttttt
     2281 ccccaattaa tttgccctat tgagtgcttt tgtgggcctt ctgtaaacat tgcctcaatg
     2341 atgacaagga ggaggaggaa aatttggtgg ggagatggga gaaaaaataa ttgaaaaaag
     2401 atgtatagct ttattttttc cagattattt atgtgcagtg caagcaccat ccctgagtcc
     2461 tttccatgtg ttgcacatag cagaattctg tacatagagc ctggccgctt tgttgtcgtt
     2521 tcttctactt ttattacttt ccttttcctt ttgtcaagtg ccattgaagt gttacctcat
     2581 gaaaaatatt tgttttgtaa taaagataat aattcccaga gaaa
//
