LOCUS       NM_001005246            2038 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Rattus norvegicus dystrophin (Dmd), transcript variant Dp71c, mRNA.
ACCESSION   NM_001005246
VERSION     NM_001005246.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2038)
  AUTHORS   Yamanouchi,K., Kato,S., Tanaka,Y., Ikeda,M., Oshimo,Y., Shiga,T.,
            Hatamoto,K., Chambers,J., Imamura,T., Hiramatsu,R., Uchida,K.,
            Matsuda,F., Matsuwaki,T. and Kohsaka,T.
  TITLE     Identification and characterization of dystrophin-locus-derived
            testis-specific protein: A testis-specific gene within the intronic
            region of the rat dystrophin gene
  JOURNAL   J Reprod Dev 70 (2), 55-64 (2024)
   PUBMED   38246612
  REMARK    GeneRIF: Identification and characterization of
            dystrophin-locus-derived testis-specific protein: A testis-specific
            gene within the intronic region of the rat dystrophin gene.
REFERENCE   2  (bases 1 to 2038)
  AUTHORS   Chikamoto,A., Tochinai,R., Sekizawa,S.I. and Kuwahara,M.
  TITLE     Plasticity occurs in a specific phenotype of neurons in the nucleus
            tractus solitarius of dystrophin gene-mutated rats
  JOURNAL   Eur J Neurosci 58 (11), 4282-4297 (2023)
   PUBMED   37933572
  REMARK    GeneRIF: Plasticity occurs in a specific phenotype of neurons in
            the nucleus tractus solitarius of dystrophin gene-mutated rats.
REFERENCE   3  (bases 1 to 2038)
  AUTHORS   Sanchez,A., Aragon,J., Ceja,V., Rendon,A. and Montanez,C.
  TITLE     Nuclear transport and subcellular localization of the dystrophin
            Dp71 and Dp40 isoforms in the PC12 cell line
  JOURNAL   Biochem Biophys Res Commun 630, 125-132 (2022)
   PUBMED   36155058
  REMARK    GeneRIF: Nuclear transport and subcellular localization of the
            dystrophin Dp71 and Dp40 isoforms in the PC12 cell line.
REFERENCE   4  (bases 1 to 2038)
  AUTHORS   Garcia-Cruz,C., Merino-Jimenez,C., Aragon,J., Ceja,V.,
            Gonzalez-Assad,B., Reyes-Grajeda,J.P. and Montanez,C.
  TITLE     Overexpression of the dystrophins Dp40 and Dp40L170P modifies
            neurite outgrowth and the protein expression profile of PC12 cells
  JOURNAL   Sci Rep 12 (1), 1410 (2022)
   PUBMED   35082358
  REMARK    GeneRIF: Overexpression of the dystrophins Dp40 and Dp40L170P
            modifies neurite outgrowth and the protein expression profile of
            PC12 cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2038)
  AUTHORS   Paul-Gonzalez,S., Aragon,J., Rodriguez-Martinez,G., Romo-Yanez,J.
            and Montanez,C.
  TITLE     Differential expression of Dp71 and Dp40 isoforms in proliferating
            and differentiated neural stem cells: Identification of Dp40
            splicing variants
  JOURNAL   Biochem Biophys Res Commun 560, 152-158 (2021)
   PUBMED   33989907
REFERENCE   6  (bases 1 to 2038)
  AUTHORS   Kim,T.W., Wu,K., Xu,J.L. and Black,I.B.
  TITLE     Detection of dystrophin in the postsynaptic density of rat brain
            and deficiency in a mouse model of Duchenne muscular dystrophy
  JOURNAL   Proc Natl Acad Sci U S A 89 (23), 11642-11644 (1992)
   PUBMED   1454857
REFERENCE   7  (bases 1 to 2038)
  AUTHORS   Gilgenkrantz,H., Hugnot,J.P., Lambert,M., Chafey,P., Kaplan,J.C.
            and Kahn,A.
  TITLE     Positive and negative regulatory DNA elements including a CCArGG
            box are involved in the cell type-specific expression of the human
            muscle dystrophin gene
  JOURNAL   J Biol Chem 267 (15), 10823-10830 (1992)
   PUBMED   1316911
REFERENCE   8  (bases 1 to 2038)
  AUTHORS   Blake,D.J., Love,D.R., Tinsley,J., Morris,G.E., Turley,H.,
            Gatter,K., Dickson,G., Edwards,Y.H. and Davies,K.E.
  TITLE     Characterization of a 4.8kb transcript from the Duchenne muscular
            dystrophy locus expressed in Schwannoma cells
  JOURNAL   Hum Mol Genet 1 (2), 103-109 (1992)
   PUBMED   1301145
REFERENCE   9  (bases 1 to 2038)
  AUTHORS   Rapaport,D., Lederfein,D., den Dunnen,J.T., Grootscholten,P.M., Van
            Ommen,G.J., Fuchs,O., Nudel,U. and Yaffe,D.
  TITLE     Characterization and cell type distribution of a novel, major
            transcript of the Duchenne muscular dystrophy gene
  JOURNAL   Differentiation 49 (3), 187-193 (1992)
   PUBMED   1377655
REFERENCE   10 (bases 1 to 2038)
  AUTHORS   Malhotra,S.B., Hart,K.A., Klamut,H.J., Thomas,N.S., Bodrug,S.E.,
            Burghes,A.H., Bobrow,M., Harper,P.S., Thompson,M.W., Ray,P.N. et
            al.
  TITLE     Frame-shift deletions in patients with Duchenne and Becker muscular
            dystrophy
  JOURNAL   Science 242 (4879), 755-759 (1988)
   PUBMED   3055295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            Transcript Variant: This variant (Dp71c) lacks an in-frame segment
            including three exons in the coding region, as compared to variant
            Dp71a. The encoded isoform 71c lacks an internal segment, as
            compared to isoform Dp71a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY326949.2, SRR26643298.31996.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000021.1  53279044-53279153
            111-172             JAXUCZ010000021.1  53284659-53284720
            173-247             JAXUCZ010000021.1  53318603-53318677
            248-449             JAXUCZ010000021.1  53334640-53334841
            450-535             JAXUCZ010000021.1  53337242-53337327
            536-693             JAXUCZ010000021.1  53339700-53339857
            694-860             JAXUCZ010000021.1  53370970-53371136
            861-972             JAXUCZ010000021.1  53373367-53373478
            973-1109            JAXUCZ010000021.1  53375560-53375696
            1110-1353           JAXUCZ010000021.1  53410739-53410982
            1354-1477           JAXUCZ010000021.1  53411720-53411843
            1478-1570           JAXUCZ010000021.1  53423513-53423605
            1571-1602           JAXUCZ010000021.1  53430585-53430616
            1603-2038           JAXUCZ010000021.1  53435293-53435728
FEATURES             Location/Qualifiers
     source          1..2038
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq21"
     gene            1..2038
                     /gene="Dmd"
                     /gene_synonym="DNADMD1"
                     /note="dystrophin"
                     /db_xref="GeneID:24907"
                     /db_xref="RGD:2507"
     exon            1..110
                     /gene="Dmd"
                     /gene_synonym="DNADMD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1614
                     /gene="Dmd"
                     /gene_synonym="DNADMD1"
                     /note="isoform Dp71c is encoded by transcript variant
                     Dp71c; apodystrophin-3; apodystrophin-I; dystrophin,
                     muscular dystrophy; dystrophin-related"
                     /codon_start=1
                     /product="dystrophin isoform Dp71c"
                     /protein_id="NP_001005246.1"
                     /db_xref="GeneID:24907"
                     /db_xref="RGD:2507"
                     /translation="MREHLKGHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKL
                     RRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVN
                     VPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGF
                     CDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMR
                     LEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSG
                     RVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLE
                     GDNMETNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
                     RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPML
                     LRVVGSQTSESMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNAPGKPMREDTM"
     exon            111..172
                     /gene="Dmd"
                     /gene_synonym="DNADMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            173..247
                     /gene="Dmd"
                     /gene_synonym="DNADMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..449
                     /gene="Dmd"
                     /gene_synonym="DNADMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            450..535
                     /gene="Dmd"
                     /gene_synonym="DNADMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..693
                     /gene="Dmd"
                     /gene_synonym="DNADMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..860
                     /gene="Dmd"
                     /gene_synonym="DNADMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..972
                     /gene="Dmd"
                     /gene_synonym="DNADMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1109
                     /gene="Dmd"
                     /gene_synonym="DNADMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1353
                     /gene="Dmd"
                     /gene_synonym="DNADMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1477
                     /gene="Dmd"
                     /gene_synonym="DNADMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1570
                     /gene="Dmd"
                     /gene_synonym="DNADMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1602
                     /gene="Dmd"
                     /gene_synonym="DNADMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..2038
                     /gene="Dmd"
                     /gene_synonym="DNADMD1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttgacttt cggggagccc cgtggctcgg acaagcttac tcctccgcgc taagcgccct
       61 cccctgactg cctgtgaaat ccttacaacc atgagggaac acctcaaagg ccacgagacc
      121 caaacaactt gttgggacca tcccaaaatg acagagctct accagtcttt agctgacctg
      181 aataatgtca ggttctccgc ttataggact gccatgaagc tcagaagact ccagaaggcc
      241 ctttgcttgg atctcttgag cctgtcagct gcatgtgacg ccttggacca gcacaacctc
      301 aagcaaaatg atcagcccat ggatatcctg cagataatta actgtttgac tactatttat
      361 gaccgtctgg agcaagagca caacaatttg gtcaatgtcc ctctctgtgt ggatatgtgt
      421 ctcaactggc ttctcaatgt ttatgatacg ggacgaacag ggaggatccg tgtcctgtct
      481 tttaaaactg gcatcatttc tctgtgtaaa gcacacttgg aagacaagta cagatacctt
      541 ttcaagcaag tggcaagttc aaccggcttt tgtgaccagc gtagactggg tcttcttctg
      601 catgattcta ttcaaatccc aagacagttg ggtgaagttg cctcctttgg gggcagtaac
      661 attgagccga gtgtcaggag ctgtttccag tttgccaata ataaacctga gattgaagcc
      721 gctctcttcc ttgactggat gcgtctggaa ccccagtcta tggtgtggct gccggtcttg
      781 cacagagtgg ctgctgctga aacagccaag catcaggcca agtgtaacat ctgtaaggag
      841 tgtccaatca ttggattcag gtacagaagc ctgaaacact ttaattatga catctgccaa
      901 agctgctttt tttctggccg agttgctaag ggccataaaa tgcactaccc catggtagag
      961 tactgcactc cgactacatc tggagaagat gttcgtgact ttgccaaggt actgaaaaac
     1021 aaatttcgaa ccaaaaggta ttttgcgaag catccccgaa tgggctacct tccagtgcag
     1081 actgtgttag agggggacaa catggaaaca aatctgcaag cagaatatga tcgtctgaag
     1141 cagcagcatg agcataaagg cctgtcccca ctgccgtctc ctcctgagat gatgcccacc
     1201 tctccccaga gtcccaggga tgctgaactc attgctgagg ccaagctact gcgccaacac
     1261 aaaggacgtc tggaagccag gatgcaaatc ctggaagacc acaataaaca actggagtct
     1321 cagttacata gactgaggca gctcctggag caaccccagg ctgaggccaa ggtgaatggc
     1381 accacggtgt cctctccttc tacctcgctg cagaggtcag atagcagtca gcctatgctg
     1441 ctccgagtgg ttggcagtca aacttcagaa tctatgggtg aggaagatct tctgagtcct
     1501 ccccaggaca caagcacagg gttagaagaa gtgatggagc aactcaacaa ctccttccct
     1561 agttcaagag gaagaaatgc ccctggaaag ccaatgagag aggacacaat gtaggaagcc
     1621 ttttccacat ggcagatgat ttgggcagag cgatggagtc cttagtttca gtcatgatag
     1681 atgaagaagg agcagaataa atgttttaca actcctgacc cccgcatggt ttttataata
     1741 ttcgtacaac aaagaggatt agacagtaag cgtttacaag aaataaatct atatttttgt
     1801 gaagggtagt ggtactatac tgtagatttc agtagtttct aagtctgtta ttgttttgtt
     1861 aacaatggca ggttttacac gtctatgcaa ttgtacaaaa aagttaaaag aaaacatgta
     1921 aaatcttgat agctaaataa cttgccattt ctttatatgg aacgcatttt gggttgttta
     1981 aaaatttata acagttataa agaaagattg taaactaaag tgtgctttat aaaaaagt
//
