LOCUS       NM_001130567            2589 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus DNA meiotic recombinase 1 (Dmc1), mRNA.
ACCESSION   NM_001130567 XM_001075521 XM_343290
VERSION     NM_001130567.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2589)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2589)
  AUTHORS   Finsterbusch,F., Ravindranathan,R., Dereli,I., Stanzione,M.,
            Trankner,D. and Toth,A.
  TITLE     Alignment of Homologous Chromosomes and Effective Repair of
            Programmed DNA Double-Strand Breaks during Mouse Meiosis Require
            the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein
  JOURNAL   PLoS Genet 12 (10), e1006393 (2016)
   PUBMED   27760146
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2589)
  AUTHORS   Wei,X., Das,J., Fragoza,R., Liang,J., Bastos de Oliveira,F.M.,
            Lee,H.R., Wang,X., Mort,M., Stenson,P.D., Cooper,D.N., Lipkin,S.M.,
            Smolka,M.B. and Yu,H.
  TITLE     A massively parallel pipeline to clone DNA variants and examine
            molecular phenotypes of human disease mutations
  JOURNAL   PLoS Genet 10 (12), e1004819 (2014)
   PUBMED   25502805
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2589)
  AUTHORS   Jorgensen,A., Nielsen,J.E., Blomberg Jensen,M., Graem,N. and
            Rajpert-De Meyts,E.
  TITLE     Analysis of meiosis regulators in human gonads: a sexually
            dimorphic spatio-temporal expression pattern suggests involvement
            of DMRT1 in meiotic entry
  JOURNAL   Mol Hum Reprod 18 (11), 523-534 (2012)
   PUBMED   22899867
REFERENCE   5  (bases 1 to 2589)
  AUTHORS   Llano,E., Herran,Y., Garcia-Tunon,I., Gutierrez-Caballero,C., de
            Alava,E., Barbero,J.L., Schimenti,J., de Rooij,D.G.,
            Sanchez-Martin,M. and Pendas,A.M.
  TITLE     Meiotic cohesin complexes are essential for the formation of the
            axial element in mice
  JOURNAL   J Cell Biol 197 (7), 877-885 (2012)
   PUBMED   22711701
REFERENCE   6  (bases 1 to 2589)
  AUTHORS   Yang,F., Eckardt,S., Leu,N.A., McLaughlin,K.J. and Wang,P.J.
  TITLE     Mouse TEX15 is essential for DNA double-strand break repair and
            chromosomal synapsis during male meiosis
  JOURNAL   J Cell Biol 180 (4), 673-679 (2008)
   PUBMED   18283110
REFERENCE   7  (bases 1 to 2589)
  AUTHORS   Li,X.C. and Schimenti,J.C.
  TITLE     Mouse pachytene checkpoint 2 (trip13) is required for completing
            meiotic recombination but not synapsis
  JOURNAL   PLoS Genet 3 (8), e130 (2007)
   PUBMED   17696610
  REMARK    Erratum:[PLoS Genet. 2007 Sep 7;3(9):e168. Li, Xin [corrected to
            Li, Xin Chenglin]]
REFERENCE   8  (bases 1 to 2589)
  AUTHORS   Reinholdt,L.G. and Schimenti,J.C.
  TITLE     Mei1 is epistatic to Dmc1 during mouse meiosis
  JOURNAL   Chromosoma 114 (2), 127-134 (2005)
   PUBMED   15928951
REFERENCE   9  (bases 1 to 2589)
  AUTHORS   Di Giacomo,M., Barchi,M., Baudat,F., Edelmann,W., Keeney,S. and
            Jasin,M.
  TITLE     Distinct DNA-damage-dependent and -independent responses drive the
            loss of oocytes in recombination-defective mouse mutants
  JOURNAL   Proc Natl Acad Sci U S A 102 (3), 737-742 (2005)
   PUBMED   15640358
REFERENCE   10 (bases 1 to 2589)
  AUTHORS   Ward,J.O., Reinholdt,L.G., Hartford,S.A., Wilson,L.A., Munroe,R.J.,
            Schimenti,K.J., Libby,B.J., O'Brien,M., Pendola,J.K., Eppig,J. and
            Schimenti,J.C.
  TITLE     Toward the genetics of mammalian reproduction: induction and
            mapping of gametogenesis mutants in mice
  JOURNAL   Biol Reprod 69 (5), 1615-1625 (2003)
   PUBMED   12855593
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Jul 28, 2008 this sequence version replaced
            XM_343290.3, XM_001075521.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132291, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2589
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2589
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h"
                     /note="DNA meiotic recombinase 1"
                     /db_xref="GeneID:362960"
                     /db_xref="RGD:1307611"
     exon            1..117
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h"
                     /inference="alignment:Splign:2.1.0"
     exon            118..533
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h"
                     /inference="alignment:Splign:2.1.0"
     exon            534..617
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h"
                     /inference="alignment:Splign:2.1.0"
     CDS             567..1589
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h"
                     /note="DMC1 dosage suppressor of mck1 homolog,
                     meiosis-specific homologous recombination"
                     /codon_start=1
                     /product="meiotic recombination protein DMC1/LIM15
                     homolog"
                     /protein_id="NP_001124039.1"
                     /db_xref="GeneID:362960"
                     /db_xref="RGD:1307611"
                     /translation="MKEDQVVQEESGFQDEEESLFQDIDLLQKHGINMADIKKLKSVG
                     ICTIKGIQMTTRRALCNVKGLSEAKVEKIKEAANKLIEPGFLTAFQYSEKRKMVFHIT
                     TGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLCVTAQLPGADGYSGGKIIFID
                     TENTFRPDRLRDIADRFNVDHDAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAGIFK
                     LLIVDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGA
                     TMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATFAITTGG
                     IGDAKE"
     exon            618..662
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h"
                     /inference="alignment:Splign:2.1.0"
     exon            663..809
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h"
                     /inference="alignment:Splign:2.1.0"
     exon            810..892
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h"
                     /inference="alignment:Splign:2.1.0"
     exon            893..945
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h"
                     /inference="alignment:Splign:2.1.0"
     exon            946..987
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1060
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1152
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1226
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1341
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1402
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1519
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..2589
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cactacagca aactacatat gttagatttc cctaaatcgt cttgttgcgc tctttgcagc
       61 tctccggtat actgttgatg tcttcaaaca agttgcccaa aagttcctgg attttagagt
      121 ccatgttcca ccactgccct tcttcacctc ggagacccga agacctgctc caggatcctc
      181 ccagccaccc tcactagaac ccctgccgca cactccgctc tgccatgcgt tttatcccag
      241 attccctagg agatttgccc tacccttgtt ctgtagctaa tcccagcccc gccccacacc
      301 ctagccccgc ccacagcacc agccccgccc tataccccaa gccccgccca cactggggtc
      361 ttgcttcaga agtcctcctt cggcgccaaa ccatagatat tcgacgactg tgttgtcggc
      421 ctcctccacg ttctgggtcc gcgttggaat tctggactgg acgagaaagc cggagcgcga
      481 gtcgtaaagg attcaccttg aaaatctcgg ggaggctgtg ggttcgagtg gggaattgat
      541 tattttactg ctgctctcct ttcaacatga aggaggatca agttgtgcag gaagaatcgg
      601 gattccaaga tgaggaggag tctttgtttc aagacattga cctgttacaa aaacacggaa
      661 tcaacatggc tgatattaag aaactgaagt ctgtaggaat ctgtaccatc aaagggatac
      721 aaatgacaac gagaagggcc ctctgcaatg tcaaaggcct ctcagaagcc aaagtggaga
      781 agattaaaga ggcagccaat aaacttattg aaccaggatt cctaactgca tttcagtaca
      841 gcgaaaagag gaagatggtt ttccatatca ctactgggag tcaggaattt gataaattac
      901 taggaggtgg cattgaaagt atggcaatta cagaagcttt tggagaattc cgtactggaa
      961 aaactcagct gtctcatacc ctctgtgtga cagctcaact tccaggagca gatggctact
     1021 caggaggaaa gattatcttc attgatacag aaaatacttt ccgtccagat cgccttcggg
     1081 acattgctga tcgcttcaac gtagaccatg acgcagtact ggacaacgtg ctctatgcac
     1141 gtgcctatac tagcgagcat cagatggagc tacttgatta cgtagcagcc aaatttcacg
     1201 aagaagccgg cattttcaaa ctattgatcg ttgactcaat aatggcactt tttcgagtgg
     1261 atttcagtgg ccgtggagaa ttggctgaac gccagcaaaa attggcccag atgttgtcac
     1321 gactccaaaa aatctcagaa gaatataatg ttgctgtttt tgtgaccaac caaatgactg
     1381 cagatccggg agcaactatg accttccagg ctgatcccaa aaaacccatt ggcggacaca
     1441 ttctggctca cgcttcaaca acaagaataa gcttgcgaaa gggaagagga gaactgagga
     1501 ttgccaagat ttatgacagc cctgagatgc ctgaaaatga agccaccttc gcaataacca
     1561 ctggagggat cggggatgcc aaggagtagg tggggaatgg gtacagactg cttcttgctg
     1621 cttattaggg actggagaag tgggaagcag tcttcaattt acatcttgaa ataagagttt
     1681 gtttttttcc catgtgttat taaaagaaag tcagcaaaag agatgtaaag cttatattta
     1741 tcttaaaagt tccttcctga tatgtaacca actatatata acatatatat atatatatac
     1801 acacacacac acacactgca tgttgattca gaaatatgca tacatattct tgaatcagtt
     1861 gatagccaca tatgcaaaag tatgcctgtc aggtattggg gaaggggtac ccagtgccct
     1921 cccatctgcc taccacagtg agccattgag cacacaaaaa ttcaaaggag ctcagagatt
     1981 atcagccccc gaaagcccag gcttctcagc cagcatttgt tgggacacag cactatggtg
     2041 ctgggactag ggaactggat gctcttcccc aagagagaga tgtgaggaga tgtttagagt
     2101 atacacgagc tatttgtatt cacccggcag ccttcatatc catctttgca atgatagaag
     2161 agaaacatta agccaactct ttaaatcatt tggtttgtca agttgaaatg tctttttaaa
     2221 atgtattatg gtaattgggc atgatggtgc acacctgtaa tctcaatatt tgggaggtct
     2281 aagtagcttt agctccgcgg taagttcaaa gctagcctgg gctctgacaa cactgtccaa
     2341 aacaggcatg ccttgaggtt tgatagagag ttcaaagggt ttgtttgttt tttttttttt
     2401 tattttggag ctaatataaa tgtaaaatct agaactgaga cattaataga atttgtgaaa
     2461 gaacattggt tttgagtctg tgtgagacta tttaaaaatt aaaatagtaa tctgtaattg
     2521 ctacaggtga tcttttatat tgtattacct aacatgaaaa tccaaaaagt aaataaagta
     2581 ttggctacc
//
