LOCUS       NM_001107961            4096 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus diencephalon/mesencephalon homeobox 1 (Dmbx1),
            mRNA.
ACCESSION   NM_001107961 XM_001070471 XM_233404
VERSION     NM_001107961.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4096)
  AUTHORS   Fujimoto W, Shiuchi T, Miki T, Minokoshi Y, Takahashi Y, Takeuchi
            A, Kimura K, Saito M, Iwanaga T and Seino S.
  TITLE     Dmbx1 is essential in agouti-related protein action
  JOURNAL   Proc Natl Acad Sci U S A 104 (39), 15514-15519 (2007)
   PUBMED   17873059
REFERENCE   2  (bases 1 to 4096)
  AUTHORS   Kimura K, Miki T, Shibasaki T, Zhang Y, Ogawa M, Saisho H, Okuno M,
            Iwanaga T and Seino S.
  TITLE     Functional analysis of transcriptional repressor Otx3/Dmbx1
  JOURNAL   FEBS Lett 579 (13), 2926-2932 (2005)
   PUBMED   15890343
REFERENCE   3  (bases 1 to 4096)
  AUTHORS   Ohtoshi A and Behringer RR.
  TITLE     Neonatal lethality, dwarfism, and abnormal brain development in
            Dmbx1 mutant mice
  JOURNAL   Mol Cell Biol 24 (17), 7548-7558 (2004)
   PUBMED   15314164
REFERENCE   4  (bases 1 to 4096)
  AUTHORS   Zhang Y, Miki T, Iwanaga T, Koseki Y, Okuno M, Sunaga Y, Ozaki N,
            Yano H, Koseki H and Seino S.
  TITLE     Identification, tissue expression, and functional characterization
            of Otx3, a novel member of the Otx family
  JOURNAL   J Biol Chem 277 (31), 28065-28069 (2002)
   PUBMED   12055180
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JACYVU010000162.1.
            
            [WARNING] On Mar 28, 2024 this sequence was replaced by
            NM_001107961.4.
            
            On Feb 10, 2021 this sequence version replaced NM_001107961.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence based on alignments of orthologous transcripts.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMN12840130
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               JACYVU010000162.1  43952174-43952339   c
            167-345             JACYVU010000162.1  43948789-43948967   c
            346-688             JACYVU010000162.1  43948236-43948578   c
            689-4096            JACYVU010000162.1  43943520-43946927   c
FEATURES             Location/Qualifiers
     source          1..4096
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..4096
                     /gene="Dmbx1"
                     /gene_synonym="Otx3"
                     /note="diencephalon/mesencephalon homeobox 1"
                     /db_xref="GeneID:313512"
                     /db_xref="RGD:1308265"
     exon            1..166
                     /gene="Dmbx1"
                     /gene_synonym="Otx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1143
                     /gene="Dmbx1"
                     /gene_synonym="Otx3"
                     /note="orthodenticle homolog 3"
                     /codon_start=1
                     /product="diencephalon/mesencephalon homeobox protein 1"
                     /protein_id="NP_001101431.1"
                     /db_xref="GeneID:313512"
                     /db_xref="RGD:1308265"
                     /translation="MQHYGVNGYSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHAL
                     TLAERLADIILEARYGSQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMC
                     TNLPEARVQVWFKNRRAKFRKKQRSLQKEQLQKQKEAEGSHGEGKMETPASNTQLEAE
                     QPPSLPSGDPPAELQLSLSEQSASESAPEDQLDREEDSRAEEPKAEKSPGSESKVLGC
                     KRASPKADSPGSLAITPAAPAGSLLGPSHSYSSSPLSLFRLQEQFRQHMAATNNLVHY
                     SSFEVGGPAPAAAAAAAAAVPYLGVNMAPLSSLHCQSYYQSLSAAAAAHQGVWGTPLL
                     PAPPTGLAPASAALNSKTTSIENLRLRAKQHAASLGLDTLPN"
     exon            167..345
                     /gene="Dmbx1"
                     /gene_synonym="Otx3"
                     /inference="alignment:Splign:2.1.0"
     exon            346..688
                     /gene="Dmbx1"
                     /gene_synonym="Otx3"
                     /inference="alignment:Splign:2.1.0"
     exon            689..4096
                     /gene="Dmbx1"
                     /gene_synonym="Otx3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggatgccg ctatgcagca ctatggggtg aatggctact ccctgcatgc tatgaactcc
       61 ctcagtgcca tgtacaacct gcatcagcag gcggcccagc aggcccagca tgcccctgac
      121 taccggccat cagtgcatgc gcttacattg gctgagcgcc tagctgacat catcttggag
      181 gcccgctatg gctcccagca ccgtaaacaa cgtcgtagtc gcacggcatt cacagcccag
      241 cagcttgagg ccctggagaa gaccttccag aagactcatt acccagacgt ggtgatgcgt
      301 gagaggctgg ccatgtgcac caatcttccc gaggcccgcg tgcaggtgtg gttcaagaac
      361 cgcagagcca agttccgaaa gaagcagcgt agcctgcaga aagagcagct ccagaagcag
      421 aaggaggccg agggctccca cggggaaggc aagatggaga ctccagcctc aaacacacag
      481 ctggaagcag agcagcctcc cagtctcccc agtggtgacc cccctgctga acttcagctg
      541 agcctgtccg agcagtcagc cagtgaatcc gccccggaag accagctgga ccgcgaggag
      601 gactcccggg ccgaggagcc caaggctgaa aagagtcctg gatctgagag caaggtgctg
      661 gggtgcaaga gggccagccc taaggcagat tccccaggca gcctggccat aacgcctgca
      721 gccccagcgg gcagcctcct tggtccttcc cactcctact cctcgtcccc actcagcctc
      781 ttccgtctac aggagcagtt ccgccagcac atggcggcca ccaacaacct ggtgcactac
      841 tcatcttttg aagtgggcgg tcccgcacct gctgcggctg cagctgccgc cgccgcggtg
      901 ccctacctag gggtcaacat ggccccactg agctccctac actgtcagtc ctattaccaa
      961 tccctgtcag cagctgctgc tgcccaccag ggtgtgtggg ggaccccatt gctgccggcg
     1021 ccccccacag gcctggcacc tgcctcagct gccctgaaca gtaaaaccac gagcattgaa
     1081 aaccttcgct tgcgggccaa gcagcacgct gcctccctgg gactcgatac actccccaat
     1141 tgactgcctg gcttccaacc caaccatggt cttaggtgtt cccctatctc ggtcccatgg
     1201 ttattcccag aaggctctcc gagttctcca agaactaact tcgagagccc agggatgctg
     1261 gggcctggag tccttccact ttgtctccct tcttcagagt cccaacccca agtgaatccc
     1321 acacaccctc tgcatggccc tgcttggacc ccatggaggt caaatgggga ggaggtgagc
     1381 aactggcctc ccctccccgg tattgcctcc tcccctgctc cctcactagt aagttgatgt
     1441 gtggaatgtg atataaatat aaatatataa aactatattt tcaggcactg cctgccccag
     1501 gccccctttc cctgttctcc tcacatctca ctgataccct tgcctctgag attctctcca
     1561 gcagttgttc tctctctctc tctctctctc tctctctctc tctctctctc tctctctctc
     1621 tctctctctc tctctctctc ctctctctct ctcctctctt tttcttcctc ctcctcttga
     1681 tttctcccac ccccctgcag ccccattgcc tctgtctaca tccctgtccc actacctacc
     1741 tggatctaac tgctatgccg tcccttggcc tttggtgctg gctgtattgt tgtcctatat
     1801 tctcagtgtt tcctttgggc ttgtggtgtt cggttttagt cactttgttt cttcctgttt
     1861 ctcttctgct ctgcttgcct atctcctccc tcaacctgaa ccctctctag gcaactcttc
     1921 catcccatac cccaagagtc aacaaagccc tacttgaaga ccctggagcg acaggcagga
     1981 ggtagcccct agcctcacag catctcccag atattaggaa gggctcacag tcacctttcc
     2041 ttctctttcc ttgcttggag taccagctcc tcagattgca gaggggcatg tggtggcact
     2101 ggaacagcaa tctctttgca gggttctagc ctcccttatc agcgagtgcg agtgaagcct
     2161 tatggccaca cacggtctca ggatttgttg acttccagtg ggagtaggag cttctgtcta
     2221 tatgtcacta gcacggcaag gtgtgctctt acaggctacc ctgctctgca gactcccttt
     2281 cagggtggtg tggcattggg caagcccagt actttctggg attgtcttgc ctggataaga
     2341 tgactaagaa gattctgttt atttccaacc acccatagcc tctaaccttg tatggcagag
     2401 gctttggtta ggtctaacaa tgaccttcat tacaaacacc cagagaggcc cgatgagtaa
     2461 gttagaacat tactgttgtt ttgctgagga acagtgagtc ctgcatacct gaagctctct
     2521 gtgggtaccg cctcagtttc tcagtaaatg cattcctttc tgggttagac aatctggatt
     2581 tggtcctatt ttacttggat tccagtgcga gccttggggg ctactccatt tccatgccca
     2641 tggtgagggg tgggtaagat gacttggata gatttgtggt tatgattccc aagccccaca
     2701 cccacacaat gggttgcctg gcatggctgg cctacagagc caataatgcc caccttagta
     2761 aggacagtct ggactagggt aggaggagag ggctttggcc agtaaaaggt ggggagggga
     2821 ataacctgag acaggagaag catgacagaa acaggagaat cgagcatgaa tgagcctttg
     2881 aacacgaggt gactggcctc gtgagagtga agcagaaaac ctagaatgca gcccagtagt
     2941 cccacttcca cacagtgagc accaaaggca gttgagggtt tcttaagaag gggtatcttc
     3001 ctgggatctg gaatccggaa ggcgagtcca aagccttgtg aacatcagag gaggagaaac
     3061 ttggccaagg ggatgagagg ttagcagatc tgaggggttc tgtggagggt tgggtagggt
     3121 tcagtggccc atggttaccc tattgtggtt agcttcaaga aattatgttt ctgaaatgtc
     3181 tcatctagaa ttgggcacag ggctgaaact gtctttctag tcctgggtgc aaatgaccga
     3241 ttgtcactgg gacttgggat ctaaccatcc ccagtctccc caaccctcta agaaggaagg
     3301 ccacccgagg ttgtattctg tcacgacaca agcctggttt accctaggct tttcaaaaag
     3361 ctcttagatc tttgtcattt gttctctcat ttgctgaccc aaacccacaa ggccagagaa
     3421 ggaagggaag tcataggtgg gtgttatcct cagggatgtc aagttaattt agggtaccag
     3481 actcaggtac tcaaagcagc tgaaagagaa ggggttggga gagagagata accatgtctt
     3541 cttggggtga ttagatggcg taattttttt gaagatatta gagggcatga gtatggcagg
     3601 tgaacccact tgctggacat tactgatgga atctctccca ggcctgctgg tcactttgga
     3661 cagagaaccc aaggactaaa cccttacgag cccttcaagg aaaagtcctg ctcctctctg
     3721 ctccttcccg tttgaggtct cctttgctct gcttcgtcac ttccctagag catggttcag
     3781 gggcctgggt ccccgcctct atgcagaggc tgattggctg tacagaccgc tttccaaacc
     3841 agctgttttg tgaccacttg tgcttagagg ttgtaccggc ccttggcaaa aaacccaccg
     3901 tgtattgtgt ttatttattc tgttagttaa agaagcaaaa ctcaaacctc tcactttccc
     3961 ttgtcctgcc ccctgcatag cacagcatga tgctctgtcc cgtgtatctg tctgtcagtc
     4021 tgttggcctc acttcctgtg actttgtgac ctgttctttg tcctaattgg ctaataaaag
     4081 agaacctggc agcaca
//
