LOCUS       NM_012943               1390 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus distal-less homeobox 5 (Dlx5), mRNA.
ACCESSION   NM_012943
VERSION     NM_012943.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1390)
  AUTHORS   Li,X., Wu,Y., Xie,F., Zhang,F., Zhang,S., Zhou,J., Chen,D. and
            Liu,A.
  TITLE     miR-339-5p negatively regulates loureirin A-induced hair follicle
            stem cell differentiation by targeting DLX5
  JOURNAL   Mol Med Rep 18 (2), 1279-1286 (2018)
   PUBMED   29901112
  REMARK    GeneRIF: these results suggest that miR3395p negatively regulated
            loureirin Ainduced HFSC differentiation by targeting DLX5,
            resulting in Wnt/betacatenin signaling pathway inhibition.
REFERENCE   2  (bases 1 to 1390)
  AUTHORS   Garaffo,G., Conte,D., Provero,P., Tomaiuolo,D., Luo,Z.,
            Pinciroli,P., Peano,C., D'Atri,I., Gitton,Y., Etzion,T.,
            Gothilf,Y., Gays,D., Santoro,M.M. and Merlo,G.R.
  TITLE     The Dlx5 and Foxg1 transcription factors, linked via miRNA-9 and
            -200, are required for the development of the olfactory and GnRH
            system
  JOURNAL   Mol Cell Neurosci 68, 103-119 (2015)
   PUBMED   25937343
REFERENCE   3  (bases 1 to 1390)
  AUTHORS   Takai,H., Mezawa,M., Choe,J., Nakayama,Y. and Ogata,Y.
  TITLE     Osteogenic transcription factors and proto-oncogene regulate bone
            sialoprotein gene transcription
  JOURNAL   J Oral Sci 55 (3), 209-215 (2013)
   PUBMED   24042587
  REMARK    GeneRIF: results demonstrate that overexpression of Runx2, Dlx5 or
            c-Src stimulates BSP transcription, and suggest that Runx2, Dlx5
            and c-Src might be crucial transcriptional regulators of
            mineralization and bone formation
REFERENCE   4  (bases 1 to 1390)
  AUTHORS   Singh,M., Del Carpio-Cano,F.E., Monroy,M.A., Popoff,S.N. and
            Safadi,F.F.
  TITLE     Homeodomain transcription factors regulate BMP-2-induced
            osteoactivin transcription in osteoblasts
  JOURNAL   J Cell Physiol 227 (1), 390-399 (2012)
   PUBMED   21503878
  REMARK    GeneRIF: OA transcription is differentially regulated by Dlx3,
            Dlx5, and Msx2 during osteoblast differentiation.
REFERENCE   5  (bases 1 to 1390)
  AUTHORS   Hie,M., Iitsuka,N., Otsuka,T., Nakanishi,A. and Tsukamoto,I.
  TITLE     Zinc deficiency decreases osteoblasts and osteoclasts associated
            with the reduced expression of Runx2 and RANK
  JOURNAL   Bone 49 (6), 1152-1159 (2011)
   PUBMED   21893222
REFERENCE   6  (bases 1 to 1390)
  AUTHORS   Merlo,G.R., Paleari,L., Mantero,S., Genova,F., Beverdam,A.,
            Palmisano,G.L., Barbieri,O. and Levi,G.
  TITLE     Mouse model of split hand/foot malformation type I
  JOURNAL   Genesis 33 (2), 97-101 (2002)
   PUBMED   12112878
REFERENCE   7  (bases 1 to 1390)
  AUTHORS   Eisenstat,D.D., Liu,J.K., Mione,M., Zhong,W., Yu,G., Anderson,S.A.,
            Ghattas,I., Puelles,L. and Rubenstein,J.L.
  TITLE     DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal
            forebrain differentiation
  JOURNAL   J Comp Neurol 414 (2), 217-237 (1999)
   PUBMED   10516593
REFERENCE   8  (bases 1 to 1390)
  AUTHORS   Liu,J.K., Ghattas,I., Liu,S., Chen,S. and Rubenstein,J.L.
  TITLE     Dlx genes encode DNA-binding proteins that are expressed in an
            overlapping and sequential pattern during basal ganglia
            differentiation
  JOURNAL   Dev Dyn 210 (4), 498-512 (1997)
   PUBMED   9415433
REFERENCE   9  (bases 1 to 1390)
  AUTHORS   Shirasawa,T., Sakamoto,K. and Tkahashi,H.
  TITLE     Molecular cloning and evolutional analysis of a mammalian homologue
            of the Distal-less 3 (Dlx-3) homeobox gene
  JOURNAL   FEBS Lett 351 (3), 380-384 (1994)
   PUBMED   7915995
REFERENCE   10 (bases 1 to 1390)
  AUTHORS   Zhao,G.Q., Zhao,S., Zhou,X., Eberspaecher,H., Solursh,M. and de
            Crombrugghe,B.
  TITLE     rDlx, a novel distal-less-like homeoprotein is expressed in
            developing cartilages and discrete neuronal tissues
  JOURNAL   Dev Biol 164 (1), 37-51 (1994)
   PUBMED   7913069
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L24443.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L24443.1, D31734.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1390
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..1390
                     /gene="Dlx5"
                     /gene_synonym="RDLX"
                     /note="distal-less homeobox 5"
                     /db_xref="GeneID:25431"
                     /db_xref="RGD:2506"
     exon            1..533
                     /gene="Dlx5"
                     /gene_synonym="RDLX"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1048
                     /gene="Dlx5"
                     /gene_synonym="RDLX"
                     /note="DLX-3; homeobox protein DLX-3"
                     /codon_start=1
                     /product="homeobox protein DLX-5"
                     /protein_id="NP_037075.1"
                     /db_xref="GeneID:25431"
                     /db_xref="RGD:2506"
                     /translation="MTGVFDRRVPSIRSGDFQAPFPTSAAMHHPSQESPTLPESSATD
                     SDYYSPAGAAPHGYCSPTSASYRKALNPYQYQYHSVNGSAAGYPAKAYADYGYASPYH
                     QYGGAYNRVPSATSQPEKEVAEPEVRMVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQ
                     YLALPERAELAASLGLTQTQVKIWFQNKRSKIKKIMKNGEMPPEHSPSSSDPMACNSP
                     QSPAVWEPQGSSRSLSHHPHAHPTTSNQSPASSYLENSASWYPSAASSINSHLPPPGS
                     LQHPLALASGTLY"
     exon            534..718
                     /gene="Dlx5"
                     /gene_synonym="RDLX"
                     /inference="alignment:Splign:2.1.0"
     exon            719..1390
                     /gene="Dlx5"
                     /gene_synonym="RDLX"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacagagcct ccacgactcc cagcctcctc ctccccgccg ccgccgccac cgccgccgcc
       61 tcctcttcct cctcctcctc cctcgctccc acagccatgt ctgcttagac cagagcagct
      121 ccacagccaa ttctggcagc agcggccgcc tcaataggac agccaccgcc cgggagctat
      181 gacaggagtg tttgacagaa gagtcccaag catccgatcc ggcgacttcc aagctccgtt
      241 cccgacgtcc gccgccatgc accacccgtc tcaggaatcg ccaactttgc cggagtcctc
      301 ggccaccgat tctgactact acagtcccgc gggggccgcc cctcatggct actgctctcc
      361 tacctctgct tcttaccgca aagcgctcaa cccataccag taccagtatc acagcgtgaa
      421 cggctccgca gccggctacc cggccaaggc ttatgcggac tacggctacg ccagccccta
      481 ccaccagtac ggaggcgcct acaaccgagt cccgagtgcc accagccagc cagagaaaga
      541 agtggccgag ccagaggtga ggatggtgaa tggtaaacca aagaaagttc gtaaacccag
      601 gactatttat tccagctttc agctggccgc tttacagaga aggtttcaga agactcagta
      661 cctcgccctg ccagaacgcg cggagttggc cgcctctcta ggactgacgc aaacacaggt
      721 gaaaatctgg tttcagaaca aaagatccaa gatcaagaag atcatgaaaa acggggagat
      781 gcccccggag cacagtccca gctccagcga ccctatggcg tgtaactcgc cacagtcacc
      841 agcggtgtgg gagccccagg gctcatcccg ctctctcagc caccaccctc atgcccaccc
      901 tacgacctcc aaccagtccc ccgcgtccag ctacctggag aactcggctt cctggtaccc
      961 aagtgcagcc agctcaatca attcccacct gccaccgcct ggctccctgc agcacccgct
     1021 ggcactggcc tccgggacgc tttattagat gggctactct ctcttgctca gttttgggac
     1081 tacagtgttt tcctgtttta gaaatcagaa agaaaggaat tcatacgggg atgtttgaac
     1141 aatggaaaca aagattcatg tgtaaagctt tttttttgca tgtaagttat tgcatttcaa
     1201 aggaccccgc cccttttttt acgaaaagaa cccttttttg cgcaactgtg gacactatca
     1261 atggtgcctt gaaatctatg acctcaactt ttcaaaaaga cttttttcaa tgttatttta
     1321 accgtgtaaa taagtgtaga tagaggaatt aaactgtata ttctggataa ataaaattat
     1381 ttcgaccatg
//
