LOCUS       NM_001105832            2643 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus distal-less homeobox 3 (Dlx3), mRNA.
ACCESSION   NM_001105832 XM_001081312 XM_220869
VERSION     NM_001105832.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2643)
  AUTHORS   Cai H, Zhu X, Li Z, Zhu Y and Lang J.
  TITLE     lncRNA/mRNA profiling of endometriosis rat uterine tissues during
            the implantation window
  JOURNAL   Int J Mol Med 44 (6), 2145-2160 (2019)
   PUBMED   31638262
  REMARK    GeneRIF: In conclusion, the changes in the expression of lncRNAs,
            mRNAs and proteins (Adamts7, P2ry6, Dlx3 and TP53) may possibly
            affect endometrial receptivity in rats with endometriosis during
            the implantation window, probably resulting in implantation failure
            of the embryo.
REFERENCE   2  (bases 1 to 2643)
  AUTHORS   Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M,
            Kivioja T, Morgunova E and Taipale J.
  TITLE     DNA-dependent formation of transcription factor pairs alters their
            binding specificity
  JOURNAL   Nature 527 (7578), 384-388 (2015)
   PUBMED   26550823
REFERENCE   3  (bases 1 to 2643)
  AUTHORS   Duverger O, Zah A, Isaac J, Sun HW, Bartels AK, Lian JB, Berdal A,
            Hwang J and Morasso MI.
  TITLE     Neural crest deletion of Dlx3 leads to major dentin defects through
            down-regulation of Dspp
  JOURNAL   J Biol Chem 287 (15), 12230-12240 (2012)
   PUBMED   22351765
REFERENCE   4  (bases 1 to 2643)
  AUTHORS   Singh M, Del Carpio-Cano FE, Monroy MA, Popoff SN and Safadi FF.
  TITLE     Homeodomain transcription factors regulate BMP-2-induced
            osteoactivin transcription in osteoblasts
  JOURNAL   J Cell Physiol 227 (1), 390-399 (2012)
   PUBMED   21503878
  REMARK    GeneRIF: OA transcription is differentially regulated by Dlx3,
            Dlx5, and Msx2 during osteoblast differentiation.
REFERENCE   5  (bases 1 to 2643)
  AUTHORS   Nishiyama A, Xin L, Sharov AA, Thomas M, Mowrer G, Meyers E, Piao
            Y, Mehta S, Yee S, Nakatake Y, Stagg C, Sharova L, Correa-Cerro LS,
            Bassey U, Hoang H, Kim E, Tapnio R, Qian Y, Dudekula D, Zalzman M,
            Li M, Falco G, Yang HT, Lee SL, Monti M, Stanghellini I, Islam MN,
            Nagaraja R, Goldberg I, Wang W, Longo DL, Schlessinger D and Ko MS.
  TITLE     Uncovering early response of gene regulatory networks in ESCs by
            systematic induction of transcription factors
  JOURNAL   Cell Stem Cell 5 (4), 420-433 (2009)
   PUBMED   19796622
REFERENCE   6  (bases 1 to 2643)
  AUTHORS   Hassan MQ, Javed A, Morasso MI, Karlin J, Montecino M, van Wijnen
            AJ, Stein GS, Stein JL and Lian JB.
  TITLE     Dlx3 transcriptional regulation of osteoblast differentiation:
            temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins
            to chromatin of the osteocalcin gene
  JOURNAL   Mol Cell Biol 24 (20), 9248-9261 (2004)
   PUBMED   15456894
  REMARK    GeneRIF: Results describe gene regulation by Dlx3 in relation to
            that of Msx2 and Dlx5 during osteoblast differentiation.
REFERENCE   7  (bases 1 to 2643)
  AUTHORS   Morasso MI, Grinberg A, Robinson G, Sargent TD and Mahon KA.
  TITLE     Placental failure in mice lacking the homeobox gene Dlx3
  JOURNAL   Proc Natl Acad Sci U S A 96 (1), 162-167 (1999)
   PUBMED   9874789
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_220869.3, XM_001081312.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132263,
                              SAMD00132265 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2643
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..2643
                     /gene="Dlx3"
                     /note="distal-less homeobox 3"
                     /db_xref="GeneID:287638"
                     /db_xref="RGD:1304875"
     exon            1..510
                     /gene="Dlx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1049
                     /gene="Dlx3"
                     /codon_start=1
                     /product="homeobox protein DLX-3"
                     /protein_id="NP_001099302.1"
                     /db_xref="GeneID:287638"
                     /db_xref="RGD:1304875"
                     /translation="MSGSFDRKLSSILTDISSSLSCHAGSKDSPTLPESSVTDLGYYS
                     APQHDYYSGQPYGQTVNPYTYHHQFNLNGLAGTGAYSPKSEYTYGGSYRQYGAYREQP
                     LPAQDPVSVKEEPEAEVRMVNGKPKKVRKPRTIYSSYQLAALQRRFQKAQYLALPERA
                     ELAAQLGLTQTQVKIWFQNRRSKFKKLYKNGEVPLEHSPNNSDSMACNSPPSPALWDT
                     SSHSTPAPTRNPLPPPLPYSASPNYLDDPTNSWYHTQNLSGPHLQQQPPQPATLHHAS
                     PGPPPNPGAVY"
     exon            511..701
                     /gene="Dlx3"
                     /inference="alignment:Splign:2.1.0"
     exon            702..2643
                     /gene="Dlx3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacgctgag agaggcacgc agctactgac cgacgaccgg cgatggtcta ggcgcccctt
       61 ggccaccccc acccccgacg cgaccgcgtc ctgccctcgc cctctggaca cacaccccac
      121 ctgggctcct ccgtccgttc ggcgctcctc ggaggaagcc cgggggtgtt gcggcgctcg
      181 ccagcatgag cggctccttc gatcgcaagc tcagcagcat cctcaccgac atctccagct
      241 cgcttagctg ccatgcgggc tccaaggact cgcccaccct gcccgagtct tcggtcactg
      301 acctgggcta ttacagcgct ccccaacatg actactactc gggccagccc tacggccaga
      361 cggtgaaccc ctatacctac caccaccagt tcaatctcaa tgggctcgca ggcaccggcg
      421 cttactcgcc caagtcggaa tatacctacg ggggatccta ccgacagtat ggagcgtacc
      481 gggagcagcc tttgcctgcc caggacccag tgtcggtgaa agaggagccg gaagccgagg
      541 tacgcatggt gaacggcaag cccaagaagg tccgaaagcc gcgaacgatc tactccagct
      601 atcagctggc tgccctgcag cgccgtttcc agaaagccca gtatctggcc ttgcctgagc
      661 gcgccgagct agctgcacag ctgggcctca cacaaacaca ggtgaaaatc tggttccaga
      721 accgtcgctc caagttcaaa aagctctaca agaatgggga ggtgccactg gaacacagtc
      781 ccaacaacag cgattccatg gcctgcaact caccaccatc accggcactc tgggacacat
      841 cttcccattc cactccagcc cctacccgaa atccgctgcc cccaccgctc ccatacagtg
      901 cctcccccaa ctacctggac gaccccacca actcttggta ccacacacag aacctcagtg
      961 gaccccactt acagcagcag ccacctcagc cggccaccct gcaccatgcc tcccctgggc
     1021 ccccgcctaa ccctggggct gtgtactgag tacccacctg gcctgcaatc tcccacgaag
     1081 gacccccccc ccaggactaa ggcagaaggt gccctgtcct agagacactc aggaatcatc
     1141 gaggggcaca ggggaaagac tctcttcccc ctcccttgtc ccttcttcca ggggcccaag
     1201 aacctccaga tgagaaatgc atggaccaag gatgccccct taaaacaacc tccctccccc
     1261 tgcttagact ggggtgccct ccagatggag aggagttcca ccccaggggg gaaaggaagc
     1321 ccatgctctt tgctccagaa acccggattg cctctagatg gcttttcaaa tcaccttcca
     1381 gcttttcaaa cacagtagag acctccaaag tgggaaagcc agagtgtttg caggtctacc
     1441 tgtgctgggg caccaggggc catggattcc agcactgcca gagctaaagc accaggggca
     1501 acaacacctt cttgagccac tctttaaaga cattggacat accatcacgt ctgagcctca
     1561 agatgggggc ctgacctagc cccccactgt tctccagccc tcattaggat ttgagggtca
     1621 aaccaaagaa aactccccta aatgtgggaa ccttttgata tccagggctt tcaagggaag
     1681 aagtaaagga gccatctatc tctctgcccc ttccctgggg aagaggactg ttcatgtctt
     1741 ttcccaagga cccatttctt cttccatgta caggactttg cacaactctg gttttaaaag
     1801 ctgttgaaac ctaggacaac aatgggcatt gttaacagtt aggaccaaaa tccactcatc
     1861 tccgagcggg cagttctgct ctgccctgcc cccgctcacc ccttcatttt tctcccagta
     1921 agttggcagt ctggggggag gggtcaaacc cccaactctc tacagagata taccaggcaa
     1981 gaacaaaacc ccaaataccc gcttcaccgc agctttggga acagattgcg tccgctcccc
     2041 tgcaggatgc aagtgaggat ccaggagaca agaggaggtc tagaactcag tgccttaggg
     2101 gtaaggctgg cagcttgggc agctggtacc actgcctctc cctagcccag gcatcccccc
     2161 aaagctaact ttcttctgcc ccctgatgtg gtaaaacatc gaagaaagga gaggtaaaag
     2221 actatagttt tatatatata tatatatata tatatatata tatatacata tatgtatata
     2281 tatactatgg ggtttttgtt tttctttctt tctttctttc tttctttctt tctttctttc
     2341 tttctttttt ttttaaagag caaccaagag aagcagtctc ctcccttgtg gtttcctatt
     2401 tatgtgaccc tgttcctcct ggaccaatct ccctgtgtgt tgcaagcaga aagatggata
     2461 tgggctcctg ctggatttgg gtttcgtggg atgttcagga gcaaggagag atgtggtggg
     2521 tctccgagtc ccacctcaaa gggacaggaa tgaagtcagc tcccacccct cccccgcctt
     2581 cccatttctg ctttcttact ggaccagtct ttatatataa tgttaataat aaaaaaaaaa
     2641 aaa
//
