LOCUS       NM_001100531            2757 bp    mRNA    linear   ROD 04-FEB-2024
DEFINITION  Rattus norvegicus distal-less homeobox 1 (Dlx1), mRNA.
ACCESSION   NM_001100531 XM_001059233 XM_230987
VERSION     NM_001100531.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2757)
  AUTHORS   Bokenkamp,R., van Brempt,R., van Munsteren,J.C., van den
            Wijngaert,I., de Hoogt,R., Finos,L., Goeman,J., Groot,A.C.,
            Poelmann,R.E., Blom,N.A. and DeRuiter,M.C.
  TITLE     Dlx1 and Rgs5 in the ductus arteriosus: vessel-specific genes
            identified by transcriptional profiling of laser-capture
            microdissected endothelial and smooth muscle cells
  JOURNAL   PLoS One 9 (1), e86892 (2014)
   PUBMED   24489801
  REMARK    GeneRIF: Rgs5 and Dlx1 represent novel molecular targets for the
            regulation of ductus arteriosus maturation and closure.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2757)
  AUTHORS   Wang,B., Long,J.E., Flandin,P., Pla,R., Waclaw,R.R., Campbell,K.
            and Rubenstein,J.L.
  TITLE     Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in
            Dlx1/2 mutants
  JOURNAL   J Comp Neurol 521 (7), 1561-1584 (2013)
   PUBMED   23042297
REFERENCE   3  (bases 1 to 2757)
  AUTHORS   Delogu,A., Sellers,K., Zagoraiou,L., Bocianowska-Zbrog,A.,
            Mandal,S., Guimera,J., Rubenstein,J.L., Sugden,D., Jessell,T. and
            Lumsden,A.
  TITLE     Subcortical visual shell nuclei targeted by ipRGCs develop from a
            Sox14+-GABAergic progenitor and require Sox14 to regulate daily
            activity rhythms
  JOURNAL   Neuron 75 (4), 648-662 (2012)
   PUBMED   22920256
REFERENCE   4  (bases 1 to 2757)
  AUTHORS   Feng,L., Eisenstat,D.D., Chiba,S., Ishizaki,Y., Gan,L. and
            Shibasaki,K.
  TITLE     Brn-3b inhibits generation of amacrine cells by binding to and
            negatively regulating DLX1/2 in developing retina
  JOURNAL   Neuroscience 195, 9-20 (2011)
   PUBMED   21875655
REFERENCE   5  (bases 1 to 2757)
  AUTHORS   Petryniak,M.A., Potter,G.B., Rowitch,D.H. and Rubenstein,J.L.
  TITLE     Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate
            acquisition in the developing forebrain
  JOURNAL   Neuron 55 (3), 417-433 (2007)
   PUBMED   17678855
REFERENCE   6  (bases 1 to 2757)
  AUTHORS   Pleasure,S.J., Anderson,S., Hevner,R., Bagri,A., Marin,O.,
            Lowenstein,D.H. and Rubenstein,J.L.
  TITLE     Cell migration from the ganglionic eminences is required for the
            development of hippocampal GABAergic interneurons
  JOURNAL   Neuron 28 (3), 727-740 (2000)
   PUBMED   11163262
REFERENCE   7  (bases 1 to 2757)
  AUTHORS   Eisenstat,D.D., Liu,J.K., Mione,M., Zhong,W., Yu,G., Anderson,S.A.,
            Ghattas,I., Puelles,L. and Rubenstein,J.L.
  TITLE     DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal
            forebrain differentiation
  JOURNAL   J Comp Neurol 414 (2), 217-237 (1999)
   PUBMED   10516593
REFERENCE   8  (bases 1 to 2757)
  AUTHORS   Liu,J.K., Ghattas,I., Liu,S., Chen,S. and Rubenstein,J.L.
  TITLE     Dlx genes encode DNA-binding proteins that are expressed in an
            overlapping and sequential pattern during basal ganglia
            differentiation
  JOURNAL   Dev Dyn 210 (4), 498-512 (1997)
   PUBMED   9415433
REFERENCE   9  (bases 1 to 2757)
  AUTHORS   Qiu,M., Bulfone,A., Ghattas,I., Meneses,J.J., Christensen,L.,
            Sharpe,P.T., Presley,R., Pedersen,R.A. and Rubenstein,J.L.
  TITLE     Role of the Dlx homeobox genes in proximodistal patterning of the
            branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter
            morphogenesis of proximal skeletal and soft tissue structures
            derived from the first and second arches
  JOURNAL   Dev Biol 185 (2), 165-184 (1997)
   PUBMED   9187081
REFERENCE   10 (bases 1 to 2757)
  AUTHORS   Robel,L., Ding,M., James,A.J., Lin,X., Simeone,A., Leckman,J.F. and
            Vaccarino,F.M.
  TITLE     Fibroblast growth factor 2 increases Otx2 expression in precursor
            cells from mammalian telencephalon
  JOURNAL   J Neurosci 15 (12), 7879-7891 (1995)
   PUBMED   8613727
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 24, 2008 this sequence version replaced
            XM_001059233.1, XM_230987.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2757
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q23"
     gene            1..2757
                     /gene="Dlx1"
                     /note="distal-less homeobox 1"
                     /db_xref="GeneID:296500"
                     /db_xref="RGD:1309593"
     exon            1..862
                     /gene="Dlx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             550..1317
                     /gene="Dlx1"
                     /note="homeobox Dlx1"
                     /codon_start=1
                     /product="homeobox protein DLX-1"
                     /protein_id="NP_001094001.1"
                     /db_xref="GeneID:296500"
                     /db_xref="RGD:1309593"
                     /translation="MTMTTMPESLNSPVSGKAVFMEFGPPNQQMSPSPMSHGHYSMHC
                     LHSAGHSQPDGAYSSASSFSRPLGYPYVNSVSSHASSPYISSVQSYPGSASLAQSRLE
                     DPGADSEKSTVVEGGEVRFNGKGKKIRKPRTIYSSLQLQALNRRFQQTQYLALPERAE
                     LAASLGLTQTQVKIWFQNKRSKFKKLMKQGGAALEGSALANGRALSAGSPPVPPGWNP
                     NSSSGKGSGSSAGSYVPSYTSWYPSAHQEAMQQPQLM"
     exon            863..1062
                     /gene="Dlx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..2757
                     /gene="Dlx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggcgttgg gggcgggcga agggtgggga cagcaagggg gagggcgacg gcagggcgcg
       61 gctggttggt ttctggggcg ggaagcgcgc gagggaggcg ggaggctgga gtcgcgcgcc
      121 ttcgaggtcc cagcgcggac gccgcagccc attgtgcgtc ccgttccgcg cgctctgttg
      181 cagaggagcc ccggccggga cgtgtggacc cgactctccc caggcccggc cgcgtcgccc
      241 gctctagtcc agcagagccg gagcttctcg gaccaatccc cggtgattat gcaagagagc
      301 cgaccaatca gctccaccag ctcatgaata tttatgacct tggctgagtc aaagctttga
      361 accgagtttg gggagctcgg cagcatcatg cttagacttt tcaaagagac aaactccatt
      421 ttcttatgaa tggaaagtga aaacccctgt tccgcttaaa ttgggttcct tcctgtcctg
      481 agaaacatag agacccccaa aagggaagca gaggagaaaa agacccacac ccagaccccg
      541 cgagaagaga tgaccatgac caccatgcca gaaagtctca acagcccggt gtcgggcaag
      601 gctgtgttta tggagtttgg gccgcccaac cagcaaatgt ctccttctcc catgtcccac
      661 gggcactact ccatgcactg tttacactcg gcgggccatt cgcagcccga cggtgcctac
      721 agttcggcct catccttctc ccgaccgctg ggctacccct acgtcaactc ggtcagcagc
      781 cacgcgtcca gcccctacat cagttccgtg cagtcctacc ccggcagcgc cagcctcgcc
      841 cagagccgcc tggaggaccc aggggcggac tccgagaaga gcaccgtggt ggaaggcgga
      901 gaagtgcgct ttaacggcaa agggaaaaag atccgtaaac ccaggacaat ttattccagt
      961 ttgcagttgc aggctttgaa ccggaggttc caacaaactc agtacctagc tctgcctgag
     1021 agggcggagc tggcggcctc cttgggactc acacagactc aggtcaagat atggttccag
     1081 aacaaacgct ccaagttcaa gaagctgatg aagcaaggcg gggcagctct ggagggcagc
     1141 gcgctggcga atggcagggc cttgtctgcc ggctccccac cggtaccacc cggctggaat
     1201 ccgaattcct cctctgggaa gggctccggc agcagcgctg gctcctacgt ccccagctac
     1261 acgtcgtggt atccctcagc gcaccaagaa gctatgcagc agcctcaact gatgtgaggt
     1321 tatcagttcg cactcacccg cttcctgccc atctcccttg gcccggcccc tcccgcctcc
     1381 aggttcatcc actcattcgc acgccctggg ccggaaggag aagggcccaa gggcgagggc
     1441 gggggacgta aaaataaaag aaaaaggaac agtgaaggct tgctgcctcc tcggagcccc
     1501 taaaaatctg gcccagcgac ttttcagctc tgggcttgaa cctggtttgg gccacggtga
     1561 cagcagagtg acctcaaagc gcaggcacaa ccactggaga cagccagtgc aacaagacaa
     1621 gccgctggac ccgaccagac tctcagcttt gtgagactat caggaaaaaa aaattacgta
     1681 ggagggggaa atatgctctt ttttcggttc tgtccgtctt tgtctccttt ttgcaccgtc
     1741 tgtgcgccga agtcaaggtc ctcgtgtgtc tgctgtcctc tccaaaaagt caccagatct
     1801 gagccacact ggtctgccgg cagcccatca cgaaccctgg aacgcttttt ttctgaatgg
     1861 tcttcttccg ggccctgctt caccatctgt gtagcttgtt tgggcaatgg ggggaatcgg
     1921 agggaggggg gttaatttat tgaaaaacag acgctgagtg ttggccaatt ccaagttctc
     1981 tgagacatgg agtgggcact gtccaaacac actatttacc ttaaacacac cagaagaggg
     2041 aacaaggatg ggatggtggc tttttaaggt acctggtaac ttttgtactt tgttggaatg
     2101 gagaagtgga ggcagagtga tttgcatttt acacgaccca catgattaaa aaataacaaa
     2161 agaaatagtg aagtaaggaa agatatgtca agccaacaga atgttgtcaa aaacgtttgg
     2221 acaagaacac ccggccaaga agaaaaagca tactttgggc agcaagagag aggaccaagt
     2281 gggttttgga gagaaaataa tttgtcctgt gaaagcaccc caattccagg tcgcttgaaa
     2341 gtcagacaca agcagcttta aatgatcccc agtggctcga ccacagaaca caagtcatca
     2401 ccctgaacgc acagcctctg gtgcaggacc taatcgttgt acatattatt attgttattg
     2461 ttgttattaa ttattattat tgttctgtaa acacgttgca caagcttagc ctctttccgt
     2521 tccgtcgtgt gtggctgtaa accccaatgc tttgtgaaaa tgagaatctt gacattttac
     2581 ttgtgaaatt tggaaaatgt gaccgattga aatcaaccgt gttttgtgtt ctctatgtca
     2641 aagtttagtt ttatattgag aatgttaact tattgctttg tatctcgggg agtgggggaa
     2701 ctttgtaaat aagttataaa gtttctttga gacagtaaaa ttatggtttc aagaaag
//
