LOCUS       NM_001107760            3409 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus delta like canonical Notch ligand 4 (Dll4), mRNA.
ACCESSION   NM_001107760 XM_001080829 XM_230472
VERSION     NM_001107760.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3409)
  AUTHORS   Guo,X., Jiang,P., Pan,M., Ding,Y., Lin,Y., Jiang,T., Li,R.,
            Wang,W., Dai,Y., Wang,S., Cao,Y., Lin,H., Yang,M., Liu,W. and
            Tao,J.
  TITLE     Overexpression of miR-124 in astrocyte improves neurological
            deficits in rat with ischemic stroke via DLL4 modulation
  JOURNAL   Exp Neurol 370, 114571 (2023)
   PUBMED   37848121
  REMARK    GeneRIF: Overexpression of miR-124 in astrocyte improves
            neurological deficits in rat with ischemic stroke via DLL4
            modulation.
REFERENCE   2  (bases 1 to 3409)
  AUTHORS   Niu,H., Gao,N., Dang,Y., Guan,Y. and Guan,J.
  TITLE     Delivery of VEGF and delta-like 4 to synergistically regenerate
            capillaries and arterioles in ischemic limbs
  JOURNAL   Acta Biomater 143, 295-309 (2022)
   PUBMED   35301145
REFERENCE   3  (bases 1 to 3409)
  AUTHORS   Harvey,D.C., De Zoysa,P., Toubat,O., Choi,J., Kishore,J.,
            Tsukamoto,H. and Kumar,S.R.
  TITLE     Concomitant genetic defects potentiate the adverse impact of
            prenatal alcohol exposure on cardiac outflow tract maturation
  JOURNAL   Birth Defects Res 114 (3-4), 105-115 (2022)
   PUBMED   34859965
REFERENCE   4  (bases 1 to 3409)
  AUTHORS   Wang,S., Zhu,G., Jiang,D., Rhen,J., Li,X., Liu,H., Lyu,Y., Tsai,P.,
            Rose,Y., Nguyen,T., White,R.J., Pryhuber,G.S., Mariani,T.J., Li,C.,
            Mohan,A., Xu,Y. and Pang,J.
  TITLE     Reduced Notch1 Cleavage Promotes the Development of Pulmonary
            Hypertension
  JOURNAL   Hypertension 79 (1), 79-92 (2022)
   PUBMED   34739767
REFERENCE   5  (bases 1 to 3409)
  AUTHORS   Zhu,Y., Hu,J., Du,X., Fang,Q., Zhou,Y. and Chen,K.
  TITLE     Correlation of serum delta-like ligand-4 level with the severity of
            diabetic retinopathy
  JOURNAL   BMC Endocr Disord 21 (1), 157 (2021)
   PUBMED   34362349
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3409)
  AUTHORS   Noguera-Troise,I., Daly,C., Papadopoulos,N.J., Coetzee,S.,
            Boland,P., Gale,N.W., Lin,H.C., Yancopoulos,G.D. and Thurston,G.
  TITLE     Blockade of Dll4 inhibits tumour growth by promoting non-productive
            angiogenesis
  JOURNAL   Nature 444 (7122), 1032-1037 (2006)
   PUBMED   17183313
REFERENCE   7  (bases 1 to 3409)
  AUTHORS   Krebs,L.T., Shutter,J.R., Tanigaki,K., Honjo,T., Stark,K.L. and
            Gridley,T.
  TITLE     Haploinsufficient lethality and formation of arteriovenous
            malformations in Notch pathway mutants
  JOURNAL   Genes Dev 18 (20), 2469-2473 (2004)
   PUBMED   15466160
REFERENCE   8  (bases 1 to 3409)
  AUTHORS   Duarte,A., Hirashima,M., Benedito,R., Trindade,A., Diniz,P.,
            Bekman,E., Costa,L., Henrique,D. and Rossant,J.
  TITLE     Dosage-sensitive requirement for mouse Dll4 in artery development
  JOURNAL   Genes Dev 18 (20), 2474-2478 (2004)
   PUBMED   15466159
REFERENCE   9  (bases 1 to 3409)
  AUTHORS   Hozumi,K., Negishi,N., Suzuki,D., Abe,N., Sotomaru,Y., Tamaoki,N.,
            Mailhos,C., Ish-Horowicz,D., Habu,S. and Owen,M.J.
  TITLE     Delta-like 1 is necessary for the generation of marginal zone B
            cells but not T cells in vivo
  JOURNAL   Nat Immunol 5 (6), 638-644 (2004)
   PUBMED   15146182
REFERENCE   10 (bases 1 to 3409)
  AUTHORS   Shutter,J.R., Scully,S., Fan,W., Richards,W.G., Kitajewski,J.,
            Deblandre,G.A., Kintner,C.R. and Stark,K.L.
  TITLE     Dll4, a novel Notch ligand expressed in arterial endothelium
  JOURNAL   Genes Dev 14 (11), 1313-1318 (2000)
   PUBMED   10837024
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            [WARNING] On Jul 19, 2024 this sequence was replaced by
            NM_001107760.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001080829.1, XM_230472.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3409
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..3409
                     /gene="Dll4"
                     /note="delta like canonical Notch ligand 4"
                     /db_xref="GeneID:311332"
                     /db_xref="RGD:1309740"
     exon            1..381
                     /gene="Dll4"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..2373
                     /gene="Dll4"
                     /note="delta-like protein 4; delta4; drosophila Delta
                     homolog 4; delta-like 4"
                     /codon_start=1
                     /product="delta-like protein 4 precursor"
                     /protein_id="NP_001101230.1"
                     /db_xref="GeneID:311332"
                     /db_xref="RGD:1309740"
                     /translation="MTPGSRSACRWALLLLAVLWPQRAAGSGIFQLRLQEFANERGML
                     ANGRPCEPGCRTFFRICLKHYQATFSEGPCTFGNVSTPVLGTNSFVIRDKNSGSGRNP
                     LQLPFNFTWPGTFSLNIQAWHTPGDDLRPETSPGNSLISQIIIQGSLAVGKNWKSDEQ
                     NNTLTRLRYSYRVVCSDNYYGDSCSRLCKKRDDHFGHYECQPDGSLSCLPGWTGKYCD
                     QPICLSGCHEQNGYCSKPDECNCRPGWQGPLCNECIPHNGCRHGTCTIPWQCACDEGW
                     GGLFCDQDLNYCTHHSPCKNGSTCSNSGPRGYTCTCLPGYTGEHCELELSKCASNPCR
                     NGGSCKDHENSYHCLCPPGYYGQHCEHSTLTCADSPCFNGGSCRERNQGASYACECPP
                     NFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRTCRCRPGFTGTHCELHISDCARSPCA
                     HGGTCHDLENGPVCTCPAGFSGRRCEVRITNDACASGPCFNGATCYTGLSPNNFVCNC
                     PYGFVGSRCEFPVGLPPSFPWVAVSLGVGLVVLLVLLVMVAVAVRQLRLRRPDDDSRE
                     AMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKLQNHTLDYNLAPGFLGR
                     GSTPGKYPHSDKSLGEKVPLRLHSEKPACRISAICSPRDSMYQSVCLISEERNECVIA
                     TEV"
     exon            382..651
                     /gene="Dll4"
                     /inference="alignment:Splign:2.1.0"
     exon            652..709
                     /gene="Dll4"
                     /inference="alignment:Splign:2.1.0"
     exon            710..973
                     /gene="Dll4"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1034
                     /gene="Dll4"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1165
                     /gene="Dll4"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1335
                     /gene="Dll4"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1555
                     /gene="Dll4"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..2258
                     /gene="Dll4"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2367
                     /gene="Dll4"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..3409
                     /gene="Dll4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctgctcgc tggccaggaa cccgtggcca agagccgcag ccaaagcctc ttgggtgcag
       61 tgtactcccg cactagcccg cttgagaccc taggatttgc tccaggacac gtacttagag
      121 cagccaccgc ccagtcgccc tcacctggat tacctaccga ggcatcgagc agcggagttt
      181 tcgagaaagc gacgagggag cagcgtcccg agaggaatca gcttttcagg aactcggttg
      241 gcagacggac ttgcaggaga gcgacatccc aacaagcaga ttcagagccc ccgagtggag
      301 aggacacccc aagggatgac gcctgggtcc cggagcgcct gtcgctgggc gctactgctg
      361 ctggcggtcc tgtggccgca gcgcgcggcg ggctccggca tcttccagtt gcggctgcag
      421 gagttcgcca acgagcgcgg tatgctggcc aatgggcggc cctgcgagcc cggctgccgg
      481 actttcttcc gaatctgcct taagcattac caggcaacct tctccgaggg accctgcacc
      541 tttggcaatg tctccacgcc ggtattgggc accaactcct tcgtcatcag ggacaagaat
      601 agcggcagtg gtcgtaaccc tcttcaattg cccttcaatt ttacctggcc gggaaccttc
      661 tcactcaaca tccaagcttg gcacacgccg ggagacgacc tgcggccaga gacttcacca
      721 ggaaattcac ttatcagcca aatcatcatc caaggctccc ttgctgtggg taagaattgg
      781 aaatcagatg agcaaaataa caccctcaca agactgcgct actcttaccg ggtcgtctgc
      841 agcgacaact actatggaga tagctgttct cgcctgtgca agaagcgcga tgaccacttc
      901 ggacattatg agtgccaacc agatggcagc ctgtcctgcc tgccgggctg gactgggaaa
      961 tactgtgatc agcctatatg tctttctggc tgtcatgagc agaatggcta ctgcagcaag
     1021 ccagatgagt gcaactgccg tccaggttgg cagggcccct tatgcaatga atgtatcccc
     1081 cacaatggct gtcgtcatgg cacctgcacc atcccctggc aatgtgcctg cgatgagggc
     1141 tggggaggtc tgttttgtga ccaagatctt aattactgca ctcaccactc tccgtgcaag
     1201 aatggatcaa cttgctccaa cagtgggccg aggggctata cctgcacctg tctcccaggc
     1261 tacactggtg agcactgtga gctggaactc agcaagtgtg ccagcaaccc ctgtcgaaat
     1321 ggtggcagct gtaaggacca tgagaatagc taccactgcc tgtgtccccc gggctactat
     1381 ggccagcact gtgaacacag taccttgacc tgtgcggatt caccctgctt caatggaggc
     1441 tcctgccggg agcgcaacca gggggccagt tatgcctgcg agtgtccccc taacttcact
     1501 gggtccaact gtgagaagaa agttgacagg tgtaccagca acccctgtgc caatggaggt
     1561 cagtgcctga acagaggtcc aagccggacc tgccgctgtc gacctggatt cacaggcacc
     1621 cactgtgaac tgcacatcag cgattgtgcc cgaagccctt gtgcccatgg gggcacttgc
     1681 cacgatctgg agaacgggcc tgtgtgcacc tgccctgctg gcttttctgg caggcgctgc
     1741 gaggtgcgga taaccaacga cgcctgtgcc tcaggaccct gcttcaatgg ggccacttgc
     1801 tacactggcc tctccccaaa caactttgtc tgcaactgtc cttatggctt tgtgggcagc
     1861 cgctgcgagt ttcccgtggg cttgccaccc agcttcccct gggtagctgt ctccctgggt
     1921 gtggggctgg tggtactgct ggtgttgctg gtcatggtgg cagtggctgt gcggcagctg
     1981 cggcttcgga ggcccgatga cgacagcagg gaagccatga acaatttgtc agacttccag
     2041 aaggacaacc taatccctgc tgcccagctc aagaacacaa accagaagaa ggagctggaa
     2101 gtggattgtg gcctggacaa gtccaactgt ggcaaactgc agaaccacac actggactat
     2161 aatctggccc caggattcct ggggcggggg agcacgcctg ggaagtatcc tcacagcgac
     2221 aagagtttag gagagaaggt gccacttcgg ttacacagtg aaaagccggc atgtcgaata
     2281 tcagcgatat gctcccccag ggactctatg taccagtcag tatgtttgat atcagaagag
     2341 aggaacgaat gtgtcattgc cacagaggta taaggcagga gcctactcag acacccagct
     2401 tcggcccagc agctgggcct tccttctgca ttgtttacat tgcatcctgg atgggacatc
     2461 tttagtatgc acagtgctgc tctgaggagg aggaggaaga agaggagaag gaggaggaat
     2521 ggcatgaact ggacagactg tgaacctgcc cagagtcgag ccacttctgc acaccttcag
     2581 gagtctgtct ggcctcagat gggcagcgcc atcaagggaa gagtcaaggg gccagaggaa
     2641 catcagttga gctgatatct aaggtgcctc ttggacttgg acttgctctg ccaacagtgg
     2701 tcatcgtgga gctcttgact gttctccaga gagtggcagt ggccctagtg ggtcttggcg
     2761 ctgctgtagc tcctgtgggc atctgtattt ccaaagtgcc tttgcccaga ctccatcctt
     2821 acagctgggc cccaatgaga aagcagagag gagacttgca agggacaggc ctcctgtagg
     2881 cagaacagcc ttggagtctg gcatttagca ggagctaccc tgcaggtgag gagagcctga
     2941 gggggctggt gtgaatctcg cctctgacca cagcaggtgg ggtgccacct acaacctctg
     3001 ggcgagagtt ggtcctctcc ctggtcctgg tgcctctggg ctcatgtgag cagatgagtt
     3061 tagggccccc tttgccagcc aggggtacag gcctaactgg ggagctcagg gcctttatgc
     3121 taaaactcca ataagggaga gaggggtggt gctgtggcct aggcccttcc ttccctcata
     3181 cccatttctg tgcccttgag cctgggctct accagtgccc actgctgccc cgagaccaac
     3241 cttgaagccg atcttcaaaa atcaataata tgaggttttg ttttgttttg tagtttattt
     3301 tggaatctag tattttgata atttaagaat cagaagcact ggcctttcta cattttataa
     3361 cattattttg tatataatgt gtatttataa tatggaacag atgtgtaca
//
