LOCUS       NM_053666               1972 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus delta like canonical Notch ligand 3 (Dll3), mRNA.
ACCESSION   NM_053666
VERSION     NM_053666.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1972)
  AUTHORS   Fiuza,U.M. and Arias,A.M.
  TITLE     Cell and molecular biology of Notch
  JOURNAL   J Endocrinol 194 (3), 459-474 (2007)
   PUBMED   17761886
  REMARK    Review article
REFERENCE   2  (bases 1 to 1972)
  AUTHORS   Ladi,E., Nichols,J.T., Ge,W., Miyamoto,A., Yao,C., Yang,L.T.,
            Boulter,J., Sun,Y.E., Kintner,C. and Weinmaster,G.
  TITLE     The divergent DSL ligand Dll3 does not activate Notch signaling but
            cell autonomously attenuates signaling induced by other DSL ligands
  JOURNAL   J Cell Biol 170 (6), 983-992 (2005)
   PUBMED   16144902
REFERENCE   3  (bases 1 to 1972)
  AUTHORS   Kusumi,K., Mimoto,M.S., Covello,K.L., Beddington,R.S., Krumlauf,R.
            and Dunwoodie,S.L.
  TITLE     Dll3 pudgy mutation differentially disrupts dynamic expression of
            somite genes
  JOURNAL   Genesis 39 (2), 115-121 (2004)
   PUBMED   15170697
REFERENCE   4  (bases 1 to 1972)
  AUTHORS   Irvin,D.K., Nakano,I., Paucar,A. and Kornblum,H.I.
  TITLE     Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3
            expression during late embryonic and postnatal brain development
            suggest multiple functional roles in progenitors and differentiated
            cells
  JOURNAL   J Neurosci Res 75 (3), 330-343 (2004)
   PUBMED   14743446
REFERENCE   5  (bases 1 to 1972)
  AUTHORS   Zhang,N., Norton,C.R. and Gridley,T.
  TITLE     Segmentation defects of Notch pathway mutants and absence of a
            synergistic phenotype in lunatic fringe/radical fringe double
            mutant mice
  JOURNAL   Genesis 33 (1), 21-28 (2002)
   PUBMED   12001066
REFERENCE   6  (bases 1 to 1972)
  AUTHORS   Dunwoodie,S.L., Clements,M., Sparrow,D.B., Sa,X., Conlon,R.A. and
            Beddington,R.S.
  TITLE     Axial skeletal defects caused by mutation in the spondylocostal
            dysplasia/pudgy gene Dll3 are associated with disruption of the
            segmentation clock within the presomitic mesoderm
  JOURNAL   Development 129 (7), 1795-1806 (2002)
   PUBMED   11923214
REFERENCE   7  (bases 1 to 1972)
  AUTHORS   Sparrow,D.B., Clements,M., Withington,S.L., Scott,A.N., Novotny,J.,
            Sillence,D., Kusumi,K., Beddington,R.S. and Dunwoodie,S.L.
  TITLE     Diverse requirements for Notch signalling in mammals
  JOURNAL   Int J Dev Biol 46 (4), 365-374 (2002)
   PUBMED   12141422
REFERENCE   8  (bases 1 to 1972)
  AUTHORS   Bulman,M.P., Kusumi,K., Frayling,T.M., McKeown,C., Garrett,C.,
            Lander,E.S., Krumlauf,R., Hattersley,A.T., Ellard,S. and
            Turnpenny,P.D.
  TITLE     Mutations in the human delta homologue, DLL3, cause axial skeletal
            defects in spondylocostal dysostosis
  JOURNAL   Nat Genet 24 (4), 438-441 (2000)
   PUBMED   10742114
REFERENCE   9  (bases 1 to 1972)
  AUTHORS   Dunwoodie,S.L., Henrique,D., Harrison,S.M. and Beddington,R.S.
  TITLE     Mouse Dll3: a novel divergent Delta gene which may complement the
            function of other Delta homologues during early pattern formation
            in the mouse embryo
  JOURNAL   Development 124 (16), 3065-3076 (1997)
   PUBMED   9272948
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053666.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF084576.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                JAXUCZ010000001.1  92697244-92697316   c
            74-355              JAXUCZ010000001.1  92696830-92697111   c
            356-413             JAXUCZ010000001.1  92695806-92695863   c
            414-668             JAXUCZ010000001.1  92693924-92694178   c
            669-886             JAXUCZ010000001.1  92693574-92693791   c
            887-1109            JAXUCZ010000001.1  92691986-92692208   c
            1110-1689           JAXUCZ010000001.1  92690123-92690702   c
            1690-1774           JAXUCZ010000001.1  92689892-92689976   c
            1775-1972           JAXUCZ010000001.1  92689577-92689774   c
FEATURES             Location/Qualifiers
     source          1..1972
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1972
                     /gene="Dll3"
                     /note="delta like canonical Notch ligand 3"
                     /db_xref="GeneID:114125"
                     /db_xref="RGD:70953"
     exon            1..73
                     /gene="Dll3"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1780
                     /gene="Dll3"
                     /note="delta-like protein 3; delta3; drosophila Delta
                     homolog 3"
                     /codon_start=1
                     /product="delta-like protein 3 precursor"
                     /protein_id="NP_446118.2"
                     /db_xref="GeneID:114125"
                     /db_xref="RGD:70953"
                     /translation="MVSLQVSSLPQTLILAFLLPQALPAGVFELQIHSFGPGPGPGTP
                     RSPCNARGPCRLFFRVCLKPGVSQEAAESLCALGAALSTSGPVYTEQPGVPAAALSLP
                     DGLVRVPFRDAWPGTFSLIIETWREQLGERAAGPAWNLLARVAGRRRLAAGAPWARDV
                     QRTGAWELHFSYRARCEPPAVGAACARLCRSRSAPSRCGPGLRPCTPFPDECEAPRES
                     LTVCRAGCSPEHGYCEEPDECHCLEGWTGPLCTVPVSTSSCLNSRVSGPAGTGCLLPG
                     PGPCDGNPCANGGSCSETPGSFECACPRGFYGPRCEVSGVTCADGPCFNGGLCVGGED
                     PDSAYVCHCPPAFQGSNCERRVDRCSLQPCQNGGLCLDLGHALRCRCRAGFAGPRCEH
                     DLDDCAGRACANGGTCVEGGGARRCSCALGFGGRDCRERADPCASRPCAHGGRCYAHF
                     SGLVCACAPGYMGVRCEFAVRPDGADAVPAAPRGLRQADSQRFLLPPALGLLAAAALA
                     GAALLLIHVRRRGPGRDTGTRLLSGTREPSVHTLPDALNNLRLQDGAGDGPSSSADWN
                     HPEDGDSRSIYVIPAPSIYAREA"
     exon            74..355
                     /gene="Dll3"
                     /inference="alignment:Splign:2.1.0"
     exon            356..413
                     /gene="Dll3"
                     /inference="alignment:Splign:2.1.0"
     exon            414..668
                     /gene="Dll3"
                     /inference="alignment:Splign:2.1.0"
     exon            669..886
                     /gene="Dll3"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1109
                     /gene="Dll3"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1689
                     /gene="Dll3"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1774
                     /gene="Dll3"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1972
                     /gene="Dll3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccaaaagca atggtctccc tgcaggtgtc ttcacttccc cagacgctga tcctggcttt
       61 tctccttccc caggcactgc cagctggtgt cttcgagcta caaattcatt ctttcgggcc
      121 aggaccaggc cccgggaccc cacgctcccc ctgcaacgcc cgaggccctt gccgcctctt
      181 cttcagggtc tgcctgaaac cgggagtctc ccaggaggcc gccgagtccc tgtgcgccct
      241 gggcgcagca ctgagcacga gcggcccggt ctacacggag cagcctggag tgccagcggc
      301 tgccttgtcg ttgcctgatg gcctcgtgcg tgtgcctttc cgcgatgcct ggccgggcac
      361 cttttccctc atcattgaaa cctggagaga gcagctggga gagcgtgctg cagggcccgc
      421 ctggaaccta ttagcgcgtg tggccggtcg cagacgcctg gctgctggag ccccgtgggc
      481 ccgcgatgtg cagcgcacag gcgcatggga gttgcacttc tcataccgcg cgcgctgtga
      541 gccccctgcg gttggggccg cctgcgcgcg cctgtgccgc tcgcgcagcg ccccctcgcg
      601 gtgtggccca ggactgcgcc cctgcacgcc attcccagac gagtgtgaag ccccgcgtga
      661 gtccctaacc gtatgtcgag cgggctgcag ccctgagcac ggctactgtg aagaacctga
      721 cgaatgccat tgcctggagg gctggactgg acccctctgc acggtccctg tctccaccag
      781 cagctgcctg aactcccggg tctctggtcc tgccggcact ggatgccttt tacctgggcc
      841 tggaccctgt gatgggaacc catgtgccaa tgggggcagc tgtagtgaaa ccccgggctc
      901 ctttgaatgt gcctgtcccc ggggattcta tgggcctcga tgtgaggtga gcggggtgac
      961 atgcgcagat ggaccctgct tcaatggcgg cttgtgtgtt ggcggtgaag atcctgactc
     1021 tgcctatgtc tgtcactgcc cacctgcttt ccaaggctct aactgtgaga ggagggtgga
     1081 ccgctgtagc ctgcagcctt gtcagaatgg cggcctctgc cttgacctgg gacatgcgct
     1141 gcgctgccgc tgtcgcgcgg gattcgccgg gccacgctgc gagcacgacc tggacgactg
     1201 cgccggccgc gcctgtgcca acggcggcac gtgcgtggag ggcggcggcg cgcgccgctg
     1261 ctcgtgtgcg ctgggcttcg gcgggcgcga ctgtcgggaa cgcgcggacc cctgcgcctc
     1321 tcgcccctgc gcccatggag gccgttgcta cgcccacttc tccggccttg tctgcgcctg
     1381 cgcgcccggc tacatgggtg tgagatgcga gttcgctgtg cgccccgacg gcgcggacgc
     1441 cgtgcccgcg gctccgcggg gcctgaggca ggctgactca cagcgcttcc ttctgcctcc
     1501 cgccttgggg ctgctggcgg ccgcagcttt ggccggcgcc gctctcttgc tcatccacgt
     1561 tcgccgccga ggtcctggcc gggatactgg gactcgcctg ctttccggga cccgggagcc
     1621 ttcggtccac acgctcccgg atgcactcaa caacctgagg ttacaagacg gtgctgggga
     1681 tggccccagc tcgtcggctg actggaatca tcccgaagat ggggactctc gatctattta
     1741 tgtcatacca gccccttcca tttacgcacg agaggcctga tgctgctcct tctctgccat
     1801 cgtctggaga tggagcctga atgattttat ttgctttgtg gtgtgtccaa tccctgcccc
     1861 acaccgactg gaggctgttt aatagggctt tattgtacat attgcttatt tataacctag
     1921 tttttgttat cgccccagag acatctataa aggttcttat tttgatcaac ta
//
