LOCUS       NM_032063               3117 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus delta like canonical Notch ligand 1 (Dll1), mRNA.
ACCESSION   NM_032063
VERSION     NM_032063.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3117)
  AUTHORS   Kohara,Y., Kitazawa,S., Kitazawa,R., Haraguchi,R., Arai,K.,
            Amasaki,H. and Soeta,S.
  TITLE     Localization of DLL1- and NICD-positive osteoblasts in cortical
            bone during postnatal growth in rats
  JOURNAL   Biochem Biophys Res Commun 529 (2), 186-190 (2020)
   PUBMED   32703409
  REMARK    GeneRIF: Localization of DLL1- and NICD-positive osteoblasts in
            cortical bone during postnatal growth in rats.
REFERENCE   2  (bases 1 to 3117)
  AUTHORS   Jiang,S., Da,Y., Han,S., He,Y. and Che,H.
  TITLE     Notch ligand Delta-like1 enhances degranulation and cytokine
            production through a novel Notch/Dok-1/MAPKs pathway in vitro
  JOURNAL   Immunol Res 66 (1), 87-96 (2018)
   PUBMED   29181775
  REMARK    GeneRIF: these results showed that Dll1 enhanced RBL-2H3 cell
            degranulation and cytokine production via a novel Notch/downstream
            of tyrosine kinases 1 (Dok-1)/MAPKs pathway, suggesting Notch
            signaling was a key mediator in the effect phase of food allergy
REFERENCE   3  (bases 1 to 3117)
  AUTHORS   Kakuda,S. and Haltiwanger,R.S.
  TITLE     Deciphering the Fringe-Mediated Notch Code: Identification of
            Activating and Inhibiting Sites Allowing Discrimination between
            Ligands
  JOURNAL   Dev Cell 40 (2), 193-201 (2017)
   PUBMED   28089369
REFERENCE   4  (bases 1 to 3117)
  AUTHORS   Preusse,K., Tveriakhina,L., Schuster-Gossler,K., Gaspar,C.,
            Rosa,A.I., Henrique,D., Gossler,A. and Stauber,M.
  TITLE     Context-Dependent Functional Divergence of the Notch Ligands DLL1
            and DLL4 In Vivo
  JOURNAL   PLoS Genet 11 (6), e1005328 (2015)
   PUBMED   26114479
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3117)
  AUTHORS   Czajkowski,M.T., Rassek,C., Lenhard,D.C., Brohl,D. and
            Birchmeier,C.
  TITLE     Divergent and conserved roles of Dll1 signaling in development of
            craniofacial and trunk muscle
  JOURNAL   Dev Biol 395 (2), 307-316 (2014)
   PUBMED   25220152
REFERENCE   6  (bases 1 to 3117)
  AUTHORS   Gray,G.E., Mann,R.S., Mitsiadis,E., Henrique,D., Carcangiu,M.L.,
            Banks,A., Leiman,J., Ward,D., Ish-Horowitz,D. and
            Artavanis-Tsakonas,S.
  TITLE     Human ligands of the Notch receptor
  JOURNAL   Am J Pathol 154 (3), 785-794 (1999)
   PUBMED   10079256
REFERENCE   7  (bases 1 to 3117)
  AUTHORS   Mitsiadis,T.A., Fried,K. and Goridis,C.
  TITLE     Reactivation of Delta-Notch signaling after injury: complementary
            expression patterns of ligand and receptor in dental pulp
  JOURNAL   Exp Cell Res 246 (2), 312-318 (1999)
   PUBMED   9925746
REFERENCE   8  (bases 1 to 3117)
  AUTHORS   Mitsiadis,T.A., Hirsinger,E., Lendahl,U. and Goridis,C.
  TITLE     Delta-notch signaling in odontogenesis: correlation with
            cytodifferentiation and evidence for feedback regulation
  JOURNAL   Dev Biol 204 (2), 420-431 (1998)
   PUBMED   9882480
REFERENCE   9  (bases 1 to 3117)
  AUTHORS   Lewis,A.K., Frantz,G.D., Carpenter,D.A., de Sauvage,F.J. and
            Gao,W.Q.
  TITLE     Distinct expression patterns of notch family receptors and ligands
            during development of the mammalian inner ear
  JOURNAL   Mech Dev 78 (1-2), 159-163 (1998)
   PUBMED   9858718
REFERENCE   10 (bases 1 to 3117)
  AUTHORS   Lindsell,C.E., Boulter,J., diSibio,G., Gossler,A. and Weinmaster,G.
  TITLE     Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3
            genes identify ligand-receptor pairs that may function in neural
            development
  JOURNAL   Mol Cell Neurosci 8 (1), 14-27 (1996)
   PUBMED   8923452
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_032063.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U78889.2, SRR26360186.1272750.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               JAXUCZ010000001.1  64992937-64993274   c
            339-632             JAXUCZ010000001.1  64992417-64992710   c
            633-693             JAXUCZ010000001.1  64991675-64991735   c
            694-951             JAXUCZ010000001.1  64991214-64991471   c
            952-1012            JAXUCZ010000001.1  64989408-64989468   c
            1013-1143           JAXUCZ010000001.1  64988693-64988823   c
            1144-1313           JAXUCZ010000001.1  64988401-64988570   c
            1314-1530           JAXUCZ010000001.1  64988069-64988285   c
            1531-2305           JAXUCZ010000001.1  64986182-64986956   c
            2306-2423           JAXUCZ010000001.1  64985951-64986068   c
            2424-3117           JAXUCZ010000001.1  64985161-64985854   c
FEATURES             Location/Qualifiers
     source          1..3117
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..3117
                     /gene="Dll1"
                     /note="delta like canonical Notch ligand 1"
                     /db_xref="GeneID:84010"
                     /db_xref="RGD:70949"
     exon            1..338
                     /gene="Dll1"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..2429
                     /gene="Dll1"
                     /note="delta-like protein 1; delta1; drosophila Delta
                     homolog 1"
                     /codon_start=1
                     /product="delta-like protein 1 precursor"
                     /protein_id="NP_114452.2"
                     /db_xref="GeneID:84010"
                     /db_xref="RGD:70949"
                     /translation="MGRRSALALAVVSALLCQVWSSGVFELKLQEFVNKKGLLGNRNC
                     CRGGSGPPCACRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGAGIDPA
                     FSNPIRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLTTQRHLTVGEEWSQ
                     DLHSSGRTDLRYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKMCDPGWKGQ
                     YCTDPICLPGCDDQHGYCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQ
                     EGWGGLFCNQDLNYCTHHKPCRNGATCTNTGQGSYTCSCRPGYTGANCELEVDECAPS
                     PCRNGGSCTDLEDSYSCTCPPGFYGKVCELSAMTCADGPCFNGGRCSDNPDGGYTCHC
                     PAGFSGFNCEKKIDLCSSSPCSNGAKCVDLGNSYLCRCQTGFSGRYCEDNVDDCASSP
                     CANGGTCRDSVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHQRGQRYMCECAQ
                     GYGGANCQFLLPEPPPDLIVAAQGGSFPWVAVCAGVVLVLLLLLGCAAVVVCVRLKLQ
                     KHQPPPDPCGGETETMNNLANCQREKDVSVSIIGATQIKNTNKKADFHGDHGADKSSF
                     KARYPTVDYNLIRDLKGDEATVRDAHSKRDTKCQSQGSVGEEKSTSTLRGGEVPDRKR
                     PESVYSTSKDTKYQSVYVLSAEKDECVIATEV"
     exon            339..632
                     /gene="Dll1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..693
                     /gene="Dll1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..951
                     /gene="Dll1"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1012
                     /gene="Dll1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1143
                     /gene="Dll1"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1313
                     /gene="Dll1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1530
                     /gene="Dll1"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..2305
                     /gene="Dll1"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2423
                     /gene="Dll1"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..3117
                     /gene="Dll1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacaaaacca gaaagcaggc gaccctcact tacccgtgga ctggaagcca gaagaagagg
       61 aaaccgaaag ttgtcctttc tcagtgcctc gcagagctct tgtcagggac atagctgtag
      121 caccgcaccc tcctgaagcg acctggcccg atatcacacc tggagccgag aggcgccttt
      181 ccaccagtgc tcctcgggtc acatagactt tccgggcatc cctgggtctt tgaagaagaa
      241 agaaaagagg atactctagg agagcaaggg cgtccagcgg taccatgggc cgtcggagcg
      301 cgctagccct tgccgtggtc tcagccctgc tgtgccaggt ctggagctct ggcgtatttg
      361 agctgaagct gcaggagttc gtcaacaaga aggggctgct ggggaaccgc aactgctgcc
      421 gcgggggctc tggcccgccg tgcgcctgca ggaccttctt tcgcgtatgc ctcaagcatt
      481 accaggccag cgtgtccccg gagccaccct gcacctacgg cagtgcggtc acgccagtgc
      541 tgggtgtcga ctccttcagc ctgcctgatg gcgcaggcat cgaccccgcc ttcagcaacc
      601 ccatccgatt ccccttcgga ttcacctggc caggtacctt ctctctgatc attgaagccc
      661 tccacacaga ttctcctgac gacctcgcaa cagaaaaccc agaaagactc atcagccgcc
      721 tgaccacaca gaggcacctc actgtgggag aagagtggtc tcaggacctt cacagtagcg
      781 gccgcacaga cctccgctac tcttaccggt ttgtgtgtga tgaacactac tatggagaag
      841 gctgctccgt gttctgccga ccgcgggatg atgcctttgg ccacttcacc tgcggggaga
      901 gaggggagaa gatgtgcgac cctggctgga aaggccagta ctgcactgac cccatttgtc
      961 tgccaggctg tgatgaccaa catggatatt gtgacaaacc gggggaatgc aagtgcagag
     1021 ttggctggca gggccgctac tgcgatgaat gcatccgata cccaggctgt ctccatggta
     1081 cctgccagca gccctggcag tgtaactgcc aggaaggctg ggggggcctc ttctgcaacc
     1141 aggatctgaa ctactgcact caccataagc catgcaggaa cggagccacc tgcaccaaca
     1201 cgggccaggg gagctacaca tgctcttgcc gacccgggta tacaggggcc aactgtgagc
     1261 tggaggtaga tgagtgtgct cccagcccct gcaggaatgg agggagctgc acggatcttg
     1321 aggacagcta ctcttgcacc tgccctcctg gcttctatgg caaggtctgt gagctgagcg
     1381 ccatgacgtg tgcagatggt ccttgcttca atgggggacg atgttcggat aaccccgatg
     1441 gaggctacac ctgccattgc cctgcgggct tctctggctt caactgtgag aagaagattg
     1501 atctctgtag ctcttcccct tgttctaacg gtgccaagtg tgtggacctc ggcaactcct
     1561 acctgtgccg atgtcagact ggcttctccg ggaggtactg cgaggacaat gtggatgact
     1621 gtgcctcttc tccctgtgca aacgggggca cctgccggga cagtgtgaac gatttctcct
     1681 gtacctgccc acctggctac acaggcagga actgcagcgc ccctgtcagc aggtgtgagc
     1741 atgcaccctg tcataacggg gccacctgcc accagagggg ccaacgctac atgtgtgagt
     1801 gcgcccaggg ctatggcggc gccaactgcc agttcctgct ccctgagcca ccaccagacc
     1861 tcatagtggc ggcccagggc gggtccttcc cctgggtggc tgtgtgtgcc ggggtggtgc
     1921 ttgtcctcct gctgctgctg ggctgtgctg ctgtggtggt ctgcgtccgg ctgaagctac
     1981 agaaacacca gcctccgcct gatccttgcg ggggagagac agagaccatg aacaacctag
     2041 ccaattgcca gcgtgagaag gatgtttctg ttagcatcat tggggctaca cagatcaaga
     2101 acaccaacaa gaaggcggac tttcatgggg accatggtgc tgacaagagc agctttaagg
     2161 cccgataccc cactgtggac tataacctca ttcgagacct caagggagat gaagccacgg
     2221 tcagggatgc acacagcaaa cgtgacacca agtgccagtc acagggctct gtaggagaag
     2281 agaagagcac ctcaacgctc aggggtgggg aggttcccga cagaaaaagg cccgaatctg
     2341 tctactctac ttcaaaggac accaagtacc agtcggtgta tgttctatct gcagaaaagg
     2401 atgagtgtgt tatagcgact gaggtttaag gtggaagtga tgtggcaaag ttcccatttc
     2461 tcttaaataa aattccaagg atatagcccc gaggaatgct gctgagagag gaaagggaga
     2521 ggaaacccca gggactgctg ctgagaaaca gactcaggcg gagctggttc tctcggagtt
     2581 agcagaggcg ccggacactg ccagcccagg cgttggctgc cgctgtactg cctgctggat
     2641 gttcccgttg cactatggac agttgctttg aagagtatat atttaaatgg acgagtgact
     2701 tgattcacac aggaagcacg cactgccgga catgtctatc ttggattact atgagccagt
     2761 ctttccttga actagaaaca caactgcctt tattgtcctt tttgatactg aaatgtggtt
     2821 tgtttttttt ttttttctag aaggggaaaa aaaacgtgtg ttattttttt ggatttgtaa
     2881 aaatattttt catgatatct gtaaagcttg agtattttgt gatgttcatt ttttttataa
     2941 tttaaatttt tggtaaatat gtacaaaggc acttcgggtc tatgtgacta tatttttttg
     3001 tatataaatg tatttatgga atattgtgca aatgttattt gagttttttt tactgttttg
     3061 ttaatgaaga aattcatttt aaaaatattt ttccaaaata aatataatga actacaa
//
